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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
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  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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2018 Innovation in Regulatory Science Research Awards

Burroughs Wellcome Fund’s (BWF’s) Innovation in Regulatory Science Awards provide up to $500,000 over five years to academic investigators developing new methodologies or innovative approaches in regulatory science that will ultimately inform the regulatory decisions the Food and Drug Administration (FDA) and others make. These awards are open to U.S. and Canadian citizens or permanent […]
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Two crowdsourcing “challenges” from the European Food Safety Authority (EFSA)

EFSA taps into the crowd: data mining, geospatial mapping: http://www.efsa.europa.eu/en/press/news/171116 Can you create an algorithm to extract meaningful data from a wide range of scientific literature? Do you have ideas for depicting the uncertainties linked to data? Your idea could win you a cash prize and help EFSA provide scientific advice that is essential for […]
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Data Available for Project on Predictive Models for Acute Oral Toxicity

NICEATM invites participation in a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies. Data to train models for this project are now available on the NICEATM website. ICCVAM agencies identified multiple endpoints of interest for this project, including identification of “very toxic” […]
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NIEHS Webinar Series on Adverse Outcome Pathways Continues November 29

The Superfund Research Program of the National Institute of Environmental Health Sciences (NIEHS) is presenting a webinar series on adverse outcome pathways (AOPs), structured ways to represent biological events leading to adverse health effects. The second webinar in the series will be presented November 29. Presenters will discuss the development of AOPs and how they […]
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FDA Requests Comments on Draft Guidance for Reproductive Toxicity Testing

The U.S. Food and Drug Administration (FDA) has requested comment on draft guidance ICH S5(R3), “Detection of Toxicity to Reproduction for Human Pharmaceuticals.” This document clarifies the qualification and potential use of alternative assays to assess reproductive risk and includes a list of compounds suggested for qualification of assays. FDA recognizes that this list is […]
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ICATM Position Paper on Skin Sensitization Available

A position paper by representatives of the International Cooperation on Alternative Test Methods (ICATM) proposes practical ways to further promote the regulatory use and facilitate adoption of non-animal defined approaches for skin sensitization assessments. The paper, published online November 10 by Archives of Toxicology, is a work product of the October 2016 workshop, International Regulatory […]
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National Academy of Sciences Workshop On “Understanding Pathways to a Paradigm Shift in Toxicity Testing and Decision Making” Begins November 20

Discuss the key factors that influence how new science is incorporated into the environmental health decision making process at a free National Academies of Sciences, Engineering, and Medicine workshop on November 20-21 in Washington, DC and via webcast. New approaches for understanding the toxicity of chemicals in humans—from high-throughput cell-based in vitro studies to tissue […]
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ICCVAM Initiates Project on Predictive Models for Acute Oral Toxicity

The ICCVAM Acute Toxicity Workgroup is initiating a global project to develop in silico models of acute oral systemic toxicity that predict specific endpoints needed by regulatory agencies. These endpoints include identification of “very toxic” chemicals (LD50 less than 50 mg/kg) and “nontoxic” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for […]
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NIH Awards $2.34 Million to GBSI for Training to Improve Research Reproducibility

WASHINGTON, D.C., November 13, 2017 – The National Institutes of Health (NIH) has awarded the Global Biological Standards Institute (GBSI) $2.34 million over five years for a groundbreaking experimental design training project to improve reproducibility in preclinical research. The project, entitled “Producing Reproducible Experiments by Promoting Reverse Experimental Design” (PREPaRED),* is a collaborative educational partnership […]
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Improving Species Extrapolation for Protecting Endangered Species

Planning to be in Minneapolis next week for the Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting? Please join us for “Improving Species Extrapolation for Protecting Endangered Species: What Is Available and What Is Needed?” Currently, data used to protect endangered species has the unintended consequence of helping to increase animal testing […]
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FDA Releases Draft Guidances on In Vitro Metabolism and Drug Interactions Studies

The FDA recently issued two draft guidances for public comment: In Vitro Metabolism and Transporter-Mediated Drug-Drug Interaction Studies Clinical Drug Interactions Studies – Study Design, Data, Analysis, and Clinical Implications Together, the two draft guidances provide a systemic, risk-based approach to help drug developers evaluate investigational new drugs for potential drug-drug interactions (DDIs) during drug […]
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EPA Update to EDSP Stakeholders: Nov. 6 Virtual Meeting of FIFRA SAP

Source: EDSP Listserv EPA will hold a virtual FIFRA SAP meeting on the charge questions on the “Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways.” This virtual meeting will be held on November 6, 2017, from approximately 2 p.m. to 5 p.m. via adobe connect. […]
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AltTox Editorial Board Member Dr. Albert Li, In Vitro ADMET Laboratories, is Stage Two Winner of EPA’s Toxicity Testing Challenge

Announcing the Transform Toxicity Testing Challenge Stage Two Winners Source: https://www.epa.gov/innovation/announcing-transform-toxicity-testing-challenge-stage-two-winners Scientists from EPA, NCATS, and NIEHS/NTP are using high speed, automated screening technologies called high-throughput screening (HTS) assays to rapidly test whether some of the thousands of chemicals in use may affect human health. However, since current HTS assays do not fully incorporate chemical […]
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Presentations and Videocast of SACATM Meeting Available

Presentations from the September 18-19 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) are available on the NTP website. Video recordings of the meeting are also available on the National Institutes of Health Videocast website. View recording of the September 18 session View recording of the September 19 session SACATM meets annually […]
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OECD releases five new Integrated Approaches to Testing and Assessment Case Studies

The Integrated Case Studies Project was launched in 2015 to increase experience with the use of Integrated Approaches For Testing And Assessment (IATA) by developing case studies, which constitute examples of predictions that are fit for regulatory use. The aim is to create common understanding of using novel methodologies and the generation of considerations/guidance stemming […]
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JSAAE’s 11th Mandom International Research Grants on Alternative to Animal Experiments is accepting applications

The Japanese Society for Alternatives to Animal Experiments (JSAAE) announced that applications are being accepted for the 11th Mandom International Research Grants on Alternative to Animal Experiments from September 2017 through January 2018 (application deadline January 31, 2018). Eligible applicants are researchers around the world, mainly focusing on Asia, who are members of the JSAAE.  […]
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Job opening: Research and Testing Coordinator at The Physicians Committee for Responsible Medicine

The Physicians Committee for Responsible Medicine is seeking a Research and Testing Coordinator to contribute to our efforts to replace animals in basic and medical research with human-relevant research methods by implementing education and outreach programs and conducting research. If you are a professional with a degree in the life sciences, apply today! https://www.pcrm.org/about/careers/research-and-testing-coordinator
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ARDF: THE ALTERNATIVES IN RESEARCH CHALLENGE

The Alternatives in Research (AiR) Challenge is a program intended to stimulate innovative research that advances medical progress through the use of methods that do not involve animals. The program focus is on biomedical research, given that animal use in this area far exceeds that in safety testing and scientific education. It is anticipated that […]
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GBSI BioPolicy Summit 2017 Explores Technologies for Improved Preclinical Research Reproducibility – October 16

Global Biological Standards Institute’s 3rd annual BioPolicy Summit: “Improving Reproducibility of Research Through Digital Tools, Technologies and Laboratory Automation,” will bring a diverse and interdisciplinary group of participants together—biologists, tech programmers, instrumentation manufacturers, the maker community, journals, and funders—to explore how the newest life science research tools and technology can enhance reproducibility in preclinical research.  […]
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Researchers, beware: humanized mice not human enough to study stem cell transplants

Source: https://blog.cirm.ca.gov/2017/08/23/researchers-beware-humanized-mice-not-human-enough-to-study-stem-cell-transplants/       August 23, 2017, Todd Dubnicoff “A researcher’s data is only as good as the experimental techniques used to obtain those results.” “And a Stanford University study published yesterday in Cell Reports, calls into question the accuracy of a widely used method in mice that helps scientists gauge the human immune system’s response to […]
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NIEHS Offers Grants for Development of Culture Models

The National Institute of Environmental Health Sciences (NIEHS) is providing grants for development of novel in vitro systems using cells from experimental animal models typically used for toxicology testing. The intent is that these systems will replicate biological responses within the corresponding animal tissues or organs. When developed and validated, these systems will provide information […]
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New Review Describes Use of AOPs in EPA Screening Program

A review in the September issue of the journal Environmental Health Perspectives describes how the U.S. Environmental Protection Agency (EPA) uses adverse outcome pathway (AOP) and toxicity pathway frameworks in its Endocrine Disruptor Screening Program. The review describes how these frameworks help to establish biologically plausible links between endocrine mechanisms and apical responses when those […]
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SACATM Meeting September 18-19

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 18-19 at the Natcher Conference Center, National Institutes of Health (NIH), Bethesda, Maryland. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences (NIEHS) regarding statutorily mandated duties of ICCVAM and activities of NICEATM. The […]
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Award to Attend the Institute for In Vitro Sciences’ January 2018 Practical Methods for In Vitro Toxicology Workshop

The PETA International Science Consortium Ltd. is proud to announce an early-career scientist award to participate in the Institute for In Vitro Sciences’ (IIVS) 2018 Practical Methods for In Vitro Toxicology Workshop. The award will fund workshop registration ($1,950 USD), as well as airfare and hotel accommodations (up to $1,000 USD). The workshop hosted by […]
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EURL ECVAM Call for Tender – Review of non-animal methods used in disease research

The JRC’s EURL ECVAM has launched a study to collect and describe non-animal methods being used for basic and applied research into neurodegenerative, respiratory tract and cardiovascular diseases, and breast cancer. Access : http://ted.europa.eu/udl?uri=TED:NOTICE:316352-2017:TEXT:EN:HTML Submission deadline: 18th September 2017 Short description: A collection of non-animal methods shall be provided in use for basic and applied […]
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EFSA seeking contract services to implement in vitro battery for developmental neurotoxicity assessment

Implementation and interpretation of in vitro testing battery for the assessment of developmental neurotoxicity OC/EFSA/PRAS/2017/01 Source: https://www.efsa.europa.eu/en/tenders/tender/170803 Published: 3 August 2017 Deadline: 20 October 2017, Local time: 14:30 (CET) Published in the Official Journal of the European Union on 03/08/2017 – OJ NUMBER: 2017/S 147-303487 [see description below] The tender documentation can be accessed in the document library […]
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NICEATM and ICCVAM Activities at World Congress

NICEATM and ICCVAM scientists will be active participants at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences, which runs August 20-24 in Seattle, Washington. ICCVAM members will co-chair four presentation sessions and participate on roundtable panels on regulatory issues and big data. NICEATM and ICCVAM scientists will also share their […]
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Slides Available from BioMed21 Workshop

Presenters’ slides from the June 26-27 workshop “BioMed21 – A Human Pathway-based Approach to Disease and Medicine” are now available. The presentations from government, academic, and industry scientists addressed how to implement a human systems-biology platform for understanding disease and improving interventions. The workshop was co-organized by NICEATM and the Human Toxicology Project Consortium. In […]
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ECETOC Human Exposure Assessment Tools Database: heatDB

Source: http://www.ecetoc.org/mediaroom/ecetoc-launches-public-directory-exposure-data-sources-exposure-tools/ The Human Exposure Assessment Tools Database (heatDB) is a resource for risk assessors to use to quickly search and locate human exposure tools and data available in the public domain…. In parallel with this database, ECETOC Technical Report no. 126 provides analysis, discussion and case studies demonstrating different uses of some the different […]
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CVB Update on In Vivo Potency Tests for 2 Leptospira Serogroups Could Reduce Animal Use

CVB NOTICE NO. 17-06: Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Pomona and Grippotyphosa The Center for Veterinary Biologics (CVB) recently added CVB Notice 17-06 Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Pomona and Grippotyphosa to its website. The purpose of this Notice […]
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EPAA Refinement Prize

Source: http://ec.europa.eu/growth/sectors/chemicals/epaa/3rs-awards_en The EPAA is proud to announce its 2017 Refinement Prize. This prize of €6000 will be granted to a laboratory technician, animal caretaker or technologist who has demonstrated outstanding achievements in implementing and raising awareness of Refinement of animal testing. The purpose of this prize is to target those actually implementing alternative approaches […]
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NIH funding to study impact of microenvironment on lung progenitor cell phenotype and function

RFA-HL-18-022: The Impact of Microenvironment on Lung Progenitor Cell Function (R01): https://grants.nih.gov/grants/guide/rfa-files/RFA-HL-18-022.html Purpose: “This Funding Opportunity Announcement (FOA) invites applications for basic research to elucidate the impact of microenvironment, which includes cellular components of the niche, extracellular matrix, and soluble factors, on lung progenitor cell phenotype and function during development, homeostasis, repair and regeneration. Multi-disciplinary […]
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NIEHS Small Business Phase II Grants for Alternative Methods Development

The National Institute of Environmental Health Sciences is funding grants to U.S. small businesses for development of medium- to high-throughput assays. Assays developed under these grants should evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. The ability to incorporate genetic diversity […]
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Postdoctoral Fellow Opportunity in Computational Toxicology at NIEHS

A computational toxicology postdoctoral fellowship is available at the National Institute of Environmental Health Sciences (NIEHS). The successful candidate will develop and apply computational methods, tools, and applications across projects in the areas of computational toxicology, bioinformatics, and computational biology. Candidates should have a Ph.D. in computational biology, computer science, biomedical engineering, bioinformatics, or a […]
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NICEATM Research Featured in Special Issue of Reproductive Toxicology

NICEATM Deputy Director Nicole Kleinstreuer is a coauthor of three articles in a special issue of Reproductive Toxicology that focuses on developmental angiogenesis. The three articles coauthored by Kleinstreuer describe projects conducted with the U.S. Environmental Protection Agency and other collaborators that use high throughput screening assays to identify and characterize potential vascular disrupting chemicals. […]
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Registration Extended for BioMed21 Workshop on Human Disease Pathways

Registration has been extended for the June 26-27 workshop “BioMed21: A Human Pathways Approach to Disease Research.” The workshop will explore existing systems biology projects and approaches, and consider how these projects might be better coordinated to optimally improve disease understanding and interventions. Speakers include scientists from the U.S. Food and Drug Administration, National Institutes […]
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EPA Announces Meetings, Requests Nominations of Panel Members

The Environmental Protection Agency will hold two meetings of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) in the coming months. Both meetings will be held at EPA in Arlington, Virginia. The FIFRA SAP provides scientific advice, information, and recommendations to the EPA Administrator on pesticides and pesticide-related issues impacting health […]
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IIVS Opens New In Vitro Respiratory Laboratory, Marking 20 Years of Innovation in Non-Animal Testing

GAITHERSBURG, MD – June 13, 2017 – The Institute for In Vitro Sciences (IIVS), a leader in non-animal test methods, marked its 20th year with the opening of a new state-of-the-art in vitro respiratory exposure laboratory. The 1,000 square foot facility expands IIVS’ non-animal testing services to include rapid evaluation of potential respiratory hazards associated […]
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HHS issues PHS 2017-2 SBIR and STTR Omnibus Grant Solicitations

Source: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-17-070.html The 2017 Omnibus Grant Solicitations of the NIH, CDC, and FDA are now available for the SBIR and STTR (NIH only) programs. The 2017 SBIR/STTR Omnibus solicitations and accompanying resources can be found below: SBIR: PA-17-302 STTR: PA-17-303 2017 Program Descriptions and Research Topics and Appendix A (SBA approved topics for budget waivers) […]
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Slides and Video Available from ICCVAM Public Forum

Presenters’ slides and the webcast recording of the May 23 ICCVAM public forum are available. Presentations at this year’s public forum included updates from eight ICCVAM member agencies, as well as summaries of ICCVAM’s interactions with several international organizations. NICEATM Director Warren Casey presented a plan for the development of a U.S. strategic roadmap to […]
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ACI’s Cleaning Product Ingredient Safety Initiative Webinar

Source: ACI e-newsletter A free webinar hosted by the American Cleaning Institute will provide in-depth information on the development and navigation of its online safety database for hundreds of chemicals in the U.S. consumer cleaning product supply chain. ACI’s Cleaning Product Ingredient Safety Initiative features high-throughput screening-level human health risk assessments for the nearly 600 […]
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