NIH funding for research in systems developmental biology

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NIH funding for research in systems developmental biology

Author: Sherry Ward, AltTox

Systems Developmental Biology for Understanding Embryonic Development and the Ontogeny of Structural Birth Defects (R01) (PAR-15-020):

Application Due Dates:
Earliest Submission Date: December 15, 2014
Letter of Intent Due Date: 30 days before the application due date
Application Due Date(s): January 15, 2015, November 10, 2015, November 10, 2016, by 5:00 PM local time of applicant organization.

Eligible Organizations:
• Higher Education Institutions
• Nonprofits
• For-Profit Organizations
• Governments
• Other

Funding Opportunity Description:

…. Systems developmental biology is an emergent field utilizing the approaches of systems biology to integrate the expanding molecular-level knowledge of genes, proteins, biochemical, biophysical and cellular processes into networks of interacting components that result in embryonic development. Systems developmental biology offers the potential to complement the reductionist focus of modern developmental biology and provide a more comprehensive understanding of the causal relationships leading to normal and abnormal embryogenesis.

…. In contrast to focusing exclusively on the properties of individual molecules and pathways, systems biology centers on understanding how biological components work together to produce system-wide outcomes. One type of systems biology approach is a “top-down” data-driven “omics” approach which seeks to identify components and potential network interactions within a biological system. In contrast, a second type of systems biology is a “bottom-up” approach which focuses on building models of interactions to provide a predictive understanding of the causal relationships driving physiological and developmental processes. These approaches are often combined and may require the integration of expertise across traditionally separated scientific disciplines potentially involving the collaboration of biologists, clinicians, physicists, chemists and computer scientists.

Research Scope
Application of systems biology tools to address developmental questions in many ways represents a paradigm shift for developmental biology and birth defects research. Since these approaches and their application are evolving, this FOA is not intended to be proscriptive in scope.

Examples of research areas of interest include but are not limited to:
• Efforts to compile new and to integrate existing data sets regarding signaling pathways, signal transduction cascades, biophysical processes, epigenetic modifications, and transcription factor hierarchies into regulatory network models of developmental processes;
• Analysis of existing or new data sets to identify connections between genes, pathways, or processes that are involved in developmental processes or the formation of structural birth defects;
• Experimental validation of network models for developmental processes;
• Development of computational or experimental tools for constructing, perturbing, and/or validating models of developmental processes;
• Development of or improvements to computational tools for displaying network models of developmental processes, particularly those that predict outcomes from in silico perturbations.

For further information, see the Funding Opportunity Announcement at: