NICEATM Requests Data on Zebrafish Embryo Chemical Screening
NICEATM requests available data and information on zebrafish embryo screening tests and protocol design, including pharmacokinetics measurements. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce developmental effects in offspring. Respondents to this data request should provide information on any activities relevant to the development or validation of zebrafish embryo screening assays.
NICEATM specifically requests information on efforts to optimize zebrafish embryo screening tests and protocol design including comparisons of (1) zebrafish strains, (2) embryos with and without an intact chorion, and (3) static and static renewal exposures. NICEATM is also interested in developing a better understanding of pharmacokinetics in the zebrafish embryo model and requests available data on chemical uptake.
More information on this data request, including guidelines for data submission, is available on the NICEATM website. The deadline for receipt of the requested information is December 30, 2016.