NICEATM Publication Describes In Vitro to In Vivo Extrapolation Models

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NICEATM Publication Describes In Vitro to In Vivo Extrapolation Models

An article in Environmental Health Perspectives describes in vitro to in vivo extrapolation models developed by NICEATM. These approaches accurately estimate chemical exposure levels that elicit positive responses in the rodent uterotrophic bioassay. A workflow to run these models is freely available and can be parameterized entirely using freely available in silico tools.
Reference: Casey et al. 2018. Evaluation and optimization of pharmacokinetic models for in vitro to in vivo extrapolation of estrogenic activity for environmental chemicals. Environmental Health Perspectives.

Catherine Sprankle
Catherine Sprankle
Communications Specialist for NICEATM