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Improved in vitro and in vivo concordance in gene expression using co-culture models

Researchers from West Virginia University and the National Institute for Occupational Safety and health (NIOSH), who elucidated toxicity pathways involved in mouse pulmonary exposures to multi-walled carbon nanotubes in previous publications, have now begun to investigate the use of in vitro cellular models for assessing nanoparticle toxicity. In a recent publication in the journal Toxicology, […]
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“Systematic review and evidence integration for literature-based environmental health science assessments”

The use of systematic review is gaining widespread regulatory use as a means of integrating, evaluating, and translating existing evidence on a variety of human health issues, and for potentially reducing the need for additional studies. The authors of a recent publication in Environmental Health Perspectives note that there is also “increasing interest in applying […]
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“Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe”

In this paper published recently in Regulatory Toxicology and Pharmacology, Marie-Jeanne W.A. Schiffelers and co-authors reconstruct and analyze the process of regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study as a replacement for the two generation study. (Disclosure: AltTox Management Team member Bas J. Blaauboer is one of the co-authors on […]
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Matrix properties can alter cellular biological function through physical changes in the cells: Matrix influence on human cell motility

Article citation: Petrie, R.J., Koo, H., & Yamada, K.M. (August 29, 2014). Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science 345 (6200), pp. 1062-1065. Petrie, et al. (2012) had previously observed different mechanisms of cell movement in primary human fibroblasts, depending upon the matrix on which the […]
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