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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
  • advertisements are not permitted
  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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IIVS Releases Training Video to Replace Animals in Phototoxicity Testing

IIVS Releases Training Video to Replace Animals in Testing For Immediate Release Media Contact: Laura Henning 240-454-8459 lhenning@iivs.org GAITHERSBURG, MD – October 12, 2016 – Funded by a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA), the Institute for In Vitro Sciences, Inc.(IIVS) has released a technical training video that describes […]
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Invitation: Symposium on ‘Phasing out animal experiments, the next steps: applying openness, scientific justification and transparent reporting’

Especially for our European colleagues, notice of an upcoming symposium organized by the newly created Netherlands National Committee for the protection of animals used for scientific purposes (NCad) on December 8, 2016 in Brussels –registration ends Nov 1. From the program description: “The purpose of this symposium is to discuss whether the current animal use […]
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NICEATM and PISC Convene Meeting on Inhalation Alternatives

NICEATM and the PETA International Science Consortium (PISC) organized an expert meeting on “Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-regulatory Data Requirements.” Participants in the meeting, held September 22-23, 2016, in Bethesda, MD, identified four key activities needed to reduce and replace animal use for required inhalation toxicity testing: […]
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Raymond Tice Honored by ARDF

Raymond Tice, former NICEATM Deputy Director and National Toxicology Program (NTP) Biomolecular Screening Branch chief, received the William and Eleanor Cave Award from the Alternatives Research and Development Foundation (ARDF). The William and Eleanor Cave Award is given to recognize contributions to advancing alternatives to the use of animals in testing, research, or education. The […]
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ICCVAM Advisory Committee Discusses Roadmap for Replacing Six Acute Toxicity Tests

The Scientific Advisory Committee for Alternative Toxicological Methods, which advises NICEATM and ICCVAM, met at the National Institute of Environmental Health Sciences in Research Triangle Park, NC, on September 27. ICCVAM agencies outlined a roadmap for the replacement of animals for the six most commonly used acute toxicity tests: ocular and dermal irritation; dermal sensitization; […]
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Many in vitro and in silico approaches encouraged in new funding opportunity from the Bill & Melinda Gates Foundation – Proposals due November 9

Grant Opportunity title: Develop Novel Platforms to Accelerate Contraceptive Drug Discovery (Round 18) Source: http://gcgh.grandchallenges.org/challenge/develop-novel-platforms-accelerate-contraceptive-drug-discovery-round-18 Deadline: 9 Nov 2016 – 11:30am PST The Challenge While access to a range of appropriate and desirable contraceptive methods can have a broad beneficial impact on the lives of women, men and their families, this goal is currently not […]
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2017 CAAT Academy Program is available

Francois Busquet, CAAT Academy The CAAT Academy training program for 2017 has been published. The following sessions will be offered: Organs-on-a-chip @MIMETAS, Leiden (NL) In vitro skin & eye models – Part 1 @VUB, Brussels (BE) Liver models and AOP @Biopredic International, Rennes (FR) EDC in vitro models @Biodetection Systems, Amsterdam (NL) ADME @KUL, Leuven […]
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Advancing non-animal testing methods: first set of novel knowledge tools published

Catherine Willett, HSUS From the European Commission: The Organisation for Economic Co-operation and Development (OECD) has recently published the first five adverse outcome pathways (AOP), three of which have been developed by the JRC. The AOPs are novel knowledge management tools in toxicology and are useful for supporting risk assessment to human health. They are […]
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Three Key Approaches to Increasing Research Antibody Validation Defined at GBSI Workshop

Sherry Ward, AltTox Event Was Most Representative Gathering of Scientific Experts Ever Convened on the Topic PACIFIC GROVE, Calif., September 28, 2016—Leading experts from the international biomedical research community announced today that they have the fundamentals of what will become the first detailed standardized guidelines for validating research antibodies. The outcomes of this week’s Antibody […]
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Conference: New Frontiers in 3D Cell Culture-based Screening Technologies

Catherine Willet, HSUS Full-day event on 3D microtissue models for more relevant translational screening methods and safety testing October 13 Baltimore, MD, USA Advanced 3D tissue models are changing the shape of in vitro testing for drug discovery and development from flat, monolayer cell culture to more complex 3D systems providing greater physiological relevance. The […]
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BRAIN Initiative Updates: NSF encourages researchers with expertise in data science; Initiative seeks to include more diverse fields of science

Sherry Ward, AltTox NSF Announces Data Resources for the BRAIN Initiative September 22, 2016 …NSF, a partner in the BRAIN Initiative® supporting fundamental research across a spectrum of disciplines within neuroscience, has released a Dear Colleague Letter (see below) encouraging researchers with expertise in data science to partner with BRAIN Initiative projects, including projects funded by the […]
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NICEATM Director Participates in Congressional Briefing

Catherine Sprankle, NICEATM NICEATM Director Warren Casey was a panelist for a September 13 Congressional briefing on “Alternatives to Animal Testing: Emerging Uses and Policy Implications.” Casey and other panelists discussed how to use non-animal and alternative toxicology and safety testing methods to better protect consumers and public health while using fewer animals. Topics considered […]
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Computational Biology Symposium at NIH September 16

Catherine Sprankle, NICEATM PLoS Computational Biology is presenting a Computational Biology Symposium on the National Institutes of Health campus on Friday, September 16, from 9:30 a.m.-4:00 p.m. Keynote speakers will include Dr. David J. Lipman of the National Center for Biotechnology Information, Dr. Jennifer Lippincott-Schwartz of the Eunice Kennedy Shriver National Institute of Child Health […]
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FDA Seeks Comment on Draft Guidance for Toxicokinetics Studies

Catherine Sprankle, NICEATM A U.S. Food and Drug Administration (FDA) notice in the September 8 Federal Register requested comments on draft guidance titled “ICH S3A Guidance: Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies—Questions and Answers.” The draft guidance facilitates interpretation of the ‘‘S3A Guidance: The Assessment of Systemic Exposure […]
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NICEATM Workshop Report Recognized as an NIEHS Paper of the Month

Catherine Sprankle, NICEATM The September issue of the Environmental Factor, the newsletter of the National Institute of Environmental Health Sciences (NIEHS), recognized the report on the Collaborative Workshop on Aquatic Models and 21st Century Toxicology as an NIEHS Intramural Paper of the Month. The workshop, organized by NICEATM and North Carolina State University, reviewed emerging […]
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Announcement of 2016 ARDF Alternatives Research Grant awards

Sue A. Leary, ARDF The Alternatives Research & Development Foundation (ARDF) is pleased to announce the recipients of the 2016 Alternatives Research Grants. Luca Cucullo, PhD Texas Tech University Health Sciences Center, Amarillo, TX A humanized blood-brain tumor barrier model to assess drug delivery of chemotherapeutic treatment Dongeun (Dan) Huh, PhD University of Pennsylvania, Philadelphia, […]
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Employment Opportunity: Corporate Liaison for PETA’s Regulatory Testing Department

Katherine Groff, PETA International Science Consortium Ltd. PETA’s Regulatory Testing Department is seeking a Corporate Liaison to join its growing team. This person will work with major corporations to replace and reduce animal testing. A successful candidate will attend corporate meetings and scientific conferences and maintain expertise in nonanimal test methods and international regulatory requirements. […]
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CAAT Academy: Kidney toxicity testing and best practices

Francois Busquet, CAAT Dates: September 22-23, 2016 Location: Vienna, Austria, Evercyte Laboratories This 2-days training will give a comprehensive overview of the most relevant and robust 2D and 3D kidney cell culture models and in vitro applications for the assessment of kidney-associated cytotoxicity. Webinar will be available during the training but for the presentations only. […]
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Upcoming calls for proposals

Sherry Ward, AltTox Engineering Next-Generation Human Nervous System Microphysiological Systems (R21) (PAR-16-397) and (R01) (PAR-16-398) Application Receipt/Submission Date(s): Standard dates apply through January 8, 2020 This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) with improved fidelity to complex human brain, spinal, peripheral nervous system and/or […]
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U.S. Strategy and Roadmap for Implementing 21st Century Toxicity Testing Approaches

Catherine Sprankle, NICEATM The focus of the September 27 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will be topics related to the development of a U.S. strategy and roadmap for implementing 21st century toxicity testing approaches. Background material and specific questions to be discussed by SACATM are included in an “In […]
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Funding Opportunity for Alternative Methods Development

Catherine Sprankle, NICEATM The National Toxicology Program Interagency Center for the Evaluation of Alternative Methods (NICEATM) encourages U.S. small businesses involved in alternative methods development to apply for Small Business Innovation Research (SBIR) Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing offered by the National Institute of […]
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Chips in Space: Webinar September 6

Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the Center for the Advancement of Science in Space are promoting a new program for research on the International Space Station United States National Laboratory (ISS-NL): we’re sending tissue chips to space! This program will leverage recent advances in tissue engineering and microfabrication […]
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OECD lists newly “endorsed” AOPS

Catherine Willet, HSUS OECD has created a new web page to list Adverse Outcome Pathways that have undergone scientific review by experts and have been agreed by the OECD National Coordinators to represent the current state of knowledge: Four of the first five AOPs to have undergone this review are now posted: Adverse Outcome Pathway […]
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NIH request for comments on scope of animal-human chimera research – deadline extended to September 6

Sherry Ward, AltTox “The National Institutes of Health (NIH) is requesting public comment on a proposal to amend Section IV and Section V of the NIH Guidelines for Human Stem Cell Research, and on the proposed scope of certain human-animal chimera research that will be considered internally by an NIH steering committee to provide programmatic […]
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CRACK IT Announces 4 New Challenges; Partners Sought for Other Projects

Sherry Ward, AltTox The 2016 CRACK IT Challenges competition consists of the following four Challenges: Maximise: “To develop reliable predictions which confidently classify mixtures of chemicals for acute oral toxicity, skin and eye irritation with a focus on relevance for human safety. These should fulfill acute GHS Classification and Labeling requirements for non-encapsulated agrochemical mixtures […]
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ICCVAM 2014-2015 Biennial Progress Report Now Available

Catherine Sprankle, NICEATM The ICCVAM 2014-2015 Biennial Progress Report is now available on the National Toxicology Program website. This report, prepared in accordance with requirements of the ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3), describes ICCVAM and ICCVAM agency activities from January 2014 through December 2015. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized […]
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Webinar Series on Inhalation Toxicity Concludes September 8

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The last webinar in the series will be Thursday, September 8, from 11:00 a.m. to 12:30 p.m. EDT. Dan Huh, Ph.D., University of Pennsylvania, […]
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Workshop Report on Carcinogenicity of Mixtures Now Available

Catherine Sprankle, NICEATM An August 2015 workshop sponsored by the National Institute of Environmental Health Sciences evaluated the scientific support for the Low-Dose Mixture Hypothesis of Carcinogenesis and developed a research agenda. A report from this workshop is now available on the Environmental Health Perspectives website. NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., was a breakout […]
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Unilever offering annual award to promote alternatives in China

Catherine Willet, HSUS Unilever has launched an award to promote development and application of alternatives in China. The award called “Chinese Society of Toxicology Toxicology Unilever Alternatives Awards” was set up by Chinese society of toxicology, funded by Unilever. Two types of awards were announced: “Chinese Society of Toxicology Toxicology alternatives Unilever Innovation Award” (3 winners) and the “Chinese Society of Toxicology […]
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NICEATM Requests Information on Acute Toxicity Testing Technologies

Catherine Sprankle, NICEATM In a July 18 Federal Register notice, NICEATM requested data and information on approaches and technologies currently used to identify substances with the potential to cause acute systemic toxicity when swallowed, inhaled, or absorbed through the skin. Respondents should provide information on any activities relevant to the development or validation of alternatives […]
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OECD publishes guidance document on waiving mammalian acute toxicity tests

Kate Willett, HSUS The OECD has published a Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests. From the introduction: The OECD Guidelines for the Testing of Chemicals are continually evolving to reflect changing assessment practices. Acute toxicity tests are an area of focus for developing alternative assays to address animal […]
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Beagle Freedom Prize for Non-Animal Methods

Sherry Ward, AltTox Beagle Freedom Project will award $250,000 in grants to applicants whose goal is to replace the common use of dogs and other animals in research, testing, and/or education with a non-animal approach. A total of five possible awards of $50,000 are scheduled, or larger sized grants are available to fewer awardees depending […]
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REACH annexes amended on use alternative methods

Sherry Ward, AltTox The European Chemicals Agency (ECHA) provides the latest news on chemical registration obligations under REACH on their REACH 2018 web page. “The REACH requirements for skin corrosion/irritation, serious eye damage/eye irritation, acute dermal toxicity and skin sensitisation are changing, making non-animal testing the default requirement.” The changes and new requirements are explained […]
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European Pharmacopoeia Commission adopts revised general chapter on monocyte activation test to facilitate reduction in animal testing

Sherry Ward, AltTox Source: https://www.edqm.eu/en/node/15240 “During its 155th Session, held in Strasbourg on 21-22 June 2016, the European Pharmacopoeia Commission adopted a revision of the general chapter Monocyte-activation test (2.6.30) in order to make it more widely useable by stakeholders and thus facilitate a reduction in testing on live animals.” The press release provides additional […]
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FDA requests additional information to address data gaps for consumer hand sanitizers

Sherry Ward, AltTox The US Food and Drug Administration issued a proposed rule requesting additional scientific data to support the safety and effectiveness of certain active ingredients used in consumer antiseptic rubs (hand sanitizers) marketed over-the-counter (OTC). The FDA’s request for more data is intended to help the agency ensure that regular use of these […]
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LUSH prize for in vitro research, training, advocacy

Kate Willett, HSUS There is just one month left to nominate for Lush Prize 2016, the biggest annual prize fund supporting the complete replacement of animal testing, across science, campaigns and lobbying, with a focus on toxicology / safety testing. Nominations close at midnight on 24th July (wherever you are in the world!) so don’t delay […]
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NICEATM Requests Data and Information on Developmental Toxicity Test Methods

Catherine Sprankle, NICEATM In a Federal Register notice published today, NICEATM requested available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to […]
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Today: EPA Webinar Provides Overview of TSCA Reform

Catherine Sprankle, NICEATM In a webinar today (June 30) at 2:00 p.m. Eastern time, the U.S. Environmental Protection Agency (EPA) will review changes to the newly amended Toxic Substances Control Act (TSCA). The webinar is free and open to the public, and preregistration is not required. View the webinar: Overview of TSCA Reform The Frank […]
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Order your FREE Copy of Cyprotex’s Chemical and Cosmetics Testing Guide

Helen Gill, Cyprotex Discovery Ltd Cyprotex’s Chemical and Cosmetics Testing Guide is a valuable resource for anyone involved in safety testing of industrial chemicals, pesticides, cosmetics and personal care products. It covers current legislation, skin and ocular testing approaches, mutagenicity/genotoxicity testing and endocrine disruption testing, and focuses predominantly on non-animal testing methods. Order your free […]
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Information Day on “Progress in Alternative Methods in Toxicology and Biomedicine”

Mardas Daneshian, CAAT-Europe at the University of Konstanz Information Day on “Progress in Alternative Methods in Toxicology and Biomedicine” July 8th 2016 09:00 – 16:00 Konzil Konstanz, Konstanz, Germany Toxicology traditionally relies on the use of animals to derive information relevant for human wellbeing and safety. Today, human cell-based alternative methods to animal use have […]
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FDA Issues Final Guidance and Presents Webinar on Biological Evaluation of Medical Devices

Catherine Sprankle, NICEATM The U.S. Food and Drug Administration (FDA) has issued a final guidance document on the use of International Standard ISO 10993-1, “Biological Evaluation of Medical Devices – Part 1: Evaluation and Testing Within a Risk Management Process.” FDA developed the guidance document to assist industry in preparing applications and notifications on medical […]
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EPA Releases Training Videos on Data Requirements for Antimicrobials

Catherine Sprankle, NICEATM The U.S. Environmental Protection Agency (EPA) is releasing five training videos providing guidance on EPA’s 40 CFR Part 158W data requirements for antimicrobial pesticides. These training videos will help the public and the pesticide industry better understand the pesticide registration process and make the process more efficient and transparent. The videos include […]
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NIH Releases a Request for Information Seeking Guidance for Opportunities in Neuroethics; Responses Due July 29, 2016

Sherry Ward, AltTox Source: https://brainupdate.nih.gov/2016/06/07/nih-releases-a-request-for-information-seeking-guidance-for-opportunities-in-neuroethics June 7, 2016 NIH solicits input to identify a set of core ethical issues associated with research involving the human brain and resulting from advancements in neurotechnology research and development…. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative® is aimed at revolutionizing our understanding of the human brain. By […]
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View presentations from NTP’s Botanical Dietary Supplement Safety Workshop

Sherry Ward, AltTox Videocasts now available for the April 26-27, 2016 NTP workshop, “Addressing challenges in the assessment of botanical dietary supplement safety.” Overall, it was a well-organized and informative meeting with excellent presentations. The many challenges in assessing the safety of botanical products coupled with an emerging demand for their safety assessment suggests this […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.