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EURL ECVAM publishes recommendations on use of non-animal approaches for skin sensitization testing

“The JRC’s European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has published its recommendation on the use of non-animal approaches for skin sensitisation (allergy) testing. This document builds on the progress made in the area since the publication of the EURL ECVAM strategy in 2013 and provides EURL ECVAM views on the […]
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OECD QSAR Toolbox Version 4.0 Webinar June 1

“To increase the regulatory acceptance of (Q)SAR methods, the OECD is developing a QSAR Toolbox to make (Q)SAR technology readily accessible, transparent, and less demanding in terms of infrastructure costs. Version 4.0 of the QSAR Toolbox was released in April 2017. The OECD and ECHA are hosting a Webinar on June 1, 2017 to demonstrate its […]
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NIH funding to study cellular mechanisms of aging

Novel Cell Non-autonomous Mechanisms of Aging (RFA-AG-18-009): https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-18-009.html  Background: The distinction between cell autonomous and non-autonomous effects driving aging was originally motivated by studies of development where some cells have the autonomous ability to differentiate whereas other cells differentiate through signals from neighboring cells. In the past few decades, most studies on the molecular mechanisms […]
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Two EFSA Public Consultations with May 1 deadlines

Public consultation on Guidance on The Use of the Weight of Evidence Approach in Scientific Assessments: http://www.efsa.europa.eu/en/consultations/call/170306-0 Deadline: 1 May 2017 Public consultation on Guidance for the identification of biological relevance of adverse/ positive health effects from experimental animal and human studies: http://www.efsa.europa.eu/en/consultations/call/170306 Deadline: 1 May 2017
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The Global 3Rs Awards Program 2017 call for nominations

The Global 3Rs Awards program recognizes significant innovative contributions toward the 3Rs of animal research to advance ethical science, by any researcher (nominated author, principal investigator, or research team leader) in academia or industry in any area of biology (e.g., basic science, discovery, development, teaching, testing, manufacture for new medicines, vaccines, medical devices or healthcare […]
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10th World Congress Abstract Submission Deadline Extended to April 24, 2017

The 10th World Congress on Alternatives and Animal Use in the Life Sciences, The 3Rs in Action, will take place at the Washington State Convention Center in Seattle, Washington, USA on August 20-24, 2017. See the congress website for information on the program, registration, abstract submission, and housing: http://wc10seattle.org/2017/Home.aspx The abstract submission deadline has been […]
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Event Listings on AltTox

We are now back to maintaining a comprehensive list of Meetings & Events, primarily those focused on alternative methods for toxicity testing, but also other events on research, technologies, and policy that could benefit the development or use of non-animal methods for research and testing. Deadlines for relevant awards, fellowships, and grants are also listed […]
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EFSA: Two public consultations on new draft guidance

Public consultation on Guidance on The Use of the Weight of Evidence Approach in Scientific Assessments Deadline:  1 May 2017 Document (1.3 MB) EFSA’s Scientific Committee has developed a draft guidance document on the use of the weight of evidence approach in scientific assessments for use in all areas under EFSA’s remit.  The guidance document […]
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ECHA: New advice on using non-animal test methods

Source: https://echa.europa.eu/-/new-advice-on-using-non-animal-test-methods ECHA’s updated guidance gives advice on how to use non-animal test methods, which are now the default for many endpoints. Registrants are encouraged to take the changes into account when deciding their testing strategies. Helsinki, 24 January 2017 – The guidance takes into account the recently changed REACH information requirements, which made non-animal testing […]
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FDA Regulatory Science Extramural R&D Project Funding

To spur innovation in the field of regulatory science FDA funds extramural research using various contract mechanisms and grants to address broad Agency challenges within FDA’s scientific priority areas: Regulatory Science Extramural Research and Development Projects Extramural Research Funded Through the Broad Agency Announcement (BAA), Solicitation Number: FDABAA-16-00122 The purpose of this BAA is to solicit proposals that focus on […]
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NAS Project Webinar: Incorporating 21st Century Science into Risk-Based Evaluations, January 6, 2017

Join a webinar on Friday, January 6 at 2:00 for the release of a new report that describes how 21st century science can be used to advance risk assessment and support decision-making ultimately to improve public health and the environment. The report considers recent advances in exposure science, toxicology, and epidemiology; describes application of 21st […]
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New EPA Guidance for Testing Pesticides Will Reduce Animal Testing

For Release: November 29, 2016 Source: https://www.epa.gov/pesticides/new-epa-guidance-testing-pesticides-will-reduce-animal-testing-0 EPA is issuing guidance for requesting waivers of acute dermal toxicity testing requirements for pesticide formulations, which will lead to fewer animal tests for acute dermal toxicity for pesticides. Last March, EPA released a “Draft Retrospective Analysis for Waiving Acute Dermal Toxicity Tests for Pesticide Formulations,” which included guidance […]
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DB-ALM Updates

DB-ALM updates, November 2016 New Content Since our last communication, 26 new method descriptions of advanced and alternative methods at all stages of development and acceptance have been published. Comprehensive descriptions of novel approach methods with summaries and/or protocols compliant with regulatory guidelines, undergoing scientific validation or developed and evaluated in EU integrated research projects, are […]
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NTP Board of Scientific Counselors Meeting on December 15; comments on ICCVAM strategy due November 30

NTP Board of Scientific Counselors Meeting Date: December 14-15, 2016 Location: Research Triangle Park, North Carolina Register to attend in person or via webcast at: http://ntp.niehs.nih.gov/about/org/bsc/meetings Dr. Warren Casey will present “Strategy for implementing the vision for regulatory toxicity testing in the 21st century” on December 15. Meeting Agenda: http://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/december/agenda20161214_508.pdf Written Comments are due by […]
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U.S. EPA TSCA Stakeholder Meeting, December 14, 2016, Washington, DC

Did you see our Tweet below about this important upcoming event? U.S. EPA TSCA Stakeholder Meeting – New Chemicals Program Wednesday, December 14, 2016, 9:00 AM – 12:00 PM EST Ronald Reagan Building and International Trade Center, Washington, DC Event information and registration to attend in person or via webcast are available here: https://www.eventbrite.com/e/us-epa-tsca-stakeholder-meeting-new-chemicals-program-registration-29286083464 EPA […]
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2016 International Foundation for Ethical Research (IFER) Graduate Fellowship Awards

The International Foundation for Ethical Research (IFER) Board of Directors announced funding for three new Graduate fellowships in October. The new research projects are: T.J. Puls (graduate student) and Dr. Sherry Voytik-Harbin (faculty advisor), Purdue University, Engineering novel 3D tumor-stroma to bridge the gap between preclinical model and human clinical outcomes Danh Truong (graduate student) […]
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Dermal Technology Laboratory received the prestigious Queens’ Award for Enterprise in 2016

“Dermal Technology Laboratory (DTL) has been awarded one of the most coveted accolades in UK business. In recognition of its international growth and success over the past five years. DTL, based at Keele University Science and Innovation Park has received a Queen’s Award for Enterprise.” “Dermal Technology Laboratory specialises in in vitro dermal absorption studies that […]
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NIH funding announcement: Microphysiological Systems for Disease Modeling and Efficacy Testing

Source: http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-16-017.html Title: Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing (UG3/UH3)  Funding Opportunity Announcement: RFA-TR-16-017 Purpose The purpose of the Microphysiological Systems (MPS) for Disease Modeling and Efficacy Testing Program is to develop highly reproducible and translatable in vitro models for preclinical efficacy studies through discovery and validation of translatable biomarkers, development of […]
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IIVS Releases Training Video to Replace Animals in Phototoxicity Testing

IIVS Releases Training Video to Replace Animals in Testing For Immediate Release Media Contact: Laura Henning 240-454-8459 lhenning@iivs.org GAITHERSBURG, MD – October 12, 2016 – Funded by a grant from the European Partnership for Alternative Approaches to Animal Testing (EPAA), the Institute for In Vitro Sciences, Inc.(IIVS) has released a technical training video that describes […]
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Many in vitro and in silico approaches encouraged in new funding opportunity from the Bill & Melinda Gates Foundation – Proposals due November 9

Grant Opportunity title: Develop Novel Platforms to Accelerate Contraceptive Drug Discovery (Round 18) Source: http://gcgh.grandchallenges.org/challenge/develop-novel-platforms-accelerate-contraceptive-drug-discovery-round-18 Deadline: 9 Nov 2016 – 11:30am PST The Challenge While access to a range of appropriate and desirable contraceptive methods can have a broad beneficial impact on the lives of women, men and their families, this goal is currently not […]
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Three Key Approaches to Increasing Research Antibody Validation Defined at GBSI Workshop

Sherry Ward, AltTox Event Was Most Representative Gathering of Scientific Experts Ever Convened on the Topic PACIFIC GROVE, Calif., September 28, 2016—Leading experts from the international biomedical research community announced today that they have the fundamentals of what will become the first detailed standardized guidelines for validating research antibodies. The outcomes of this week’s Antibody […]
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BRAIN Initiative Updates: NSF encourages researchers with expertise in data science; Initiative seeks to include more diverse fields of science

Sherry Ward, AltTox NSF Announces Data Resources for the BRAIN Initiative September 22, 2016 …NSF, a partner in the BRAIN Initiative® supporting fundamental research across a spectrum of disciplines within neuroscience, has released a Dear Colleague Letter (see below) encouraging researchers with expertise in data science to partner with BRAIN Initiative projects, including projects funded by the […]
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Announcement of 2016 ARDF Alternatives Research Grant awards

Sue A. Leary, ARDF The Alternatives Research & Development Foundation (ARDF) is pleased to announce the recipients of the 2016 Alternatives Research Grants. Luca Cucullo, PhD Texas Tech University Health Sciences Center, Amarillo, TX A humanized blood-brain tumor barrier model to assess drug delivery of chemotherapeutic treatment Dongeun (Dan) Huh, PhD University of Pennsylvania, Philadelphia, […]
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Upcoming calls for proposals

Sherry Ward, AltTox Engineering Next-Generation Human Nervous System Microphysiological Systems (R21) (PAR-16-397) and (R01) (PAR-16-398) Application Receipt/Submission Date(s): Standard dates apply through January 8, 2020 This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) with improved fidelity to complex human brain, spinal, peripheral nervous system and/or […]
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NIH request for comments on scope of animal-human chimera research – deadline extended to September 6

Sherry Ward, AltTox “The National Institutes of Health (NIH) is requesting public comment on a proposal to amend Section IV and Section V of the NIH Guidelines for Human Stem Cell Research, and on the proposed scope of certain human-animal chimera research that will be considered internally by an NIH steering committee to provide programmatic […]
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CRACK IT Announces 4 New Challenges; Partners Sought for Other Projects

Sherry Ward, AltTox The 2016 CRACK IT Challenges competition consists of the following four Challenges: Maximise: “To develop reliable predictions which confidently classify mixtures of chemicals for acute oral toxicity, skin and eye irritation with a focus on relevance for human safety. These should fulfill acute GHS Classification and Labeling requirements for non-encapsulated agrochemical mixtures […]
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Beagle Freedom Prize for Non-Animal Methods

Sherry Ward, AltTox Beagle Freedom Project will award $250,000 in grants to applicants whose goal is to replace the common use of dogs and other animals in research, testing, and/or education with a non-animal approach. A total of five possible awards of $50,000 are scheduled, or larger sized grants are available to fewer awardees depending […]
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REACH annexes amended on use alternative methods

Sherry Ward, AltTox The European Chemicals Agency (ECHA) provides the latest news on chemical registration obligations under REACH on their REACH 2018 web page. “The REACH requirements for skin corrosion/irritation, serious eye damage/eye irritation, acute dermal toxicity and skin sensitisation are changing, making non-animal testing the default requirement.” The changes and new requirements are explained […]
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European Pharmacopoeia Commission adopts revised general chapter on monocyte activation test to facilitate reduction in animal testing

Sherry Ward, AltTox Source: https://www.edqm.eu/en/node/15240 “During its 155th Session, held in Strasbourg on 21-22 June 2016, the European Pharmacopoeia Commission adopted a revision of the general chapter Monocyte-activation test (2.6.30) in order to make it more widely useable by stakeholders and thus facilitate a reduction in testing on live animals.” The press release provides additional […]
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FDA requests additional information to address data gaps for consumer hand sanitizers

Sherry Ward, AltTox The US Food and Drug Administration issued a proposed rule requesting additional scientific data to support the safety and effectiveness of certain active ingredients used in consumer antiseptic rubs (hand sanitizers) marketed over-the-counter (OTC). The FDA’s request for more data is intended to help the agency ensure that regular use of these […]
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NIH Releases a Request for Information Seeking Guidance for Opportunities in Neuroethics; Responses Due July 29, 2016

Sherry Ward, AltTox Source: https://brainupdate.nih.gov/2016/06/07/nih-releases-a-request-for-information-seeking-guidance-for-opportunities-in-neuroethics June 7, 2016 NIH solicits input to identify a set of core ethical issues associated with research involving the human brain and resulting from advancements in neurotechnology research and development…. The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative® is aimed at revolutionizing our understanding of the human brain. By […]
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View presentations from NTP’s Botanical Dietary Supplement Safety Workshop

Sherry Ward, AltTox Videocasts now available for the April 26-27, 2016 NTP workshop, “Addressing challenges in the assessment of botanical dietary supplement safety.” Overall, it was a well-organized and informative meeting with excellent presentations. The many challenges in assessing the safety of botanical products coupled with an emerging demand for their safety assessment suggests this […]
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Evidence-based Toxicology Collaboration news

Sherry Ward, AltTox The Evidence-based Toxicology Collaboration (EBTC) at Johns Hopkins Bloomberg School of Public Health is a collaboration of stakeholders “united in their vision to improve the public health outcomes and reduce human impact on the environment by bringing evidence-based approaches to safety sciences.” EBTC news this week includes their launch of an attractive, […]
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EUSAAT & Linz 2016: Abstracts and Young Scientist Travel Awards applications – Deadlines Extended to June 15

Sherry Ward, AltTox EUSAAT Young Scientist Travel Awards (YSTA) To get elected for the EUSAAT 2016 YSTA program, young scientists up to 35 years, e.g. graduate, postgraduate, or PhD students, must submit three documents until 15th June 2016: an abstract via our online submission form an application form for the EUSAAT 2016 YSTA program, and provide a […]
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NIH Common Fund Request for Information by June 22 on “Characterizing and Understanding the Organization of Individual Cells within Human Tissues”

Sherry Ward, AltTox Source: http://grants.nih.gov/grants/guide/notice-files/NOT-RM-16-025.html Notice Number: NOT-RM-16-025 Key Dates         Release Date: May 26, 2016         Response Date: June 22, 2016 Issued by Office of Strategic Coordination (Common Fund) Purpose This is a Request for Information (RFI) to solicit input regarding a proposal for a new Common Fund program aimed at characterizing and understanding organization […]
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Horizon 2020 SME Innovation Associate: Connecting European small and medium-sized enterprises (SMEs) with researchers

Sherry Ward, AltTox The European Union recently launched a EUR 7 million pilot action aiming to support dynamic SMEs in recruiting researchers to explore innovative business ideas. Enterprises have until 30 June 2016 to submit a 10-page application explaining the business idea, the required skills and the envisaged role of the researcher within the company. […]
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NAVS Selects 2016 Humane Science Award Recipients at Intel ISEF

Contributor: Sherry Ward, AltTox Source: http://act.navs.org/site/MessageViewer?em_id=1384.0&dlv_id=5282 Last week, NAVS honored promising young scientists at the Intel International Science and Engineering Fair (Intel ISEF) —the world’s largest international science competition for high school students—in Phoenix, Arizona. This is the 15th year that we have participated in this preeminent science fair—presenting our annual Humane Science Award, which […]
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US-Canada Regulatory Cooperation Council Meeting: May 4-5, Washington, DC

Contributor: Sherry Ward, AltTox Source: USDA Animal and Plant Health Inspection Service Weekly Digest Bulletin, 04/19/2016 Dear RCC stakeholders: We invite you to participate in the U.S.–Canada Regulatory Cooperation Council Stakeholder Meeting, to be held at the Embassy of Canada in Washington, D.C. on May 4-5 2016. Please indicate your attendance at this two-day event […]
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New environmental policy reports from Science for Environment Policy

Contributor: Sherry Ward, AltTox Science for Environment Policy, a free news and information service published by Directorate-General Environment, European Commission, has published two new reports as part of their work to support policymakers with “quality environmental research for evidence-based policy.” Identifying emerging risks for environmental policies. Future Brief 13: “While identifying, predicting and monitoring known […]
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NIH funding: Cell line identification tools; Human tissue models for infectious disease

Contributor: Sherry Ward, AltTox Tools for Cell Line Identification (SBIR [R43/R44]); PA-16-186 Due Dates: Standard dates through April 6, 2019 Funding Opportunity Purpose: This Funding Opportunity Announcement (FOA) is intended to address the problem of misidentified cell lines. Many advances in biomedical science have arisen from studies of cultured cell lines, which are widely used […]
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EDQM symposium, “The Challenges of Quality Requirements for Fish Vaccines,” call for posters by April 15

Contributor: Sherry Ward, AltTox Source: European Pharmacopoeia Work Programme Symposium 10 May 2016 to 11 May 2016; Oslo, Norway Programme Overview Global production of fish from aquaculture has grown substantially in the past decade and this growth has brought with it many economic benefits and challenges. Like other forms of animal production, disease prevention and […]
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Vaccines for Veterinary Use: A step further on the 3Rs path

Contributor: Sherry Ward, AltTox Source: European Pharmacopoeia News 10 March 2016 As part of the Ph. Eur. Commission’s efforts to replace in vivo with in vitro methods, around 40 inactivated vaccine-specific monographs and the general monograph Vaccines for veterinary use (0062) were adopted at its 153rd Session in November 2015. These texts will be published […]
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Mechanistic Oral Absorption Modeling and Simulation – FDA Workshop, May 19, 2016

Contributor: Sherry Ward, AltTox Source: Federal Register FDA public workshop: Mechanistic Oral Absorption Modeling and Simulation for Formulation Development and Bioequivalence Evaluation Date: May 19, 2016, from 8:30 a.m. to 4:30 p.m.; must register on or before April 19, 2016 Location: FDA Conference Center at the White Oak Campus, Maryland Purpose of the workshop Share […]
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