Testing Supplies, Cells, Tissue, Software
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Testing Supplies, Cells, Tissues, Software
Some of the many suppliers that provide useful in vitro testing supplies, cells lines, and other biological reagents.
3DBiomatrix: Perfecta3D™ Hanging Drop Plate – 96- and 384-well, high-throughput format, 3D cell culture plates for life sciences research and drug discovery/testing applications that simplifies and streamlines spheroid formation and testing
ADMEcell: in vitro assay kits for drug discovery include: CacoReady Kit (Caco-2 for in vitro assessment of intestinal permeability) and MDR-1 and BCRP Kits (cell-based assays for evaluation of drug interactions with the P-gp/MDR1 transporter)
Advanced CellSystems: CellSystems® 3D skin models: EST-1000 and AST-2000
Aniara: cellular toxicology screening products: Xenometrix test systems for mutagenicity; cytotoxicity high throughput screening test kits utilizing various endpoints
APSciences: Integrated Multiple Organ Culture (idMOC), a test platform using primary human, rat, or mouse cells from multiple organs which are physically discrete but interconnected by a common medium for studying drug efficacy, metabolism, toxicity
CCS Cell Culture Service: Princess® Instant Assays provides frozen cells in multiwell plates ready for cytotoxicity, proliferation, and inflammation assays
Cellix Ltd.: microfluidics systems capable of mimicking microcapillaries with blood flow in a robust, in vitro format; the continuous flow cell-based assays enable in vitro studies on cell adhesion, migration, and transmigration, thereby reducing the number of intravital microscopy studies; different biochips, pumping solutions, and software are available
CellSystems Biotechnologie Vertrieb GmbH: cell biology products including human primary cells, 3D skin cell systems, and cell models for angiogenesis, blood-brain-barrier and inhalation toxicology
Corning Life Sciences: GentestTM products for ADMET assays includes tissue fractions, P450/UGT enzymes, Supersomes™, and drug transporters; products for metabolism studies include: recombinant drug metabolizing enzymes, human- and animal-derived hepatocytes and tissue fractions, antibodies, chemical substrates, metabolites, and inhibitors
DiscoverX Corporation: complete cell-based assay kits for drug discovery, toxicity, and life sciences research 
EMD-Millipore Corporation: high content analysis kits for detecting neurotoxicity and neurite outgrowth in cells; multiplex kidney toxicity panels; Guava cell toxicity assay; MilliTrace stem cell kits; PyroDetect System, a Monocyte-Activation Test using cryo-preserved human whole blood and interleukin-1ß detection
Epithelix Sàrl: in vitro 2D and 3D models of primary human cells: airway epithelium of different origin, keratinocytes and dermal fibroblasts
Gentaur Molecular Products: Vitotox™, a high throughput bacterial genotoxicity assay to detect DNA damage caused by genotoxic compounds
Gentronix: GreenScreen HC human cell-based genotoxicity screening assay; GreenScreen GC eukaryotic genotoxicity and cytotoxicity assay; BlueScreen HC luminescent assay
INDIGO Biosciences, Inc.: CRO and product supplier specializing in nuclear receptor assays for drug discovery and toxicology screening; products include ready-to-use Nuclear Receptor kits and fluorescence-based Live Cell Multiplex (LCM) assay to quantify relative number of live cells in treated wells (stand-alone assay or coupled with NR assay)
In Vitro International: acellular in vitro tests: Corrositex dermal corrosion testing assay; Irritection Assay System for ocular and dermal irritation
J-TEC (Japan Tissue Engineering Co., Ltd.): LabCyte cultured human tissues, including the LabCyte EPI-MODEL cultured human epidermis for skin irritation/corrosion/metabolism/percutaneous penetration testing
Lena Biosciences: SeedEZ 3D cell culture drug screening system provides consistent 3D cell culture, co-culture and multilayered tissue models with immune and inflammatory components for ADME Tox, biopharmaceutical (monoclonal antibody) testing, repeat drug dose efficacy and long term incubation/clearance studies
MatTek Corporation: human cell-based 3D tissue models and assays for toxicology and product development testing for cosmetic, chemical, and pharmaceutical industries; tissue models include skin, ocular, respiratory (tracheal/bronchial; alveolar), small intestine, vaginal, and oral epithelial, as well as human dendritic cells and T-cells; some models validated and accepted by regulatory authorities (OECD, EPA, ICH, EU Guidelines)
MD Biosciences: cell based assays such as ImmuneProfiler™ for screening of anti-inflammatory properties of substances
Medicyte Gmbh: upcyte® Hepatocyte, in vitro MN Genotox Kit, and upcyte® Hepatocyte Cytotox Kit: upcyte® Hepatocytes proliferate and express Phase I and II like primary hepatocytes, therefore optimized for MN Genotox and Cytotox Assays; upcyte® Hepatocyte can be cultured in 2D or 3D, and monocultured or co-cultured with upcyte® HDMECs or primary vericyte® HDMECs
Molecular Toxicology, Inc.: genotoxicity and mutagenicity assay kits, including Moltox FT genetox assay kits (Salmonella and E. coli mutation assays); SOS/UMU kits; Ames Assay Kit
NCIMB Ltd: MARA Toxicity Test Kit, a microbial array for chemical and nanoparticle toxicity testing for ecotoxicology; extensive microbial culture collection is being used to develop new toxicity arrays
Neuromics: primary and stem cell-based assay kits
Novus Biologicals: wide range of reagents, test kits, and supplies
R&D Systems: tools for cell biology research, including ELISA assays and microplate-based antibody array for multi-protein detection
Seahorse Bioscience: XF Extracellular Flu Analyzer measures effects on cell metabolism; determines basal oxygen consumption, glycolysis rates, ATP turnover, and respiratory capacity in single experiment
Sistemic: kit-based products include: SistemQC™ to characterise cells, including stem cells (cell identity, purity, potency, and safety); SistemTOX™; , SistemKB™; SistemRNA™
SkinEthic Laboratories: human epidermal and epithelial models for in vitro test applications for the pharmaceutical, chemical, and consumer product industry; some models, like Episkin, are validated
Stratatech Corp.: StrataTest® human skin model composed of both an epidermis and a dermis (full thickness) for in vitro testing applications
StratiCELL: in vitro 3D skin models
Xenometrix AG: in vitro test kits include: Ames II / Ames MPF Microfluctuation Assays; Xenometrix Cytotoxicity Screening Kits – determine up to four cytotoxicity parameters from same sample; Ames MPF 98/100 AQUA – a novel mutagenicity test kit for testing water quality
XenoTech, LLC: products for in vitro drug metabolism-related research: microsomes, cryopreserved hepatocytes from human and other species, CYP antibodies directed against CYP enzymes, and more
American Type Culture Collection (ATCC): supplies many types of cells lines and bioproducts
AMS Biotechnology: products for stem cell research, including embryonic stem cells, adult stem cells, and reagents to create iPS cells
Asterand, plc.: provides human biomaterials for drug testing (human primary cells & cell lines, RNA, tissue microarrays, frozen & fixed human tissues)
ATCC-LCG Promochem Partnership: facilitates distribution of ATCC cultures and bioproducts to life science researchers in Europe
AvantiCell Science, Ltd. (Ayr, Scotland): bovine and goat primary mammary epithelial cells
BioE, Inc.: Multi-Lineage Progenitor Cell™, a human umbilical cord blood-derived, clonal, multipotent stem cell line; unique cell reagents
Biopredic International: human and animal reagents (tissues, primary cells, cell lines, blood products, fluids); recognized worldwide for expertise in liver products (tissues, primary cells), including the HepaRG® cell line (http://www.heparg.com/), and Silensomes™ human pooled liver microsomes irreversibly inactivated for one specific CYP
CELLnTEC Advanced Cell Systems AG: novel culture media, primary and long-term epithelial cells (human and rodent), and methods/protocols necessary for establishment of 2D and 3D cultures for creation of specific cellular micro-environments; human primary cells currently available: epidermal keratinocytes, dermal fibroblasts, and corneal, gingival, and bladder epithelial cells
Cellular Dynamics International: iCell™ Cardiomyocytes and iCell™ Neurons derived from induced pluripotent stem cells for drug discovery and toxicity testing
CellzDirect: hepatocyte cells and cell products
EMD-Millipore Corporation: various cell lines and media including human corneal epithelial cells; stem cell lines and kits that express green fluorescent protein (GFP) under the control of various embryonic and neural stem cell markers
ESI BIO: ESI human embryonic stem cell (hESC) lines derived under cGMP conditions; PureStem® progenitor cells clonally derived from human embryonic stem cell lines
European Collection of Cell Cultures (ECACC)
GE Healthcare Life Sciences: stem cell-derived tools for toxicology
German Collection of Micro-Organisms and Cell Cultures
Health Protection Agency Culture Collections
ICELLTIS: human primary cells for in vitro testing
InSphero AG: provides scaffold-free 3-dimensional microtissues in ready-to-use 96-well microwell formats for biomedical, pharmaceutical, and toxicity testing applications; tumor, rat liver, and custom-made microtissues are available
International Stem Cell Registry: 1584 stem cell line records that include name, provider, availability, characterization, and publications
InvivoSciences, Inc.: products for drug discovery using 3D engineered tissues, including the Palpator™ High Throughput Device, the Mini-Construct Chamber™, and 3D Cell Culture Inserts
Life Technologies™ Cell Lines Database
Lonza Group Ltd: primary human and animal cells with customized media systems, Clonetics® and Poietics® Cell Systems
MatTek Corporation: human cell-based 3D tissue models and assays for toxicology and product development testing for cosmetic, chemical, and pharmaceutical industries; tissue models include skin, ocular, respiratory (tracheal/bronchial; alveolar), small intestine, vaginal, and oral epithelial, as well as human dendritic cells and T-cells; some models validated and accepted by regulatory authorities (OECD, EPA, ICH, EU Guidelines)
Musculoskeletal Transplant Foundation (MTF): supplies pieces of human bone, skin, and other tissues, and FlexHD, an acellular dermal matrix, primarily for surgery
National Cancer Institute (NCI): tissue, cell lines, databases, arrays, etc. primarily for cancer research
National Cell Culture Centre (NCCC): division of Biovest International; provides customized, large scale cell culture services
National Disease Research Interchange (NDRI): not-for-profit corporation primarily funded by the NIH and dedicated to providing researchers with human cells, tissues, and organs for research purposes
National Human Neural Stem Cell Bank: provides neural stem cells harvested from the post-natal, post-mortem, human and animal brain to the research community for stem cell research; sponsored by the Children’s Hospital of Orange County
National Stem Cell Bank (NSCB) at WiCell: established to acquire, characterize and distribute the 21 human embryonic stem cell lines and their sub-clones to federally funded research programs; they currently have 13 of the 21 cell lines in the federal registry
Neuromics: cells including neuronal and stem cells, cell-based assay kits
Neuro-Zone srl: primary cells, stem cells, and cell lines
NIH Human Embryonic Stem Cell Registry: lists the derivations of stem cells that are eligible for federal funding and provides contact information for acquiring the cell lines
Precision Bioservices: AccuCell® cryopreserved Human Peripheral Blood Mononuclear Cells and Cord Blood Mononuclear Cells; highly purified subsets such as Monocytes, T-cells, and B-cells; custom processing and characterization studies from normal and disease state donors
PRIMACYT Cell Culture Technology GmbH: fresh and cryopreserved human and animal hepatocytes; dermal fibroblasts and keratinocytes; related cell growth media and products, including HEPAC2 serum-free human hepatocyte culture system
ProBioGen: specializes in mammalian cell engineering and cell culture: design of custom immortalized cell lines for vaccine and protein production, or for other customer needs
PromoCell GmbH: human cells, media, cell biology products, andchemically-defined and xeno-free culture system for human pluripotent stem cells (hPSC)
Puracyp: human hepatic microsomes and reagents for drug metabolism studies
ReachBio, LLC: primary human cell products include various types of peripheral blood, bone marrow, and cord cells; ColonyGEL™ methylcellulose-based media for colony-forming cell (CFC) assays
ReproCELL, Inc.: iPSC human cell lines (neurons, cardiomyocytes, hepatocytes), feeder cells, and reagents for the cultivation and preservation of stem cells
Riken BioResource Center, Cell Search System
RoosterBio: Human bone marrow and adipose-derived Mesenchymal Stem Cells (MSCs); hMSC High Productivity Media Kits, and hMSC Working Cell Banks
SciKon Innovation, Inc.: human matrix cell culture surface; human stellates; human hepatocyte cryopreserved cells
Sigma Life Science: range of quality cell lines, including genetically modified cell lines that model different types of cancer
TCS Cellworks, Ltd.: human cell-based research products and cells
tebu-bio laboratories: various cryopreserved primary cells; cell biology services such as cell amplification, differentiation, transfection, mycoplasma testing, establishes cellular models overexpressing or silencing a protein of interest
Tissue Solutions, Ltd.: freshly isolated human cells and cell lines; fresh human tissues including skin; human biofluids and blood; banked human diseased and normal samples
Trevigen, Inc.: knockdown cell lines deficient in a DNA repair gene mRNA transcript that can be used to identify gene responsible for DNA repair mechanism
UK Human Tissue Bank: not-for-profit organization that provides human tissues for biomedical research
Vitro Diagnostics, Inc. (dba Vitro Biopharma): “Tools for Stem Cell and Drug Development™,” a series of products including human stem cell lines, cell line derivatives, and medical devices for mesenchymal stem cell research, development of induced pluripotent stem cells, and stem cell therapy for cancer
Vitro Biopharma, Inc: characterized cell lines and culture media, including a variety of labelled human mesenchymal stem cell lines and their derivatives, chondrocytes, osteoblasts, and several primary human cell lines
Zen Bio: human adult stem cells, preadipocytes, adipocytes, primary human hepatocytes; specialized media
AMS Biotechnology: products for stem cell research, including optimized growth medium and supplements, extracellular matrices, and feeder cells
BRTI Life Sciences: Cell-Mate3D™ is a tissue-like and chemically defined 3D cell culture matrix that creates more biologically relevant and complex 3D tissue organoids; ideal for stem cells, cancer cells, fibroblasts, hepatocytes, and co-cultures
CELLINK: universal bioink optimized for 3D Bioprinting of human tissue; CELLMIXER to mix cells with bioink; STARTINK-Kit, 3D Bioprinting kit includes CELLINK, CELLMIXER, Binding Agent, and empty cartridges; INKREDIBLE desktop bioprinter (http://www.cellink3d.com/)
Clontech Laboratories, Inc.: kits and reagents for gene discovery, regulation, and function; cell culture reagents; stem cell research; human stem cells
Corning Life Sciences: cell culture media, reagents, and labware include Corning®, Costar®, Falcon®, Matrigel®, and cellgro® brands
Cell Preservation Solutions, LLC: develops novel solutions for preserving cells and tissues, and their storage and transportation (including stem cells); develops optimized mediums; provides DMSO-free cryopreservation solutions, and animal protein-free and serum-free media
CellSystems Biotechnologie Vertrieb GmbH: cell biology products including human primary cells and optimised cell culture media
EMD-Millipore Corporation: research and cell culture supplies & reagents, including stem cell media and reagents and HEScGRO animal component-free medium for culturing human embryonic stem cells in their undifferentiated state
ESI BIO: stem cell reagents include: BioLite antibodies for characterization of ES and iPS cells; HyStem Hydrogels for cellular matrices
FiberCell Systems, Inc.: hollow fiber cell culture systems for in vitrotoxicology studies of drug bio-availability
ICELLTIS: 96-well plates and other biomaterials for 3D culture and high content screening
Innovative Chemistry, Inc.: AuthentiKit™ System for cell culture quality control
Invitrogen: Gibco® Cell Culture Systems includes serum-free and specialty cell culture media and reagents’ 3D cell culture products; stem cell reagents and protocols
InvivoSciences, Inc.: products for drug discovery using 3D engineered tissues, including the Palpator™ High Throughput Device, the Mini-Construct Chamber™, and 3D Cell Culture Inserts
KIYATEC, Inc.: 3DKUBE™ 3D Cell Culture Plasticware: culture chambers with flow and scaffold options
Life Technologies™ Corporation
Mirus Bio, LLC: cell transfection and electroporation reagents; new 3D Transfection System combines Reinnervate’s alvetex® 3D Cell Culture Plates and Mirus Bio’s TransIT®-3D Transfection Reagent
Neuromics: media and reagents for primary and stem cells
Novus Biologicals: wide range of reagents, test kits, and supplies
PromoCell GmbH: human cells, media, and cell biology products
R&D Systems: stem cell and cell culture products
ReachBio, LLC: primary human cell products and cells; ColonyGEL™ methylcellulose-based media for colony-forming cell (CFC) assays
Reinnervate Limited: innovative new cell culture technologies including: Alvetex® – an inert polystyrene scaffold for cells to grow and form complex 3D cell structures in the laboratory, and synthetic small molecules that mediate cell differentiation in vitro – the first of these is ec23™, a synthetic retinoid that induces neurogenesis
SEFREC: database for serum-free cell culture (cells & media)
Sigma-Aldrich Media Expert®: comprehensive source of information on cell culture media components and formulation, including primary functions for each component in cell culture applications
StemCell Technologies, Inc.: provides specialized media and cell separation products and contract services
Stemgent, Inc.: stem cell qualified reagents and tools, including cell lines, media, transfection reagents, and more
Trevigen, Inc.: kits for 3-D cell culture standardized for assessing effects on genetic alteration or cell proliferation in 3-D cultures; high-throughput 96-well format
Vitro Diagnostics, Inc. (dba Vitro Biopharma): “Tools for Stem Cell and Drug Development™,” a series of products including specialized stem cell media
Worthington Biochemical Corporation: Hepatocyte Isolation System provides preoptimized combination of enzymes, buffers, and culture media to minimize lot-to-lot variation and improve quality of isolated hepatocytes; Animal Origin Free (AOF) enzymes for biopharma & vaccine production applications
ZET Serum Free Cell Culture Media – Updated Product Guide 1/2004-05: provides sources for obtaining animal-free cell culture media and reagents
Other Lab Supplies & Equipment
AbD Serotec: research and diagnostic antibodies
Affymetrix: DNA chips and microarrays
Applied Biosystems: instruments, consumables, software, and services for analyzing nucleic acids (DNA and RNA), small molecules, and proteins
Axoin Biosystems: single-well Muse and multiwell Maestro multielectrode array (MEA) systems provide a unified and scalable platform for experiments ranging from basic cellular electrophysiology to high-throughput screening for cardiotoxicity and neurotoxicity testing
BD Biosciences: products for research include antibodies, and reagents for western blotting, immunofluorescence, ELISA; instrumentation and reagents for flow cytometry
Beckman Coulter, Inc.: cellular automation systems to automate cellular assays
Bellbrook Labs: Transcreener™ Assay Platform, a HTS platform using proprietary fluorescent detection for screening families of enzymes at one time; uses microfluidics to bring cellular models into a fully automated high throughput environment
BioAssay Systems: biochemical and cell-based assays for both routine laboratory testing and high-throughput drug discovery: oxidative stress, cytotoxicity, cell proliferation, enzyme assays, reporter gene assays
Biocompare: large array of life science products and information
Bionas GmbH: Bionas® cell-based analyzing systems for continuous determination of cell physiology
Biontex Laboratories: mammalian cell transfection reagents
BioTek Instruments, Inc.: automation tools for ADME/Tox processes; validated microplate ADME/Tox applications include: drug permeability assessment; passive and active drug transport studies; biochemical metabolic enzyme inhibition profiling; multiplexed cell-based CYP450 induction and inhibition profiling; and cytotoxicity profiling
Cayman Chemical: biomedical research products including a variety of assay kits
Cell Sciences: immunochemicals for life science research, including cytokines, ELISA and ELISPOT kits, monoclonal and polyclonal antibodies, and matched antibody pairs for do-it-yourself assays
Cell Signaling Technology: reagents and assays for studying cell signaling pathways
CellASIC: microfluidic platforms for cell and tissue based applications; innovative approach enables cells to be maintained in a more biologically relevant condition
Cellectricon: microfluidic biochips as miniaturized cell-based screening devices: Cellaxess™ electroporation technology for transfection of tissue explants and adherent cells; Dynaflow™ System for ion channel drug discovery
Cellomics, Inc.: proprietary platforms for cell-based assays
Cell Technology, Inc.: reagents and assay kits for cell-based assays
Cellular Research, Inc.: Molecular Indexing™ technology provides fast, simple, and absolute quantitation of mRNA targets in single cells and small samples while eliminating sampling error, amplification bias, and external controls; same sample can be repeatedly analyzed and compared across platforms
Chromocyte: online resource for the design of multi-parameter flow cytometry experiments, and for identifying reagent sources for flow cytometry and other antibody-related techniques
CorSolutions, LLC: microfluidic equipment such as pumps, probe stations, and flow meters
CYTOO SA: micropattern-based products for cell-based assays: CYTOO chip™; CYTOO plate™; CYTOO chamber™ for live cell imaging
Detroit R&D: development and manufacture of ELISA, antibodies, and assay kits for research, diagnosis, and treatment of cardiovascular disease and cancer
EcoArray, Inc.: microarrays for ecotoxicity and endocrine disruptor testing: fathead minnow oligonucleotide arrays; reagents & solutions; use of EcoArray database for data interpretation, and discounts for participation in data sharing program to build capacity of predictive company database
Epigentek: tools and kits for epigenetic research
Exiqon: mRNA and microRNA research reagents and resources; bioinformatics tools ands services for probe design
FiberCell Systems, Inc.: hollow fiber cartridge systems for in vitro toxicology testing: used to model pharmacologic bio-availability and to culture epithelial cells
Fluidigm Corporation: proprietary microfluidic systems consisting of instruments and consumables (chips, assays, other reagents) for life science applications such as single-cell genomics, gene expression, and SNP genotyping
Fluxion Biosciences: BioFlux System for live cell analysis under shear flow for cell biology applications from high content analysis to pharmacological screening in a high throughput and low volume well-plate format
GE Healthcare: In Cell Analyzer for high content analysis (HCA)
Harvard Apparatus: tissue slice chamber systems, isolated organ perfusion systems, and cell culture equipment; catalog of products for regenerative medicine research
Hudson Robotics, Inc.: laboratory automation and robotics equipment
IV Tech Srl: in vitro technology start-up offering LiveBox perfused culture systems with single or double flow inlets and outlet, as well as custom consulting services
Kitmondo, Ltd.: online marketplace for used lab and medical equipment
LabX.com: a media service for the exchange of scientific equipment, where buyers and sellers of new, used, surplus, and refurbished scientific and laboratory equipment can find items, negotiate terms, and complete transactions online
Lonza: cell viability and toxicology assays
Luminex Corporation: xMAP® technology bioassay platform; multiplexing (multiple unique assays) within a single sample
Miltenyi Biotec: products for cell biology, immunology, regenerative medicine, and molecular biology
Multi Channel Systems GmbH (Reutlingen, Germany): high-performance measuring instruments and equipment in the field of electrophysiology, including in vitro microelectrode array systems
National Institute for Biological Standards and Control (NIBSC): provides International Biological Standards and other biological reference materials that are independently certified to the international quality standard BS EN ISO 9001:2000
Olympus Corporation: professional opto-digital products from microscopes for training and routine tasks to high-end system solutions in the fields of life science
Optometrics Corporation: SPF-290S ANALYZER SYSTEM, an UV spectrophotometer optimized for in vitro SPF assays for sunscreens, cosmetic products, and fabrics; compliant with FDA 21 CFR
OriGene Technologies: tissue qPCR arrays; transfections arrays; transfection reagents
Oxford Biomedical Research: biochemical assay kits, antibodies, cDNA probes, etc.
Perceptive Instruments, Ltd: image analysis and data processing software and instrumentation for research and testing including genetic toxicology (including Ames, MLA, and Comet Assay) and immunology assays
PerkinElmer, Inc.: cell-based assay reagents and cellular pathway mapping kits
ProBioGen: development of custom cell lines; in vitro production of monoclonal antibodies & adaptation to serum-free media
Promega: bioluminescent cytochrome P450 assays; cellular and genomic assay reagents & kits; protocols; online tools
R&D Systems: supplier of biological and research products, including antibodies and ELISA kits
SBH Sciences: cytokines and antibodies for cell-based assays; also provides bioassay testing services
Shelf Scientific: Lazar micro probes to measure ions (Na, Cl, K), pH, pO2, and pCO2; nitric oxide measurement system; ArrowDox™ Micro Oxidation-Reduction Measurement System for samples as small as 5 microliters with micro electrode that fits directly into 96-well plates or microcentrifuge tubes
Sigma Aldrich: antibodies, media, chemicals, other research reagents
tebu-bio laboratories: reagents for cell biology, drug discovery, in vitro ADME-Tox; laboratory services
Thermo Scientific: life science products include high content cell screening and cell imaging tools, and the Cellomics ToxInsight In Vitro Toxicity Platform for multiplexed assessment of toxicity targets in cells
Trevigen, Inc.: products for research: DNA damage, apoptosis, molecular biology, cell differentiation, angiogenesis
VitroCell Systems: VitroCell for in vitro culture and exposure to gases or complex mixtures
Zymo Research Corporation: epigenetics research reagents; other lab supplies and reagents
ADMET Predictor™: computer software for advanced predictive modeling of ADME/Tox properties from molecular structures; builds predictive models of new properties from user’s data
Aniara CelTox Software: for cytotoxicity analysis
Ariadne Genomics: Pathway Studio software for pathway and molecular interaction analysis
ArrayTrack: utilized by US FDA for review of genomic data submissions; integrated solution for managing, analyzing, and interpreting microarray gene expression data; provides statistical and visualization tools, and functional information about genes, proteins, and pathways for biological interpretation
Biocompare: pathway analysis and genomic sequence analysis software
Biographics Laboratory 3R (Biograf 3R) (Basel, Switzerland): software products for computational methods to replace animal testing
BIOVA: QSAR Workbench (formerly Accelrys), Electronic Lab Notebook, and other IT solutions for life sciences
Cellnomica: software for modeling and simulation of multicellular systems such as tissue, organs, and organisms
CombiStats: computer program for statistical analysis of data from biological dilution assays or potency assays; can perform calculations according to: parallel line, slope ratio, probit, 4-parameter logistic curve, and more models
Cytoscape: open source software for visualizing molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles, and other attribution data
DART (Decision Analysis by Ranking Techniques): software tool for ranking chemicals according to their environmental and toxicological concern based on the most recent ranking theories; different kinds of order ranking methods are implemented, and can be used to rank chemicals on the basis of more than one variable
Decision Forest: novel pattern recognition method for analysis of microarray, SELDI-TOF MS, and SAR data
Decisioneering: risk analysis and data simulation software
DiscoveryQuant™ Software (Applied Biosystems): mass spectrometry software for early high-throughput ADME testing to improve speed and efficiency of drug candidate analyses
ECETOC Targeted Risk Assessment (TRA) Tools: Workers Exposure Tool, Consumer Exposure Tool, and Environmental Exposure Tool available for free download for tiered approach to calculating exposure to and risks from chemicals
Endocrine Disruptor Knowledge Base: scientific resources including a biological activity database, (Q)SAR training sets, and computational models to predict estrogen and androgen activity
US EPA ECOSAR (Ecological Structure Activity Relationships): program to estimate the toxicity of industrial chemicals discharged into water to aquatic organisms such as fish, invertebrates, and algae; toxicity is predicted using Structure Activity Relationships
US EPA Exposure Assessment Tools & Models
Foodrisk.org: exposure, dose-response, statistical modeling and simulation tools, and more
Genedata AG: computational software solutions for biotech, pharmaceuticals, and life sciences; includes products for large-scale experimental research processes in molecular profiling, target discovery, integrative statistical analysis, as well as custom built
GlodSim: simulation software for decision and risk analysis
Ingenuity Pathway Analysis (IPA): chemical pathway analysis software and database: build pathways, assess toxicity profiles, prioritize biomarkers, metabolite data analysis
JMP: statistical software
Leadscope, Inc.: combine and build databases; build prediction models
Lhasa Limited: non-profit company specializing in the development of expert computer systems for toxicity and metabolism prediction which include Derek for Windows, Meteor and Vitic
MultiCASE, Inc.: computer programs designed to assess the potential pharmacological activity, toxicity, and metabolic transformation of new chemicals
NCGC CurveFit: automated curve fitting and classification software
NIEHS: free software for genomics, biostatistics, molecular biology, and more
OECD QSAR Toolbox (Version 2.3): for grouping chemicals into classes; guide to Version 2.3 modifications
PBT Profiler: developed as a voluntary screening tool to identify Pollution Prevention (P2) opportunities for chemicals without experimental data; uses a subset of P2 Assessment Framework computer-based tools to help identify chemicals that potentially may persist, bioaccumulate, and be toxic to aquatic life
Perceptive Instruments, Ltd: image analysis and data processing software and instrumentation for research and testing including genetic toxicology (including Ames, MLA, and Comet Assay) and immunology assays
Premier Biosoft International: lifescience software for microarrays, PCR, primer design, and more; bioinformatics software development and assay design services
Risk Assessment Information System: various risk assessment tools
SAS Institute, Inc.: data analysis software: statistical and simulation
Scorecomets: online resource for the comet assay by Perceptive Instruments Ltd; comet assay news, method, advice, and information; online interactive trouble shooting guide; download free 30-day trial of Comet Assay IV comet assay scoring system
Simcyp Population-based ADME Simulator: platform for modelling and simulation of drug absorption, distribution, metabolism and excretion (ADME) in virtual populations from in vitro data [Consortium membership required] (free ADME tools)
Simulations Plus, Inc.: ADMET Predictor™ software; GastroPlus™ software for oral absorption and pharmacokinetic simulation
Spatial Analysis and Decision Assistance (SADA): free software incorporates tools from environmental assessment fields, including integrated modules for visualization, geospatial analysis, statistical analysis, human health risk assessment, ecological risk assessment, cost/benefit analysis, sampling design, and decision analysis
Stat4tox (Software for the Statistical Evaluation of In Vitro Assays): open-source software tool that provides statistical analysis for toxicological data, including dose-response data; can be used for analysis of in vitro concentration-response curves, including estimation of EC50 values and the interpretation of both the statistical significance and biological relevance of observed effects
Syracuse Research Corporation: Environmental Science Estimation Software – variety of programs available
tebu-bio laboratories: CacoReady Software™ for analysis and management of data from in vitro studies for prediction of intestinal absorption; Noraymet ADMETM for management of in vitro ADME studies and use of in vitro ADME to predict human pharmacokinetic
Toxmatch: open-source software that encodes several chemical similarity indices to facilitate the grouping of chemicals into categories and read-across
ToxRTool (Toxicological data Reliability Assessment Tool): [under Publications link] software-based tool provided by ECVAM for evaluating quality of toxicological data
Toxtree: open-source software tool that places chemicals into categories and predicts toxicological effect by applying decision tree approaches (around 10 decision trees currently implemented)
VEGA (Virtual models for Evaluating the properties of chemicals within a Global Architecture): new and open-source platform for (Q)SAR and read across for REACH; includes models for phys-chem, environmental, ecotoxicological, and toxicological properties
VirtualToxLab™: in silico tool for predicting toxic potential of drugs and chemicals; simulates and quantifies chemical interactions with human protein via (Q)SAR; includes 12 validated models
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