Version 2 of S1500+ Human Gene Set Now Available
Contributor: Catherine Sprankle, NICEATM
National Institute of Environmental Health Sciences and National Toxicology Program (NTP) scientists along with Tox21 partners have developed a list of environmentally responsive genes to be used in toxicogenomics approaches to screening large numbers of chemicals. Genes on the list were identified through both bioinformatics approaches and experimental data establishing certain genes’ importance to responses to toxicity. The recently updated “S1500+” gene list contains approximately 2750 genes that will be used to evaluate transcriptional changes in human cells or tissues in response to chemical exposure. These genes may also be useful for biomarker development and basic research efforts. More information and the gene list are available on the NTP website.