ICCVAM Advisory Committee Discusses Roadmap for Replacing Six Acute Toxicity Tests

The Scientific Advisory Committee for Alternative Toxicological Methods, which advises NICEATM and ICCVAM, met at the National Institute of Environmental Health Sciences in Research Triangle Park, NC, on September 27. ICCVAM agencies outlined a roadmap for the replacement of animals for the six most commonly used acute toxicity tests: ocular and dermal irritation; dermal sensitization; and acute oral, dermal, and inhalation toxicity. In addition, the advisory committee’s input was requested on developing a strategy to implement human-based predictive approaches for complex toxicological endpoints such as developmental toxicity and carcinogenicity. Materials from the meeting are available on the National Toxicology Program website.