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In the Spotlight

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Novel technologies to overcome challenges faced by the pharmaceutical and chemical industries

Industry, small and medium-sized enterprises and academia are coming together, through the NC3Rs CRACK IT program, to solve three challenges faced by the pharmaceutical and chemical industries; all of which should reduce the number of animals used in scientific research. Nine research and development consortia have been awarded up to £100,000 each, as part of […]
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Baden-Württemberg calls for applications for research funding and 3Rs prize

Author: Sonja von Aulock, ALTEX The Ministry of Rural Affairs and Consumer Protection of Baden-Württemberg is accepting applications for research funding to a total of € 400,000 and for the 3Rs prize for exceptional contributions to reducing or refining animal experiments in research or education, which carries prize money of € 25,000. Eligible research projects […]
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PISC Statement on REACH Annex inclusion of EORGTS

Author: Jessica Sandler, People for the Ethical Treatment of Animals Three years after the extended one-generation reproductive toxicity test (EORGTS) – which has the potential to halve the number of animals used in reproductive tests – was accepted by the OECD, the EORGTS has been incorporated into the REACH Annexes. At the same time, however, […]
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International Foundation for Ethical Research Graduate Fellowships

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) The International Foundation for Ethical Research (IFER), a program of the National Anti-Vivisection Society (NAVS), is now accepting pre-proposal applications for its 2015-2016 Graduate Fellowships. Applications are due no later than 5:00 pm CDT on Monday, April 20, 2015. IFER Graduate Fellowships are one-year […]
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Grants Available from the Alternatives Research and Development Foundation

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) The Alternatives Research and Development Foundation (ARDF) is soliciting proposals for its 2015 Alternatives Research Grant Program. Grants of up to $40,000 are available to support individual projects of scientific merit and feasibility with potential to significantly reduce or replace laboratory animal use. Preference […]
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EFSA/WHO draft report on TTC approach open for public comment until March 29

Author: Sherry Ward, AltTox Source: EFSA “News in brief” (http://www.efsa.europa.eu/en/press/news/150212a.htm) February 12, 2015 EFSA and the World Health Organization (WHO) have published the draft conclusions and recommendations of their joint workshop on the Threshold of Toxicological Concern approach. The report is now open for public consultation until 29 March. The aim of the three-day expert […]
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A brief introduction to Systematic Review

Posted: February 13, 2015 The exponential proliferation of biomedical data in scientific literature and public databases make systematic reviews more necessary than ever. At the same time, a corresponding proliferation of powerful computing aids to search, aggregate, and evaluate this literature make systematic reviews increasingly thorough and useful. In the field of toxicology especially, systematic […]
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OECD publishes two Test Guidelines on human hazard endpoint skin sensitization

Author: Marilyn Matevia, HSUS From the OECD: “The OECD has just published two new Test Guidelines on human health hazard endpoint skin sensitisation. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). Test […]
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New EPA Guidance Would Reduce Use of Lab Animals and Increase Relevant Acute Toxicity Data on Pesticides; Comments on draft guidance due by March 10

Posted: February 6, 2015 In an effort to help expand the acceptance of alternative methods for acute toxicity testing, EPA’s Office of Pesticide Programs has released a new draft guidance document. The agency is accepting comments on the draft guidance for 60 days, until March 10, 2015. With the rapid advances in science and continual […]
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Improved in vitro and in vivo concordance in gene expression using co-culture models

Researchers from West Virginia University and the National Institute for Occupational Safety and health (NIOSH), who elucidated toxicity pathways involved in mouse pulmonary exposures to multi-walled carbon nanotubes in previous publications, have now begun to investigate the use of in vitro cellular models for assessing nanoparticle toxicity. In a recent publication in the journal Toxicology, […]
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EPA invitation for comments on Draft EDSP Test Guidelines

Author: Marilyn Matevia, HSUS “Draft Test Guidelines; Endocrine Disruptor Screening Program Test Guidelines (Series 890); Three Tier 2 Non-Mammalian Tests; Notice of Availability and Request for Comment Pages 5107 – 5109 [FR DOC # 2015-01836] SUMMARY: EPA is announcing the availability of three draft test guidelines for public review and comment that are being added […]
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Webinar on Alternative Approaches to Acute Toxicity Testing March 5

Author: Gilly Stoddart, PETA International Science Consortium, Ltd. The PETA International Science Consortium Ltd., Physicians Committee for Responsible Medicine, NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, and Chemical Watch are pleased to invite you to a webinar discussion on acute systemic toxicity. This webinar is the fifth in a series of six […]
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Upcoming Class in Baltimore, Maryland: Revolution in Toxicology 101

Author: Jamie Derita, Center for Alternatives to Animal Testing Newbie Upcoming Class in Baltimore: Revolution in Toxicology 101 February 24-25, 2015 Mt Washington Conference Center 5801 Smith Avenue Baltimore, MD 21209 REGISTRATION IS NOW OPEN! Toxicology is undergoing revolutionary change in the early 21st century. It’s not easy, however, to achieve an overview of these […]
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“Systematic review and evidence integration for literature-based environmental health science assessments”

The use of systematic review is gaining widespread regulatory use as a means of integrating, evaluating, and translating existing evidence on a variety of human health issues, and for potentially reducing the need for additional studies. The authors of a recent publication in Environmental Health Perspectives note that there is also “increasing interest in applying […]
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EU funding: New approaches to improve predictive human safety testing

Author: Sherry Ward, AltTox The application deadline of February 24, 2015 is approaching for Horizon 2020 program’s call for proposals, “New approaches to improve predictive human safety testing” (PHC-3-2015) (https://ec.europa.eu/research/participants/portal4/desktop/en/opportunities/h2020/topics/9078-phc-33-2015.html#tab1). “Scope: Proposals should capitalise on advances in all relevant fields of science to understand complex biological pathways of toxicological relevance and to identify early markers […]
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NIH events in February: NCATS Workshop and AIMBE/NIH Workshop

Author: Sherry Ward, AltTox Both events are free but have registration limitations. NCATS Assay Guidance Workshop for High-Throughput Screening and Lead Discovery: http://www.ncats.nih.gov/news-and-events/events/events.html Fifth AIMBE/NIH Workshop on Validation and Qualification of New In Vitro Tools and Models for the Pre-clinical Drug Discovery Process http://www.nibib.nih.gov/news-events/meetings-events/fifth-aimbenih-workshop-validation-and-qualification-new-vitro-tools-and
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New FRAME Experimental Design school arranged

Author: Horst Spielmann, Free University Berlin, Professor for Regulstory Toxicology & retired from ZEBET at the Federal Institute for Risk Assessment Next FRAME Training School announced The next FRAME Training School will be held at the University of Coimbra, Coimbra, Portugal on 30 March – 1 April 2015. Training School Background FRAME runs regular training […]
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NTP Releases Handbook on Systematic Review

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The NTP Office of Heath Assessment and Translation (OHAT) at the National Institute of Environmental Health Sciences has released a handbook describing standard operating procedures for implementing systematic review in OHAT evaluations. The handbook also includes OHAT’s tool for assessing study quality, or “risk of bias,” that applies a […]
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NTP Offers Travel Awards

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The National Toxicology Program (NTP) is seeking to increase awareness and familiarity within the research community with high-throughput screening efforts and associated data and tools, and to foster the training of postdoctoral fellows and new and early-stage investigators in this area. As part of this effort, NTP will provide […]
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Workshop on In Vitro Tools and Models for Drug Discovery

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM A free workshop on “Validation and Qualification of New In Vitro Tools and Models for the Pre-clinical Drug Discovery Process” will be presented at the National Institutes of Health (NIH) on February 12. The workshop is being organized by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) in […]
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Draft EPA Process Document Available for Comment

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM A draft U.S. Environmental Protection Agency document describing a “Process for Establishing and Implementing Alternative Approaches to Traditional In Vivo Acute Toxicity Studies” is now available for comment. The document describes a transparent, stepwise process for evaluating and implementing alternative methods of testing for acute oral, dermal, and inhalation […]
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Sad News

Author: Catherine Willett, HSUS The Management Team at AltTox would like to express our deep shock and sadness at the sudden loss of a great friend and colleague and AltTox Editorial Board member, Ed Carney. Ed was a leading reproductive toxicologist who contributed enormously to the fields of predictive toxicology and toxicokinetics. He was an […]
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Funding Announcement for predictive multiscale models for biomedical research

Author: Sherry Ward, AltTox Funding Opportunity Announcement: Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental, and Clinical Research (PAR-15-085): http://grants.nih.gov/grants/guide/pa-files/PAR-15-085.html Purpose The goal of this interagency funding opportunity announcement (FOA) is to support the development of multiscale models to accelerate biological, biomedical, behavioral, environmental and clinical research. The NIH, ARO, DOE, FDA, NASA, NSF, and […]
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Reminder: ICCVAM webinar on Reverse Toxicokinetics – January 27, 2015

Author: Marilyn Matevia, HSUS Reminder from ICCVAM: “ICCVAM TO PRESENT WEBINAR ON REVERSE TOXICOKINETIC MODELS ICCVAM is presenting a webinar on ‘Reverse Toxicokinetics: Using In Vitro Data to Estimate Exposures that Could Be Associated with Adverse Effects In Vivo’ on January 27. The webinar will focus on the development and application of reverse toxicokinetic models […]
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OPP’s process for alt approaches to traditional in vivo acute toxicity studies

Author: Jessica Sandler, People for the Ethical Treatment of Animals PETA is pleased that the EPA’s Office of Pesticide Programs (OPP) has taken the next step in establishing a process for accepting alternative approaches to animal testing when evaluating pesticide toxicity by releasing a draft document entitled “Process for establishing & implementing alternative approaches to […]
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Late-Breaking Abstract Submission Site for SOT 2015 Closes January 12

Author: Marilyn Matevia, HSUS From SOT, a reminder that the Late-Breaking Abstract Submission Site closes January 12: “Your abstract must be submitted online by 11:59 pm EST on the posted deadline. Please select the Late Breaking Submission option in the submission section of the website [https://sot2015.abstractcentral.com/]. (The “Abstract Submission” option applies to the October deadline […]
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New search tool for FDA Guidance Documents

Author: Sherry Ward, AltTox A new feature on the FDA.gov website provides the ability to search for all draft and final FDA guidance documents from this location: http://www.fda.gov/RegulatoryInformation/Guidances/default.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery “You can search for documents using key words, and you can narrow or filter your results by product, date issued, FDA organizational unit, type of document, subject, […]
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7.9 million awarded in 2014 by NIH Single Cell Analysis Program

Author: Sherry Ward, AltTox Today’s NIH news release, “Seeking single cells’ secrets” (http://www.nih.gov/news/health/dec2014/nimh-30.htm), describes grants awarded in 2014 supported by the NIH Common Fund’s Single Cell Analysis Program (SCAP) (http://commonfund.nih.gov/Singlecell/index). The funded research topics were summarized in the news release as follows: One group of projects is validating and refining already established technologies for studying […]
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New OECD Guidance Document 211 for “non-guideline in vitro test methods“

Author: Horst Spielmann, Free University Berlin, Professor for Regulstory Toxicology & retired from ZEBET at the Federal Institute for Risk Assessment The following Environment, Health and Safety publication is now available from the Series on Testing and Assessment Title: Guidance document for describing non-guideline in vitro test methods (No.211) http://www.oecd.org/chemicalsafety/testing/seriesontestingandassessmentpublicationsbynumber.htm This guidance document is intended […]
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Ruling on PETA complaint a victory for animals used in EU chemical tests

Author: Jessica Sandler, People for the Ethical Treatment of Animals http://investing.businessweek.com/research/markets/news/article.asp?docKey=600-201412111108M2______EUPR_____bb8100000f54c8f2_3600-1 London – In a landmark decision that could save millions of animals from suffering and death in laboratory experiments, the European Ombudsman has determined that the European Chemicals Agency (ECHA), the agency responsible for overseeing the largest animal testing programme in the world, is […]
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“Regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study within Europe”

In this paper published recently in Regulatory Toxicology and Pharmacology, Marie-Jeanne W.A. Schiffelers and co-authors reconstruct and analyze the process of regulatory acceptance and use of the Extended One Generation Reproductive Toxicity Study as a replacement for the two generation study. (Disclosure: AltTox Management Team member Bas J. Blaauboer is one of the co-authors on […]
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Allen Institute for Cell Science established to study the cell

Author: Sherry Ward, AltTox Paul Allen has provided $100 million in support to launch the new Allen Institute for Cell Science in Seattle, Washington (http://www.nbcnews.com/science/science-news/billionaire-paul-allen-pledges-100-million-cell-science-institute-n263601). The Institute will engage in projects that “study the cell as an integrated system” (http://www.alleninstitutecellscience.org/). As their first project, the Allen Cell Observatory intends to develop “novel visual, dynamic, predictive […]
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Webinar series Dec 9-11 on intellectual property protection for small business

Author: Sherry Ward, AltTox This three-part webinar series will provide participants with insightful tips for success on getting a patent or registering a trademark or copyright. Get answers from USPTO and U.S. Copyright Office senior intellectual property experts Elizabeth Dougherty, Anthony Knight, Susan Anthony, Craig Morris, and Sylvester Simpkins. The information shared will help you […]
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Author: Marilyn Matevia, HSUS “Eawag, the Swiss Federal Institute of Aquatic Science and Technology, conducts research to achieve the dual goals of meeting direct human needs for water and maintaining the function and integrity of aquatic ecosystems. The Department of Environmental Toxicology (Utox) invites applications for a Group Leader in Molecular Ecotoxicology (Tenure Track) The […]
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Lush Prizes 2014

Author: Martin Stephens, Johns Hopkins Center for Alternatives to Animal Testing The 2014 Lush Prizes for outstanding work towards non-animal alternatives were recently announced. Congratulations to all the winners, who are listed here: http://www.lushprize.org/. A special congratulations to my colleagues Francois Busquet and Thomas Hartung, who received a lobbying prize for their work advancing alternatives […]
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New “In the Spotlight” article on AltTox.org

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) “Cosmetics Regulation animal test ban declared subordinate to REACH registration testing requirements by ECHA” by AltTox Contributing Editor, Sherry Ward Read it here: http://alttox.org/cosmetics-regulation-animal-test-ban-declared-subordinate-reach-registration-testing-requirements-echa/
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Cosmetics Regulation animal test ban declared subordinate to REACH registration testing requirements by ECHA

Published: November 25, 2014 On October 27, 2014, the European Chemicals Agency (ECHA) published a short article titled “Clarity on interface between REACH and the Cosmetics Regulation” (ECHA/NA/14/46). The ECHA clarification, in full, was the following: “To meet the requirements of the new Cosmetics Regulation (Regulation (EC) No 1223/2009) cosmetic products are prohibited to be […]
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Grant opportunity: Novel Assays for Screening the Effects of Chemical Toxicants

Author: Marilyn Matevia, HSUS Two NIH/NIEHS funding opportunity announcements request applications from small business concerns (SBCs) “to develop medium- to high-throughput assays to evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. The ability to incorporate genetic diversity in these assays would […]
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