Additional sources of information on scientific and policy issues relevant to the development and use of non-animal test methods.
Alternatives Websites
3R Research Foundation Bulletin and News
AltTox
Altweb
Johns Hopkins Center for Alternatives to Animal Testing (CAAT)
CCAC Three Rs Search Guide
Dr Hadwen Trust
ECVAM Database Service on Alternative Methods to Animal Experimentation (DB-ALM)
European Centre for the Validation of Alternative Methods (ECVAM)
European Consensus Platform for Alternatives (ECOPA)
European Society of Toxicology In Vitro (ESTIV)
European Commission Sixth Framework Programme (FP6) websites:
ACuteTox: project for developing in vitro methods to predict human acute toxicity
ARTEMIS: project for developing an in vitro 3D neural tissue-like model that can mimick memory acquisition/learning for use in pharmacology and toxicology applications
carcinoGENOMICS: project for developing in vitro methods to assess the carcinogenic potential of compounds
COMICS: project for developing in vitro Comet assay and cell arrays for screening chemicals for potential genotoxic and cytotoxic effects
EXERA: project for the development of 3D in vitro models of estrogen-reporter mouse tissues for pharmaco-toxicological analysis of nuclear receptors-interacting compounds
Forinvitox: project for promoting the transfer of alternative tests into products for end users
FunGenES: project on functional genomics in mouse embryonic stem cells
INVITROHEART: project for developing stable human cardiomyocyte cell lines and in vitro human models for pharmaceutical and toxicology testing
Liintop:project for developing in vitro liver and intestine models for pharmacokinetic and pharmacodynamic studies
NHR DEVTOX: project for conducting a prospective analysis of the role and mechanisms of nuclear hormone receptors in developmental and reproductive biology and determining their potential for this application
OSIRIS: project for optimized strategies for risk assessment of industrial chemicals through integration of non-test and test information
PREDICTOMICS: project for developing a novel testing platform for chronic liver and kidney toxicity that will reduce animal testing
ReProTect: project for developing an integrated set of tests for assessing reproductive/ developmental toxicity
Sens-it-iv: project for developing in vitro methods to assess potential lung or skin sensitizers
TOXDROP: project for developing "nanodrop" cell microarrays for high content toxicity screening
European Commission Seventh Framework Programme (FP7) websites:
AXLR8: project to increase networking, information exchange, problem solving, and collaboration among scientific disciplines and stakeholder groups to accelerate the transition to a toxicity pathway-based paradigm for chemical safety assessment
CADASTER: case studies on the Development and Application of In Silico Techniques for Environmental hazard and Risk assessment
COSMOS: integrated in silico models for the prediction of human repeated dose toxicity of COSMetics to Optimise Safety
CREAM: network of partner institutions working to develop ecological models for the risk assessment of chemicals, primarily pesticides
DETECTIVE: detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems; part of SEURAT-1 cluster
diXa Project: Data Infrastructure for Chemical Safety
ESNATS Project: project for developing a novel all-in-one toxicity test platform based on embryonic stem cells to accelerate drug development and provide an alternative to animal tests
EUROECOTOX: integration of European activities on the replacement and reduction of animal experiments in ecotoxicology
HeMiBio: Hepatic Microfluidic Bioreactor; part of SEURAT-1 cluster
NanoTEST: project for alternative testing strategies for the assessment the toxicological profile of nanoparticles used in medical diagnostics
NOTOX: predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures; part of SEURAT-1 cluster
OpenTox: website platform intended to support the development and validation of in silico models and algorithms and their integration with other alternative test methods
Predict-IV: project to develop strategies for assessing drug safety by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in silico modelling
SCR&Tox: Stem Cells for Relevant efficient extended and normalized Toxicology; part of SEURAT-1 cluster
SEURAT-1: collaboration of 6 research projects with the goal of developing knowledge and technology to replace in vivo repeated dose systemic toxicity testing with non-animal methods
ToxBank: supporting integrated data analysis and servicing of alternative testing methods in toxicology; part of SEURAT-1 cluster
VITROCELLOMICS: project for developing stable cell lines and in vitro human liver models for preclinical drug testing by the pharmaceutical industry
Fund for the Replacement of Animals in Medical Experiments (FRAME)
Go3R: search engine for locating information on replacement, reduction, and refinement alternative methods
Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
Institute for In Vitro Sciences, Inc. (IIVS)
In Vitro Testing Industrial Platform (IVTIP)
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
Netherlands Centre for Alternatives to Animal Use (NCA)
QSARs and REACH, A Guide to Sources of Information and Advice: resource of tools, information sources, and experts compiled by PETA UK
Tracking System for Alternative test methods Review, Validation and Approval in the context of EU Regulations on Chemicals (TSAR): Joint Research Center of the European Commission website for tracking the validation status of alternative methods
University of California-Davis Center for Animal Alternatives Information
Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments (ZEBET), Federal Institute for Risk Assessment (BfR), Germany
Centre for Alternative and Complementary Methods to Animal Testing (ZET), Austria
Scientific Websites/Glossaries
ACS Interactive Periodic Table of the Elements
ADMETnews.net: news and application resource for laboratory scientists utilizing ADME-Toxicology
Allen Brain Atlas: resource for research, news, and events in neuroscience and genomics
Biology Online: biology wiki, a resource for biology related information; biology forum, biology discussion boards
Cancer Cell Line Encyclopedia: genetic and molecular information for nearly 1,000 cancer cell lines; provides public access analysis and visualization of DNA copy number, mRNA expression and mutation data for about 1000 cell lines. Published results: Barretina, et al. (2012). The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Available here.
CASCADE ACERT (Association for Collaboration in Endocrine Research and Training) (Brussels, Belgium): European network within endocrine research for training, risk assessment, and collaborative partnership
Cold Spring Harbor Laboratory Press: Online access to scientific books, journals, laboratory manuals, protocols, and symposia
DevTox: resource for researchers in developmental toxicology; includes harmonized nomenclature and a database of images
The Dictionary of Cell and Molecular Biology, 3rd Edition
Ecotoxicology & Models: information and resources related to ecotoxicology and modeling, including: toxicokinetic and toxicodynamic modeling; applications in risk assessment of chemicals; and links to ecotoxicology models, software, databases, publications, and people
European Science Foundation (ESF)
Glossary of Biotechnology Terms
Immunogenicity Knowledge Base
Intute: Science, Engineering and Technology: internet resources covering the physical sciences, engineering, computing, geography, mathematics and environmental science
Merck's Interactive Periodic Table of the Elements
National Academy of Sciences
National Pesticide Information Center (NPIC)
Omics Gateway
Periodic Table Live
R&D Systems Interactive Pathways & Processes: stem cell and cell culture products
Science/AAAS
Stem Cell Research News
Toxipedia: wiki-website for toxicology and other public health professional to share information with other professionals and the public
Government Websites/Information
Chemicals Policy Initiative: An organization formed to advance policy debate on reforming chemicals policy in the United States; their website contains information and resources on US Federal and state chemicals policy, as well as chemicals policy in Canada, Latin America, Europe, Africa, and Asia-Pacific regions
Community Research & Development Information Service (CORDIS): European research & development and innovation activities
EDQM's Alternatives to Animal Testing Conference Proceedings (April 23-24, 2008)
EPA Chemical Safety
EPA's Pesticide Program
European Commission FP6 and FP7 projects concerned with alternative testing
FDA National Center for Toxicological Research: highlights and other publications
Federal Register: official daily publication for rules, proposed rules, and notices of US Federal agencies and organizations, as well as executive orders and other presidential documents
Human Health Risk and Environmental Analysis Group at ORNL
Inside the Cell: online book by National Institute of General Medical Sciences, NIH
Legislative Information: from the Library of Congress
MedLinePlus: Medical Dictionary; Medical Encyclopedia
US National Institutes of Health (NIH)
NIH Stem Cell Information
National Institute of Environmental Health Sciences
National Science Foundation
Risk Assessment Information System: risk assessment information and tools
Science.gov: science information provided by US government agencies
Technical Reports
6th World Congress Abstracts
BioCompare Technical Articles database
CAAT Technical Reports
Catalog of Hazardous Chemicals in China (English Edition) (2002) (CIRS)
ECETOC publications: includes technical reports, monographs, JACC Reports, which are comprehensive reviews of toxicological and ecotoxicological data on individual chemical substances; scientific briefing papers; and ECETOC publications in peer-reviewed journals
Environmental Risk Assessment and Management (ERASM)
NAS report, Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
NAS report, Assessing Risks to Endangered and Threatened Species from Pesticides (2013) 
NAS report, Exposure Science in the 21st Century: A Vision and a Strategy (2012) (commentaries on this report: http://www.nature.com/jes/journal/v23/n1/pdf/jes2012109a.pdf and http://ehp.niehs.nih.gov/1206170/)
NAS report, Science and Decisions: Advancing Risk Assessment (2009)
NAS report, Toxicity Testing in the Twenty-first Century: A Vision and a Strategy
Regulations on Safe Management of Hazardous Chemicals in China (2011) (CIRS)
Skin Care Forum
Stem Cells in Predictive Toxicology: 35-page report based on workshop held July 2008 by the California Institute for Regenerative Medicine (CIRM), the California agency devoted to stem cell research
Other Informational Websites
The British Library
EurActiv: European news and policy issues
Google U.S. Government Search: Search engine for U.S. Federal government websites
Google Scholar
International Calling Codes
Universal Currency Converter
US Library of Congress
US National Library of Medicine
Wikipedia: encyclopedia of user generated information
The World Clock: time zone converter
Worldometer: world statistics updated in real time
WWW Virtual Library
Patent Searches
European Patent Office
FreePatentsOnline
Google Patent Search
Japan Patent Office
Stem Cell Patents
United States Patent and Trademark Office Electronic Business Center
Newsletters/E-mail Alerts
AltTox Digest
Altweb News
ATCC cellpassages
ChemADVISOR e-newsletter
EC's Institute for Health and Consumer Protection (IHCP) newsletters: various topics including chemical and cosmetic safety
ECETOC e-Newsletter
The ECHA Newsletter
ECVAM Newsletter
epa-pesticides-updates e-newsletter
ecopa e-bulletin
FRAME News newsletter
IUTOX newsletter
NAS Emerging Science for Environmental Health Decisions newsletters
- Computational Toxicology: From Data Analyses to Applications
- Early Indicators of Disease: Predicting Later-Life Outcomes of Early-Life Exposures
- Epigenetics: Use of Emerging Science and Technologies to Explore Epigenetic Mechanisms Underlying the Developmental Basis for Disease
- The Exposome: A Powerful Approach for Evaluating Environmental Exposures and Their Influences on Human Disease
- The Microbiome: Implications of the Microbiome for Environmental Health
- Stem Cells: Stem Cell Models for Environmental Health
NCA Newsletter
NC3Rs e-newsletter
NICEATM-ICCVAM E-mail List
NIEHS, Environmental Factor
NKCA Newsletter
NLM-Tox-Enviro-Health-L: email announcement list to broadcast updates on resources, services, and outreach in toxicology and environmental health
NTP News Updates
Science for Environment Policy, DG Environment News Alert Service
SOT IVAM newsletters
Stemgent Times eNewsletter
USDA APHIS Stakeholder Registry e-mail updates
Books
Assay Guidance Manual: open access eBook providing guidance for developing high-throughput screening (HTS) assays to identify probes that modulate activity of biological targets, pathways, and/or cellular phenotypes
The ECVAM Search Guide: Good Search Practice on Animal Alternatives: Guidance for finding high quality information on relevant alternative strategies and methods to animal experiments
The Three Rs and the Humanity Criterion: an abridged version of The Principles of Humane Experimental Technique by Russell and Burch
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