This section is intended to provide a readily accessible list of validated non-animal toxicity test methods for those looking for a validated non-animal alternative method/protocol.
The test methods listed in this section have been judged to be scientifically valid by the European Centre for the Validation of Alternative Methods (ECVAM), the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and/or the Organisation for Economic Co-operation and Development (OECD). Although uncommon, a test method may also have been accepted for regulatory use without formal validation (e.g. dermal penetration).
Although the OECD encourages validation of a test method prior to its adoption as a Test Guideline (TG), validation is not a prerequisite for TG adoption. OECD TGs are generally accepted worldwide as relevant methods for evaluating human health toxicity endpoints, and are the methods accepted under the Globally Harmonized System for Classification and Labeling of Chemicals (GHS). Accordingly, we list the in vitro test methods incorporated into OECD TGs, even when they may not have been formally validated.
A comprehensive table of validated and regulatory-accepted alternative test methods (in vivo and in vitro) is also provided in the following section of AltTox: Validated/Accepted Alternative Methods.
Please view the list of alternatives for each toxicity endpoint to the right. The Additional Resources for Non-animal Toxicity Test Methods section provides links to other organizations and databases with information on alternative toxicity test methods.
Common abbreviations used in these sections:
ECVAM: European Centre for the Validation of Alternative Methods
ESAC: ECVAM Scientific Advisory Committee
ICCVAM: Interagency Coordinating Committee on the Validation of Alternative Methods
OECD: Organisation for Economic Co-operation and Development
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