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Guidance for Community Blog readers and contributors

The AltTox Community Blog replaced the AltTox Forum February 2015. The messages in the archived AltTox Forum, however, are still available for reading.

AltTox.org users are welcome to browse and read Community Blog messages. Only registered users, however, can post messages directly to the blog.

Blog User Agreement for registered users:
  • appropriate content includes scientific and policy news related to in vitro and in silico methods for toxicity testing, meeting announcements, funding information, and other relevant information
  • the Blog is moderated, and messages beyond the scope of AltTox or otherwise inappropriate will be removed
  • copyrighted material will not be posted without permission
  • sources of information and related links (when known/available) will be included
  • advertisements are not permitted
  • messages posted by external parties express the views of the author, and not necessarily the views of AltTox team members or AltTox sponsors; AltTox does not warrant the accuracy, completeness, or usefulness of any information presented by external parties

Please report offensive or inappropriate content to info@alttox.org

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CRACK IT Announces 4 New Challenges; Partners Sought for Other Projects

The 2016 CRACK IT Challenges competition consists of the following four Challenges: Maximise: “To develop reliable predictions which confidently classify mixtures of chemicals for acute oral toxicity, skin and eye irritation with a focus on relevance for human safety. These should fulfil acute GHS Classification and Labelling requirements for non-encapsulated agrochemical mixtures using existing information […]
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ICCVAM 2014-2015 Biennial Progress Report Now Available

The ICCVAM 2014-2015 Biennial Progress Report is now available on the National Toxicology Program website. This report, prepared in accordance with requirements of the ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3), describes ICCVAM and ICCVAM agency activities from January 2014 through December 2015. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized in the report […]
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Webinar Series on Inhalation Toxicity Concludes September 8

NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The last webinar in the series will be Thursday, September 8, from 11:00 a.m. to 12:30 p.m. EDT. Dan Huh, Ph.D., University of Pennsylvania, and Kelly BeruBe, […]
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Workshop Report on Carcinogenicity of Mixtures Now Available

An August 2015 workshop sponsored by the National Institute of Environmental Health Sciences evaluated the scientific support for the Low-Dose Mixture Hypothesis of Carcinogenesis and developed a research agenda. A report from this workshop is now available on the Environmental Health Perspectives website. NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., was a breakout group moderator and […]
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Unilever offering annual award to promote alternatives in China

Unilever has launched an award to promote development and application of alternatives in China. The award called “Chinese Society of Toxicology Toxicology Unilever Alternatives Awards” was set up by Chinese society of toxicology, funded by Unilever. Two types of awards were announced: “Chinese Society of Toxicology Toxicology alternatives Unilever Innovation Award” (3 winners) and the “Chinese Society of Toxicology Toxicology Unilever alternatives contribution […]
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NICEATM Requests Information on Acute Toxicity Testing Technologies

In a July 18 Federal Register notice, NICEATM requested data and information on approaches and technologies currently used to identify substances with the potential to cause acute systemic toxicity when swallowed, inhaled, or absorbed through the skin. Respondents should provide information on any activities relevant to the development or validation of alternatives to in vivo […]
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OECD publishes guidance document on waiving mammalian acute toxicity tests

Kate Willett, HSUS The OECD has published a Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests. From the Introduction: The OECD Guidelines for the Testing of Chemicals are continually evolving to reflect changing assessment practices. Acute toxicity tests are an area of focus for developing alternative assays to address animal […]
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Beagle Freedom Prize for Non-Animal Methods

Beagle Freedom Project will award $250,000 in grants to applicants whose goal is to replace the common use of dogs and other animals in research, testing, and/or education with a non-animal approach. A total of five possible awards of $50,000 are scheduled, or larger sized grants are available to fewer awardees depending on the nature, […]
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REACH annexes amended on use alternative methods

The European Chemicals Agency (ECHA) provides the latest news on chemical registration obligations under REACH on their REACH 2018 web page. “The REACH requirements for skin corrosion/irritation, serious eye damage/eye irritation, acute dermal toxicity and skin sensitisation are changing, making non-animal testing the default requirement.” The changes and new requirements are explained in the following […]
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European Pharmacopoeia Commission adopts revised general chapter on monocyte activation test to facilitate reduction in animal testing

Source: https://www.edqm.eu/en/node/15240 “During its 155th Session, held in Strasbourg on 21-22 June 2016, the European Pharmacopoeia Commission adopted a revision of the general chapter Monocyte-activation test (2.6.30) in order to make it more widely useable by stakeholders and thus facilitate a reduction in testing on live animals.” The press release provides additional information, including the […]
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FDA requests additional information to address data gaps for consumer hand sanitizers

Sherry Ward, AltTox The US Food and Drug Administration issued a proposed rule requesting additional scientific data to support the safety and effectiveness of certain active ingredients used in consumer antiseptic rubs (hand sanitizers) marketed over-the-counter (OTC). The FDA’s request for more data is intended to help the agency ensure that regular use of these […]
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LUSH prize for in vitro research, training, advocacy

Kate Willett, HSUS There is just one month left to nominate for Lush Prize 2016, the biggest annual prize fund supporting the complete replacement of animal testing, across science, campaigns and lobbying, with a focus on toxicology / safety testing. Nominations close at midnight on 24th July (wherever you are in the world!) so don’t delay […]
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NICEATM Requests Data and Information on Developmental Toxicity Test Methods

Contributor: Catherine Sprankle, NICEATM In a Federal Register notice published today, NICEATM requested available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals […]
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Today: EPA Webinar Provides Overview of TSCA Reform

Catherine Sprankle, NICEATM In a webinar today (June 30) at 2:00 p.m. Eastern time, the U.S. Environmental Protection Agency (EPA) will review changes to the newly amended Toxic Substances Control Act (TSCA). The webinar is free and open to the public, and preregistration is not required. View the webinar: Overview of TSCA Reform The Frank […]
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Order your FREE Copy of Cyprotex’s Chemical and Cosmetics Testing Guide

Helen Gill, Cyprotex Discovery Ltd Cyprotex’s Chemical and Cosmetics Testing Guide is a valuable resource for anyone involved in safety testing of industrial chemicals, pesticides, cosmetics and personal care products. It covers current legislation, skin and ocular testing approaches, mutagenicity/genotoxicity testing and endocrine disruption testing, and focuses predominantly on non-animal testing methods. Order your free […]
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Information Day on “Progress in Alternative Methods in Toxicology and Biomedicine”

Mardas Daneshian, CAAT-Europe at the University of Konstanz Information Day on “Progress in Alternative Methods in Toxicology and Biomedicine” July 8th 2016 09:00 – 16:00 Konzil Konstanz, Konstanz, Germany Toxicology traditionally relies on the use of animals to derive information relevant for human wellbeing and safety. Today, human cell-based alternative methods to animal use have […]
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FDA Issues Final Guidance and Presents Webinar on Biological Evaluation of Medical Devices

Catherine Sprankle, NICEATM The U.S. Food and Drug Administration (FDA) has issued a final guidance document on the use of International Standard ISO 10993-1, “Biological Evaluation of Medical Devices – Part 1: Evaluation and Testing Within a Risk Management Process.” FDA developed the guidance document to assist industry in preparing applications and notifications on medical […]
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EPA Releases Training Videos on Data Requirements for Antimicrobials

Catherine Sprankle, NICEATM The U.S. Environmental Protection Agency (EPA) is releasing five training videos providing guidance on EPA’s 40 CFR Part 158W data requirements for antimicrobial pesticides. These training videos will help the public and the pesticide industry better understand the pesticide registration process and make the process more efficient and transparent. The videos include […]
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NIH Releases a Request for Information Seeking Guidance for Opportunities in Neuroethics; Responses Due July 29, 2016

Sherry Ward, AltTox Source: https://brainupdate.nih.gov/2016/06/07/nih-releases-a-request-for-information-seeking-guidance-for-opportunities-in-neuroethics June 7, 2016 NIH solicits input to identify a set of core ethical issues associated with research involving the human brain and resulting from advancements in neurotechnology research and development…. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative® is aimed at revolutionizing our understanding of the human brain. By […]
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View presentations from NTP’s Botanical Dietary Supplement Safety Workshop

Sherry Ward, AltTox Videocasts now available for the April 26-27, 2016 NTP workshop, “Addressing challenges in the assessment of botanical dietary supplement safety.” Overall, it was a well-organized and informative meeting with excellent presentations. The many challenges in assessing the safety of botanical products coupled with an emerging demand for their safety assessment suggests this […]
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Evidence-based Toxicology Collaboration news

Sherry Ward, AltTox The Evidence-based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health is a collaboration of stakeholders “united in their vision to improve the public health outcomes and reduce human impact on the environment by bringing evidence-based approaches to safety sciences.” EBTC news this week includes their launch of an attractive, […]
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ICCVAM Public Forum Slides and Webcast Recording Available

Catherine Sprankle, NICEATM Presentation slides and a recording of the webcast of the May 25 ICCVAM public forum are now available on the NICEATM website. At the May 25 meeting at the National Institutes of Health, representatives from 12 ICCVAM member agencies were joined by stakeholder group representatives and over 100 webcast viewers. Agencies presented […]
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Webinar Series on Inhalation Toxicity Continues June 28

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The next webinar will be Tuesday, June 28, from 11:00 a.m. to noon EDT. Marco Corvaro, Ph.D., Dow AgroSciences, will present on the “GHS […]
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Job Opening: Toxicologist, Physicians Committee for Responsible Medicine

Ashley Felder, PCRM The Physicians Committee for Responsible Medicine is currently looking for a Toxicologist to join our growing Research Policy Team. We’re looking for someone that will spearhead our efforts to implement human-relevant test methods and minimize the use of animals in domestic and international chemical testing policies and guidelines. The candidate will work […]
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EUSAAT & Linz 2016: Abstracts and Young Scientist Travel Awards applications – Deadlines Extended to June 15

Sherry Ward, AltTox EUSAAT Young Scientist Travel Awards (YSTA) To get elected for the EUSAAT 2016 YSTA program, young scientists up to 35 years, e.g. graduate, postgraduate, or PhD students, must submit three documents until 15th June 2016: an abstract via our online submission form an application form for the EUSAAT 2016 YSTA program, and provide a […]
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NIH Common Fund Request for Information by June 22 on “Characterizing and Understanding the Organization of Individual Cells within Human Tissues”

Sherry Ward, AltTox Source: http://grants.nih.gov/grants/guide/notice-files/NOT-RM-16-025.html Notice Number: NOT-RM-16-025 Key Dates         Release Date: May 26, 2016         Response Date: June 22, 2016 Issued by Office of Strategic Coordination (Common Fund) Purpose This is a Request for Information (RFI) to solicit input regarding a proposal for a new Common Fund program aimed at characterizing and understanding organization […]
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Horizon 2020 SME Innovation Associate: Connecting European small and medium-sized enterprises (SMEs) with researchers

Sherry Ward, AltTox The European Union recently launched a EUR 7 million pilot action aiming to support dynamic SMEs in recruiting researchers to explore innovative business ideas. Enterprises have until 30 June 2016 to submit a 10-page application explaining the business idea, the required skills and the envisaged role of the researcher within the company. […]
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NAVS Selects 2016 Humane Science Award Recipients at Intel ISEF

Contributor: Sherry Ward, AltTox Source: http://act.navs.org/site/MessageViewer?em_id=1384.0&dlv_id=5282 Last week, NAVS honored promising young scientists at the Intel International Science and Engineering Fair (Intel ISEF) —the world’s largest international science competition for high school students—in Phoenix, Arizona. This is the 15th year that we have participated in this preeminent science fair—presenting our annual Humane Science Award, which […]
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2017 CAAT Grant Pre-proposals: Deadline extended to May 16

Contributor: Pascaline Clerc, HSUS Deadline for preproposals: May 16, 2016 The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report, Toxicity Testing in the 21st Century: A Vision and a Strategy in the following areas: Proposals Relating to Toxicology: Maximum grant amount is […]
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ICCVAM Advisory Committee to Discuss Developing a U.S. National 3Rs Strategy

Contributor: Catherine Sprankle, NICEATM The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet Sept. 27-28, 2016, at NIEHS in Research Triangle Park, North Carolina. SACATM advises ICCVAM, NICEATM, and the NIEHS director on activities relevant to the ICCVAM mission. The focus of this year’s SACATM meeting will be to discuss and develop recommendations […]
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Register by Friday to Attend ICCVAM Public Forum

Contributor: Catherine Sprankle, NICEATM Friday, May 13, is the in-person registration deadline to attend the ICCVAM public forum. While webcast viewing will be available, those wishing to make a public statement are encouraged to attend in person to enable face-to-face dialog with ICCVAM members. Registration for webcast viewing will be available through the end of […]
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Agenda Available for ICCVAM Public Forum

Contributor: Catherine Sprankle, NICEATM An agenda is available for the May 25 ICCVAM public forum. Representatives from the Environmental Protection Agency, the Food and Drug Administration, the Department of Defense, and other ICCVAM member agencies will present updates on activities related to the development and validation of test methods and approaches that may replace, reduce, […]
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US-Canada Regulatory Cooperation Council Meeting: May 4-5, Washington, DC

Contributor: Sherry Ward, AltTox Source: USDA Animal and Plant Health Inspection Service Weekly Digest Bulletin, 04/19/2016 Dear RCC stakeholders: We invite you to participate in the U.S.–Canada Regulatory Cooperation Council Stakeholder Meeting, to be held at the Embassy of Canada in Washington, D.C. on May 4-5 2016. Please indicate your attendance at this two-day event […]
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New environmental policy reports from Science for Environment Policy

Contributor: Sherry Ward, AltTox Science for Environment Policy, a free news and information service published by Directorate-General Environment, European Commission, has published two new reports as part of their work to support policymakers with “quality environmental research for evidence-based policy.” Identifying emerging risks for environmental policies. Future Brief 13: “While identifying, predicting and monitoring known […]
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NIH funding: Cell line identification tools; Human tissue models for infectious disease

Contributor: Sherry Ward, AltTox Tools for Cell Line Identification (SBIR [R43/R44]); PA-16-186 Due Dates: Standard dates through April 6, 2019 Funding Opportunity Purpose: This Funding Opportunity Announcement (FOA) is intended to address the problem of misidentified cell lines. Many advances in biomedical science have arisen from studies of cultured cell lines, which are widely used […]
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EDQM symposium, “The Challenges of Quality Requirements for Fish Vaccines,” call for posters by April 15

Contributor: Sherry Ward, AltTox Source: European Pharmacopoeia Work Programme Symposium 10 May 2016 to 11 May 2016; Oslo, Norway Programme Overview Global production of fish from aquaculture has grown substantially in the past decade and this growth has brought with it many economic benefits and challenges. Like other forms of animal production, disease prevention and […]
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Vaccines for Veterinary Use: A step further on the 3Rs path

Contributor: Sherry Ward, AltTox Source: European Pharmacopoeia News 10 March 2016 As part of the Ph. Eur. Commission’s efforts to replace in vivo with in vitro methods, around 40 inactivated vaccine-specific monographs and the general monograph Vaccines for veterinary use (0062) were adopted at its 153rd Session in November 2015. These texts will be published […]
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ICCVAM to Hold Public Forum May 25

Contributor: Catherine Sprankle, NICEATM ICCVAM will hold a public forum on Wednesday, May 25, 2016, from 9:00 a.m. to approximately 4:00 p.m. at the National Institutes of Health Natcher Conference Center in Bethesda, Maryland. Representatives of the federal agencies on ICCVAM will be present to hear ideas and suggestions from interested stakeholders and the public. […]
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NCATS and FDA Hold Workshop on Assay Development for High Throughput Screening

Contributor: Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the U.S. Food and Drug Administration (FDA) will hold a workshop on April 5-6, 2016, at the Harvey W. Wiley Federal Building in College Park, Maryland, for scientists involved in assay development for high throughput screening and lead optimization. The goal of […]
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Mechanistic Oral Absorption Modeling and Simulation – FDA Workshop, May 19, 2016

Contributor: Sherry Ward, AltTox Source: Federal Register FDA public workshop: Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation Date: May 19, 2016, from 8:30 a.m. to 4:30 p.m.; must register on or before April 19, 2016 Location: FDA Conference Center at the White Oak Campus, Maryland Purpose of the workshop Share […]
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Join SETAC in Advancing the Adverse Outcome Pathway Concept

Contributor: Marilyn Matevia, HSUS An announcement from the Society of Environmental Toxicology and Chemistry (SETAC): “The Society for Environmental Toxicology and Chemistry (SETAC) is initiating a horizon scanning effort to advance the science and application of the Adverse Outcome Pathway (AOP) framework. This horizon scanning approach will allow us to identify and begin to address […]
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New Guidance Documents for Pesticide Testing and GHS Pilot Program Support EPA OPP’s Goal to Reduce Animal Testing

Contributor: Sherry Ward, AltTox Sources: EPA Pesticide Program Updates (e-newsletter), March 17, 2016; and Letter to Stakeholders… Yesterday, in this open letter to stakeholders, EPA’s Office of Pesticide Programs (OPP) announced progress on “its goal to significantly reduce the use of animals in acute effects testing”: Letter to Stakeholders on EPA Office of Pesticide Programs’s Goal to Reduce Animal Testing […]
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The AltTox Forum is now the AltTox Community Blog. To search historical postings from the AltTox Forum, visit its original address. For instructions on posting or subscribing, click on the teal box at the top of this page.

The views expressed in the AltTox Community Blog are those of the individuals posting them and not necessarily those of their home institution.