Kleinstreuer Appointed NICEATM Deputy Director

Home / Community Blog / Kleinstreuer Appointed NICEATM Deputy Director

Community Blog

Kleinstreuer Appointed NICEATM Deputy Director

Congratulations to Nicole Kleinstreuer!

From: NICEATM News – January 22, 2016

Nicole Kleinstreuer, Ph.D., has been named deputy director of NICEATM. Kleinstreuer most recently worked for ILS, the NICEATM support contractor, where she led the NICEATM computational toxicology group. In her new role as NICEATM deputy director she will continue to lead NICEATM computational toxicology projects, as well as interacting with NICEATM’s U.S. and international partners and stakeholders.

Kleinstreuer’s research focuses on mathematical and computational modeling of biological systems and those systems’ susceptibility to perturbations that result in adverse health outcomes. She was a key contributor to a strategy that combines in vitro high throughput assays and computational models for measuring estrogen receptor bioactivity (described in Browne et al., 2015), which has been accepted by the U.S. Environmental Protection Agency (EPA) as an alternative to three existing Tier 1 tests in the Endocrine Disruptor Screening Program. She was also lead author on the 2014 Nature Biotechnology paper, “Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms,” recognized as the best paper of 2014 by the Society of Toxicology’s Biotechnology Specialty Section.

A native of Raleigh, North Carolina, Kleinstreuer received her Ph.D. in biomedical engineering from the University of Canterbury in Christchurch, New Zealand, and B.S. degrees in mathematics and biomedical engineering from the University of North Carolina at Chapel Hill (UNC-CH). Prior to joining ILS, she completed postdoctoral training at the EPA’s National Center for Computational Toxicology. Kleinstreuer also maintains an adjunct faculty appointment at the Eshelman School of Pharmacy at UNC-CH.