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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
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Please report offensive or inappropriate content to info@alttox.org

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FDA Final Guidance on Toxicokinetics Studies Available

In a May 10 Federal Register notice, the U.S. Food and Drug Administration (FDA) announced availability of final guidance on the benefits and limitations of the use of microsampling techniques in toxicokinetics studies. Benefits of these techniques include reducing the numbers of animals needed for these studies. View all FDA guidance documents
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Workshop on Pyrogen Testing Methods September 18-19

NICEATM is co-organizing a workshop on September 18-19 with the PETA International Science Consortium to discuss non-animal approaches for pyrogen testing. The workshop will be held at NIH in Bethesda, Maryland, and will focus on the use of the monocyte activation test (MAT) as a standalone release test for medical devices. Registration and materials will […]
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OECD looking for assays for Non-Genotoxic Carcinogens

The Organization for Economic Cooperation and Development (OECD) is looking for assays that could be used within the context of an Integrated Approach to Testing and Assessment to assess a chemicals potential for non-genotoxic carcinogenicity assessment. If you have or are developing such an assay, please let OECD know about it before June 15, 2018. […]
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NICEATM Requests Information on Technologies for Identifying Developmental Toxicants

NICEATM requests available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce adverse effects in offspring. Respondents to this request should […]
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Comments on EPA Draft Strategy Due May 11

Comments on a U.S. Environmental Protection Agency (EPA) draft strategy to reduce use of vertebrate animals in chemical testing are due Friday, May 11. The draft strategy and related documents are available at https://www.regulations.gov/ under docket EPA-HQ-OPPT-2017-0559. Comments received will be considered in the Agency’s development of the final strategy. The Frank R. Lautenberg Chemical […]
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NIEHS Webinars to Discuss New Approaches and Methodologies for Chemical Safety Evaluation

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program is hosting a webinar series highlighting research that may be useful as new approaches and methodologies for toxicity testing. This series coincides with recent initiatives found in the EPA draft strategic plan discussed above and the Strategic Roadmap for Establishing New Approaches to Evaluate […]
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Award to Attend the 20th International Congress on In Vitro Toxicology

Early-career scientists are invited to apply for an award to attend the 20th International Congress on In Vitro Toxicology (ESTIV2018). This award, presented by the PETA International Science Consortium Ltd., will give a postgraduate student, postdoctoral fellow, or new researcher the opportunity to gain a better understanding of state-of-the-science non-animal testing strategies. The conference will include lectures […]
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EPA Releases ToxCast Owner’s Manual

The U.S. Environmental Protection Agency (EPA) recently released its ToxCast Owner’s Manual. Since its launch in 2007, EPA’s Toxicity Forecaster (ToxCast) high throughput screening program has generated data for approximately 1,800 chemicals for more than 700 assay endpoints, making ToxCast a major contributor to the federal Tox21 collaboration. All ToxCast data is publicly available. The […]
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FDA CDER Funding Opportunity Announcement

Funding Opportunity Announcement: Development of a virtual bioequivalence trial simulation platform that integrates population pharmacokinetic modeling algorithms into physiologically-based pharmacokinetic models (U01) (RFA-FD-18-018) Objective: The purpose of this project is to develop and implement a virtual bioequivalence trial simulation platform that can be used to perform population-based statistical analysis in complex and computationally intensive physiologically […]
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Registration Open for ICCVAM Public Forum

Registration is open for ICCVAM’s May 24 Public Forum. The meeting will be held from 9:00 a.m. to 4:00 p.m. at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. The meeting will also be webcast. Information about the meeting is available on the NICEATM website. ICCVAM holds annual public forums to share information […]
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REACHing for Alternatives to Animal Testing

The series of webinars, co-hosted by Chemical Watch and the PETA International Science Consortium Ltd., on alternative testing approaches for meeting REACH requirements is now available online. Perspectives on the Development, Evaluation, and Application of in Silico Approaches to Predicting Toxicity Speakers: Grace Patlewicz (US Environmental Protection Agency) and Mark Cronin (Liverpool John Moores University) […]
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Integrated Chemical Environment Adds Formulations Viewer

A recent update to the NICEATM Integrated Chemical Environment (ICE) added a formulations viewer that allows users to explore toxicity data on formulations and their active ingredients. ICE currently includes data for about 700 formulations from six-pack studies for pesticide registration: acute oral, dermal, and inhalation toxicity; skin sensitization; and skin and eye irritation. Active […]
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NIH Requests Comments on Draft Strategic Plan for Data Science

To capitalize on the opportunities presented by advances in data science, the National Institutes of Health (NIH) is developing a Strategic Plan for Data Science. This plan describes NIH’s overarching goals, strategic objectives, and implementation tactics for promoting the modernization of the NIH-funded biomedical data science ecosystem. NIH published a Request for Information that seeks […]
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Next Deadline for Small Business Grants April 5

The National Institute of Environmental Health Sciences offers funding for small businesses developing technologies of interest to the Tox21 program. These technologies include improved or expanded testing methods for toxicity screening, computational approaches for predictive toxicology, and other technologies such as alternative or improved methods for fixing and preserving tissues. The funding is offered as […]
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Papers Published Describing Analysis of Defined Approaches to Skin Sensitization

A collaboration between NICEATM and Cosmetics Europe has produced two papers describing important resources for non-animal approaches to identifying potential skin sensitizers. The first paper describes a database that includes data from human, animal, and five non-animal tests for 128 chemicals. The chemicals in the database represent a wide variety of chemistries and use categories. […]
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NICEATM and ICCVAM Activities at SOT

Consider adding these sessions to your Society of Toxicology annual meeting itinerary: In Vitro Toxicology Lecture and Luncheon: Monday, March 12, 11:30 a.m.-1:00 p.m., Hemisfair Ballroom C1 “More than Skin Deep: When Alternative Approaches Outperform Animal Tests,” NICEATM Deputy Director Nicole Kleinstreuer U.S. EPA’s Toxic Substances Control Act: Strategy for Alternative Test Methods to Reduce […]
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Internship Opportunities with the U.S. Air Force

The U.S. Air Force School of Aerospace Medicine is accepting applications for its High Performance Computing Internship Program. Interns are being recruited to work on four projects: High-performance computing of quantitative structure activity relationship models applied to toxicology and adverse outcome cellular pathway analysis Application of machine learning and image analytics methods to improve assessment […]
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Computers outperform lab rats in detecting toxic chemicals

“UL, the science safety company, and Johns Hopkins University have embarked on joint research that has resulted in findings that Artificial Intelligence (AI) is superior in finding toxic substances to traditional animal testing. Beyond being more effective, UL’s Cheminformatics REACHAcross™ software computer processing can be performed in a matter of seconds and at a fraction […]
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NIH solicits next-generation retina organoids in prize competition – WebEx informational session today!

Source: https://www.nih.gov/news-events/news-releases/nih-solicits-next-generation-retina-organoids-prize-competition A competition for radical ideas in the fight against blindness will move to its next phase by challenging participants to build functioning human retina prototypes. The National Eye Institute (NEI) 3-D Retina Organoid Challenge (NEI 3-D ROC 2020) is a $1-million federal prize competition designed to generate lab-grown human retinas from stem cells. […]
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Cefic-LRI Innovative Science Award Competition: Alignment of Adverse Outcome Pathway concept in toxicology with needs of risk assessment

Source: http://cefic-lri.org/news/cefic-lri-innovative-science-award-2018-competition-is-open/ The topic of the Cefic-LRI Innovative Science Award 2018 is “Improved alignment of the Adverse Outcome Pathway (AOP) concept in toxicology with the needs of risk assessment.” The Cefic-LRI Innovative Science Award, a €100.000 prize, supports promising new research in the field of mammalian and environmental toxicology. Applications are open until March 18, […]
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Chinese NIFDC calls for comment on DPRA and STE for safety assessment of cosmetic ingredients

On Feb 5th 2018 , the National Institutes for Food and Drug Control (NIFDC) of the Chinese FDA (CFDA) released a bulletin  calling for comments on two alternatives methods for safety assessment of cosmetic ingredients: the in chemico Direct Peptide Reactivity Assay for skin sensitization (OECD TG 442C)  and the in vitro Short-Term Exposure test for eye […]
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OECD launches the QSAR Toolbox version 4.2

The EHS Hazard Assessment programme is actively working to increase the regulatory acceptance of QSARs methods, tools and approaches such as the QSAR Toolbox and to make these technologies more accessible and transparent. The QSAR toolbox is a software application intended to the use of governments, chemical industry and other stakeholders in filling gaps in […]
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ICCVAM Elects Co-chairs

At its January 24 meeting, ICCVAM elected Anna Lowit, U.S. Environmental Protection Agency (EPA), and Emily Reinke, Department of Defense, to serve two-year terms as co-chairs of ICCVAM. Lowit is a senior science advisor in the EPA Office of Pesticide Programs. She has been a member of ICCVAM since 2011 and has served as an […]
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U.S. Strategic Roadmap Published

ICCVAM has coordinated the development of “A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States.” It describes a framework for safety testing that will provide more human-relevant toxicology data while reducing the use of animals. Prepared with support from NICEATM, it was published January […]
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Feb. 8 Webinar to Introduce New Funding Opportunity from Human Biomolecular Atlas Program

The NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) (https://commonfund.nih.gov/hubmap) aims to develop a framework for functional mapping the human body with cellular resolution to enhance our understanding of cellular organization-function. HuBMAP will accelerate the development of the next generation of tools and techniques to generate 3D tissue maps using validated high-content, high-throughput imaging and […]
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GRADUATE FELLOWSHIPS FOR ALTERNATIVES TO THE USE OF ANIMALS IN SCIENCE

The International Foundation for Ethical Research (IFER) is now accepting pre-proposal applications for 2018-2019 Graduate Fellowships. Applications are due no later than 11:59 PM CST on Monday, April 30, 2018. IFER Graduate Fellowships are one-year grants of up to $12,500 for projects that support the development, acceptance and implementation of innovative scientific methodologies that advance […]
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National Academies of Sciences, Engineering, and Medicine Workshop on “Informing Environmental Health Decisions Through Data Integration ” Begins on February 20

Integrating large quantities of data from multiple, disparate sources can create new opportunities to understand complex environmental health questions. However, combining new types and larger quantities of data to inform a specific decision presents many new challenges. For example, investigators must develop methods to reliably integrate data from designed experiments with data re-purposed from other uses, […]
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Registration and Abstract Submission Open for Meeting on High Throughput Screening and Environmental Risk Assessment

The Society of Environmental Toxicology and Chemistry will hold a meeting on High Throughput Screening and Environmental Risk Assessment, State of the Science and Emerging Applications on April 16-18 at the Durham Convention Center in Durham, North Carolina. This meeting will provide environmental toxicologists and risk assessors with an introduction to high throughput data and […]
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REACHing for Alternatives to Animal Testing

A New Webinar Series on Modern Testing Strategies for REACH The PETA International Science Consortium Ltd., an organisation that promotes reliable and relevant regulatory testing approaches that protect human health and the environment while eliminating the use of animals, and Chemical Watch, the leading global regulatory news and information service for the chemical industry, have […]
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USDA Issues Updated Guidance on Vaccine Testing Exemptions

The U.S. Department of Agriculture (USDA) Center for Veterinary Biologics recently added Veterinary Services (VS) Memorandum 800.116 Target Animal Safety Testing Exemption to its website. View all VS Memoranda VS Memorandum No. 800.116, signed in August 2017, replaces an earlier version issued in July 2013. The memorandum provides guidance to licensed firms on requesting an […]
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NIH Human BioMolecular Atlas Program: 2 funding opportunities and Jan. 11 webinar

“In organisms consisting of multiple cell types, diverse cells with different functions and structures develop as we grow and age. The organization and variability of these cells have a profound impact on the function of different tissues, process of aging, and emergence of diseases and conditions. Recently developed technologies are allowing researchers to explore cells […]
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ICCVAM Communities of Practice Webinar January 23

The fourth ICCVAM Communities of Practice webinar will be presented January 23, 2018, on the topic “Machine Learning in Toxicology: Fundamentals of Application and Interpretation.” NICEATM is organizing this webinar on behalf of ICCVAM. This webinar will explore the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that […]
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Grants Offer Support for Tissue Chip Development

The National Institutes of Health (NIH) has announced several funding opportunities for research and development of microphysiological systems (MPS; “tissue chips”) for studying human physiology and assessing toxicity and safety of new drugs and other substances. All of these funding opportunities are open to U.S.-based for-profit, non-profit, academic, and government institutions. NIH is offering 1-2 […]
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USDA Releases Guidance Documents on Animal Health

The U.S. Department of Agriculture (USDA) administers the Animal Welfare Act, which sets standards for the humane care and treatment of animals used in research. USDA Animal Care has developed two Tech Notes for Animal Welfare Act licensees and registrants to help improve adherence to animal welfare standards. “Incentives for Identifying, Reporting, Correcting, and Preventing […]
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National Academies of Sciences Workshop on “The Promise of Genome Editing Tools to Advance Environmental Health Research” Begins on January 10

Recent scientific advances have made genome editing technologies—a suite of biological tools for making precise additions, deletions, and alterations to the DNA and RNA of living cells– more rapid, efficient, and flexible than ever before. Join experts in molecular biology, toxicology, and public health to explore opportunities for using genome (and epigenome) editing technologies in […]
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EPA Requests Nominees for Scientific Advisory Panel

EPA is seeking nominations of ad hoc members for its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP). The FIFRA SAP will meet in 2018 to consider physiologically based pharmaokinetic models to address species differences in pharmacokinetics for pesticide active ingredients. The request for nominees was published in a December 18 Federal […]
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IVIVE Workshop Report Available

A manuscript summarizing a February 2016 workshop, In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, and a preceding webinar series was published online December 5 by the journal Toxicology In Vitro. The manuscript is available on the journal’s website. The workshop report discusses activities and resources that promote inclusion of […]
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NIDDK Offers Support for Development of Tissue Chips

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is establishing a new research consortium “Microphysiological Systems for Modeling Diabetes.” This consortium will support the development and validation of human tissue chips that closely mimic the normal physiology of key metabolic tissues, including the pancreatic islet, liver, skeletal muscle, and white adipose tissue. […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.