Sources for in vitro protocols and summary reviews of test methods, as well as and other methods used infor non-animal toxicology research and testing.
For search strategies, search engines, and databases that can assist in locating alternative test methods see this page: Searching for Non-animal Toxicity Test Methods
Non-animal Toxicity Testing Protocols/Test Guidelines/Summary Reviews
3D Cell Culture Knowledge Center: 3D cell culture protocols, white papers, videos, and more
3R Research Foundation 3R Info Bulletins
AnimAlt-ZEBET: full-text database of evaluated alternative methods to animal experiments
Assay Guidance Manual: open access eBook providing guidance for developing and validating high-throughput screening (HTS) assays
CPSC's Policy on Animal Testing: supplement to CPSC's proposed statement of policy on animal testing to help industry determine what tests currently are acceptable and available for meeting the labeling requirements of the Federal Hazardous Substances Act (FHSA)
Current Protocols in Toxicology: subscription-based database of protocols
DB-ALM ECVAM Database Service on Alternative Methods to Animal Experimentation: includes INVITTOX database protocols and validated ECVAM test methods
EDQM Alternatives to Animal Testing webpage: 3Rs approaches in the develoment and quality control of biologicals and vaccines; animal welfare progress in European Pharmacopoeia monographs
EUROECOTOX database of bioassays
EURL ECVAM: validated ECVAM test methods and related documents
European Centre for the Validation of Alternative Methods (ECVAM)
ICCVAM: validated ICCVAM test methods and related documents; U.S. and International Acceptance of Alternative Methods, 1998-2012: includes links to validated protocols and test guidelines; ICCVAM-recommended protocols
JaCVAM: JaCVAM statements on reviewed test methods
National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs): access to articles and guidelines
OECD Guidelines for the Testing of Chemicals: Test Guidelines; draft Test Guidelines; Guidance Documents; draft Guidance Documents
R&D Systems protocols: cell proliferation, cell staining, stem cells, multiplex assays, and more
(Q)SAR/In Silico Tools
JRC QSAR Model Inventory: online database which hosts structured and peer-reviewed information on QSAR Models
OECD QSAR Toolbox: software to fill gaps in (eco-)toxicity data needed for assessing the hazards of chemicals
US EPA ECOSAR (Ecological Structure Activity Relationships)
US EPA Toxicity Estimation Software Tool (T.E.S.T.): software enables toxicity estimates from a chemical's molecular structure using (Q)SAR methodologies
More software/QSAR tools on this page: Testing Supplies, Cells, Tissues, Software
General Laboratory Protocols
BioTechniques Protocols Guide: annual collections of optimized procedures and protocols
Cold Spring Harbor Protocols: subscription-based journal; free trial subscription offered
Common Laboratory Recipes Calculator
Current Protocols in Cell Biology: subscription-based database of protocols
Current Protocols videos
Invitrogen iProtocol™ Online Library: access to over 900 methods from Current Protocols by John Wiley & Sons, Inc. and ~600 validated experimental protocols developed by Invitrogen scientists
Journal of Visualized Experiments (JoVE): peer-reviewed journal publishing biological research and protocols in a video format
Methods of Pharmacology and Toxicology: 
book series providing methods and protocols in all areas of pharmacological and toxicological research
Molecular Station: an online resource for laboratory protocols
Nature Protocols: subscription-based journal; some open-access articles
Nature Protocol Exchange: open resource where scientists can share, search for, and/or comment on a protocol;
Nucleic Acids Research (NAR) Methods: methods published in NAR 1999-present
Protocol Online: an online resource for laboratory protocols
SciClips Bioprotocols Database: unique collection of protocols from journals and patents
SciClips Video Protocols
Sigma-Aldrich Applications Center
Springer Protocols: subscription-based database of reproducible laboratory protocols in the life and biomedical sciences
Stembook Protocols: stem cell protocols
Stemgent Video Library: lab protocols for stem cells
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