Archives

Tag Archives for: "EPA"
Home / EPA

Journal Watch

Posted in Journal Watch on

High-throughput platform for predicting kidney toxicity is part of new international collaboration between Singapore researchers and US EPA to advance non-animal approaches to chemical safety testing

Researchers from the Institute of Bioengineering and Nanotechnology and the Bioinformatics Institute at the Agency for Science, Technology and Research (A*STAR) in Singapore have reported significant breakthroughs in the development of an animal-free approach for predicting the toxicity of drugs and other substances to the human kidney (i.e., nephrotoxicity). The proximal tubule cells (PTCs) of […]
0Read More
Posted in In the Spotlight on

The Year in Review: AltTox Editorial Board members reflect on significant technology and policy developments in 2015

Posted: December 28, 2015 For the final “In the Spotlight” article of 2015, we asked AltTox Editorial Board members to identify what they saw as the most significant development for non-animal chemical safety testing, in the realms of technology or policy. Here is what some of them had to say. Bas Blaauboer: “An important step […]
0Read More
Posted in In the Spotlight on

In the US and EU, proposals are advanced to reduce the use of animals for acute systemic toxicity testing

Acute systemic toxicity refers to the adverse reactions that occur within 24 hours of oral or dermal exposure to a substance, or within 4 hours of inhalation exposure. In traditional toxicity testing procedures it is measured by the median lethal dose (LD50 for oral or dermal routes of exposure, or LC50 – median lethal concentration […]
0Read More
Posted in Community Blog on

New issue of CSS Pathways from the US EPA

Contributor: Sherry Ward, AltTox The August 2015 issues of CSS Pathways (http://www2.epa.gov/sites/production/files/2015-08/documents/august_2015_css_pathways_external.pdf) reports many developments in chemical safety research and testing by US EPA researchers. Several approaches to assessing potential endocrine disruptors are reported: EPA introduces new technology to screen chemicals for endocrine disruption High-throughput model predicts estrogen receptor activity Advancing methods to evaluate thyroid […]
0Read More
Posted in Community Blog on

New EPA Guidance: Alternate Testing Framework for Classification of Eye Irritation Potential of EPA Pesticide Products

Author: Marilyn Matevia, HSUS The EPA has released updated guidance for testing antimicrobial cleaning products for their potential to cause eye irritation. From the EPA announcement: This updated guidance document, effective immediately, describes a testing framework for assessing eye irritation potential of EPA-registered antimicrobial cleaning products using three in vitro/ex vivo assays (non-animal tests): Bovine […]
0Read More
Posted in In the Spotlight on

New EPA Guidance Would Reduce Use of Lab Animals and Increase Relevant Acute Toxicity Data on Pesticides; Comments on draft guidance due by March 10

Posted: February 6, 2015 In an effort to help expand the acceptance of alternative methods for acute toxicity testing, EPA’s Office of Pesticide Programs has released a new draft guidance document. The agency is accepting comments on the draft guidance for 60 days, until March 10, 2015. With the rapid advances in science and continual […]
0Read More