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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
  • advertisements are not permitted
  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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ECETOC Human Exposure Assessment Tools Database: heatDB

Source: http://www.ecetoc.org/mediaroom/ecetoc-launches-public-directory-exposure-data-sources-exposure-tools/ The Human Exposure Assessment Tools Database (heatDB) is a resource for risk assessors to use to quickly search and locate human exposure tools and data available in the public domain…. In parallel with this database, ECETOC Technical Report no. 126 provides analysis, discussion and case studies demonstrating different uses of some the different […]
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CVB Update on In Vivo Potency Tests for 2 Leptospira Serogroups Could Reduce Animal Use

CVB NOTICE NO. 17-06: Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Pomona and Grippotyphosa The Center for Veterinary Biologics (CVB) recently added CVB Notice 17-06 Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Pomona and Grippotyphosa to its website. The purpose of this Notice […]
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EPAA Refinement Prize

Source: http://ec.europa.eu/growth/sectors/chemicals/epaa/3rs-awards_en The EPAA is proud to announce its 2017 Refinement Prize. This prize of €6000 will be granted to a laboratory technician, animal caretaker or technologist who has demonstrated outstanding achievements in implementing and raising awareness of Refinement of animal testing. The purpose of this prize is to target those actually implementing alternative approaches […]
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NIH funding to study impact of microenvironment on lung progenitor cell phenotype and function

RFA-HL-18-022: The Impact of Microenvironment on Lung Progenitor Cell Function (R01): https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-18-022.html Purpose: “This Funding Opportunity Announcement (FOA) invites applications for basic research to elucidate the impact of microenvironment, which includes cellular components of the niche, extracellular matrix, and soluble factors, on lung progenitor cell phenotype and function during development, homeostasis, repair and regeneration. Multi-disciplinary […]
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NIEHS Small Business Phase II Grants for Alternative Methods Development

The National Institute of Environmental Health Sciences is funding grants to U.S. small businesses for development of medium- to high-throughput assays. Assays developed under these grants should evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. The ability to incorporate genetic diversity […]
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Postdoctoral Fellow Opportunity in Computational Toxicology at NIEHS

A computational toxicology postdoctoral fellowship is available at the National Institute of Environmental Health Sciences (NIEHS). The successful candidate will develop and apply computational methods, tools, and applications across projects in the areas of computational toxicology, bioinformatics, and computational biology. Candidates should have a Ph.D. in computational biology, computer science, biomedical engineering, bioinformatics, or a […]
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NICEATM Research Featured in Special Issue of Reproductive Toxicology

NICEATM Deputy Director Nicole Kleinstreuer is a coauthor of three articles in a special issue of Reproductive Toxicology that focuses on developmental angiogenesis. The three articles coauthored by Kleinstreuer describe projects conducted with the U.S. Environmental Protection Agency and other collaborators that use high throughput screening assays to identify and characterize potential vascular disrupting chemicals. […]
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Registration Extended for BioMed21 Workshop on Human Disease Pathways

Registration has been extended for the June 26-27 workshop “BioMed21: A Human Pathways Approach to Disease Research.” The workshop will explore existing systems biology projects and approaches, and consider how these projects might be better coordinated to optimally improve disease understanding and interventions. Speakers include scientists from the U.S. Food and Drug Administration, National Institutes […]
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EPA Announces Meetings, Requests Nominations of Panel Members

The Environmental Protection Agency will hold two meetings of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) in the coming months. Both meetings will be held at EPA in Arlington, Virginia. The FIFRA SAP provides scientific advice, information, and recommendations to the EPA Administrator on pesticides and pesticide-related issues impacting health […]
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IIVS Opens New In Vitro Respiratory Laboratory, Marking 20 Years of Innovation in Non-Animal Testing

GAITHERSBURG, MD – June 13, 2017 – The Institute for In Vitro Sciences (IIVS), a leader in non-animal test methods, marked its 20th year with the opening of a new state-of-the-art in vitro respiratory exposure laboratory. The 1,000 square foot facility expands IIVS’ non-animal testing services to include rapid evaluation of potential respiratory hazards associated […]
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HHS issues PHS 2017-2 SBIR and STTR Omnibus Grant Solicitations

Source: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-070.html The 2017 Omnibus Grant Solicitations of the NIH, CDC, and FDA are now available for the SBIR and STTR (NIH only) programs. The 2017 SBIR/STTR Omnibus solicitations and accompanying resources can be found below: SBIR: PA-17-302 STTR: PA-17-303 2017 Program Descriptions and Research Topics and Appendix A (SBA approved topics for budget waivers) […]
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Slides and Video Available from ICCVAM Public Forum

Presenters’ slides and the webcast recording of the May 23 ICCVAM public forum are available. Presentations at this year’s public forum included updates from eight ICCVAM member agencies, as well as summaries of ICCVAM’s interactions with several international organizations. NICEATM Director Warren Casey presented a plan for the development of a U.S. strategic roadmap to […]
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ACI’s Cleaning Product Ingredient Safety Initiative Webinar

Source: ACI e-newsletter A free webinar hosted by the American Cleaning Institute will provide in-depth information on the development and navigation of its online safety database for hundreds of chemicals in the U.S. consumer cleaning product supply chain. ACI’s Cleaning Product Ingredient Safety Initiative features high-throughput screening-level human health risk assessments for the nearly 600 […]
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OECD EHS News

OECD’s Environment, Health and Safety News is a newsletter produced about every 8 months that provides updates on events and activities of the OECD Environment, Health, and Safety Programme. Some of the news items in the latest issue, March 2017, are summarized here: The launch of the e.AOP.Portal search engine, the main entry point for […]
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June Workshop to Focus on Human Disease Pathways

A June 26-27 workshop at the National Institutes of Health in Bethesda, Maryland, will focus on human pathway-based approaches to disease and medicine. The “BioMed21” workshop will explore existing systems biology projects and approaches, and consider how these projects might be better coordinated to optimally improve disease understanding and interventions. The workshop is being organized […]
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EURL ECVAM publishes recommendations on use of non-animal approaches for skin sensitization testing

“The JRC’s European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published its recommendation on the use of non-animal approaches for skin sensitisation (allergy) testing. This document builds on the progress made in the area since the publication of the EURL ECVAM strategy in 2013 and provides EURL ECVAM views on the […]
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OECD QSAR Toolbox Version 4.0 Webinar June 1

“To increase the regulatory acceptance of (Q)SAR methods, the OECD is developing a QSAR Toolbox to make (Q)SAR technology readily accessible, transparent, and less demanding in terms of infrastructure costs. Version 4.0 of the QSAR Toolbox was released in April 2017. The OECD and ECHA are hosting a Webinar on June 1, 2017 to demonstrate its […]
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NICEATM Deputy Director, Collaborators Comment on Progress Toward Animal Replacement

NICEATM Deputy Director Nicole Kleinstreuer and a number of NICEATM collaborators in academia, industry, and animal welfare organizations commented on progress toward replacing animals for chemical safety testing in the April 24 issue of Chemical and Engineering News. The article “Big Data, Big Deadlines Spur Change in Toxicity Testing” is available on the C&E News […]
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NIH funding to study cellular mechanisms of aging

Novel Cell Non-autonomous Mechanisms of Aging (RFA-AG-18-009): https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-18-009.html  Background: The distinction between cell autonomous and non-autonomous effects driving aging was originally motivated by studies of development where some cells have the autonomous ability to differentiate whereas other cells differentiate through signals from neighboring cells. In the past few decades, most studies on the molecular mechanisms […]
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Two EFSA Public Consultations with May 1 deadlines

Public consultation on Guidance on The Use of the Weight of Evidence Approach in Scientific Assessments: http://www.efsa.europa.eu/en/consultations/call/170306-0 Deadline: 1 May 2017 Public consultation on Guidance for the identification of biological relevance of adverse/ positive health effects from experimental animal and human studies: http://www.efsa.europa.eu/en/consultations/call/170306 Deadline: 1 May 2017
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The Global 3Rs Awards Program 2017 call for nominations

The Global 3Rs Awards program recognizes significant innovative contributions toward the 3Rs of animal research to advance ethical science, by any researcher (nominated author, principal investigator, or research team leader) in academia or industry in any area of biology (e.g., basic science, discovery, development, teaching, testing, manufacture for new medicines, vaccines, medical devices or healthcare […]
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TSCA webinar:

Emerging Science and Alternative Test Methods in Implementing the LCSA On Wednesday, April 19, Covington and Gradient will host the second live webinar on Lautenberg Chemical Safety for the 21st Century Act (LCSA) implementation, “Emerging Science and Alternative Test Methods in Implementing the LCSA,” featuring guest speakers from the U.S. Environmental Protection Agency and The […]
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Registration Open for May 23 ICCVAM Public Forum

Registration is open to attend the ICCVAM Public Forum on May 23 at the National Institutes of Health in Bethesda, Maryland. ICCVAM holds annual public forums to share information and facilitate direct communication of ideas and suggestions from stakeholders. ICCVAM agencies will give presentation on their activities relevant to the ICCVAM mission. This year’s forum […]
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10th World Congress Abstract Submission Deadline Extended to April 24, 2017

The 10th World Congress on Alternatives and Animal Use in the Life Sciences, The 3Rs in Action, will take place at the Washington State Convention Center in Seattle, Washington, USA on August 20-24, 2017. See the congress website for information on the program, registration, abstract submission, and housing: http://wc10seattle.org/2017/Home.aspx The abstract submission deadline has been […]
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Request for Public Input: ICCVAM Strategic Roadmap

ICCVAM Strategic Roadmap To Establish New Approaches for Evaluating the Safety of Chemicals and Medical Products in the United States (Reposted from: https://ntp.niehs.nih.gov/pubhealth/evalatm/natl-strategy/index.html) In 2007 the National Research Council published the seminal report “Toxicity Testing in the 21st Century: A Vision and a Strategy” that envisioned using human-based assays and model information to provide a […]
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Event Listings on AltTox

We are now back to maintaining a comprehensive list of Meetings & Events, primarily those focused on alternative methods for toxicity testing, but also other events on research, technologies, and policy that could benefit the development or use of non-animal methods for research and testing. Deadlines for relevant awards, fellowships, and grants are also listed […]
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EFSA: Two public consultations on new draft guidance

Public consultation on Guidance on The Use of the Weight of Evidence Approach in Scientific Assessments Deadline:  1 May 2017 Document (1.3 MB) EFSA’s Scientific Committee has developed a draft guidance document on the use of the weight of evidence approach in scientific assessments for use in all areas under EFSA’s remit.  The guidance document […]
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NICEATM and ICCVAM Activities at SOT

A new page on the NICEATM website summarizes NICEATM and ICCVAM activities at the upcoming meeting of the Society of Toxicology. NICEATM and ICCVAM will be participating in two exhibitor-hosted sessions. “Developing an Implementation Strategy for Toxicity Testing in the 21st Century” will be Monday, March 13, at 12 noon in CC Room 340. This […]
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New Agency Joins ICCVAM

The National Institute of Standards and Technology has joined the Interagency Coordinating Committee on the Validation of Alternative Methods. NIST participation will provide ICCVAM with interest and experience in the study of process controls, measurement artifacts, and interlaboratory testing. ICCVAM was established to facilitate and promote development and regulatory acceptance of new toxicological tests with […]
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Hands-On Seminar: Creating an Adverse Outcome Pathway in the AOP Wiki

If you are attending the Society of Toxicology’s annual meeting in Baltimore next month, the Human Toxicology Project Consortium (HTPC) and the Physicians Committee for Responsible Medicine (PCRM) invite you to deepen your understanding of the AOP Wiki and gain experience entering an Adverse Outcome Pathway in a structured, hands-on seminar Tuesday evening, March 14. […]
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SOT Satellite Meeting: Updates on Activities Related to 21st Century Toxicology and Related Efforts

If you’re planning to attend the Society of Toxicology conference in Baltimore this March, please join the Center for Alternatives to Animal Testing (CAAT), the Human Toxicology Project Consortium (HTPC), and the Human Toxome Project Consortium for the annual satellite meeting on 21st century toxicology activities and related efforts, Thursday, March 16 from noon to […]
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AltTox at SOT 2017 in Baltimore, Maryland

As in previous years, AltTox Editorial Board and Management Team members will be at the annual meeting of the Society of Toxicology (Baltimore, Maryland) to share research with thousands of other toxicologists. AltTox Editorial Board and/or Management Team members are co-authors of the following posters (listed by abstract #/poster board #): 1209/333: Systematic Reviews as […]
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ARDF announces 2017 Alternatives Research Grant cycle is open

Sue Leary, ARDF The Alternatives Research & Development Foundation (ARDF), which funds and promotes alternatives to the use of laboratory animals in research, testing, and education, is currently soliciting research proposals. • Maximum award per project: $40,000 • Deadline: May 1, 2017 (for electronic submission, request Dropbox by April 27, 2017) • Notification of recipients: […]
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National Academy of Sciences Workshop On “Advances in Causal Understanding for Risk Based Decision Making” Begins March 6

Solmaz Barazesh Spence, The National Academies of Sciences, Engineering, and Medicine Discuss the current thinking surrounding causal models, how novel approaches and tools are relevant for environmental health, and how they can be incorporated into the decision making process at a free National Academies of Sciences, Engineering, and Medicine workshop on March 6-7 in Washington, […]
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The Humane Society of the United States solicits nominations for the 2017 Russell and Burch Award

The Humane Society of the United States welcomes nominations of scientists who have made outstanding contributions to the advancement of alternative methods in the areas of research, testing, or higher education for the Russell and Burch Award. Alternative methods—also known as the Three Rs—are methods that can replace or reduce the use of animals, or […]
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NICEATM Webinar Series on Zebrafish Screening Begins Thursday

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins this Thursday, February 2, at 11:30 a.m. with “Introduction to Zebrafish Screening.” This webinar will provide an overview of the NTP’s Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) program and review the variability […]
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ECHA: New advice on using non-animal test methods

Source: https://echa.europa.eu/-/new-advice-on-using-non-animal-test-methods ECHA’s updated guidance gives advice on how to use non-animal test methods, which are now the default for many endpoints. Registrants are encouraged to take the changes into account when deciding their testing strategies. Helsinki, 24 January 2017 – The guidance takes into account the recently changed REACH information requirements, which made non-animal testing […]
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ICCVAM Communities of Practice Webinar January 24

The third ICCVAM Communities of Practice webinar will be presented January 24 on the topic “Incorporating Chemical Information: Resources, Limitations, and Characterizing the Domain of Applicability for 21st Century Toxicity Testing.” This webinar is being organized on behalf of ICCVAM by NICEATM and hosted by the U.S. Environmental Protection Agency’s National Center for Computational Toxicology. […]
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NICEATM to Present Webinar Series on Zebrafish Screening

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins on February 2. This three-part webinar series will consider the issues of protocol variability in zebrafish screening studies and how some of these issues might be addressed by implementation of standardized nomenclature systems. The webinars are […]
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NTP Level of Concern Study Phase 2 Recruitment

The National Toxicology Program uses Level of Concern categories to communicate its opinion about whether an environmental substance might cause adverse effects in humans. This study aims to update the Level of Concern categories to better inform and protect public health. If you are a public health professional who is familiar with toxicological risk communication […]
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Request for proposals – Award for a VITROCELL® In Vitro Inhalation Exposure System

The PETA International Science Consortium Ltd. is accepting proposals that will demonstrate application of a VITROCELL® in vitro exposure system to reduce and replace the use of animals in inhalation testing (Deadline 30 March 2017). The award winner, who will be selected based on the proposal’s scientific merit and its potential to replace animal testing, […]
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FDA Regulatory Science Extramural R&D Project Funding

To spur innovation in the field of regulatory science FDA funds extramural research using various contract mechanisms and grants to address broad Agency challenges within FDA’s scientific priority areas: Regulatory Science Extramural Research and Development Projects Extramural Research Funded Through the Broad Agency Announcement (BAA), Solicitation Number: FDABAA-16-00122 The purpose of this BAA is to solicit proposals that focus on […]
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NAS Project Webinar: Incorporating 21st Century Science into Risk-Based Evaluations, January 6, 2017

Join a webinar on Friday, January 6 at 2:00 for the release of a new report that describes how 21st century science can be used to advance risk assessment and support decision-making ultimately to improve public health and the environment. The report considers recent advances in exposure science, toxicology, and epidemiology; describes application of 21st […]
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NICEATM-EPA AR Pathway Article Named Editors’ Choice

NICEATM Deputy Director Nicole Kleinstreuer is the lead author on a paper describing an androgen receptor pathway model that incorporates 11 high throughput screening assays. “Development and Validation of a Computational Model for Androgen Receptor Activity,” which was published online on November 18 in Chemical Research in Toxicology, has been selected as an ACS Editor’s […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.