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In the Spotlight

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The Year in Review: AltTox Editorial Board members reflect on significant technology and policy developments in 2015

Posted: December 28, 2015 For the final “In the Spotlight” article of 2015, we asked AltTox Editorial Board members to identify what they saw as the most significant development for non-animal chemical safety testing, in the realms of technology or policy. Here is what some of them had to say. Bas Blaauboer: “An important step […]
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Improved in vitro and in vivo concordance in gene expression using co-culture models

Researchers from West Virginia University and the National Institute for Occupational Safety and health (NIOSH), who elucidated toxicity pathways involved in mouse pulmonary exposures to multi-walled carbon nanotubes in previous publications, have now begun to investigate the use of in vitro cellular models for assessing nanoparticle toxicity. In a recent publication in the journal Toxicology, […]
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Matrix properties can alter cellular biological function through physical changes in the cells: Matrix influence on human cell motility

Article citation: Petrie, R.J., Koo, H., & Yamada, K.M. (August 29, 2014). Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science 345 (6200), pp. 1062-1065. Petrie, et al. (2012) had previously observed different mechanisms of cell movement in primary human fibroblasts, depending upon the matrix on which the […]
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