Workshop to Discuss Key Activities Needed to Predict Acute Toxicity

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Workshop to Discuss Key Activities Needed to Predict Acute Toxicity

NICEATM and the Physicians Committee for Responsible Medicine will hold a workshop titled “Mind the Gaps: Prioritizing Activities to Meet Regulatory Needs for Acute Systemic Toxicity” on October 30-31 at the National Institutes of Health. The workshop is free and open to the public but attendees must preregister by October 24.

Acute systemic toxicity tests are the most commonly performed type of safety test worldwide. Participants in this workshop will consider approaches available to assess acute lethality associated with chemicals and chemical mixtures, with the purpose of designing comprehensive strategies to predict toxicity while avoiding animal tests. The envisioned specific areas for discussion will include:

  • Defining how to calculate the LD50 of a chemical mixture/formulated product
  • Identifying gaps where model (or assay) development or optimization is needed
  • Understanding regulatory needs for model (or assay) outputs
  • Pinpointing the types of mechanistic information that would be useful
  • Establishing the feasibility of using artificial intelligence in model development
Catherine Sprankle
Catherine Sprankle
Communications Specialist for NICEATM