Community Blog

Home / Community Blog

AltTox Community Blog

Blog User Agreement, and instructions for posting or subscribing to the AltTox Community Blog
How to subscribe to the Community Blog

Use the RSS option in the left sidebar, or join the AltTox listserv: send an email to alttox-request@freelists.org, with the word “subscribe” on the subject line, OR visit http://www.freelists.org/list/alttox and sign up directly.

How to post new items to the Community Blog

Please send them to info@alttox.org; include your name and affiliation so that we can credit you as the contributor! If you will be contributing news items frequently and would prefer to post them yourself, please request a new log-in ID and instructions from info@alttox.org.

Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
  • advertisements are not permitted
  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

Posted in Community Blog on

National Academies of Sciences Workshop on “The Promise of Genome Editing Tools to Advance Environmental Health Research” Begins on January 10

Recent scientific advances have made genome editing technologies—a suite of biological tools for making precise additions, deletions, and alterations to the DNA and RNA of living cells– more rapid, efficient, and flexible than ever before. Join experts in molecular biology, toxicology, and public health to explore opportunities for using genome (and epigenome) editing technologies in […]
0Read More
Posted in Community Blog on

EPA Requests Nominees for Scientific Advisory Panel

EPA is seeking nominations of ad hoc members for its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP). The FIFRA SAP will meet in 2018 to consider physiologically based pharmaokinetic models to address species differences in pharmacokinetics for pesticide active ingredients. The request for nominees was published in a December 18 Federal […]
0Read More
Posted in Community Blog on

IVIVE Workshop Report Available

A manuscript summarizing a February 2016 workshop, In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, and a preceding webinar series was published online December 5 by the journal Toxicology In Vitro. The manuscript is available on the journal’s website. The workshop report discusses activities and resources that promote inclusion of […]
0Read More
Posted in Community Blog on

NIDDK Offers Support for Development of Tissue Chips

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is establishing a new research consortium “Microphysiological Systems for Modeling Diabetes.” This consortium will support the development and validation of human tissue chips that closely mimic the normal physiology of key metabolic tissues, including the pancreatic islet, liver, skeletal muscle, and white adipose tissue. […]
0Read More
Posted in Community Blog on

EURL ECVAM Status Report 2017 on alternative methods now available

EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2017) Download here: http://publications.jrc.ec.europa.eu/repository/handle/JRC108831 “Every year, EURL ECVAM prepares a Status Report with the primary purpose to inform its stakeholders … on updates on the status of alternative methods and approaches. The [2017] EURL ECVAM status report provides updates […]
0Read More
Posted in Community Blog on

Informational Webinar on Tissue Chip Grants December 14

The Center for the Advancement of Science in Space (CASIS) has partnered with the National Institutes of Health (NIH) and the National Science Foundation (NSF) to fund new opportunities for conducting research onboard the International Space Station. The NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space promotes the development of tissue chips to […]
0Read More
Posted in Community Blog on

Proposals for Organotypic Culture Models Due December 12

The National Institute of Environmental Health Sciences (NIEHS) is offering Small Business Innovation Research (SBIR) grants to develop novel in vitro systems using cells from experimental animal models typically used for toxicology testing. The intent is that these systems will replicate biological responses within the corresponding animal tissues or organs. When developed and validated, these […]
0Read More
Posted in Community Blog on

Journal to Focus on Inhalation Toxicity: Submit Articles by December 15

The journal Applied In Vitro Toxicology is accepting manuscript submissions for a special issue on alternative approaches for inhalation toxicity testing. Submissions must be received by December 15. Inhalation toxicity testing provides information for hazard labeling and risk management of chemicals when there is potential for exposure of the respiratory tract. Regulatory test guidelines typically […]
0Read More
Posted in Community Blog on

FDA Launches Predictive Toxicology Roadmap

In an article published December 6 on the FDA Voice blog, the U.S. Food and Drug Administration (FDA) announced publication of FDA’s Predictive Toxicology Roadmap for integrating predictive toxicology methods into safety and risk assessments. The Predictive Toxicology Roadmap presents a framework for new or enhanced FDA engagement in the science of toxicology that includes […]
0Read More
Posted in Community Blog on

EPA Webinar on Steroidogenesis Assay December 14

The U.S. Environmental Protection Agency (EPA) will present a webinar titled “High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis” on Thursday, December 14, from 11:00 a.m.-noon U.S. Eastern Time. The speaker is Dr. Derik Haggard, ORISE Postdoctoral Fellow with the EPA National Center for Computational Toxicology. […]
0Read More
Posted in Community Blog on

HESI’s Emerging Issues Proposal Solicitation

ILSI’s Health and Environmental Sciences Institute (HESI) seeks your suggestions for priority emerging scientific issues (human or environmental health) that should be addressed through a focused, multi-sector collaborative program. One or more of the proposals will be selected to from a new scientific collaborative program within HESI. This is not a grant program and no […]
0Read More
Posted in Community Blog on

2018 Innovation in Regulatory Science Research Awards

Burroughs Wellcome Fund’s (BWF’s) Innovation in Regulatory Science Awards provide up to $500,000 over five years to academic investigators developing new methodologies or innovative approaches in regulatory science that will ultimately inform the regulatory decisions the Food and Drug Administration (FDA) and others make. These awards are open to U.S. and Canadian citizens or permanent […]
0Read More
Posted in Community Blog on

Two crowdsourcing “challenges” from the European Food Safety Authority (EFSA)

EFSA taps into the crowd: data mining, geospatial mapping: http://www.efsa.europa.eu/en/press/news/171116 Can you create an algorithm to extract meaningful data from a wide range of scientific literature? Do you have ideas for depicting the uncertainties linked to data? Your idea could win you a cash prize and help EFSA provide scientific advice that is essential for […]
0Read More
Posted in Community Blog on

Data Available for Project on Predictive Models for Acute Oral Toxicity

NICEATM invites participation in a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies. Data to train models for this project are now available on the NICEATM website. ICCVAM agencies identified multiple endpoints of interest for this project, including identification of “very toxic” […]
0Read More
Posted in Community Blog on

NIEHS Webinar Series on Adverse Outcome Pathways Continues November 29

The Superfund Research Program of the National Institute of Environmental Health Sciences (NIEHS) is presenting a webinar series on adverse outcome pathways (AOPs), structured ways to represent biological events leading to adverse health effects. The second webinar in the series will be presented November 29. Presenters will discuss the development of AOPs and how they […]
0Read More
Posted in Community Blog on

FDA Requests Comments on Draft Guidance for Reproductive Toxicity Testing

The U.S. Food and Drug Administration (FDA) has requested comment on draft guidance ICH S5(R3), “Detection of Toxicity to Reproduction for Human Pharmaceuticals.” This document clarifies the qualification and potential use of alternative assays to assess reproductive risk and includes a list of compounds suggested for qualification of assays. FDA recognizes that this list is […]
0Read More
Posted in Community Blog on

ICATM Position Paper on Skin Sensitization Available

A position paper by representatives of the International Cooperation on Alternative Test Methods (ICATM) proposes practical ways to further promote the regulatory use and facilitate adoption of non-animal defined approaches for skin sensitization assessments. The paper, published online November 10 by Archives of Toxicology, is a work product of the October 2016 workshop, International Regulatory […]
0Read More
Posted in Community Blog on

National Academy of Sciences Workshop On “Understanding Pathways to a Paradigm Shift in Toxicity Testing and Decision Making” Begins November 20

Discuss the key factors that influence how new science is incorporated into the environmental health decision making process at a free National Academies of Sciences, Engineering, and Medicine workshop on November 20-21 in Washington, DC and via webcast. New approaches for understanding the toxicity of chemicals in humans—from high-throughput cell-based in vitro studies to tissue […]
0Read More
Posted in Community Blog on

ICCVAM Initiates Project on Predictive Models for Acute Oral Toxicity

The ICCVAM Acute Toxicity Workgroup is initiating a global project to develop in silico models of acute oral systemic toxicity that predict specific endpoints needed by regulatory agencies. These endpoints include identification of “very toxic” chemicals (LD50 less than 50 mg/kg) and “nontoxic” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for […]
0Read More
Posted in Community Blog on

NIH Awards $2.34 Million to GBSI for Training to Improve Research Reproducibility

WASHINGTON, D.C., November 13, 2017 – The National Institutes of Health (NIH) has awarded the Global Biological Standards Institute (GBSI) $2.34 million over five years for a groundbreaking experimental design training project to improve reproducibility in preclinical research. The project, entitled “Producing Reproducible Experiments by Promoting Reverse Experimental Design” (PREPaRED),* is a collaborative educational partnership […]
0Read More
Posted in Community Blog on

Improving Species Extrapolation for Protecting Endangered Species

Planning to be in Minneapolis next week for the Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting? Please join us for “Improving Species Extrapolation for Protecting Endangered Species: What Is Available and What Is Needed?” Currently, data used to protect endangered species has the unintended consequence of helping to increase animal testing […]
0Read More
Posted in Community Blog on

FDA Releases Draft Guidances on In Vitro Metabolism and Drug Interactions Studies

The FDA recently issued two draft guidances for public comment: In Vitro Metabolism and Transporter-Mediated Drug-Drug Interaction Studies Clinical Drug Interactions Studies – Study Design, Data, Analysis, and Clinical Implications Together, the two draft guidances provide a systemic, risk-based approach to help drug developers evaluate investigational new drugs for potential drug-drug interactions (DDIs) during drug […]
0Read More
Posted in Community Blog on

EPA Update to EDSP Stakeholders: Nov. 6 Virtual Meeting of FIFRA SAP

Source: EDSP Listserv EPA will hold a virtual FIFRA SAP meeting on the charge questions on the “Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways.” This virtual meeting will be held on November 6, 2017, from approximately 2 p.m. to 5 p.m. via adobe connect. […]
0Read More
Posted in Community Blog on

AltTox Editorial Board Member Dr. Albert Li, In Vitro ADMET Laboratories, is Stage Two Winner of EPA’s Toxicity Testing Challenge

Announcing the Transform Toxicity Testing Challenge Stage Two Winners Source: https://www.epa.gov/innovation/announcing-transform-toxicity-testing-challenge-stage-two-winners Scientists from EPA, NCATS, and NIEHS/NTP are using high speed, automated screening technologies called high-throughput screening (HTS) assays to rapidly test whether some of the thousands of chemicals in use may affect human health. However, since current HTS assays do not fully incorporate chemical […]
0Read More
Posted in Community Blog on

Presentations and Videocast of SACATM Meeting Available

Presentations from the September 18-19 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) are available on the NTP website. Video recordings of the meeting are also available on the National Institutes of Health Videocast website. View recording of the September 18 session View recording of the September 19 session SACATM meets annually […]
0Read More
Posted in Community Blog on

OECD releases five new Integrated Approaches to Testing and Assessment Case Studies

The Integrated Case Studies Project was launched in 2015 to increase experience with the use of Integrated Approaches For Testing And Assessment (IATA) by developing case studies, which constitute examples of predictions that are fit for regulatory use. The aim is to create common understanding of using novel methodologies and the generation of considerations/guidance stemming […]
0Read More
Posted in Community Blog on

JSAAE’s 11th Mandom International Research Grants on Alternative to Animal Experiments is accepting applications

The Japanese Society for Alternatives to Animal Experiments (JSAAE) announced that applications are being accepted for the 11th Mandom International Research Grants on Alternative to Animal Experiments from September 2017 through January 2018 (application deadline January 31, 2018). Eligible applicants are researchers around the world, mainly focusing on Asia, who are members of the JSAAE.  […]
0Read More
Posted in Community Blog on

Job opening: Research and Testing Coordinator at The Physicians Committee for Responsible Medicine

The Physicians Committee for Responsible Medicine is seeking a Research and Testing Coordinator to contribute to our efforts to replace animals in basic and medical research with human-relevant research methods by implementing education and outreach programs and conducting research. If you are a professional with a degree in the life sciences, apply today! https://www.pcrm.org/about/careers/research-and-testing-coordinator
0Read More
Posted in Community Blog on

ARDF: THE ALTERNATIVES IN RESEARCH CHALLENGE

The Alternatives in Research (AiR) Challenge is a program intended to stimulate innovative research that advances medical progress through the use of methods that do not involve animals. The program focus is on biomedical research, given that animal use in this area far exceeds that in safety testing and scientific education. It is anticipated that […]
0Read More
Posted in Community Blog on

GBSI BioPolicy Summit 2017 Explores Technologies for Improved Preclinical Research Reproducibility – October 16

Global Biological Standards Institute’s 3rd annual BioPolicy Summit: “Improving Reproducibility of Research Through Digital Tools, Technologies and Laboratory Automation,” will bring a diverse and interdisciplinary group of participants together—biologists, tech programmers, instrumentation manufacturers, the maker community, journals, and funders—to explore how the newest life science research tools and technology can enhance reproducibility in preclinical research.  […]
0Read More
Posted in Community Blog on

Researchers, beware: humanized mice not human enough to study stem cell transplants

Source: https://blog.cirm.ca.gov/2017/08/23/researchers-beware-humanized-mice-not-human-enough-to-study-stem-cell-transplants/       August 23, 2017, Todd Dubnicoff “A researcher’s data is only as good as the experimental techniques used to obtain those results.” “And a Stanford University study published yesterday in Cell Reports, calls into question the accuracy of a widely used method in mice that helps scientists gauge the human immune system’s response to […]
0Read More
Posted in Community Blog on

NIEHS Offers Grants for Development of Culture Models

The National Institute of Environmental Health Sciences (NIEHS) is providing grants for development of novel in vitro systems using cells from experimental animal models typically used for toxicology testing. The intent is that these systems will replicate biological responses within the corresponding animal tissues or organs. When developed and validated, these systems will provide information […]
0Read More
Posted in Community Blog on

New Review Describes Use of AOPs in EPA Screening Program

A review in the September issue of the journal Environmental Health Perspectives describes how the U.S. Environmental Protection Agency (EPA) uses adverse outcome pathway (AOP) and toxicity pathway frameworks in its Endocrine Disruptor Screening Program. The review describes how these frameworks help to establish biologically plausible links between endocrine mechanisms and apical responses when those […]
0Read More
Posted in Community Blog on

SACATM Meeting September 18-19

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 18-19 at the Natcher Conference Center, National Institutes of Health (NIH), Bethesda, Maryland. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences (NIEHS) regarding statutorily mandated duties of ICCVAM and activities of NICEATM. The […]
0Read More
Posted in Community Blog on

Award to Attend the Institute for In Vitro Sciences’ January 2018 Practical Methods for In Vitro Toxicology Workshop

The PETA International Science Consortium Ltd. is proud to announce an early-career scientist award to participate in the Institute for In Vitro Sciences’ (IIVS) 2018 Practical Methods for In Vitro Toxicology Workshop. The award will fund workshop registration ($1,950 USD), as well as airfare and hotel accommodations (up to $1,000 USD). The workshop hosted by […]
0Read More
Posted in Community Blog on

EURL ECVAM Call for Tender – Review of non-animal methods used in disease research

The JRC’s EURL ECVAM has launched a study to collect and describe non-animal methods being used for basic and applied research into neurodegenerative, respiratory tract and cardiovascular diseases, and breast cancer. Access : http://ted.europa.eu/udl?uri=TED:NOTICE:316352-2017:TEXT:EN:HTML Submission deadline: 18th September 2017 Short description: A collection of non-animal methods shall be provided in use for basic and applied […]
0Read More
Posted in Community Blog on

EFSA seeking contract services to implement in vitro battery for developmental neurotoxicity assessment

Implementation and interpretation of in vitro testing battery for the assessment of developmental neurotoxicity OC/EFSA/PRAS/2017/01 Source: https://www.efsa.europa.eu/en/tenders/tender/170803 Published: 3 August 2017 Deadline: 20 October 2017, Local time: 14:30 (CET) Published in the Official Journal of the European Union on 03/08/2017 – OJ NUMBER: 2017/S 147-303487 [see description below] The tender documentation can be accessed in the document library […]
0Read More
Posted in Community Blog on

NICEATM and ICCVAM Activities at World Congress

NICEATM and ICCVAM scientists will be active participants at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences, which runs August 20-24 in Seattle, Washington. ICCVAM members will co-chair four presentation sessions and participate on roundtable panels on regulatory issues and big data. NICEATM and ICCVAM scientists will also share their […]
0Read More
Posted in Community Blog on

Slides Available from BioMed21 Workshop

Presenters’ slides from the June 26-27 workshop “BioMed21 – A Human Pathway-based Approach to Disease and Medicine” are now available. The presentations from government, academic, and industry scientists addressed how to implement a human systems-biology platform for understanding disease and improving interventions. The workshop was co-organized by NICEATM and the Human Toxicology Project Consortium. In […]
0Read More
page 2 of 9

The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.