OECD releases five new Integrated Approaches to Testing and Assessment Case Studies

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OECD releases five new Integrated Approaches to Testing and Assessment Case Studies

The Integrated Case Studies Project was launched in 2015 to increase experience with the use of Integrated Approaches For Testing And Assessment (IATA) by developing case studies, which constitute examples of predictions that are fit for regulatory use. The aim is to create common understanding of using novel methodologies and the generation of considerations/guidance stemming from these case studies.

The Report on considerations from Case Studies on Integrated Approaches For Testing And Assessment highlights the learnings and lessons obtained from the review experience of the five case studies submitted to the 2016 review cycle of the IATA Case Studies project. The topics discussed in this document include the strongest aspects and uncertainties of each case study, and the document identifies areas for developing further guidance on IATA.

The five new published cases focuses on:
• Repeated-dose toxicity,
• Cumulative risk assessment and lifestage susceptibility
• Developing assessment workflows which incorporate non-animal methods.

Areas identified for further development included uncertainty analysis and reporting, decision logic for low or no toxicity predictions and how to consistently incorporate results from new approach methodologies.

Learn more about the IATA project.

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