In vitro testing and other laboratory services that support the development, use, and/or validation of non-animal test methods. If your lab has experience in conducting inter-laboratory validation of in vitro methods or conducts in vitro testing services, please contact info@alttox.org to be listed here.
4-Front Research, Ltd (Cheshire, UK): consumer healthcare testing company, including human clinical eye and skin irritation testing
Advanced CellSystems (Germany): custom designed in vitro assays using the CellSystems® 3D skin models
ADMET Group (Rockville, Maryland, US): in vitro & in vivo preclinical drug development and drug discovery contract research services; GLP studies
An-eX Analytical Services, Ltd. (Cardiff, UK): dermal research and development including in vitro human skin permeation studies performed according to the OECD 428 and other appropriate guidelines
Apredica (Watertown, Massachusetts, US): in vitro ADME toxicity screening services, including specialty toxicity assays such hemolysis, genotoxicity, cardiotoxicity, phospholipidosis, phototoxicity, mitochondrial toxicity, and reactive metabolite toxicity
APSciences, Inc. (Baltimore, Maryland, US): consulting service for in vitro ADMET for drugs and drug candidates; in vitro ADMET Laboratory Setup Service; contract testing using the in vitro Integrated Multiple Organ Culture (idMOC) technology
Asterand, plc (US and UK): recently merged with Pharmagene; supports human drug discovery by providing human biomaterials (cells, tissues, tissue microarrays, RNA) and preclinical research services using human primary cells & cell lines
Attagene, Inc. (Research Triangle Park, NC): High-throughput, cell-based assays for evaluation of mode of action and toxicity of chemicals and drugs.
Austrian Research Centers (ARC) GmbH (Seibersdorf, Austria): CRO offering in vitro and in vivo toxicology services
BIOalternatives (Gencay, France): a service company offering cell-based assays to support drug and healthcare product development
Biomaterials and Tissue Engineering Centre of Industrial Collaboration (BITECIC Ltd) (Leeds, UK): SimulateTM programme for pre-clinical evaluation of medical devices; CelTisTM programme for proteomics, cell therapy, and tissue engineering using a portfolio of well-characterized, functional human tissues and cell lines
Bionas GmbH (Rostock, Germany): Bionas® analyzing system used with variety of cell types for testing toxic effects and other cell biology applications
Biopta, Ltd. (Glasgow, UK): contract research services using human tissues
BioScience Laboratories, Inc. (Bozeman, Montana, US): in vitro and human clinical toxicology and safety testing including, ocular and skin irritation, phototoxicity, and in-use evaluations
bioskin® (Hamburg, Germany): CRO specializing in dermatology clinical trials for safety, efficacy, and biophysical measurements
BioVisible (Groningen, Germany): services include MitoxTM DNA - Mitochondrial toxicity assay to measure simultaneously the nuclear DNA and mitochondrial RNA content of the cell; assay can be used to assess toxicity and/or efficacy of antiviral treatment of cells (de Baar, et al., (2007). Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells. Antiviral Research. 76, 68-74).
BSL BioService Scientific Laboratories GmBH (Germany): contract laboratory for in vitro and in vivo toxicology
Caliper Life Sciences (Hanover, Maryland, US): CRO offering in vitro and in vivo toxicology services
Calvert Laboratories, Inc. (Olyphant, Pennsylvania, US): in vitro & in vivo contract testing for drug development
Capsant Neurotechnologies (UK): target validation platform of in vitro tissue-based screening technologies for CNS drug discovery, including ex vivo tissues (organotypic slices) and in vitro, 3-dimentional models
CeeTox, Inc. (Kalamazoo, Michigan, US): in vitro toxicity screening assays for drug discovery, including: Acute Toxicity Screen; Drug-drug Interaction Tox Screen; CardioTox Panel®
CellSystems Biotechnologie Vertrieb GmbH: cell biology products including human primary cells, 3D skin cell systems, and cell models for angiogenesis, blood-brain-barrier and inhalation toxicology
Cellumen (Pittsburgh, Pennsylvania, US): Cellular Systems Biology (CSBTM)-based profiling services and/or licenses for cell lines, next-generation reagents, and multiplexed assays for drug development; specialized services and consulting
CellzDirect (Austin, Texas; Research Triangle Park, North Carolina): human hepatocytes and microsomes for in vitro metabolism and drug-drug interaction studies; GLP
Celsis In Vitro Technologies (US, Germany, UK): in vitro ADME-Tox services, standard and custom protocols; hepatocyte cell culture and related customized services
Cenix BioScience (Germany): customized research services for cell-based applications of RNA interference (RNAi) for research and drug discovery; experience in combining high throughput RNAi with high content phenotypic analyses in cultured human and rodent cells
Centre for Advanced Research & Development on Alternative Methods (CARDAM) (Belgium): in vitro contract testing, R&D, and related activities and consulting
The Centre for Applied Genomics (Toronto, Canada): genomics services to academic, government, or private sectors clients
Cerep (France, Japan, US): in vitro screening and profiling using proprietary database BioPrint® to model clinical effects of drugs from molecular properties; assay development services
Charles River Laboratories (Worldwide): provides information to complement preclinical metabolic, toxicokinetic, and bioanalytical investigations; provides qualitative and quantitative data to address a variety of regulatory questions
Clinical Research Laboratories, Inc. (Piscataway, New Jersey, US): human clinical trials in dermatology, ophthalmology, and allergy
Clinworld (Mumbai and Bangalor, India): non-animal pre-clinical research and testing for evaluating toxicity and efficacy; GLP compliant in in vitro assay validation studies
Consumer Product Testing Co., Inc. (Fairfield, New Jersey, US): in vitro & in vivo contract testing
Covance (North Yorkshire, UK): 
toxicology services include in vitro cytotoxicity and phototoxicity testing; fish embryo test in development for ecotoxicology
Cultex® Laboratories (Hannover, Germany): in vitro exposure systems and technologies for toxicological analysis of airborne substances, such as gases and volatile compounds; experience in conducting inter-laboratory validation studies
CYTOX (Germany): toxicological testing and consultation for medical devices, supplies, cosmetics, and environmental samples
Dermac Laboratory, Inc. (Stamford, Connecticut, US): novel bioinstrumention techniques and analytical tools for noninvasive assessment of skin and hair properties (human clinical safety/efficacy testing)
EcoArray, Inc. (Alachua, Florida, US): microarray products and services for ecotoxicity and endocrine disruptor testing
EDI GmbH (Germany): ex vivo Instant Leukocyte Culture System; customized cell culture systems and immunoassays; in vitro immunotoxicology and immunopharmacology; co-cultures of immune cells with other tissues
Eggcentris (Brussels, Belgium): in vitro tests to screen compounds for reproductive toxicity (effects on fertility and embryonic development)
Entelos, Inc. (Foster City, California, US): predictive biosimulation using in silico disease models and a virtual patient approach to improve the success rates of clinical trials
Epithelix Sàrl (Switzerland): provides in vitro assays to pharmaceutical, biotech, cosmetic, and chemical industries using their own human cellular models
Eurofins-Biolab (Italy): specialised laboratory for in vitro and in vivo toxicology and ecotoxicology
Exiqon (Vedbaek, Denmark): microRNA profiling services
Fluofarma (France): contract service provider offering High Content Screening (HCS) services for target/drug discovery and in vitro toxicity testing
FRAME Alternatives Laboratory (UK): in vitro methods research and validation studies
GenPharmTox BioTech AG (Germany): offers in vitro and in vivo testing of drugs and chemicals; numerous in vitro toxicology and ADME-Tox methods offered, GLP studies
GlycoMar (Argyll, UK): screening assay services using primary human cells and cell lines; contract research services; glycobiology and enzyme products
Harlan Laboratories (UK, US, Japan, Israel): contract laboratory for in vitro and in vivo safety evaluation of chemicals, pharmaceuticals, agrochemicals, intermediates, and medical devices
Iconix Biosciences (Mountain View, California, US): toxicogenomics services to profile drug candidates based on proprietary DrugMatrix® database of microarray and pharmacology data
Institute for In Vitro Sciences (IIVS) (Gaithersburg, Maryland, US): contract laboratory for in vitro toxicology, assay optimization and validation, GLP studies, workshops & training
Kinexus Bioinformatics Corporation (Vancouver, British Columbia, Canada): systems proteomics, including antibody microarray services
Leadscope, Inc. (Columbus, Ohio, US): license and access to FDA databases; data management and decision support tools; consultancy on building toxicity databases and prediction models
Linus Pauling Institute, Cancer Chemoprotection Program Core Laboratory (Corvallis, Oregon, US): genetic toxicology testing service for dietary compounds: Salmonella mutagenicity assay (Ames test), single cell gel electrophoresis assay (SCG or Comet assay), micronucleus assay
Litron Laboratories (Rochester, New York, US): flow cytometer-based in vitro MicroFlow kits for micronucleus detection in a variety of cultured cells; assay can also provide cytotoxicity endpoints
Marin Biologic Laboratories, Inc. (Tiburon, California, US): contract testing and research laboratory for in vitro toxicology, cell biology, assay development and validation; GLP studies
MB Research Laboratories (Spinnerstown, Pennsylvania, US): contract laboratory for in vitro and in vivo toxicology testing; GLP genetic toxicology assays
Midwest BioResearch (Skokie, Illinois, US): preclinical in vitro and in vivo studies for drug development; cell-based bioassays; GLP genetic toxicology assays and novel screening assays
Miltenyi Biotec (Germany): bioinformatics and gene expression profiling services; manufacture of adult stem cells under cGMP conditions; miRNA expression profiling
North American Science Associates (NAMSA) (Northwood, Ohio, US): CRO offering in vitro and in vivo services, including biocompatibility testing
NOTOX (Netherlands HQ, Japan, Switzerland, USA, India): in vitro GLP-compliant testing services include skin irritation, skin corrosion, eye irritation, and more
PerkinElmer (Waltham, Massachusetts, US): cellular assay development service for high sensitivity, high-throughput assays; optimized reporter gene assays; biochemical enzyme and radioligand binding assays
Pharmacelsus (Saarbrücken, Germany): CRO offering in vitro and in vivo toxicology services
Phenion GmbH & Co. KG (Germany): contract laboratory owned by Henkel KGaA; in vitro cell & skin models and human in vivo studies for consumer products
PRACS Institute, Ltd. (Fargo, North Dakota, US): CRO offering pre-clinical, clinical, bioanalytical, and statistical research services to the pharmaceutical, biotechnology and skin care industries
Puracyp (Carlsbad, California, US): receptor activation, cytotoxicity, and species comparison screening services for drug discovery using proprietary cell lines
RegeneMed, Inc. (San Diego, California, US): RegeneTOX, human and animal 3-D liver tissue co-cultures; monolayer cell-based products from the same donor for comparison, stem cells and 3-D tissue; contract testing services for ADMET and efficacy assessment in drug discovery
SBH Sciences (Natick, Massachusetts, US): cytokines and antibodies for cell-based assays; also provides bioassay testing services
Simcyp Limited (Sheffield, UK): Simcyp ADME Simulator, workshops, and consultancy for ADME data interpretation and extrapolation
SIT Skin Investigation and Technology (Hamburg, Germany): CRO offering in vitro and in vivo dermatological testing services
StratiCELL (Gembloux, Belgium): CRO for in vitro regulatory safety testing (e.g. REACH) and in vitro efficacy testing; also manufactures reconstituted skin models
VaxDesigns Corporation (Orlando, Florida, US): MIMICTM System—an in vitro surrogate of the human immune system; a high-throughput, cell-based method for testing human immune response to vaccines, drugs, cosmetics, chemicals, or other products
VIB MicroArray Facility (Belgium): academic core facility providing access to a full microarray analysis service
VitroCell Systems (Germany): contract research using human cells; VitroCell chamber for in vitro studies of gases or complex mixtures
Vivacell Biotechnology GmbH (Germany): CRO offering in vitro and in vivo testing services, including GLP in vitro toxicity testing
Xceleron Ltd (York, UK): offers ultrasensitive platform technology of accelerator mass spectrometry in biomedical research and human microdosing to accelerate drug development
XCellR8 (Manchester, UK): contract research for development and optimization of cell-based methods and in vitro toxicology testing
XenoTech, LLC (Lenexa, Kansas, US): contract research and testing for in vitro drug metabolism using XenoTech reagents and hepatocytes from human and other species
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