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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
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Please report offensive or inappropriate content to info@alttox.org

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OECD launches the QSAR Toolbox version 4.2

The EHS Hazard Assessment programme is actively working to increase the regulatory acceptance of QSARs methods, tools and approaches such as the QSAR Toolbox and to make these technologies more accessible and transparent. The QSAR toolbox is a software application intended to the use of governments, chemical industry and other stakeholders in filling gaps in […]
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ICCVAM Elects Co-chairs

At its January 24 meeting, ICCVAM elected Anna Lowit, U.S. Environmental Protection Agency (EPA), and Emily Reinke, Department of Defense, to serve two-year terms as co-chairs of ICCVAM. Lowit is a senior science advisor in the EPA Office of Pesticide Programs. She has been a member of ICCVAM since 2011 and has served as an […]
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U.S. Strategic Roadmap Published

ICCVAM has coordinated the development of “A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States.” It describes a framework for safety testing that will provide more human-relevant toxicology data while reducing the use of animals. Prepared with support from NICEATM, it was published January […]
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Feb. 8 Webinar to Introduce New Funding Opportunity from Human Biomolecular Atlas Program

The NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) (https://commonfund.nih.gov/hubmap) aims to develop a framework for functional mapping the human body with cellular resolution to enhance our understanding of cellular organization-function. HuBMAP will accelerate the development of the next generation of tools and techniques to generate 3D tissue maps using validated high-content, high-throughput imaging and […]
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GRADUATE FELLOWSHIPS FOR ALTERNATIVES TO THE USE OF ANIMALS IN SCIENCE

The International Foundation for Ethical Research (IFER) is now accepting pre-proposal applications for 2018-2019 Graduate Fellowships. Applications are due no later than 11:59 PM CST on Monday, April 30, 2018. IFER Graduate Fellowships are one-year grants of up to $12,500 for projects that support the development, acceptance and implementation of innovative scientific methodologies that advance […]
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National Academies of Sciences, Engineering, and Medicine Workshop on “Informing Environmental Health Decisions Through Data Integration ” Begins on February 20

Integrating large quantities of data from multiple, disparate sources can create new opportunities to understand complex environmental health questions. However, combining new types and larger quantities of data to inform a specific decision presents many new challenges. For example, investigators must develop methods to reliably integrate data from designed experiments with data re-purposed from other uses, […]
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Registration and Abstract Submission Open for Meeting on High Throughput Screening and Environmental Risk Assessment

The Society of Environmental Toxicology and Chemistry will hold a meeting on High Throughput Screening and Environmental Risk Assessment, State of the Science and Emerging Applications on April 16-18 at the Durham Convention Center in Durham, North Carolina. This meeting will provide environmental toxicologists and risk assessors with an introduction to high throughput data and […]
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REACHing for Alternatives to Animal Testing

A New Webinar Series on Modern Testing Strategies for REACH The PETA International Science Consortium Ltd., an organisation that promotes reliable and relevant regulatory testing approaches that protect human health and the environment while eliminating the use of animals, and Chemical Watch, the leading global regulatory news and information service for the chemical industry, have […]
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USDA Issues Updated Guidance on Vaccine Testing Exemptions

The U.S. Department of Agriculture (USDA) Center for Veterinary Biologics recently added Veterinary Services (VS) Memorandum 800.116 Target Animal Safety Testing Exemption to its website. View all VS Memoranda VS Memorandum No. 800.116, signed in August 2017, replaces an earlier version issued in July 2013. The memorandum provides guidance to licensed firms on requesting an […]
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NIH Human BioMolecular Atlas Program: 2 funding opportunities and Jan. 11 webinar

“In organisms consisting of multiple cell types, diverse cells with different functions and structures develop as we grow and age. The organization and variability of these cells have a profound impact on the function of different tissues, process of aging, and emergence of diseases and conditions. Recently developed technologies are allowing researchers to explore cells […]
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ICCVAM Communities of Practice Webinar January 23

The fourth ICCVAM Communities of Practice webinar will be presented January 23, 2018, on the topic “Machine Learning in Toxicology: Fundamentals of Application and Interpretation.” NICEATM is organizing this webinar on behalf of ICCVAM. This webinar will explore the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that […]
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Grants Offer Support for Tissue Chip Development

The National Institutes of Health (NIH) has announced several funding opportunities for research and development of microphysiological systems (MPS; “tissue chips”) for studying human physiology and assessing toxicity and safety of new drugs and other substances. All of these funding opportunities are open to U.S.-based for-profit, non-profit, academic, and government institutions. NIH is offering 1-2 […]
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USDA Releases Guidance Documents on Animal Health

The U.S. Department of Agriculture (USDA) administers the Animal Welfare Act, which sets standards for the humane care and treatment of animals used in research. USDA Animal Care has developed two Tech Notes for Animal Welfare Act licensees and registrants to help improve adherence to animal welfare standards. “Incentives for Identifying, Reporting, Correcting, and Preventing […]
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National Academies of Sciences Workshop on “The Promise of Genome Editing Tools to Advance Environmental Health Research” Begins on January 10

Recent scientific advances have made genome editing technologies—a suite of biological tools for making precise additions, deletions, and alterations to the DNA and RNA of living cells– more rapid, efficient, and flexible than ever before. Join experts in molecular biology, toxicology, and public health to explore opportunities for using genome (and epigenome) editing technologies in […]
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EPA Requests Nominees for Scientific Advisory Panel

EPA is seeking nominations of ad hoc members for its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP). The FIFRA SAP will meet in 2018 to consider physiologically based pharmaokinetic models to address species differences in pharmacokinetics for pesticide active ingredients. The request for nominees was published in a December 18 Federal […]
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IVIVE Workshop Report Available

A manuscript summarizing a February 2016 workshop, In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, and a preceding webinar series was published online December 5 by the journal Toxicology In Vitro. The manuscript is available on the journal’s website. The workshop report discusses activities and resources that promote inclusion of […]
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NIDDK Offers Support for Development of Tissue Chips

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is establishing a new research consortium “Microphysiological Systems for Modeling Diabetes.” This consortium will support the development and validation of human tissue chips that closely mimic the normal physiology of key metabolic tissues, including the pancreatic islet, liver, skeletal muscle, and white adipose tissue. […]
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EURL ECVAM Status Report 2017 on alternative methods now available

EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2017) Download here: http://publications.jrc.ec.europa.eu/repository/handle/JRC108831 “Every year, EURL ECVAM prepares a Status Report with the primary purpose to inform its stakeholders … on updates on the status of alternative methods and approaches. The [2017] EURL ECVAM status report provides updates […]
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Informational Webinar on Tissue Chip Grants December 14

The Center for the Advancement of Science in Space (CASIS) has partnered with the National Institutes of Health (NIH) and the National Science Foundation (NSF) to fund new opportunities for conducting research onboard the International Space Station. The NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space promotes the development of tissue chips to […]
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Proposals for Organotypic Culture Models Due December 12

The National Institute of Environmental Health Sciences (NIEHS) is offering Small Business Innovation Research (SBIR) grants to develop novel in vitro systems using cells from experimental animal models typically used for toxicology testing. The intent is that these systems will replicate biological responses within the corresponding animal tissues or organs. When developed and validated, these […]
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Journal to Focus on Inhalation Toxicity: Submit Articles by December 15

The journal Applied In Vitro Toxicology is accepting manuscript submissions for a special issue on alternative approaches for inhalation toxicity testing. Submissions must be received by December 15. Inhalation toxicity testing provides information for hazard labeling and risk management of chemicals when there is potential for exposure of the respiratory tract. Regulatory test guidelines typically […]
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FDA Launches Predictive Toxicology Roadmap

In an article published December 6 on the FDA Voice blog, the U.S. Food and Drug Administration (FDA) announced publication of FDA’s Predictive Toxicology Roadmap for integrating predictive toxicology methods into safety and risk assessments. The Predictive Toxicology Roadmap presents a framework for new or enhanced FDA engagement in the science of toxicology that includes […]
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EPA Webinar on Steroidogenesis Assay December 14

The U.S. Environmental Protection Agency (EPA) will present a webinar titled “High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis” on Thursday, December 14, from 11:00 a.m.-noon U.S. Eastern Time. The speaker is Dr. Derik Haggard, ORISE Postdoctoral Fellow with the EPA National Center for Computational Toxicology. […]
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HESI’s Emerging Issues Proposal Solicitation

ILSI’s Health and Environmental Sciences Institute (HESI) seeks your suggestions for priority emerging scientific issues (human or environmental health) that should be addressed through a focused, multi-sector collaborative program. One or more of the proposals will be selected to from a new scientific collaborative program within HESI. This is not a grant program and no […]
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2018 Innovation in Regulatory Science Research Awards

Burroughs Wellcome Fund’s (BWF’s) Innovation in Regulatory Science Awards provide up to $500,000 over five years to academic investigators developing new methodologies or innovative approaches in regulatory science that will ultimately inform the regulatory decisions the Food and Drug Administration (FDA) and others make. These awards are open to U.S. and Canadian citizens or permanent […]
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Two crowdsourcing “challenges” from the European Food Safety Authority (EFSA)

EFSA taps into the crowd: data mining, geospatial mapping: http://www.efsa.europa.eu/en/press/news/171116 Can you create an algorithm to extract meaningful data from a wide range of scientific literature? Do you have ideas for depicting the uncertainties linked to data? Your idea could win you a cash prize and help EFSA provide scientific advice that is essential for […]
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Data Available for Project on Predictive Models for Acute Oral Toxicity

NICEATM invites participation in a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies. Data to train models for this project are now available on the NICEATM website. ICCVAM agencies identified multiple endpoints of interest for this project, including identification of “very toxic” […]
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NIEHS Webinar Series on Adverse Outcome Pathways Continues November 29

The Superfund Research Program of the National Institute of Environmental Health Sciences (NIEHS) is presenting a webinar series on adverse outcome pathways (AOPs), structured ways to represent biological events leading to adverse health effects. The second webinar in the series will be presented November 29. Presenters will discuss the development of AOPs and how they […]
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FDA Requests Comments on Draft Guidance for Reproductive Toxicity Testing

The U.S. Food and Drug Administration (FDA) has requested comment on draft guidance ICH S5(R3), “Detection of Toxicity to Reproduction for Human Pharmaceuticals.” This document clarifies the qualification and potential use of alternative assays to assess reproductive risk and includes a list of compounds suggested for qualification of assays. FDA recognizes that this list is […]
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ICATM Position Paper on Skin Sensitization Available

A position paper by representatives of the International Cooperation on Alternative Test Methods (ICATM) proposes practical ways to further promote the regulatory use and facilitate adoption of non-animal defined approaches for skin sensitization assessments. The paper, published online November 10 by Archives of Toxicology, is a work product of the October 2016 workshop, International Regulatory […]
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National Academy of Sciences Workshop On “Understanding Pathways to a Paradigm Shift in Toxicity Testing and Decision Making” Begins November 20

Discuss the key factors that influence how new science is incorporated into the environmental health decision making process at a free National Academies of Sciences, Engineering, and Medicine workshop on November 20-21 in Washington, DC and via webcast. New approaches for understanding the toxicity of chemicals in humans—from high-throughput cell-based in vitro studies to tissue […]
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ICCVAM Initiates Project on Predictive Models for Acute Oral Toxicity

The ICCVAM Acute Toxicity Workgroup is initiating a global project to develop in silico models of acute oral systemic toxicity that predict specific endpoints needed by regulatory agencies. These endpoints include identification of “very toxic” chemicals (LD50 less than 50 mg/kg) and “nontoxic” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for […]
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NIH Awards $2.34 Million to GBSI for Training to Improve Research Reproducibility

WASHINGTON, D.C., November 13, 2017 – The National Institutes of Health (NIH) has awarded the Global Biological Standards Institute (GBSI) $2.34 million over five years for a groundbreaking experimental design training project to improve reproducibility in preclinical research. The project, entitled “Producing Reproducible Experiments by Promoting Reverse Experimental Design” (PREPaRED),* is a collaborative educational partnership […]
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Improving Species Extrapolation for Protecting Endangered Species

Planning to be in Minneapolis next week for the Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting? Please join us for “Improving Species Extrapolation for Protecting Endangered Species: What Is Available and What Is Needed?” Currently, data used to protect endangered species has the unintended consequence of helping to increase animal testing […]
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FDA Releases Draft Guidances on In Vitro Metabolism and Drug Interactions Studies

The FDA recently issued two draft guidances for public comment: In Vitro Metabolism and Transporter-Mediated Drug-Drug Interaction Studies Clinical Drug Interactions Studies – Study Design, Data, Analysis, and Clinical Implications Together, the two draft guidances provide a systemic, risk-based approach to help drug developers evaluate investigational new drugs for potential drug-drug interactions (DDIs) during drug […]
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EPA Update to EDSP Stakeholders: Nov. 6 Virtual Meeting of FIFRA SAP

Source: EDSP Listserv EPA will hold a virtual FIFRA SAP meeting on the charge questions on the “Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways.” This virtual meeting will be held on November 6, 2017, from approximately 2 p.m. to 5 p.m. via adobe connect. […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.