Methods, Approaches, Programs & Policies (MAPP), formerly the Toxicity Testing Resource Center (TTRC), provides comprehensive information on non-animal methods of toxicity testing not easily found anywhere else on the Web. You will find concisely summarized information relevant to advancing in vitro, in silico, and integrated methods for toxicity testing.

Toxicity Testing

• Toxicity Testing Overview
• Table of Validated and Accepted Alternative Methods
• Toxicity Endpoints & Tests
  • Acute Systemic Toxicity
  • Biologics, Vaccines, Medical Products
  • Carcinogenicity
  • Dermal Penetration
  • Ecotoxicity
  • Endocrine Disruptors
  • Eye Irritation/Corrosion
  • Genotoxicity
  • Neurotoxicity
  • Pharmacokinetics & Metabolism
  • Photoxicity
  • Repeated Dose/Organ Toxicity
  • Reproductive & Developmental Toxicity
  • Skin Irritation/Corrosion
  • Skin Sensitization
• Emerging Technologies
  • -Omics, Bioinformatics, Computational Biology
  • Cell-based Technologies
  • Pathway-based Toxicology
  • Non-test Approaches: (Q)SARs, Read-Across
  • Integrated Testing Strategies & Risk Assessment

Regulatory Bodies & Policy

• United States: Programs & Policies
• European Union: Programs & Policies
• Japan: Programs & Policies
• Korea: Programs & Policies
• Multinational: Programs & Policies
• Validation, Regulatory Acceptance, & International Harmonization
• Overarching Challenges & Opportunities