Rodent Uterotrophic Database Now Available

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Rodent Uterotrophic Database Now Available

Contributor: Catherine Sprankle, NICEATM

An article published October 2 as an advance publication in Environmental Health Perspectives describes curation and evaluation of a database of rodent uterotrophic bioactivity. The uterotrophic assay is a widely accepted in vivo test for identifying chemicals with potential estrogen receptor agonist activity.

The new database, which includes data from studies that adhere to six criteria specified in accepted regulatory test guidelines, is being proposed as a resource both for understanding in vivo outcome variability and for evaluating performance of in vitro alternative assays that measure estrogenic activity. For example, the database was used to validate an approach that could use high-throughput assays and computational methods to replace the uterotrophic assay in the U.S. Environmental Protection Agency’s (EPA’s) Endocrine Disruptor Screening Program (see relevant article in the National Institute of Environmental Health Sciences’ August newsletter). The database is available on the National Toxicology Program website.
Reference: Kleinstreuer et al. A Curated Database of Rodent Uterotrophic Bioactivity.

Catherine Sprankle
Catherine Sprankle
Communications Specialist for NICEATM