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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
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  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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Report Outlines Predictive Toxicology Approach for Defense Applications

Contributor: Catherine Sprankle, NICEATM The National Academies Press has issued a report on “Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense.” Prepared in response to a request by the U.S. Department of Defense, the report provides a conceptual approach that could be used to evaluate chemicals that could pose threats to […]
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New FDA report: Science Moving Forward, A Progress Report to the FDA Science Board

Contributor: Sherry Ward, AltTox “Modernize Toxicology to Enhance Product Safety” is the first of the FDA’s 9 Scientific Priority Areas described on page 11 of the FDA’s new report, Science Moving Forward, A Progress Report to the FDA Science Board (http://www.fda.gov/downloads/ScienceResearch/AboutScienceResearchatFDA/UCM456328.pdf). Intramural research on a non-animal approach includes the example on page 28 where “a […]
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Call for short proposals

Contributor: Amy J. Clippinger, PETA International Science Consortium Ltd. The PETA International Science Consortium Ltd. (PISC) and MatTek Corporation are offering 3D reconstructed human tissue models – for free! MatTek’s human cell-based tissues—including dermal, ocular, respiratory, intestinal, oral, and vaginal models—are used for regulatory safety testing, product development, and basic research applications. Researchers who can […]
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ECHA follows up on registrants’ obligations to consider alternative tests

Contributor: Sherry Ward, AltTox Source: ECHA News http://echa.europa.eu/view-article/-/journal_content/title/echa-follows-up-on-registrants-obligations-to-consider-alternative-tests ECHA has analysed why registrants submitted 295 new higher tier studies on vertebrate animals without first seeking the Agency’s decision to permit such tests. In general, registrants were able to clarify why the new studies were conducted and submitted for registration purposes. However, in a number of cases […]
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Chemical Aquatic Fate and Effects (CAFE) Database released by NOAA

Contributor: Sherry Ward, AltTox Sources: ECETOC (http://www.ecetoc.org/index.php?mact=Newsroom,cntnt01,details,0&cntnt01documentid=285&cntnt01returnid=76) and NOAA (http://response.restoration.noaa.gov/cafe) The Chemical Aquatic Fate and Effects (CAFE) database (http://response.restoration.noaa.gov/oil-and-chemical-spills/chemical-spills/response-tools/download-install-and-run-cafe.html) is a software program you can use to estimate the fate and effects of thousands of chemicals, oils, and dispersants. CAFE serves as a tool to help responders in their assessment of environmental impacts from chemical […]
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The 3Rs-Centre Utrecht Life Sciences continues NKCA activities

Contributor: Jan van der Valk, 3Rs Centre-Utrech Life Sciences For 4 years (2010-2014) the Netherlands Knowledge Centre on Alternatives (NKCA) was responsible for promoting the application of the 3R-alternatives – replacement, reduction and refinement – in the Netherlands. The Centre, which was a collaboration between the RIVM and the Utrecht University, was established by the […]
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Preclinical Assays Needed to Predict Vaccine Efficacy

Contributor: Sherry Ward, AltTox Source: http://www.niaid.nih.gov/researchfunding/newsletter/2015/Pages/0715.aspx#or02 Promising preclinical data for a candidate vaccine does not guarantee efficacy in phase II/III clinical trials. Thus, NIAID seeks novel preclinical assays capable of better predicting the likelihood of success in human clinical studies based on preclinical outcomes. As researchers continue to identify new potential markers of protection, new […]
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NIEHS Offers Financial Support for Later Stages of Test Method Development

Contributor: Catherine Sprankle, NICEATM The National Institute of Environmental Health Sciences (NIEHS) will provide additional support to current federal grantees for validation and commercialization of replacement or reduction alternatives to tests required by U.S. government agencies. These Small Business Innovation Research (SBIR) Phase IIB awards will support further development of non-clinical toxicology tests for use […]
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Open position at PCRM: Science Policy Specialist

Contributor: Kristie Sullivan, PCRM The Physicians Committee is looking for a Science Policy Specialist to join our team. The ideal candidate for this position will have a basic knowledge of toxicological and pharmacological concepts including in vivo, in vitro, and in silico test methods and familiarity with the laws, regulations, and practices related to efficacy […]
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Introduction to Complexity – free, online course starts today

Contributor: Sherry Ward, AltTox The free and online course by the Santa Fe Institute, “Introduction to Complexity” (http://www.complexityexplorer.org), begins today. The purpose of this course is to help registrants learn about the tools used by scientists to understand complex systems. This is an introductory course and there are no math or other prerequisites. To see […]
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NIH Announces Strategy to Improve Reproducibility of Funded Research

Contributor: Sherry Ward, AltTox Source: http://www.niaid.nih.gov/researchfunding/newsletter/2015/Pages/0701.aspx#itn01 “In an effort to advance the highest level of scientific integrity, NIH has unveiled a strategy to improve the reproducibility of the research it funds in two June 9, 2015 Guide notices: Enhancing Reproducibility Through Rigor and Transparency and Consideration of Sex as a Biological Variable in NIH-Funded Research. […]
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ICCVAM Advisory Committee to Meet September 2

Contributor: Catherine Sprankle, NICEATM ICCVAM’s advisory committee, the Scientific Advisory Committee on Alternative Toxicological Methods, will hold its annual meeting on September 2 in the Rodbell Auditorium at NIEHS in Research Triangle Park, North Carolina. You must preregister to attend the meeting in person; the meeting will also be webcast. An agenda, other materials, and […]
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USDA Requests Comments on Petition to Revise Animal Use Reporting Requirements

Contributor: Catherine Sprankle, NICEATM The Department of Agriculture Animal and Plant Health Inspection Service (USDA APHIS) has received a petition from the National Anti-Vivisection Society (NAVS) to increase the level of detail in information collected from research facilities in their reports on animal use. NAVS is asking that the annual report required under the Animal […]
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NIH Updates Solicitation for SBIR/STTR Grant Applications

Contributor: Catherine Sprankle, NICEATM The NIH has updated the solicitation announcement for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications. The NIEHS section has been updated to include a section on “Toxicity Screening, Testing, and Modeling,” which states an interest in “technologies to improve predictivity in toxicology testing to support […]
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EPA Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program

Contributor: Sherry Ward, AltTox The Environmental Protection Agency (EPA) has published a Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program. Below is just a small part of the notice’s content. Source: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2015-0305-0001 Docket ID: EPA-HQ-OPPT-2015-0305 Abstract: Federal Register for Friday, June 19, 2015 (80 FR 35350) (FRL–9928–69 ) Use of […]
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Submit an Abstract for ASCCT 4th Annual Meeting

Contributor: Kristie Sullivan, PCRM Registration and abstract submission for the 4th Annual ASCCT Meeting are now open. Integrated Approaches to Testing and Assessment: Promises and Challenges of a More Flexible Approach to Toxicology Testing October 1-2, 2015 Environmental Protection Agency, Durham, North Carolina, US Plenary Lectures: Moving Beyond One Test: Leveraging the Whole Toolbox for […]
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EPA seeks nominations for new Chemical Safety Advisory Committee on or before July 13, 2015

Contributor: Marilyn Matevia, HSUS The purpose of the Chemical Safety Advisory Committee is to provide expert scientific advice, information, and recommendations to the Office of Pollution Prevention and Toxics (OPPT). The major objective is to provide advice and recommendations on: The scientific basis for risk assessments, methodologies, and pollution prevention measures or approaches. The EPA […]
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Board of Appeal agrees with PISC in ruling that may save 1300 animals

Author: Joseph Manuppello, People for the Ethical Treatment of Animals The European Chemical Agency’s Board of Appeal today reversed a decision by ECHA that required CINIC CHEMICALS EUROPE, Sàrl to conduct an extended one generation reproductive toxicity study (EOGRTS). ECHA had refused to consider new information after a self-imposed deadline and updates to the registrant’s […]
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National Aeronautics and Space Administration [NASA] – Centennial Challenges Program – Tissue Engineering Challenge – Request for Information

Author: Sherry Ward, AltTox https://www.fbo.gov/?s=opportunity&mode=form&tab=core&id=0905c3a33c88d0b702f92bcbe74479c1&_cview=0 Solicitation Number: NNM15ZZP006L Notice Type: public feedback is being sought – this is not a funding notice Synopsis: I. SUMMARY The Centennial Challenges Program is NASA’s flagship program for technology prize competitions (www.nasa.gov/challenges). The Centennial Challenges Program directly engages the public, academia, and industry in open prize competitions to stimulate […]
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CRACK IT Solutions: Partners sought to help develop and validate a portable bioluminescence test for botulinum neurotoxin

Author: Sherry Ward, AltTox “Researchers from University of Freiburg, Germany, are seeking partners to validate and commercialize their novel automated bioluminescence assay (BLBTest) for detecting botulinum neurotoxin (BoNT) to replace mouse bioassays. What could the Solution be used for? The BLB-Test is a portable, highly sensitive, automated assay for detecting BoNT as a replacement for […]
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New EPA Guidance: Alternate Testing Framework for Classification of Eye Irritation Potential of EPA Pesticide Products

Author: Marilyn Matevia, HSUS The EPA has released updated guidance for testing antimicrobial cleaning products for their potential to cause eye irritation. From the EPA announcement: This updated guidance document, effective immediately, describes a testing framework for assessing eye irritation potential of EPA-registered antimicrobial cleaning products using three in vitro/ex vivo assays (non-animal tests): Bovine […]
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Innocentive Posts 2 Open Innovation Challenges for In Vitro Kidney Microphysiological Systems

Author: Sherry Ward, AltTox AstraZeneca Challenge: In Vitro Proximal Tubule Model Systems: Innocentive: https://www.innocentive.com/ar/challenge/9933749 Challenge ID: 9933749 AWARD: $15,000 USD; DEADLINE: 6/26/15 “AstraZeneca is seeking innovative approaches to developing a model system of the proximal tubule in vitro. Ideally, the model should incorporate a self-contained microphysiological unit in which biologically appropriate media, fluid flow, and shear stress can […]
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Lush Prize 2015 open for nominations

Author: Craig Redmond, Lush Prize Team The Lush Prize 2015 is now open for nominations. This £250,000 (€300,000) annual prize fund rewards recent outstanding initiatives to end animal testing, particularly in the area of toxicology. It is divided into five prize categories: Science, Training, Young Researcher (under 35 years old), Lobbying and Public Awareness. £50,000 […]
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The PETA International Science Consortium Ltd and Chemical Watch to present the final in a series of free webinars on alternatives to animal testing for REACH

Author: Amy J. Clippinger, PETA International Science Consortium Ltd. The final PETA International Science Consortium Ltd/Chemical Watch webinar, “The Regulatory Processes Involved in Acceptance of Non-Animal Tests,” will be presented by Derek Knight and Karin Kilian on 10 June 2015 at 10am Eastern Daylight Time. Derek Knight (Senior Scientific Advisor, ECHA) will speak about regulatory […]
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Recent articles from ECHA explain approaches to minimize animal testing for REACH

Author: Sherry Ward, AltTox The February and April 2015 ECHA Newsletters as well as other recent articles on the ECHA website include information that could assist companies in minimizing animal testing for REACH reporting requirements. In a November 2014 AltTox article (http://alttox.org/cosmetics-regulation-animal-test-ban-declared-subordinate-reach-registration-testing-requirements-echa/), we had cited a statement from the October 2014 ECHA Newsletter that said […]
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“21st Century Understanding of Chemicals” briefing

Author: Sherry Ward, AltTox Six videos from the April 6, 2015 Congressional briefing organized by the American Chemical Society (ACS) Science & the Congress Project, ACS Corporation Associates, and the American Political Science Association (http://www.congressplus.com/events/index.cfm?action=Event_Page&eventcode=ZxyVwS&bypass=true) are now available for viewing at https://vimeo.com/album/3323655.
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NAVS Humane Science Award Recipients at Intel International Science and Engineering Fair

Author: Sherry Ward, AltTox NAVS Selects 2015 Humane Science Award Recipients at Intel ISEF May 18, 2015 Source: http://www.navs.org/science-first/2015-intel-international-science-and-engineering-fair Last week, NAVS attended the Intel International Science and Engineering Fair—the world’s largest international science competition for high school students—in Pittsburgh, Pennsylvania. There, NAVS recognized three exceptional students with our Humane Science Award. For 14 years, […]
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Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment (Workshop 9)

Author: Lynne Haber, Toxicology Excellence for Risk Assessment (TERA) Beyond Science & Decisions – Workshop 9 June 9-10, 2015 Cincinnati, Ohio – University of Cincinnati, Kettering Laboratory Auditorium Almost 60 organizations have come together under the aegis of the Alliance for Risk Assessment (ARA), to conduct a series of meetings, with the ultimate goal of […]
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USDA APHIS NOTICE: VS Memorandum 800.112 Guidelines for Validation of In Vitro Potency Assays

Author: Sherry Ward, AltTox The Center for Veterinary Biologics (CVB) recently added [05/07/2015] VS Memo 800.112 to its website, which may be accessed by clicking the following link: CVB Newly Published Information (http://www.aphis.usda.gov/wps/portal/aphis/ourfocus/animalhealth?1dmy&urile=wcm%3apath%3a%2Faphis_content_library%2Fsa_our_focus%2Fsa_animal_health%2Fsa_vet_biologics%2Fct_vb_newly_published_info). This memorandum provides guidance concerning the information a firm should provide when submitting a new potency assay for consideration by the Center for Veterinary Biologics […]
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Upcoming NRC Workshop: Metabolomics as Tool for Characterizing Exposome

Contributor: Solmaz Spence, National Academies of Sciences, Engineering, and Medicine Metabolomics—the study of the chemical fingerprints that cellular processes leave behind—is emerging as an important way to characterize exposure. On May 28-29, join the committee on Emerging Science for Environmental Health Decisions and researchers, professionals, and policy experts for a free workshop that will explore […]
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International Conference on Harmonization Regional Public Meeting, May 15

Author: Sherry Ward, AltTox [Also see the related blog post on April 13.] Preparation for International Conference on Harmonization Steering Committee and Expert Working Group Meetings in Fukuoka, Japan; Public Meeting Source: http://www.fda.gov/Drugs/NewsEvents/ucm439475.htm The Food and Drug Administration (FDA) is holding a regional public meeting on May 15, 2015, to provide information and receive comments […]
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NTP Requests Comments on Human “S1500” Gene Set

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The National Toxicology Program (NTP) requests comments on a set of human genes that have been identified and prioritized as environmentally responsive genes. This set of approximately 1500 “sentinel” genes was developed with input from the scientific community, to be used in toxicogenomics studies to screen human cells or […]
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FDA Science Forum

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The U.S. Food and Drug Administration (FDA) will hold a Science Forum on May 27-28 at their White Oak Campus in Silver Spring, Maryland. The Forum will highlight the FDA’s cutting-edge research, demonstrate how this research informs FDA’s regulatory decision-making, and provide an opportunity for internal and external participants […]
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Assessing CDERs Safety-Related Regulatory Science Needs and Identifying Priorities: Report and Request for Comments by May 18

Author: Sherry Ward, AltTox This report (March 2015; “Assessing CDERs Drug Safety Related Regulatory Science Needs and Identifying Priorities Report”) identifies drug safety-related regulatory science needs and priorities related to the mission of FDA’s Center for Drug Evaluation and Research (CDER) that would benefit from external collaborations and resources. FDA hopes to foster collaborations with […]
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Reminder: Deadline April 30 for Grants from the Alternatives Research and Development Foundation (ARDF)

Author: Sue A. Leary, Alternatives Research & Development Foundation (ARDF) The deadline is fast approaching for applications to the Alternatives Research Grant Program of ARDF. Grants of up to $40,000 are available to support individual projects of scientific merit and feasibility with potential to significantly reduce or replace laboratory animal use. Preference will be given […]
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ICCVAM Public Forum May 27

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) will hold a Public Forum on Wednesday, May 27, 2015, from 9:00 a.m. to 12:00 p.m. at the National Institutes of Health Natcher Conference Center in Bethesda, Maryland. Representatives of the federal agencies on ICCVAM will be present […]
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Health Canada and United States Food and Drug Administration Joint Public Consultation on ICH Guidelines on May 15, 2015

Author: Sherry Ward, AltTox Source: http://www.hc-sc.gc.ca/dhp-mps/consultation/drug-medic/ich_fda_rcc_ccr_notice_avis-eng.php On February 4, 2011, Prime Minister Stephen Harper and United States President Barack Obama announced the creation of the Canada-United States (U.S.) Regulatory Cooperation Council (RCC) to better align the two countries’ regulatory approaches, where possible. Under the RCC initiative, Health Canada and the U.S. Food and Drug Administration […]
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The Foundation for Advanced Education in the Sciences (FAES), NIH: Hands-on Lecture & Laboratory Training Workshops

Author: Kate Willett, HSUS The following laboratory training workshops are being offered at NIH: Bio Tech 39 | 4-Day Epigenetics (Apr 14-17, 2015) BioTech 23 | 4-Day Flow Cytometry: Principles and Methods (April 28 – May 1, 2015) BioTech 7 | 5-Day Animal and Human Cell Culture: Method and Applications (May 11–15, 2015) BioTech 27 […]
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PETA and PCRM researchers publish on in vitro methods for assessing tobacco toxicity. Survey supports prioritizing in vitro methods over animal studies.

Author: Joseph Manuppello, PETA Public Release: 1-Apr-2015 The tobacco industry and regulatory authorities should support more relevant and less costly in vitro toxicology testing methods over unreliable animal testing, according to a review of research advances published this week in the comment pages of the peer-reviewed scientific journal Alternatives to Laboratory Animals The article by […]
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Public consultation on Threshold of Toxicological Concern (TTC) Approach; deadline April 12

Author: Sherry Ward, AltTox “The Threshold of Toxicological Concern (TTC) is a methodology that may be used to assess potential human health concerns for a chemical based on its chemical characteristics and estimated exposure when chemical-specific toxicity data are scarce or absent. Overall, the TTC approach integrates data on exposure, chemical structure, metabolism, and toxicity […]
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FDA Meeting on Alternative In Vitro Bioequivalence Pathways – April 16

Author: Sherry Ward, AltTox Source: http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm438068.htm On April 16, 2015, the U.S. Food and Drug Administration will sponsor a public meeting to discuss the use of in vitro methods as a mechanism for assessing the in vivo product bioequivalence (BE) of non-systemically absorbed (locally acting) drug products intended for use in veterinary species. The meeting […]
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Big Data Outreach Meeting at SOT Meeting on March 23

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) “A discussion of the NIH BD2K initiative and how it might advance the practice of Toxicology and Risk Assessment The fields of toxicology, pharmacology and risk assessment are undergoing a revolution in the use of pathway-based approaches to evaluate the biological effects of chemicals. […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.