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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
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Please report offensive or inappropriate content to info@alttox.org

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Application of animal-free antibodies: A free webinar

* Webinar co-organized by the US National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), the PETA International Science Consortium Ltd., and the European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM). On October 15, Dr. Giulio Russo (Abcalis) will discuss the replacement of animal serum-derived secondary antibodies with […]
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Free webinars on the advantages, applications, and availability of animal-free antibodies

Join us for these free upcoming webinars on the scientific and economic advantages of animal-free antibodies, their recent novel applications, and services to produce recombinant antibodies. Date: September 16, 2020 Time: 10:00–11:00 am EDT (4:00–5:00 pm CEST) More information and registration link here: https://www.piscltd.org.uk/antibody-webinars/ Dr. Alison Gray (Afability) will discuss how animal-free antibodies are developed, […]
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Animal-free antibody webinar series

Join us on July 23 to learn more about how animal-free recombinant antibodies (rAbs) are being used to fight diseases, such as Covid-19. Sequence-defined rAbs have numerous scientific benefits over undefined, animal-derived antibodies, including higher affinity and specificity, faster generation time, and reduced immunogenicity. The US National Toxicology Program Interagency Center for the Evaluation of […]
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Kleinstreuer Assumes Leadership of NICEATM

As of January 1, Nicole Kleinstreuer has assumed the role of Acting NICEATM Director. Kleinstreuer has been NICEATM Deputy Director since 2016. Before that she worked for ILS, the NICEATM support contractor. In both roles, she has contributed significantly to the development of NICEATM’s capabilities in computational toxicology. Kleinstreuer received her Ph.D. in bioengineering from […]
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Paper Describes Framework for Evaluation of NAMs

Former NICEATM Director Warren Casey and NICEATM Acting Director Nicole Kleinstreuer are co-authors on a paper that describes a framework for evaluating new approach methodologies (NAMs). The goal of this framework, developed by a multi-stakeholder group of industry, academic, and regulatory experts, is to provide a structure to collect relevant information to build confidence that […]
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New FDA Guidance Available for In Vitro Drug Interaction Studies

The U.S. Food and Drug Administration (FDA) published “In Vitro Drug Interaction Studies – Cytochrome P450 Enzyme- and Transporter-mediated Drug Interactions Guidance for Industry” in January. This guidance is intended to help drug developers plan and evaluate studies to determine the drug-drug interaction (DDI) potential of an investigational drug product. It focuses on in vitro […]
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Paper Describes Predictive Model for Androgenic Activity

A paper now available online from Environmental Health Perspectives describes a worldwide consortium led by the U.S. Environmental Protection Agency (EPA) to develop models to virtually screen chemicals for their potential androgenic activity. The paper was coauthored by Acting NICEATM Director Nicole Kleinstreuer; the first author is Kamel Mansouri, ILS (contractor supporting NICEATM). Predictions generated […]
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Presentations Available from EPA Conference on NAMs

Presentation slides are available from the First Annual Conference on the State of the Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing, presented by the U.S. Environmental Protection Agency (EPA) on December 17. This conference was one of EPA’s commitments in the “Directive to Prioritize Efforts to Reduce Animal […]
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PETA International Science Consortium Travel Award to Attend Summer School

The PETA International Science Consortium Ltd. is offering a travel award to provide a student or early-career scientist the opportunity to attend the Summer School on Innovative Approaches in Science happening June 22-25, 2020 at Johns Hopkins University in Baltimore, Maryland, US. Focusing on innovative non-animal testing approaches, such as in vitro and computational methods, […]
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Job Opportunities for Biologists at EPA; Apply by December 26

The U.S. Environmental Protection Agency (EPA) Office of Pesticide Programs is seeking candidates for multiple biologist positions in Arlington, Virginia. Successful candidates will: • Evaluate and assess the validity of data from microorganisms, laboratory animals, and other study types to identify possible adverse effects to animals and/or humans. • Attend and participate in meetings with […]
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NIH to Provide Small Business Funding for Genetically Diverse Toxicity Tests

The National Institutes of Health (NIH) announces the availability of Small Business Innovation Research grants to support the development of chemical testing resources and approaches that better reflect the genetic diversity among human populations. The resources and approaches might include panels of human cells or cell lines, panels of cell lines generated from genetically diverse […]
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EPA Public Meeting Will Discuss Implementation of TSCA New Chemicals Program

The U.S. Environmental Protection Agency (EPA) Office of Chemical Safety and Pollution Prevention will hold a public meeting on December 10 to engage stakeholders on implementation of the Toxic Substances Control Act (TSCA) New Chemicals program. Specific topics for discussion include: Update of the document “New Chemicals Decision-Making Framework: Working Approach to Making Determinations Under […]
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Presentations Available from September 19-20 SACATM Meeting

Presentations from the recent meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) are available on the NTP website (click “Presentations” in far right column under “Meetings”). SACATM met September 19-20 in Arlington, Virginia. In presentations at the meeting, scientists from the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological […]
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NIEHS Providing Funding to Develop In Vitro Models

The National Institute for Environmental Health Sciences (NIEHS) will provide funding for U.S. small businesses to develop novel, engineered 3D or organotypic in vitro systems using cells from experimental animal models typically used for toxicology testing. When developed and validated, these animal-derived in vitro systems will help predict toxicity of chemical and drug candidates, enable […]
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EPA Releases Draft Guidance for Waiving In Vivo Avian Toxicity Studies

In a September 17 news release, the U.S. Environmental Protection Agency (EPA) announced a draft science policy to reduce testing of pesticides on birds when registering conventional outdoor pesticides. The draft policy is open for public comment until November 1; email comments to OPPeco@epa.gov. The draft policy describes the results and implications of a retrospective […]
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EPA to Fund Toxicokinetics Studies, Apply by September 24

The U.S. Environmental Protection Agency (EPA) is seeking applications for a new funding opportunity, Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations. Toxicokinetics describes the absorption, distribution, metabolism, and excretion of chemicals and their metabolites by the body. The research activities to be funded under this announcement are intended to improve the development of chemical […]
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PETA International Science Consortium Award to Attend In Vitro Workshop

The PETA International Science Consortium is holding a contest to provide a student or early-career scientist with the opportunity to attend the annual Institute for In Vitro Sciences’ Practical Methods for In Vitro Toxicology workshop in January 2020 in Gaithersburg, MD, USA. Workshop attendees will participate in lectures by experts in the field of in vitro toxicology […]
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NIH Small Business Opportunities

The National Institutes of Health (NIH) is accepting applications to two Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs to assist small businesses with commercialization of their technologies. The NIH Commercialization Accelerator Program is a competitive program designed to help small businesses with meeting their commercialization objectives. Participants selected for the […]
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SACATM to Meet September 19-20; Registration Open and Agenda Available

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet on September 19-20 at the Crowne Plaza Crystal City in Arlington, Virginia. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences regarding statutorily mandated duties of ICCVAM and activities of NICEATM. Preliminary agenda items for […]
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ICE Update Launched July 30

On July 30, NICEATM released the latest version of the Integrated Chemical Environment (ICE). ICE is a publicly available, web-based resource that provides curated data and tools to facilitate safety assessment of chemicals. ICE now includes: Updates to Tox21 data Predictions of endocrine activity using in silico models Improved performance and output standardization for the […]
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NIH to Fund Studies to Improve iPSC Reproducibility

The National Institutes of Health (NIH) is offering Small Business Innovation Research grants to develop methods that improve the reproducibility of human induced pluripotent stem cell (iPSC) derivation, growth, and differentiation. Eligible projects should seek to address the significant variability currently observed in human iPSCs in reprogramming efficiency, differentiation potential, and cell growth and stability, […]
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July 31 Webinar to Highlight Updates to ICE

A webinar titled “The Integrated Chemical Environment: Tools and Data to Support Toxicity Assessments” will be presented Wednesday, July 31 at 11:00 a.m. Eastern Daylight Time. Shannon Bell, ILS (contractor supporting NICEATM), will provide an overview of the updated Integrated Chemical Environment (ICE), a publicly available, web-based resource that provides curated data and tools to […]
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Report Available from Rabies Vaccine Workshop

A report is available from the October 2018 workshop “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) Director Warren Casey and David Allen, ILS (contractor supporting NICEATM), workshop participants, coauthored the report. This workshop, […]
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NICEATM at the Teratology Society Annual Meeting

NICEATM will give the following presentations at the annual meeting of the Teratology Society, June 22-26 in San Diego, California: An update on activities of the NTP Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) initiative: Poster Session 1, Sunday, June 23, 6:00-8:00 p.m., Nautilus Room. A poster titled “Application of a Controlled […]
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Slides and Video Available from ICCVAM Public Forum

Slides and a video recording from the May 23 ICCVAM Public Forum are available on the NICEATM website. The meeting was held at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. Over 40 attendees and more than 200 webcast viewers heard presentations by ICCVAM members representing eight U.S. agencies on current activities related […]
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OSHA and DOT Request Public Input in Advance of International Meetings

The Occupational Safety and Health Administration (OSHA) and the U.S. Department of Transportation (DOT) Pipeline and Hazardous Materials Safety Administration plan to hold separate public meetings on Thursday, June 20, in advance of July meetings of: The United Nations Sub-committee of Experts on the Globally Harmonized System of Classification and Labelling of Chemicals (OSHA) The […]
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ICE Version 2.0 Now Available

On May 20, NICEATM released a major update of the Integrated Chemical Environment (ICE). ICE provides data and tools to help develop, assess, and interpret chemical safety tests. The update introduces a new user interface to simplify searches and new tools that will let users explore chemical properties and toxicity in more detail. The new […]
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Free Workshop on Artificial Intelligence and Machine Learning June 6-7

The National Academies of Sciences, Engineering, and Medicine will hold a workshop on “Algorithms, Air Pollution, and Adverse Outcome Pathways: Leveraging Artificial Intelligence and Machine Learning to Advance Environmental Health Research and Decisions.” The workshop is June 6-7 at the National Academy of Sciences in Washington, DC, and will also be webcast. Registration is free. […]
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Small Business Grants Available from HHS; Webinar May 29

The Department of Health and Human Services (HHS) has released the 2019 Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Omnibus Grant Solicitations. These solicitations will be used by the National Institutes of Health and other offices within HHS to fund researcher-initiated projects in health, medicine, and life sciences. Projects being funded […]
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Postdoctoral Opportunity at NIST

The National Academies of Sciences, Engineering, and Medicine is supporting a postdoctoral fellow opportunity at the National Institute of Standards and Technology (NIST). The successful candidate will comprehensively examine in vitro assays to improve the repeatability and interlaboratory agreement of the assay results. Candidates must have a Ph.D. in biology, chemistry, engineering or a related […]
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Next generation knowledge: The Adverse Outcome Pathway framework as a collaborative tool

Join us on April 30, 2019 to learn and discuss the Adverse Outcome Pathway (AOP) framework. The AOP framework is a collaborative tool that applies an innovative approach for collecting mechanistic knowledge from various sources that can eventually support chemical safety assessment. The following questions will be addressed: What is the AOP framework and why […]
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Registration Open for ICCVAM Public Forum

ICCVAM will hold a public forum on Thursday, May 23, at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. The ICCVAM Public Forum is held annually to share information and facilitate direct communication of ideas and suggestions to ICCVAM from stakeholders. This year’s meeting will include presentations by NICEATM and ICCVAM members on […]
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Postdoctoral Opportunities at EPA NCCT, Other Offices

The EPA National Center for Computational Toxicology in Research Triangle Park, NC, has postdoctoral positions available for scientists with diverse expertise in computational and experimental laboratory research. These scientists will develop mathematical and computer models and new chemical testing technologies to help predict potential risk, and apply cellular, molecular, and systems biology to support better […]
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Postdoctoral Opportunities at the U.S. Army Chemical Biological Center

The National Academies of Sciences, Engineering, and Medicine are supporting two postdoctoral positions at the U.S. Army Edgewood Chemical Biological Center in Maryland. Both positions are open to U.S. citizens only. An appointment focused on in vitro models of organ toxicity will develop and optimize existing organoid systems to characterize human toxicity. While the primary […]
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EPA OCSPP Biologist/Toxicologist Positions Available, Deadlines Next Week

The U.S. Environmental Protection Agency (EPA) has positions open for Biologists/Toxicologists in the Office of Chemical Safety and Pollution Prevention (OCSPP). Multiple positions are available for each of the following opportunities. The closing date for both announcements is Thursday, March 21. The announcement at https://www.usajobs.gov/GetJob/ViewDetails/527021100 describes permanent positions for early career professionals who have completed […]
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EPA OPP Biologist/Toxicologist Positions Available, Deadlines Next Week

The U.S. Environmental Protection Agency (EPA) has positions open for biologists and related specialties in the Office of Pesticide Programs within the Office of Chemical Safety and Pollution Prevention. Multiple positions are available for each of the following opportunities. The closing date for both announcements is Monday, March 18. Successful candidates for both positions will: […]
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NICEATM Publications Honored by SOT Specialty Section

Two NICEATM publications have been honored by the Risk Assessment Specialty Section of the Society of Toxicology (SOT). “Non-animal methods to predict skin sensitization (II): an assessment of defined approaches” was awarded Best Paper of 2018 in the category of “Advancing the Science of Risk Assessment.” NICEATM Deputy Director Nicole Kleinstreuer is first author on […]
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AOP Hands-on Training: Building the Foundation for Predictive Toxicology

AOP Hands-on Training: Building the Foundation for Predictive Toxicology Wednesday, March 13, 2019 4:30 PM–6:30 PM Hilton Baltimore, Paca Room 401 West Pratt St, Baltimore, MD 21201 The Human Toxicology Project Consortium (HTPC) and the Physicians Committee for Responsible Medicine (PCRM) invite you to deepen your understanding of the Adverse Outcome Pathway framework. Following an […]
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FDA Announces Creation of Botanical Safety Consortium

In a February 11 press release, the U.S. Food and Drug Administration (FDA) announced policies aimed at modernizing the oversight and regulation of dietary supplements. Steps FDA will take to implement these policies include: Develop new ways to communicate to the public about unlawful and potentially dangerous supplement ingredients Establish a regulatory framework that evaluates […]
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Join us at our SOT satellite meeting for the latest updates on 21st century toxicology

Attending the the Society of Toxicology’s annual meeting this March? Join the Human Toxicology Project Consortium (HTPC) and the Center for Alternatives to Animal Testing (CAAT) at our annual satellite meeting on advancing 21st century toxicology activities. The meeting provides an informal setting for interested stakeholders to update one other on this important topic. A […]
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Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment

The next workshop in the “Beyond Science and Decisions” series, “Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment,” will take place February 26 and 27, 2019, at the offices of Texas Commission on Environmental Quality in Austin, Texas. The “Beyond Science and Decisions” workshop series continues and expands upon the discussion set forth […]
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Postdoctoral Opportunities Available

The U.S. Food and Drug Administration is accepting applications for postdoctoral fellows to develop human cell- and protein-based assays for assessing cardiotoxicity of new drugs. These projects are part of an initiative to design, build, and test new non-animal approaches to assess cardiotoxicity hazard. The initiative is supported jointly by the National Toxicology Program, (Biomolecular […]
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NICEATM and ICCVAM Activities at SOT

A webpage summarizing activities of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) at the March 10-14 Society of Toxicology (SOT) annual meeting is now available. Please refer to this page as you plan your SOT itinerary. […]
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