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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
  • advertisements are not permitted
  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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NICEATM Integrated Chemical Environment Updated

Updates to the NICEATM Integrated Chemical Environment (ICE) resource were launched in September and November. Successful computational toxicology projects depend on freely available, high-quality data that are formatted for use in computational workflows. ICE provides data from NICEATM and its partners, as well as other resources and tools in an environment designed to support chemical […]
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NICHD Launches Placental Analysis Tool

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) recently launched the Placental Atlas Tool (PAT). PAT is a free resource incorporating placental data from publications and public databases into a reference tool for studying placental development and function throughout pregnancy. Investigators from all backgrounds can use PAT to generate new […]
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Introducing BioMed21.org

On behalf of the AltTox.org team, we’re excited to tell you about a similar initiative we’ve recently launched: the Biomedical Research for the 21st Century (BioMed21) Collaboration. BioMed21 brings together scientists and institutions from across Europe, Asia and the Americas who share a vision of a human-focused paradigm in health research. This unique mix of […]
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Superfund Research Program Webinar Series Concludes October 1

The Superfund Research Program (SRP) Progress in Research webinar series concludes October 1 with presentations from centers at Boston University, Texas A&M University, and the University of California, Davis. The SRP Centers, funded by the National Institute of Environmental Health Sciences (NIEHS), seek practical scientific solutions to protect health, the environment, and communities from exposure […]
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Postdoctoral Opportunities Available at NTP

The U.S. Food and Drug Administration is accepting applications for postdoctoral fellows to develop human cell- and protein-based assays for assessing cardiotoxicity of new drugs. These projects are part of an initiative to design, build, and test new non-animal approaches to assess cardiotoxicity hazard. The initiative is supported jointly by the National Toxicology Program (Biomolecular […]
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Papers Describe Database and Non-animal Approach to Identifying Androgen-active Chemicals

Two recent papers in Reproductive Toxicology describe data and methods used by U.S. Environmental Protection Agency, Organisation for Economic Co-operation and Development, and NICEATM scientists and collaborators to develop a reference database and evaluate an in vitro model to identify chemicals with the potential to interact with the androgen receptor (AR). The AR model is […]
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Webinars for Rabies Vaccine Workshop Begin September 25

Registration is still open for the October 16-17 workshop, “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” The workshop will be held at the National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International Alliance for Biological Standardization. This workshop will […]
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EPA Requests Nominees for TSCA Advisory Committee

The U.S. Environmental Protection Agency (EPA) requests nominations of scientific experts for ad hoc participation and possible membership on the Toxic Substances Control Act (TSCA) Science Advisory Committee for Chemicals (SACC). The SACC will be conducting peer reviews of EPA’s risk evaluations for the first 10 chemical substance addressed under TSCA. Nominations must be submitted […]
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NICEATM Publication Describes In Vitro to In Vivo Extrapolation Models

An article in Environmental Health Perspectives describes in vitro to in vivo extrapolation models developed by NICEATM. These approaches accurately estimate chemical exposure levels that elicit positive responses in the rodent uterotrophic bioassay. A workflow to run these models is freely available and can be parameterized entirely using freely available in silico tools. Reference: Casey […]
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Kleinstreuer Comments on Pathway-based Approaches to Risk Assessment

A commentary on “Pathway-Based Approaches to Chemical Risk Assessment: A Public Health Perspective” by NICEATM Deputy Director Nicole Kleinstreuer appears in the current issue of Adverse Outcome Pathways News. Adverse Outcome Pathways News is a newsletter published by the United Kingdom’s National Centre for the Replacement Refinement & Reduction of Animals in Research. It is […]
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Update of ToxTutor Available

The National Library of Medicine has updated its online ToxTutor course. ToxTutor is a self-paced tutorial for users of NLM chemical and toxicology databases that covers the key principles of toxicology. The August 2018 release of ToxTutor adds “The Microbiome” as a new topic, expands content on alternatives to animal testing and human-on-a-chip testing approaches, […]
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Poster Abstract Deadline Extended to September 14 for Rabies Vaccine Workshop

The abstract submission deadline has been extended to September 14 for the October 16-17 workshop, “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” The workshop will be held at the National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International Alliance […]
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Registration Open for Rabies Vaccine Workshop; Poster Abstracts Due August 31

Registration is open for the October 16-17 workshop, “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” The workshop will be held at the National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International Alliance for Biological Standardization. This workshop will bring […]
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SACATM Meeting September 5-6, Registration and Agenda Available

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 5-6 in the Rodbell Auditorium, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences regarding statutorily mandated duties of ICCVAM and activities of […]
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ICATM Partners to Present Public Update September 6

A public meeting of the International Cooperation on Alternative Test Methods (ICATM) is planned for Thursday, September 6 at 2:00 p.m. following the meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM). Representatives from Brazil, Canada, China, Korea, and the United States will provide an update on 3Rs activities in their respective countries. […]
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FIFRA Advisory Panel to Meet in December, Nominations Requested

The scientific advisory panel for the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA SAP) will meet December 4-7 at the U.S. Environmental Protection Agency (EPA) in Arlington, VA. The FIFRA SAP provides independent scientific advice, recommendations, and information to the EPA Administrator relating to the impact of pesticide regulatory actions on human health and the […]
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EPA Announces Funding Opportunity to Support Alternative Methods Development

EPA is funding research to promote the development and use of alternative test methods and strategies that reduce, refine, or replace vertebrate animal testing. Pertinent research includes approaches such as analog/read-across techniques, mathematical models, and tiered-testing approaches that integrate evidence from multiple sources to help accomplish these goals. Research activities should advance the science underpinning […]
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Article Describes New Marker for Androgen Activity

An article published online July 31 in Toxicological Sciences describes the development and validation of a novel gene expression biomarker to identify AR-modulating chemicals using a pattern-matching method. This collaboration between the U.S. Environmental Protection Agency and NICEATM demonstrates how high-throughput transcriptomic approaches can be used to identify molecular targets for environmental chemicals and provide […]
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Win 3D reconstructed human respiratory tissues

The PETA International Science Consortium and Epithelix recently announced an award to provide an opportunity to researchers worldwide to win three-dimensional reconstructed human respiratory tissues from Epithelix. The awardee will receive a $5,000 award redeemable for Epithelix MucilAirTM or SmallAirTM tissues. Applicants from any sector (e.g., industry, academia, government) are encouraged to apply and the […]
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Award to Attend In Vitro Toxicology Workshop

The PETA International Science Consortium is holding a contest to provide a student or early-career scientist with the opportunity to attend the annual Institute for In Vitro Sciences’ Practical Methods for In Vitro Toxicology workshop in January 2019 in Gaithersburg, MD, USA. Workshop attendees will participate in lectures by experts in the field of in […]
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ICCVAM Publishes 2016-2017 Biennial Report

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has published its 2016-2017 Biennial Report. The report highlights member agency activities supporting toxicology innovation, as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of in vitro methods. Key ICCVAM, […]
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Funding Available for Tissue Chip Models

The National Center for Advancing Translational Sciences (NCATS) has issued funding opportunities to support development of tissue chip technologies. The National Institutes of Health and Centers for Disease Control are offering support to develop technologies and methodologies in the biomedical and behavioral sciences with potential to succeed as commercial products. As part of this opportunity, […]
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FDA Webinar on In Silico Medicine August 9

The U.S. Food and Drug Administration (FDA) will present a webinar on “What We’re Doing to Advance In Silico Medicine at FDA.” Tina Morrison, Ph.D., chair of FDA’s Modeling and Simulation Working Group and Regulatory Advisor of Computational Modeling for FDA’s Office of Device Evaluation will give an overview of in silico modeling and simulation […]
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NICEATM/EPA Project Receives EPA Award

The U.S. Environmental Protection Agency (EPA) annually recognizes outstanding scientific work of its employees with the Scientific Technological Achievement Awards (STAA). An EPA collaboration with NICEATM, “Using Novel Zebrafish Toxicity Assays to Evaluate a Predictive Model of Development Vascular Toxicity,” has received a Level III STAA, for projects accomplishing an unusually notable research or technological […]
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Small Business Funding Available for Assessing Nanomaterials Toxicity

The National Institute of Environmental Health Sciences (NIEHS) has issued a funding opportunity to support development of technologies to assess exposure of engineered nanomaterials and characterize their effects on biological systems. In particular, this funding opportunity supports development of mid- to high-throughput assays or high-content assays for characterizing the effects of specific nanomaterials on biological […]
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FDA Workshop on Dermal Safety Testing September 10

The U.S. Food and Drug Administration (FDA) is hosting a workshop on human dermal safety testing for topical drug products. Workshop participants will review current approaches to the collection of human data during clinical development of topical drug products. The workshop will also address the impact of human skin toxicity studies on drug labeling and […]
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Biologist/Toxicologist Positions Open at EPA Office of Pesticide Programs

The U.S. Environmental Protection Agency has several biologist/toxicologist positions open in the Health Effects Division and the Antimicrobials Division within the Office of Pesticide Programs. The announcement at https://www.usajobs.gov/GetJob/ViewDetails/504164300 describes a one-year developmental program which may lead to a permanent appointment. Candidates should have received bachelor’s, master’s, or doctorate degrees in biology, toxicology, or related […]
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EPA Releases Strategic Plan to Promote Alternative Methods

The U.S. Environmental Protection Agency (EPA) has published its Strategic Plan to Promote the Development and Implementation of Alternative Test Methods Within the TSCA Program. The document describes how EPA will promote development and implementation of methods and strategies that reduce, refine, or replace vertebrate animal testing to provide chemical safety information required under the […]
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Physical Scientist Opportunity at Department of Defense

The Defense Threat Reduction Agency in the Department of Defense is seeking a Physical Scientist to plan, implement, and evaluate research and development programs in drug discovery, development, and safety. Applicants must be U.S. citizens and should have (1) experience in drug discovery and development research and (2) relevant knowledge in the areas of chemistry, […]
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Translations of U.S. Strategic Roadmap Available

The Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States has been translated into Chinese, Japanese, Korean, and Portuguese. The translated documents are available on request from NICEATM. For further information, contact NICEATM at niceatm@niehs.nih.gov.
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EPA Biologist/Toxicologist Positions Available, Deadlines Next Week

The U.S. Environmental Protection Agency (EPA) has Biologist/Toxicologist positions open in the Risk Assessment Division of the Office of Pollution Prevention and Toxics within the Office of Chemical Safety and Pollution Prevention. Multiple positions are available for each of the following opportunities: The announcement at https://www.usajobs.gov/GetJob/ViewDetails/502951800 describes a one-year developmental program which may lead to […]
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Agenda and Registration Available for Workshop on Rabies Vaccine Testing

A preliminary agenda and registration are available for a workshop on Implementing Non-animal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond. The workshop will be held October 16-17 at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International […]
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Report Available from BioMed21 Workshop

The June 2017 BioMed21 workshop, co-organized by NICEATM and the Human Toxicology Project Consortium, examined actions needed to implement a human systems-biology approach to understanding disease and improving interventions. The report from the workshop has been published in the journal Drug Discovery Today.
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NICEATM Requests Information on Technologies for Detection and Measurement of Botulinum Neurotoxin

NICEATM requests available data and information on approaches and/or technologies currently used for detection and measurement of botulinum neurotoxin (BoNT). Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to detect the presence of BoNT and measure potency of BoNT preparations. Respondents to […]
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FDA Final Guidance on Toxicokinetics Studies Available

In a May 10 Federal Register notice, the U.S. Food and Drug Administration (FDA) announced availability of final guidance on the benefits and limitations of the use of microsampling techniques in toxicokinetics studies. Benefits of these techniques include reducing the numbers of animals needed for these studies. View all FDA guidance documents
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Workshop on Pyrogen Testing Methods September 18-19

NICEATM is co-organizing a workshop on September 18-19 with the PETA International Science Consortium to discuss non-animal approaches for pyrogen testing. The workshop will be held at NIH in Bethesda, Maryland, and will focus on the use of the monocyte activation test (MAT) as a standalone release test for medical devices. Registration and materials will […]
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OECD looking for assays for Non-Genotoxic Carcinogens

The Organization for Economic Cooperation and Development (OECD) is looking for assays that could be used within the context of an Integrated Approach to Testing and Assessment to assess a chemicals potential for non-genotoxic carcinogenicity assessment. If you have or are developing such an assay, please let OECD know about it before June 15, 2018. […]
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NICEATM Requests Information on Technologies for Identifying Developmental Toxicants

NICEATM requests available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce adverse effects in offspring. Respondents to this request should […]
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Comments on EPA Draft Strategy Due May 11

Comments on a U.S. Environmental Protection Agency (EPA) draft strategy to reduce use of vertebrate animals in chemical testing are due Friday, May 11. The draft strategy and related documents are available at https://www.regulations.gov/ under docket EPA-HQ-OPPT-2017-0559. Comments received will be considered in the Agency’s development of the final strategy. The Frank R. Lautenberg Chemical […]
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NIEHS Webinars to Discuss New Approaches and Methodologies for Chemical Safety Evaluation

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program is hosting a webinar series highlighting research that may be useful as new approaches and methodologies for toxicity testing. This series coincides with recent initiatives found in the EPA draft strategic plan discussed above and the Strategic Roadmap for Establishing New Approaches to Evaluate […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.