OECD lists newly “endorsed” AOPS

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OECD lists newly “endorsed” AOPS

Catherine Willet, HSUS

OECD has created a new web page to list Adverse Outcome Pathways that have undergone scientific review by experts and have been agreed by the OECD National Coordinators to represent the current state of knowledge:

Four of the first five AOPs to have undergone this review are now posted:

Adverse Outcome Pathway on chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities

Adverse Outcome Pathway on Aromatase Inhibition Leading to Reproductive Dysfunction (in Fish)

Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations

Adverse Outcome Pathway on Protein Alkylation Leading to Liver Fibrosis

From the web page introduction:

An Adverse Outcome Pathway (AOP) describes a logical sequence of causally linked events at different levels of biological organisation, which follows exposure to a chemical and leads to an adverse health effect in humans or wildlife. AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. These AOPs are available in the AOP Wiki, an interactive and virtual encyclopaedia for AOP development. Following their development and review, the endorsed AOPs are published the OECD Series on Adverse Outcome Pathways. As scientific knowledge progresses, the publication of an AOP in this series does not preclude the regular update or new contributions to a given AOP in the AOP Wiki. While the AOP Wiki is a dynamic tool, only impactful changes to the AOP will be reflected in subsequent updates of the published AOP. The number 1 in the OECD Series on Adverse Outcome Pathways is the Users’ Handbook, which is a supplement to the Guidance Document for developing and assessing AOPs. This handbook contains an updated template for AOP development and provides focused and practical instructions for both AOP developers and reviewers. For more information, please visit the OECD website on AOPs.