1. Combes, R., Balls, M., Illing, P., Bhogal, N., Dale, J., Duvé, G., Feron, V. Grindon, C., Gülden, M., Loizou, G., Priston, R. & Westmoreland, C. (2006). Possibilities for a new approach to chemicals risk assessment. FRAME Workshop Report 1. ATLA 34, 621–649.
The full workshop report contains 94 references, as well as five appendices, namely: 1. Hypothetical examples of the data available for initial risk assessments for chemicals and the toxicological information that can be derived from the test data and the literature (with 5 references); 2. The rationale for applying uncertainty factors to animal toxicity data (with 5 references); 3. A proposal for applying adjustment factors to in vitro data; 4. Modelling the distribution on chemicals in cellular in vitro systems to determine the free concentration of a test substance in vitro (with 7 references); and 5. The in vitro–in vivo extrapolation of toxic concentrations: the Equivalent Exposure concept (with 4 references).
A copy of the full report can be obtained from: michael.balls@btopenworld.com.
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