EPA Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program

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EPA Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program

Contributor: Sherry Ward, AltTox

The Environmental Protection Agency (EPA) has published a Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program. Below is just a small part of the notice’s content.

Source: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2015-0305-0001

  • Docket ID: EPA-HQ-OPPT-2015-0305
  • Abstract: Federal Register for Friday, June 19, 2015 (80 FR 35350) (FRL–9928–69 ) Use of High Throughput Assays and Computational Tools; Endocrine Disruptor Screening Program; Notice of Availability and Opportunity for Comment
  • Received Date: Jun 19, 2015
  • Comment Due Date: Aug 18, 2015

Summary

This document describes how EPA is planning to incorporate an alternative scientific approach to screen chemicals for their ability to interact with the endocrine system. This will improve the Agency’s ability to fulfill its statutory mandate to screen pesticide chemicals and other substances for their ability to cause adverse effects by their interaction with the endocrine system. The approach incorporates validated high throughput assays and a computational model and, based on current research, can serve as an alternative for some of the current assays in the Endocrine Disruptor Screening Program (EDSP) Tier 1 battery. EPA has partial screening results for over 1800 chemicals that have been evaluated using high throughput assays and a computational model for the estrogen receptor pathway. In the future, EPA anticipates that additional alternative methods will be available for EDSP chemical screening based on further advancements of high throughput assays and computational models for other endocrine pathways. Use of these alternative methods will accelerate the pace of screening, decrease costs, and reduce animal testing. In addition, this approach advances the goal of providing sensitive, specific, quantitative, and efficient screening using alternative test methods to some assays in the Tier 1 battery to protect human health and the environment.

Issues for Comment

In connection with EPA’s stated intention to use the scientific tools discussed in this Notice as alternatives to some of the current EDSP Tier 1 screening assays, EPA is specifically seeking public comment on the following:

  1. The use of the ToxCast TM“ER Model” for bioactivity as an alternative method for the current ER binding and ERTA Tier 1 screening assays.
  2. The use of the ToxCast TM“ER Model” for bioactivity as an alternative method for the current uterotrophic Tier 1 screening assay.
  3. The use of results from the ToxCast TM“ER Model” for bioactivity on over 1800 chemicals as partial screening for the estrogen receptor pathway.