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In the US and EU, proposals are advanced to reduce the use of animals for acute systemic toxicity testing

Acute systemic toxicity refers to the adverse reactions that occur within 24 hours of oral or dermal exposure to a substance, or within 4 hours of inhalation exposure. In traditional toxicity testing procedures it is measured by the median lethal dose (LD50 for oral or dermal routes of exposure, or LC50 – median lethal concentration […]
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Acute toxicity prediction across multiple species

Bhhatarai, et al. (2015), in an upcoming article in the journal Toxicological Sciences, describe their study as a milestone for non-animal approaches for acute toxicity testing as it lays “the framework for broader approaches to read-across that includes interspecies and mechanistic HTS [high-throughput screening] data and also highlights the importance of addressing systemic bioavailability.” The […]
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Report Outlines Predictive Toxicology Approach for Defense Applications

Contributor: Catherine Sprankle, NICEATM The National Academies Press has issued a report on “Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense.” Prepared in response to a request by the U.S. Department of Defense, the report provides a conceptual approach that could be used to evaluate chemicals that could pose threats to […]
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New EPA Guidance Would Reduce Use of Lab Animals and Increase Relevant Acute Toxicity Data on Pesticides; Comments on draft guidance due by March 10

Posted: February 6, 2015 In an effort to help expand the acceptance of alternative methods for acute toxicity testing, EPA’s Office of Pesticide Programs has released a new draft guidance document. The agency is accepting comments on the draft guidance for 60 days, until March 10, 2015. With the rapid advances in science and continual […]
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