Papers Published Describing Analysis of Defined Approaches to Skin Sensitization

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Papers Published Describing Analysis of Defined Approaches to Skin Sensitization

A collaboration between NICEATM and Cosmetics Europe has produced two papers describing important resources for non-animal approaches to identifying potential skin sensitizers.

  • The first paper describes a database that includes data from human, animal, and five non-animal tests for 128 chemicals. The chemicals in the database represent a wide variety of chemistries and use categories. The database is proposed as a point of reference for the evaluation and development of new testing strategies.
    Hoffmann et al. 2018. Non-animal methods to predict skin sensitization (I): the Cosmetics Europe database. Crit Rev Toxicol
  • The second paper describes an analysis of multiple non-animal data integration approaches for skin sensitization safety assessment of cosmetics ingredients using the database described above. Many of these approaches were found to perform as well or better than animal methods to predict human skin sensitization hazard.
    Kleinstreuer et al. 2018. Non-animal methods to predict skin sensitization (II): the Cosmetics Europe database.

Both papers were published February 23 in Critical Reviews in Toxicology and are available to all readers regardless of subscription status at the above links.

Catherine Sprankle
Catherine Sprankle
Communications Specialist for NICEATM