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EFSA’s 2nd Scientific Conference, October 14-16, can be followed online

Contributor: Sherry Ward, AltTox Registration to this conference is now closed, but you can follow the entire conference online: http://www.efsaexpo2015.eu/join-the-conference-online/ Conference Website: http://www.efsaexpo2015.eu/ Here are descriptions of 3 of the conference sessions: Novel chemical hazard characterization approaches – October 16 from 09:00 to 13:00 Novel tools and testing strategies are revolutionising the way that scientists […]
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Danish 3R-Center call for project applications to promote the development and implementation of the 3Rs

Contributor: Sherry Ward, AltTox On behalf of The Minister of Environment and Food, The Danish 3R-Center calls for applications to promote the development and implementation of the 3Rs. Call for project applications: http://en.3rcenter.dk/fileadmin/user_upload/images/Forskning/Call_for_project_applications_to_promote_the_development_and_implementation_of_the_3Rs_final.pdf Danish 3R-Center Research Funding: http://en.3rcenter.dk/research-funding/ Application Deadline: Wednesday October 21, 2015. Grants of up to 500.000 DKK can be applied for. Typically, […]
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Request for scientific community input on future high performance computing (HPC) needs for new agency roadmap; due by October 16

Contributor: Sherry Ward, AltTox Any ideas on future HPC needs in the 3Rs such as virtual models, in silico tools, -omics data, ITS, validation study data storage/analysis, education/training, etc.? Please consider participating in this request for a 2-page e-mail submission of your ideas. Request for Information on Science Drivers Requiring Capable Exascale High Performance Computing: […]
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Announcement: Financial support for research into alternatives to animal experiments

Contributor: Dr. Sonja von Aulock, Editor in Chief, ALTEX Announcement Financial support for research into alternatives to animal experiments The Danish organisation Forsøgsdyrenes Værn and the Danish foundation Alternativfondet announce financial support for research into the development of alternatives to animal experiments. To qualify for support it is not enough that your research is carried […]
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September Issue of the ECHA Newsletter

Contributor: Sherry Ward, AltTox The latest issue of the ECHA Newsletter  includes an article on the substitution of harmful chemicals with safer alternatives. “Looking at a different approach to substitution, ECHA Newsletter spoke with Dr Joel A. Tickner, Director and Associate Professor of Community Health and Sustainability from the University of Massachusetts Lowell, who has […]
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NIH call for proposals: Collaborative Projects to Accelerate Research in Organ Fibrosis

Contributor: Sherry Ward, AltTox Collaborative Projects to Accelerate Research in Organ Fibrosis (R01) (RFA-HL-16-003): http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-003.html Due Dates: October 22, 2015 and October 21, 2016 Purpose: While fibrogenesis is an essential process in normal wound healing, aberrant and relentless fibrogenesis in vital organs such as heart, lung, kidney, and bone marrow can lead to debilitating symptoms […]
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Request for information and nominations of experts for peer review on systematic review of immunotoxicity associated with PFOA or PFOS exposure

Contributor: Sherry Ward, AltTox Source: https://www.federalregister.gov/articles/2015/08/14/2015-20122/systematic-review-of-immunotoxicity-associated-with-exposure-to-pfoa-or-pfos-request-for-information Background: PFOA and PFOS are persistent chemicals that are widely distributed in the environment in part because of high stability and little to no expected degradation in the environment. In terms of toxicity and exposure, PFOA and PFOS are the best studied perfluoroalkyl acids, a group of compounds used […]
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New issue of CSS Pathways from the US EPA

Contributor: Sherry Ward, AltTox The August 2015 issues of CSS Pathways (http://www2.epa.gov/sites/production/files/2015-08/documents/august_2015_css_pathways_external.pdf) reports many developments in chemical safety research and testing by US EPA researchers. Several approaches to assessing potential endocrine disruptors are reported: EPA introduces new technology to screen chemicals for endocrine disruption High-throughput model predicts estrogen receptor activity Advancing methods to evaluate thyroid […]
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Sept. 10 FDA Public Meeting to Prepare for International Cooperation on Cosmetics Regulation Meeting

Contributor: Sherry Ward, AltTox Source: http://www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm454464.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery The U.S. Food and Drug Administration will hold a public meeting on September 10, 2015 to receive input from the public on various topics pertaining to the regulation of cosmetics to help the agency prepare for the International Cooperation on Cosmetics Regulation-9 (ICCR-9) meeting that will be held November […]
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Two new CRACK IT Challenges announced

Contributor: Sherry Ward, AltTox Source: http://www.crackit.org.uk/crackit-news/2015-crack-it-challenges-announced-0 The 2015 CRACK IT Challenges competition consists of two Challenges identified jointly by the NC3Rs and Sponsors. This year the competition is funded by the NC3Rs and Dstl and supported by Innovate UK (SBRI) with in-kind contribution from the Sponsors. There are five Sponsors (Unilever, GlaxoSmithKline, Stiefel, Dstl, and […]
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New FDA report: Science Moving Forward, A Progress Report to the FDA Science Board

Contributor: Sherry Ward, AltTox “Modernize Toxicology to Enhance Product Safety” is the first of the FDA’s 9 Scientific Priority Areas described on page 11 of the FDA’s new report, Science Moving Forward, A Progress Report to the FDA Science Board (http://www.fda.gov/downloads/ScienceResearch/AboutScienceResearchatFDA/UCM456328.pdf). Intramural research on a non-animal approach includes the example on page 28 where “a […]
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ECHA follows up on registrants’ obligations to consider alternative tests

Contributor: Sherry Ward, AltTox Source: ECHA News http://echa.europa.eu/view-article/-/journal_content/title/echa-follows-up-on-registrants-obligations-to-consider-alternative-tests ECHA has analysed why registrants submitted 295 new higher tier studies on vertebrate animals without first seeking the Agency’s decision to permit such tests. In general, registrants were able to clarify why the new studies were conducted and submitted for registration purposes. However, in a number of cases […]
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Chemical Aquatic Fate and Effects (CAFE) Database released by NOAA

Contributor: Sherry Ward, AltTox Sources: ECETOC (http://www.ecetoc.org/index.php?mact=Newsroom,cntnt01,details,0&cntnt01documentid=285&cntnt01returnid=76) and NOAA (http://response.restoration.noaa.gov/cafe) The Chemical Aquatic Fate and Effects (CAFE) database (http://response.restoration.noaa.gov/oil-and-chemical-spills/chemical-spills/response-tools/download-install-and-run-cafe.html) is a software program you can use to estimate the fate and effects of thousands of chemicals, oils, and dispersants. CAFE serves as a tool to help responders in their assessment of environmental impacts from chemical […]
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Preclinical Assays Needed to Predict Vaccine Efficacy

Contributor: Sherry Ward, AltTox Source: http://www.niaid.nih.gov/researchfunding/newsletter/2015/Pages/0715.aspx#or02 Promising preclinical data for a candidate vaccine does not guarantee efficacy in phase II/III clinical trials. Thus, NIAID seeks novel preclinical assays capable of better predicting the likelihood of success in human clinical studies based on preclinical outcomes. As researchers continue to identify new potential markers of protection, new […]
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Introduction to Complexity – free, online course starts today

Contributor: Sherry Ward, AltTox The free and online course by the Santa Fe Institute, “Introduction to Complexity” (http://www.complexityexplorer.org), begins today. The purpose of this course is to help registrants learn about the tools used by scientists to understand complex systems. This is an introductory course and there are no math or other prerequisites. To see […]
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NIH Announces Strategy to Improve Reproducibility of Funded Research

Contributor: Sherry Ward, AltTox Source: http://www.niaid.nih.gov/researchfunding/newsletter/2015/Pages/0701.aspx#itn01 “In an effort to advance the highest level of scientific integrity, NIH has unveiled a strategy to improve the reproducibility of the research it funds in two June 9, 2015 Guide notices: Enhancing Reproducibility Through Rigor and Transparency and Consideration of Sex as a Biological Variable in NIH-Funded Research. […]
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EPA Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program

Contributor: Sherry Ward, AltTox The Environmental Protection Agency (EPA) has published a Federal Register notice and opportunity for comment on its Endocrine Disruptor Screening Program. Below is just a small part of the notice’s content. Source: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPPT-2015-0305-0001 Docket ID: EPA-HQ-OPPT-2015-0305 Abstract: Federal Register for Friday, June 19, 2015 (80 FR 35350) (FRL–9928–69 ) Use of […]
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National Aeronautics and Space Administration [NASA] – Centennial Challenges Program – Tissue Engineering Challenge – Request for Information

Author: Sherry Ward, AltTox https://www.fbo.gov/?s=opportunity&mode=form&tab=core&id=0905c3a33c88d0b702f92bcbe74479c1&_cview=0 Solicitation Number: NNM15ZZP006L Notice Type: public feedback is being sought – this is not a funding notice Synopsis: I. SUMMARY The Centennial Challenges Program is NASA’s flagship program for technology prize competitions (www.nasa.gov/challenges). The Centennial Challenges Program directly engages the public, academia, and industry in open prize competitions to stimulate […]
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CRACK IT Solutions: Partners sought to help develop and validate a portable bioluminescence test for botulinum neurotoxin

Author: Sherry Ward, AltTox “Researchers from University of Freiburg, Germany, are seeking partners to validate and commercialize their novel automated bioluminescence assay (BLBTest) for detecting botulinum neurotoxin (BoNT) to replace mouse bioassays. What could the Solution be used for? The BLB-Test is a portable, highly sensitive, automated assay for detecting BoNT as a replacement for […]
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Innocentive Posts 2 Open Innovation Challenges for In Vitro Kidney Microphysiological Systems

Author: Sherry Ward, AltTox AstraZeneca Challenge: In Vitro Proximal Tubule Model Systems: Innocentive: https://www.innocentive.com/ar/challenge/9933749 Challenge ID: 9933749 AWARD: $15,000 USD; DEADLINE: 6/26/15 “AstraZeneca is seeking innovative approaches to developing a model system of the proximal tubule in vitro. Ideally, the model should incorporate a self-contained microphysiological unit in which biologically appropriate media, fluid flow, and shear stress can […]
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Recent articles from ECHA explain approaches to minimize animal testing for REACH

Author: Sherry Ward, AltTox The February and April 2015 ECHA Newsletters as well as other recent articles on the ECHA website include information that could assist companies in minimizing animal testing for REACH reporting requirements. In a November 2014 AltTox article (http://alttox.org/cosmetics-regulation-animal-test-ban-declared-subordinate-reach-registration-testing-requirements-echa/), we had cited a statement from the October 2014 ECHA Newsletter that said […]
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“21st Century Understanding of Chemicals” briefing

Author: Sherry Ward, AltTox Six videos from the April 6, 2015 Congressional briefing organized by the American Chemical Society (ACS) Science & the Congress Project, ACS Corporation Associates, and the American Political Science Association (http://www.congressplus.com/events/index.cfm?action=Event_Page&eventcode=ZxyVwS&bypass=true) are now available for viewing at https://vimeo.com/album/3323655.
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NAVS Humane Science Award Recipients at Intel International Science and Engineering Fair

Author: Sherry Ward, AltTox NAVS Selects 2015 Humane Science Award Recipients at Intel ISEF May 18, 2015 Source: http://www.navs.org/science-first/2015-intel-international-science-and-engineering-fair Last week, NAVS attended the Intel International Science and Engineering Fair—the world’s largest international science competition for high school students—in Pittsburgh, Pennsylvania. There, NAVS recognized three exceptional students with our Humane Science Award. For 14 years, […]
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USDA APHIS NOTICE: VS Memorandum 800.112 Guidelines for Validation of In Vitro Potency Assays

Author: Sherry Ward, AltTox The Center for Veterinary Biologics (CVB) recently added [05/07/2015] VS Memo 800.112 to its website, which may be accessed by clicking the following link: CVB Newly Published Information (http://www.aphis.usda.gov/wps/portal/aphis/ourfocus/animalhealth?1dmy&urile=wcm%3apath%3a%2Faphis_content_library%2Fsa_our_focus%2Fsa_animal_health%2Fsa_vet_biologics%2Fct_vb_newly_published_info). This memorandum provides guidance concerning the information a firm should provide when submitting a new potency assay for consideration by the Center for Veterinary Biologics […]
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International Conference on Harmonization Regional Public Meeting, May 15

Author: Sherry Ward, AltTox [Also see the related blog post on April 13.] Preparation for International Conference on Harmonization Steering Committee and Expert Working Group Meetings in Fukuoka, Japan; Public Meeting Source: http://www.fda.gov/Drugs/NewsEvents/ucm439475.htm The Food and Drug Administration (FDA) is holding a regional public meeting on May 15, 2015, to provide information and receive comments […]
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Assessing CDERs Safety-Related Regulatory Science Needs and Identifying Priorities: Report and Request for Comments by May 18

Author: Sherry Ward, AltTox This report (March 2015; “Assessing CDERs Drug Safety Related Regulatory Science Needs and Identifying Priorities Report”) identifies drug safety-related regulatory science needs and priorities related to the mission of FDA’s Center for Drug Evaluation and Research (CDER) that would benefit from external collaborations and resources. FDA hopes to foster collaborations with […]
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Health Canada and United States Food and Drug Administration Joint Public Consultation on ICH Guidelines on May 15, 2015

Author: Sherry Ward, AltTox Source: http://www.hc-sc.gc.ca/dhp-mps/consultation/drug-medic/ich_fda_rcc_ccr_notice_avis-eng.php On February 4, 2011, Prime Minister Stephen Harper and United States President Barack Obama announced the creation of the Canada-United States (U.S.) Regulatory Cooperation Council (RCC) to better align the two countries’ regulatory approaches, where possible. Under the RCC initiative, Health Canada and the U.S. Food and Drug Administration […]
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Public consultation on Threshold of Toxicological Concern (TTC) Approach; deadline April 12

Author: Sherry Ward, AltTox “The Threshold of Toxicological Concern (TTC) is a methodology that may be used to assess potential human health concerns for a chemical based on its chemical characteristics and estimated exposure when chemical-specific toxicity data are scarce or absent. Overall, the TTC approach integrates data on exposure, chemical structure, metabolism, and toxicity […]
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FDA Meeting on Alternative In Vitro Bioequivalence Pathways – April 16

Author: Sherry Ward, AltTox Source: http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm438068.htm On April 16, 2015, the U.S. Food and Drug Administration will sponsor a public meeting to discuss the use of in vitro methods as a mechanism for assessing the in vivo product bioequivalence (BE) of non-systemically absorbed (locally acting) drug products intended for use in veterinary species. The meeting […]
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