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Non-animal Methods for Toxicity Testing

References


Last Updated: December 6, 2007
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Boveri, M., Kinsner, A., Berezowski, V., Lenfant, A.M., Draing, C., Cecchelli, R., Dehouck, M.P., Hartung, T., Prieto, P. & Bal-Price, A. (2006). Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: role of pro-inflammatory cytokines and nitric oxide. Neuroscience. 137, 1193-209.

Bal-Price, A. & Brown, G.C. (2000). Nitric-oxide-induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J. Neurochem. 75, 1455-1464.

Bal-Price, A. & Brown, G. (2001). Inflammatory neurodegeneration mediated by nitric oxide fromactivated glia inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neuroscience. 21, 6480-6491.

Bremer, S. & Hartung, T. (2004). The use of embryonic stem cells for regulatory developmental toxicity testing in vitro – the current status of test development. Curr. Pharm. Des. 10, 2733-2747.

Buzanska, L., Jurga, M. & Domanska-Janik, K. (2006). Neuronal differentiation of human umbilical cord blood neural stem-like cell line. Neurodegener. Dis. 3, 19-26.

Clemedson, C., Kolman, A. & Forsby, A. (2007). The integrated acute systemic toxicity project (ACuteTox) for the optimisation and validation of alternative in vitro tests. Altern. Lab Animal. 35, 33-38.

Coecke, S., Ahr H., Blaauboer, B.J., Bremer, S., Casati, S., Castell, J., Combes, R., Corvi, R., Crespi, C.L., Cunningham, M.L., Elaut, G., Eletti, B., Freidig, A., Gennari, A., Ghersi-Egea, J.F., Guillouzo, A., Hartung, T., Hoet, P., Ingelman-Sundberg, M., Munn, S., Janssens, W., Ladstetter, B., Leahy, D., Long, A., Meneguz, A., Monshouwer, M., Morath, S., Nagelkerke, F., Pelkonen, O., Ponti, J., Prieto, P., Richert, L., Sabbioni, E., Schaack, B., Steiling, W., Testai, E., Vericat, J.A. & Worth, A. (2006). Metabolism: A bottleneck in in vitro toxicological test development. Altern. Lab Animal. 34, 49-84.

Coecke, S., Balls, M., Bowe, G., Davis, J., Gstraunthaler, G., Hartung, T., Hay, R., Merten, O.W., Price, A., Schechtman, L., Stacey, G. & Stokes W. (2005). Guidance on Good Cell Culture Practice. Altern. Lab Animal. 33, 261-287.

Coecke, S., Blaauboer, B.J., Elaut, G., Freeman, S., Freidig, A., Gensmantel, N., Hoet, P., Kapoulas, V.M., Ladstetter, B., Langley, G., Leahy, D., Mannens, G., Meneguz, A., Monshouwer, M., Nemery, B., Pelkonen, O., Pfaller, W., Prieto, P., Proctor, N., Rogiers, V., Rostami-Hodjegan, A., Sabbioni, E., Steiling, W. & van de Sandt, J.J. (2005). Toxicokinetics and metabolism. Altern. Lab Animal. 33, 147-175.

Coecke, S., Goldberg, A.M., Allen, S., Buzanska, L., Calamandrei, G., Crofton, K., Hareng, L., Hartung, T., Knaut, H., Honegger, P., Jacobs, M., Lein, P., Li, A., Mundy, W., Owen, D., Schneider, S., Silbergeld, E., Reum, T., Trnovec, T., Monnet-Tschudi, F. & Bal-Price, A. (2007). Incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies. Environ. Health Perspect. 115, 924-931.

Coecke, S., Eskes, C., Gartlon, J., Kinsner, A., Price, A., van Vliet, E., Prieto, P., Boveri, M., Bremer, S., Adler, S., Pellizzer, C., Wendel, A. & Hartung, T. (2006). The value of alternative testing for neurotoxicity in the context of regulatory needs. Environ Toxicol. and Pharmacol. 153-167.

Corvi, R., Ahr, H.J., Albertini, S., Blakey, D.H., Clerici, L., Coecke, S., Douglas, G.R., Gribaldo, L., Groten, J.P., Haase, B., Hamernik, K., Hartung, T., Inoue, T., Indans, I., Maurici, D., Orphanides, G., Rembges, D., Sansone, S.A., Snape, J.R., Toda, E., Tong, W., van Delft, J.H., Weis, B. & Schechtman, L.M. (2006). Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use. Environ. Health Perspect. 114, 420-429.

Ekwall, B., Clemedson, C., Crafoord, B., Ekwall, B., Hallander, S., Walum, E. & Bondesson, I. (1998). MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. Altern. Lab Animal. 26, 571-616.

Gartlon, J., Kinsner, A., Bal-Price, A., Coecke, S. & Clothier, R.H. (2006). Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity. Toxicol. In Vitro. 20(8), 1569-81.

Grandjean, P. & Landrigan, P.J. (2006). Developmental neurotoxicity of industrial chemicals. Lancet. 368, 2167-2178.

Hoffman, S. & Hartung, T. (2006). Towards an evidence-based toxicology. Human Exp. Toxicol. 25, 497-513.

Lein, P., Locke, P. & Goldberg, A. (2007). Meeting report: alternatives for developmental neurotoxicity testing. Environ. Health Perspect. 115, 764-768.

van Vliet, E., Stoppini, L., Balestrino, M., Eskes, C., Griesinger, C., Sobanski, T., Whelan, M., Hartung, T. & Coecke, S. (2007). Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects. Neurotoxicology. 26 (in press).

van Vliet, E., Morath, S., Eskes, C., Linge, J., Rappsilber, J., Honegger, P., Hartung, T. & Coecke, S. (2007). A novel in vitro metabolomics approach for neurotoxicity. Neurotoxicology. (in press).