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Implementing the Vision for Toxicity Testing in the 21st Century: An Opportunity for Action

Posted: August 25, 2016 In 2007 the National Research Council (NRC) published the seminal report, Toxicity Testing in the 21st Century: A Vision and a Strategy, which envisioned using information derived from human-based assays and models to provide a more efficient, predictive, and less costly system for assessing the effects of xenobiotics on human health. […]
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Good Read-Across Practice (GRAP) Guidance Workshop

Contributor: Kate Willett, HSUS March 1, 2016 10am – 4pm US Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition Wiley Building 1A003 CFSAN Auditorium 5100 Paint Branch Parkway College Park, MD 20740 Co-hosted by the US Food and Drug Administration Center for Food Safety and Advanced Nutrition (FDA-CFSAN) and the Center […]
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Posted in Journal Watch on

High-throughput platform for predicting kidney toxicity is part of new international collaboration between Singapore researchers and US EPA to advance non-animal approaches to chemical safety testing

Researchers from the Institute of Bioengineering and Nanotechnology and the Bioinformatics Institute at the Agency for Science, Technology and Research (A*STAR) in Singapore have reported significant breakthroughs in the development of an animal-free approach for predicting the toxicity of drugs and other substances to the human kidney (i.e., nephrotoxicity). The proximal tubule cells (PTCs) of […]
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Posted in Journal Watch on

Acute toxicity prediction across multiple species

Bhhatarai, et al. (2015), in an upcoming article in the journal Toxicological Sciences, describe their study as a milestone for non-animal approaches for acute toxicity testing as it lays “the framework for broader approaches to read-across that includes interspecies and mechanistic HTS [high-throughput screening] data and also highlights the importance of addressing systemic bioavailability.” The […]
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