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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
  • advertisements are not permitted
  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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AVON Breast Cancer Research Program

Contributor: Sherry Ward, AltTox Letters of Intent for research funding through the AVON Breast Cancer Research Program are due January 7, 2016 for proposals to be submitted later in 2016 (by invitation only). Research priorities Research questions [they] hope to answer to further the development of breast cancer prevention strategies include, but are not limited […]
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NCATS News

Contributor: Sherry Ward, AltTox The National Center for Advancing Translational Sciences (NCATS) is one of 27 Institutes and Centers at the National Institutes of Health (NIH). It was established in 2012 “to transform the translational science process so that new treatments and cures for disease can be delivered to patients faster” (http://www.ncats.nih.gov/about/center). One of the […]
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ICCVAM Webinar on Fundamentals of QSAR and Read-across

Contributor: Catherine Sprankle, NICEATM ICCVAM will present its second Communities of Practice webinar on Jan. 26, 2016, from 1:00-2:30 p.m. The webinar, on “Fundamentals of Using Quantitative Structure–Activity Relationship Models and Read-across Techniques in Predictive Toxicology,” is being organized on behalf of ICCVAM by NICEATM and hosted by the U.S. Environmental Protection Agency’s (EPA’s) National […]
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NICEATM Director Casey Recognized for Contributions to Animal Welfare

Contributor: Catherine Sprankle, NICEATM In a Dec. 14 announcement, the Society of Toxicology (SOT) recognized NICEATM Director Warren Casey, Ph.D., with the 2016 Enhancement of Animal Welfare Award. This award is given for advancing toxicology through the development and application of methods that replace, refine, or reduce the need for experimental animals. In recognizing the […]
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NICEATM and ICCVAM to Hold Forum at SOT

Contributor: Catherine Sprankle, NICEATM NICEATM Director Warren Casey, Ph.D. and ICCVAM Co-chair Anna Lowit, Ph.D. (U.S. Environmental Protection Agency), will lead a discussion forum during the 2016 SOT Annual Meeting. Casey and Lowit will begin the forum with summaries of recent ICCVAM and NICEATM activities, focusing on efforts to reduce animal use for acute systemic […]
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UK “roadmap” to wider use of non-animal technologies

Contributor: Marilyn Matevia, HSUS Six organizations, including NC3Rs, have published a “roadmap” to facilitate the UK’s development and embrace of non-animal technologies, Advancing Predictive Biology. In a recent blog post, NC3Rs Chief Executive Dr. Vicky Robinson provides context to the project: The roadmap is part of a wider collaboration between the six partners which has […]
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Job openings at Silent Spring Institute

Contributor: Kate Willett, HSUS The Silent Spring Institute is looking for research scientists in data science and informatics, chemistry/biochemistry and biomonitoring, and molecular biology or endocrinology. The Institute is seeking candidates for three position postings: a versatile data scientist, machine learning expert, or statistician to tackle big data problems in environmental health and breast cancer […]
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2016 Funding Opportunities

Contributor: Sherry Ward, AltTox (1) Exploratory/Developmental Bioengineering Research Grants (EBRG): http://grants.nih.gov/grants/guide/pa-files/PA-16-040.html Application due dates: March 16, July 16, and November 16, 2016 These awards are open to various types of organizations, including small business. The R21 mechanism supports short-term exploratory research projects. “The purpose of this FOA is to  encourage submission of EBRG applications which […]
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Upcoming workshop: Environment and Health – What’s the Human Microbiome Have to Do With It?

Contributor: Solmaz Spence, National Academies of Sciences, Engineering, and Medicine Workshop Title: The National Academies of Sciences, Engineering, and Medicine’s Emerging Science for Environmental Health Decisions Workshop, Environment and Health: What’s the Human Microbiome Have to Do With It? Date: January 14-15 2016 Location: Washington, D.C., and via webcast The microbiome—the collection of bacteria, viruses […]
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ARDF announces recipients of the 2015 Alternatives Research Grant Program awards

Contributor: Sue A. Leary, Alternatives Research & Development Foundation (ARDF) ARDF is pleased to announce that its 2015 Alternatives Research Grant Program has made its selections. ARDF has awarded $220,000 to scientists developing alternative methods in a variety of areas of medical research, testing, and education. Congratulations to awardees: April Davis, PhD and William Lee, […]
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New paper describes improved method for quantifying electrophiles (potential skin sensitizers)

Contributor: Amar G. Chittiboyina, PhD, National Center for Natural Product Research To add structural information to the existing in chemico methods, an NMR-based method is proposed for probing the reactivity and classification of the potential electrophiles (E) using a model thiol, DCYA. The major advantage of the NMR method is the quantitation of the actual […]
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ASCCT offering student travel awards for the 17th International Conference on QSAR in Environmental and Health Sciences

Contributor: Kristie Sullivan, PCRM The 17th International Conference on QSAR in Environmental and Health Sciences takes place June 13-17, 2016, in Miami Beach, Florida. The abstract deadline is December 4, 2015; early bird registration ends March 1, 2016. Since 1983, this meeting has been an important international gathering in the field of Environmental and Health […]
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CVB Notice 15-13: Alternative approach to hamster potency test for several Leptospira serogroups could reduce animal use by 50%

Contributor: Sherry Ward, AltTox The Center for Veterinary Biologics (CVB) recently added CVB Notice 15-13, Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Canicola and Icterohaemorrhagiae, to its website: https://www.aphis.usda.gov/animal_health/vet_biologics/publications/notice_15_13.pdf The purpose of this notice is to inform interested parties that the CVB will allow an exemption from the titration […]
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Results from the 2015 GBSI survey on cell line authentication practices

Contributor: Sherry Ward, AltTox AltTox’s May 2015 “In the Spotlight,” Are we inseparable? Reproducible bioassays and authenticated cell lines (http://alttox.org/are-we-inseparable-reproducible-bioassays-and-authenticated-cell-lines-new-initiatives-by-the-global-biological-standards-institute/), asked readers to participate in a survey on cell line authentication practices being conducted by the Global Biological Standards Institute (GBSI). The results are now available! GBSI’s Cell Authentication Survey Shows Little Progress in a […]
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Scientific Job Openings with PETA US and PETA UK

Contributor: Katherine Groff, PETA International Science Consortium Ltd. Multiple scientific positions are available in PETA US and UK offices (check out all of the positions here: http://www.piscltd.org.uk/employment-opportunities-with-peta-us-and-peta-uk), including a Corporate Liaison position in the Regulatory Testing Department with PETA US. The Corporate Liaison will oversee, develop, and carry out PETA’s work with major corporations to […]
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ECHA asks registrants about their consideration of alternative methods

Contributor: Sherry Ward, AltTox Editor’s Note: The AltTox Resource Center page, Searching for Non-animal Toxicity Test Methods, provides links to many sources of information on non-animal test methods: http://alttox.org/resource-center/searching-for-non-animal-toxicity-testing-methods/ ______________________________________ ECHA asks registrants to show how they considered alternative methods before consulting on testing proposals Source: http://echa.europa.eu/view-article/-/journal_content/title/echa-asks-registrants-to-show-how-they-considered-alternative-methods-before-consulting-on-testing-proposals To further ensure that testing on animals is […]
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New publication on non-animal affinity reagents

Contributor: Amy J. Clippinger, PETA International Science Consortium Ltd. There is a growing concern about the lack of quality and reproducibility of animal-derived antibodies, which often show poor specificity or fail to recognize their targets. Time, money, and tens of thousands of animals could be saved, while improving the reproducibility of research, by replacing animal-derived […]
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October 30 Public Meeting on the Coordinated Framework on Biotechnology

Contributor: Sherry Ward, AltTox The Environmental Protection Agency (EPA), Food and Drug Administration (FDA) and United States Department of Agriculture (USDA) will hold a public meeting on October 30, 2015, to discuss the memorandum entitled, “Modernizing the Regulatory System for Biotechnology Products,” issued by the Executive Office of the President on July 2, 2015. The […]
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EPA’s Advancing Systematic Review Workshop (Dec 16-17): Expert/Topic Nominations due November 5

Contributor: Marilyn Matevia, HSUS The US EPA’s National Center for Environmental Assessment (NCEA) is now accepting nominations for experts and topics for its December 16-17 workshop, Advancing Systematic Review for Chemical Risk Assessment. Nominations are due November 5. From the EPA’s meeting announcement: “EPA is developing and implementing a systematic review process within the IRIS […]
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Vacancy: Director, National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

Contributor: Bonnie Earnhardt, NIH/NIEHS NIEHS is seeking a dynamic, highly motivated Senior Scientist to serve as NICEATM Director.  NICEATM is the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, an office within the Division of the National Toxicology Program.  NICEATM is the primary federal resource for the development, validation, and evaluation of new […]
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Presentations from Acute Toxicity Workshop

Contributor: Catherine Sprankle, NICEATM Presentations from the Sept. 24–25 workshop on Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing are now available on the NICEATM website. At this workshop, representatives from regulatory agencies, academia, and industries developed strategies for advancing alternative methods for product safety testing that meet the needs […]
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USDA Issues Guidance on Vaccine Testing

Contributor: Catherine Sprankle, NICEATM The U.S. Department of Agriculture (USDA) Center for Veterinary Biologics (CVB) recently issued CVB Notice 15-13, Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Canicola and Icterohaemorrhagiae. The notice describes an exemption from the titration requirement in vaccination-challenge potency assays for Leptospira Serogroups Canicola and Icterohaemorrhagiae. […]
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NAS to Examine Low-dose Toxicity

Contributor: Catherine Sprankle, NICEATM A new committee of the National Academy of Sciences (NAS) will examine whether the current toxicity testing practices of the U.S. Environmental Protection Agency adequately consider adverse human health effects of low doses of endocrine-active chemicals. Committee activities will include convening a scientific workshop to support systematic reviews of human and […]
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EURL ECVAM report on alternative methods

Contributor: Kristie Sullivan, PCRM The European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published an extremely comprehensive report on all its activities related to human and ecological health, the development and validation of alternative methods, and information dissemination, and regulatory implementation. The report contains summaries of, e.g., EURL ECVAM’s activities in […]
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Rodent Uterotrophic Database Now Available

Contributor: Catherine Sprankle, NICEATM An article published October 2 as an advance publication in Environmental Health Perspectives describes curation and evaluation of a database of rodent uterotrophic bioactivity. The uterotrophic assay is a widely accepted in vivo test for identifying chemicals with potential estrogen receptor agonist activity. The new database, which includes data from studies […]
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IVIVE Webinars and Workshop

Contributor: Catherine Sprankle, NICEATM A series of four webinars on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making are being presented by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the U.S. Environmental Protection Agency (EPA). The webinar series began October 7 and […]
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New Resource for Small Business Grant Applicants

Contributor: Catherine Sprankle, NICEATM A November 4 webinar will explain how to use the ASSIST (Application Submission System and Interface for Submission Tracking) system for submitting grant applications. ASSIST is an alternative to Grants.gov downloadable forms for applying for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants. Advantages to using ASSIST […]
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Version 2 of S1500+ Human Gene Set Now Available

Contributor: Catherine Sprankle, NICEATM National Institute of Environmental Health Sciences and National Toxicology Program (NTP) scientists along with Tox21 partners have developed a list of environmentally responsive genes to be used in toxicogenomics approaches to screening large numbers of chemicals. Genes on the list were identified through both bioinformatics approaches and experimental data establishing certain […]
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Pre-Applications for Translational Science Awards

Contributor: Catherine Sprankle, NICEATM The NIH invites interested applicants to pre-apply for PAR-15-172 “Collaborative Innovation Award, Clinical and Translational Science Award (CTSA) Program (U01)”. While not required, pre-application for this award is recommended. Applicants submitting pre-applications that are meritorious and programmatically relevant will be notified of the opportunity to submit a full application. NCATS is […]
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EFSA’s 2nd Scientific Conference, October 14-16, can be followed online

Contributor: Sherry Ward, AltTox Registration to this conference is now closed, but you can follow the entire conference online: http://www.efsaexpo2015.eu/join-the-conference-online/ Conference Website: http://www.efsaexpo2015.eu/ Here are descriptions of 3 of the conference sessions: Novel chemical hazard characterization approaches – October 16 from 09:00 to 13:00 Novel tools and testing strategies are revolutionising the way that scientists […]
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EPA’s NCCT is hiring

Contributor: Marilyn Matevia, HSUS An announcement from the EPA: The US Environmental Protection Agency Office of Research Development’s National Center for Computational Toxicology (NCCT) is seeking qualified candidates for four positions 1) Computational Toxicologist, 2) Molecular Toxicologist, 3) Cell Biologist and 4) Text Mining Specialist. Below is more information about the National Center for Computational […]
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International NC3Rs Prize

Contributor: Kristie Sullivan, PCRM From the UK National Centre for the 3Rs Website: “The international NC3Rs Prize is awarded to highlight an outstanding original contribution to scientific and technological advances in the 3Rs in medical, biological or veterinary sciences published within the last three years. The prize is part of our commitment to recognise and […]
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Danish 3R-Center call for project applications to promote the development and implementation of the 3Rs

Contributor: Sherry Ward, AltTox On behalf of The Minister of Environment and Food, The Danish 3R-Center calls for applications to promote the development and implementation of the 3Rs. Call for project applications: http://en.3rcenter.dk/fileadmin/user_upload/images/Forskning/Call_for_project_applications_to_promote_the_development_and_implementation_of_the_3Rs_final.pdf Danish 3R-Center Research Funding: http://en.3rcenter.dk/research-funding/ Application Deadline: Wednesday October 21, 2015. Grants of up to 500.000 DKK can be applied for. Typically, […]
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Request for scientific community input on future high performance computing (HPC) needs for new agency roadmap; due by October 16

Contributor: Sherry Ward, AltTox Any ideas on future HPC needs in the 3Rs such as virtual models, in silico tools, -omics data, ITS, validation study data storage/analysis, education/training, etc.? Please consider participating in this request for a 2-page e-mail submission of your ideas. Request for Information on Science Drivers Requiring Capable Exascale High Performance Computing: […]
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Announcement: Financial support for research into alternatives to animal experiments

Contributor: Dr. Sonja von Aulock, Editor in Chief, ALTEX Announcement Financial support for research into alternatives to animal experiments The Danish organisation Forsøgsdyrenes Værn and the Danish foundation Alternativfondet announce financial support for research into the development of alternatives to animal experiments. To qualify for support it is not enough that your research is carried […]
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September Issue of the ECHA Newsletter

Contributor: Sherry Ward, AltTox The latest issue of the ECHA Newsletter  includes an article on the substitution of harmful chemicals with safer alternatives. “Looking at a different approach to substitution, ECHA Newsletter spoke with Dr Joel A. Tickner, Director and Associate Professor of Community Health and Sustainability from the University of Massachusetts Lowell, who has […]
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Award for Adverse Outcome Pathway Development

Contributor: Katherine Groff, PETA International Science Consortium Ltd. The European Commission’s Joint Research Centre (JRC), the US Environmental Protection Agency (EPA), and the Organisation for Economic Co-operation and Development (OECD) collaboratively created the AOP Wiki to provide the international scientific community an interactive encyclopedia for AOP development. Working with AOP Wiki organisers, the PETA International […]
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FRAME Training School dates announced

Contributor: Anne Jeffery, FRAME Details of the next FRAME Training School in experimental design and statistical analysis have been released.  It will be held in Voss, Norway from 1-3 February, 2016. When scientists carry out experiments it is vitally important they are well designed,otherwise they may waste resources or give the wrong answers. This is especially […]
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NIH call for proposals: Collaborative Projects to Accelerate Research in Organ Fibrosis

Contributor: Sherry Ward, AltTox Collaborative Projects to Accelerate Research in Organ Fibrosis (R01) (RFA-HL-16-003): http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-003.html Due Dates: October 22, 2015 and October 21, 2016 Purpose: While fibrogenesis is an essential process in normal wound healing, aberrant and relentless fibrogenesis in vital organs such as heart, lung, kidney, and bone marrow can lead to debilitating symptoms […]
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Request for information and nominations of experts for peer review on systematic review of immunotoxicity associated with PFOA or PFOS exposure

Contributor: Sherry Ward, AltTox Source: https://www.federalregister.gov/articles/2015/08/14/2015-20122/systematic-review-of-immunotoxicity-associated-with-exposure-to-pfoa-or-pfos-request-for-information Background: PFOA and PFOS are persistent chemicals that are widely distributed in the environment in part because of high stability and little to no expected degradation in the environment. In terms of toxicity and exposure, PFOA and PFOS are the best studied perfluoroalkyl acids, a group of compounds used […]
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New issue of CSS Pathways from the US EPA

Contributor: Sherry Ward, AltTox The August 2015 issues of CSS Pathways (http://www2.epa.gov/sites/production/files/2015-08/documents/august_2015_css_pathways_external.pdf) reports many developments in chemical safety research and testing by US EPA researchers. Several approaches to assessing potential endocrine disruptors are reported: EPA introduces new technology to screen chemicals for endocrine disruption High-throughput model predicts estrogen receptor activity Advancing methods to evaluate thyroid […]
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HeMiBio Project Symposium

Contributor: Stéphanie Rémola, HeMiBio Management Team In January 2011 the European Commission and Cosmetics Europe jointly launched a European research initiative aiming at a common strategy towards the replacement of current repeated dose systemic toxicity testing in human safety assessment. The aim of HeMiBio as part of this initiative was to generate a liver-simulating device […]
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Agenda Available for Sept. 2 SACATM Meeting

Contributor: Catherine Sprankle, NICEATM The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet on September 2 in the Rodbell Auditorium at NIEHS. SACATM is the advisory committee to ICCVAM. Topics to be discussed at the September 2 meeting include updates on recent activities from NICEATM and ICCVAM member agencies; international interactions and current […]
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NIH Presents Conference for Small Business Grant Applicants

Contributor: Catherine Sprankle, NICEATM The National Institutes of Health (NIH) Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) Conference will be held in Seattle, Washington, on October 27–29. This event is the largest annual conference for SBIR/STTR applicants. Presentations will provide overviews of Department of Health and Human Services (HHS) SBIR/STTR programs, funding opportunities, […]
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Links to recently published OECD in vitro test guidelines

Contributor: Kate Willett, HSUS Here are links to four recently published OECD in vitro test guidelines: Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene http://www.oecd-ilibrary.org/environment/test-no-490-in-vitro-mammalian-cell-gene-mutation-tests-using-the-thymidine-kinase-gene_9789264242241-en;jsessionid=22dh652p3oaq6.x-oecd-live-02 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring […]
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NIEHS Funding Opportunities and Resources

Contributor: Catherine Sprankle, NICEATM The National Institutes of Environmental Health Sciences (NIEHS) invites qualified small businesses to apply for the following grant opportunities: Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science: applications due Sept. 5, 2015; Jan. 5, 2016; and April 5, 2016. View Small Business Innovation Research (SBIR) grant […]
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Sept. 10 FDA Public Meeting to Prepare for International Cooperation on Cosmetics Regulation Meeting

Contributor: Sherry Ward, AltTox Source: http://www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm454464.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery The U.S. Food and Drug Administration will hold a public meeting on September 10, 2015 to receive input from the public on various topics pertaining to the regulation of cosmetics to help the agency prepare for the International Cooperation on Cosmetics Regulation-9 (ICCR-9) meeting that will be held November […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

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