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AltTox at SOT 2017 in Baltimore, Maryland

As in previous years, AltTox Editorial Board and Management Team members will be at the annual meeting of the Society of Toxicology (Baltimore, Maryland) to share research with thousands of other toxicologists. AltTox Editorial Board and/or Management Team members are co-authors of the following posters (listed by abstract #/poster board #): 1209/333: Systematic Reviews as […]
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Implementing the Vision for Toxicity Testing in the 21st Century: An Opportunity for Action

Posted: August 25, 2016 In 2007 the National Research Council (NRC) published the seminal report, Toxicity Testing in the 21st Century: A Vision and a Strategy, which envisioned using information derived from human-based assays and models to provide a more efficient, predictive, and less costly system for assessing the effects of xenobiotics on human health. […]
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Tracking progress: They say, knowledge is power

Posted: May 31, 2016 One of our content updates this month is an updated version of AltTox’s Table of Validated & Accepted Alternative Methods (“Table”). This Table, which provides a comprehensive list of alternative methods endorsed as scientifically valid by ICCVAM (United States), EURL ECVAM (European Union), and/or JaCVAM (Japan), has become one of the […]
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‘Nano’ Today

Introduction Nanotechnology encompasses a wide variety of nanosized materials, or nanomaterials (NMs), which are defined by the International Organization for Standardization (ISO) as materials with any external dimension in the nanoscale or having internal structure or surface structure in the nanoscale (ISO, 2011). There is a large number of NMs in the global marketplace with […]
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Botanical Dietary Supplement Safety Assessment and Challenges

Posted: April 1, 2016 The National Toxicology Program (NTP), an interagency program under the National Institutes of Environmental and Health Sciences (NIEHS) is organizing, April 26-27, 2016, the workshop, Addressing Challenges in the Assessment of Botanical Dietary Supplement Safety. The workshop will convene experts from government, industry, and other organizations to discuss the “challenges” and […]
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High-throughput platform for predicting kidney toxicity is part of new international collaboration between Singapore researchers and US EPA to advance non-animal approaches to chemical safety testing

Researchers from the Institute of Bioengineering and Nanotechnology and the Bioinformatics Institute at the Agency for Science, Technology and Research (A*STAR) in Singapore have reported significant breakthroughs in the development of an animal-free approach for predicting the toxicity of drugs and other substances to the human kidney (i.e., nephrotoxicity). The proximal tubule cells (PTCs) of […]
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EU ToxRisk Kicks Off

Posted: February 17, 2016 At a kick-off meeting in January, the EU launched ToxRisk, a six-year, public-private partnership with 30 million euro in funding, and a mandate to eliminate animal testing in chemical safety assessment. The international consortium is comprised of 39 member institutions – including universities, research institutions, regulatory agencies, and large and small […]
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The Year in Review: AltTox Editorial Board members reflect on significant technology and policy developments in 2015

Posted: December 28, 2015 For the final “In the Spotlight” article of 2015, we asked AltTox Editorial Board members to identify what they saw as the most significant development for non-animal chemical safety testing, in the realms of technology or policy. Here is what some of them had to say. Bas Blaauboer: “An important step […]
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Needs and Strategies for Nanomaterial Safety Assessments

Three recent papers address some of the challenges regulatory agencies and manufacturers face when it comes to nanomaterials and nanomaterial-containing products: one outlines the specific kinds of information most needed for risk assessment and management, and two describe approaches that could be standardized to make those assessments. In Biological responses to engineered nanomaterials: Needs for […]
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IFER awards 3 new graduate student fellowships for scientific research utilizing innovative animal alternative methodologies

Posted: October 14, 2015 The purpose of the International Foundation for Ethical Research (IFER) Graduate Fellowship Program is “to provide financial incentives to graduate students in science that encourage them at the earliest stages of their career to integrate innovation and discovery with ethics and respect for animals.” IFER Graduate Fellowships are awarded annually (see […]
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In the US and EU, proposals are advanced to reduce the use of animals for acute systemic toxicity testing

Acute systemic toxicity refers to the adverse reactions that occur within 24 hours of oral or dermal exposure to a substance, or within 4 hours of inhalation exposure. In traditional toxicity testing procedures it is measured by the median lethal dose (LD50 for oral or dermal routes of exposure, or LC50 – median lethal concentration […]
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New issue of CSS Pathways from the US EPA

Contributor: Sherry Ward, AltTox The August 2015 issues of CSS Pathways (http://www2.epa.gov/sites/production/files/2015-08/documents/august_2015_css_pathways_external.pdf) reports many developments in chemical safety research and testing by US EPA researchers. Several approaches to assessing potential endocrine disruptors are reported: EPA introduces new technology to screen chemicals for endocrine disruption High-throughput model predicts estrogen receptor activity Advancing methods to evaluate thyroid […]
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Links to recently published OECD in vitro test guidelines

Contributor: Kate Willett, HSUS Here are links to four recently published OECD in vitro test guidelines: Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene http://www.oecd-ilibrary.org/environment/test-no-490-in-vitro-mammalian-cell-gene-mutation-tests-using-the-thymidine-kinase-gene_9789264242241-en;jsessionid=22dh652p3oaq6.x-oecd-live-02 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring […]
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Acute toxicity prediction across multiple species

Bhhatarai, et al. (2015), in an upcoming article in the journal Toxicological Sciences, describe their study as a milestone for non-animal approaches for acute toxicity testing as it lays “the framework for broader approaches to read-across that includes interspecies and mechanistic HTS [high-throughput screening] data and also highlights the importance of addressing systemic bioavailability.” The […]
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A host of new and revised OECD test guidelines feature in vitro methods

The Organisation for Economic Co-operation and Development (OECD) establishes guidance for commerce and trade between its 34 member countries, which include countries in Europe, the United States, Canada, Mexico, Australia, New Zealand, Japan, and South Korea, with Brazil, India, Indonesia, the People’s Republic of China and South Africa participating as Key Partners. Guidance for assessing […]
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Microphysiological systems for in vitro ADME and systemic repeated dose toxicity testing

The proliferation of microfluidic systems in the scientific literature makes it difficult to keep up with this emerging technology. However, only a portion of these are microphysiological or “human-on-a-chip” systems being developed for toxicity testing applications. An interesting one that caught our eye is the article, “Chip-based human liver–intestine and liver–skin co-cultures – A first […]
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Improved in vitro and in vivo concordance in gene expression using co-culture models

Researchers from West Virginia University and the National Institute for Occupational Safety and health (NIOSH), who elucidated toxicity pathways involved in mouse pulmonary exposures to multi-walled carbon nanotubes in previous publications, have now begun to investigate the use of in vitro cellular models for assessing nanoparticle toxicity. In a recent publication in the journal Toxicology, […]
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IFER funds new graduate fellowships for research into the development of alternatives to the use of animals in science

Posted: October 15, 2014 Peggy Cunniff, President of the International Foundation for Ethical Research (IFER), and Peter O’Donovan, Executive Director of IFER, announced this week the funding of three new graduate fellowships, and the renewal of three fellowships awarded in previous years. The awards are based on recommendations of the IFER Scientific Advisory Board following […]
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