NICEATM and PISC Convene Meeting on Inhalation Alternatives
NICEATM and the PETA International Science Consortium (PISC) organized an expert meeting on “Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-regulatory Data Requirements.” Participants in the meeting, held September 22-23, 2016, in Bethesda, MD, identified four key activities needed to reduce and replace animal use for required inhalation toxicity testing:
- Establishing a database of existing toxicity data
- Preparing a state-of-the-science review on how chemicals cause inhalation toxicity and identify the non-animal methods that are available to identify such hazards
- Developing computer models to help identify testing needs
- Designing a proof-of-concept study for a non-animal testing approach
Meeting participants are currently being organized into working groups that will address each of these goals. A follow-up meeting is planned for late 2017 or early 2018 to assess progress.
Attendees at the expert meeting included representatives from U.S. regulatory agencies and academia, companies that develop non-animal tests, and chemical companies that might ultimately use these tests to address regulatory requirements.
The expert meeting followed a series of webinars presented by NICEATM and PISC that provided background and context for the in-person meeting. Information about the webinars is available on the NICEATM website.