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Computational Biology Symposium at NIH September 16

Catherine Sprankle, NICEATM PLoS Computational Biology is presenting a Computational Biology Symposium on the National Institutes of Health campus on Friday, September 16, from 9:30 a.m.-4:00 p.m. Keynote speakers will include Dr. David J. Lipman of the National Center for Biotechnology Information, Dr. Jennifer Lippincott-Schwartz of the Eunice Kennedy Shriver National Institute of Child Health […]
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FDA Seeks Comment on Draft Guidance for Toxicokinetics Studies

Catherine Sprankle, NICEATM A U.S. Food and Drug Administration (FDA) notice in the September 8 Federal Register requested comments on draft guidance titled “ICH S3A Guidance: Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies—Questions and Answers.” The draft guidance facilitates interpretation of the ‘‘S3A Guidance: The Assessment of Systemic Exposure […]
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NICEATM Workshop Report Recognized as an NIEHS Paper of the Month

Catherine Sprankle, NICEATM The September issue of the Environmental Factor, the newsletter of the National Institute of Environmental Health Sciences (NIEHS), recognized the report on the Collaborative Workshop on Aquatic Models and 21st Century Toxicology as an NIEHS Intramural Paper of the Month. The workshop, organized by NICEATM and North Carolina State University, reviewed emerging […]
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U.S. Strategy and Roadmap for Implementing 21st Century Toxicity Testing Approaches

Catherine Sprankle, NICEATM The focus of the September 27 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will be topics related to the development of a U.S. strategy and roadmap for implementing 21st century toxicity testing approaches. Background material and specific questions to be discussed by SACATM are included in an “In […]
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Funding Opportunity for Alternative Methods Development

Catherine Sprankle, NICEATM The National Toxicology Program Interagency Center for the Evaluation of Alternative Methods (NICEATM) encourages U.S. small businesses involved in alternative methods development to apply for Small Business Innovation Research (SBIR) Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing offered by the National Institute of […]
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Chips in Space: Webinar September 6

Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the Center for the Advancement of Science in Space are promoting a new program for research on the International Space Station United States National Laboratory (ISS-NL): we’re sending tissue chips to space! This program will leverage recent advances in tissue engineering and microfabrication […]
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ICCVAM 2014-2015 Biennial Progress Report Now Available

Catherine Sprankle, NICEATM The ICCVAM 2014-2015 Biennial Progress Report is now available on the National Toxicology Program website. This report, prepared in accordance with requirements of the ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3), describes ICCVAM and ICCVAM agency activities from January 2014 through December 2015. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized […]
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Webinar Series on Inhalation Toxicity Concludes September 8

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The last webinar in the series will be Thursday, September 8, from 11:00 a.m. to 12:30 p.m. EDT. Dan Huh, Ph.D., University of Pennsylvania, […]
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Workshop Report on Carcinogenicity of Mixtures Now Available

Catherine Sprankle, NICEATM An August 2015 workshop sponsored by the National Institute of Environmental Health Sciences evaluated the scientific support for the Low-Dose Mixture Hypothesis of Carcinogenesis and developed a research agenda. A report from this workshop is now available on the Environmental Health Perspectives website. NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., was a breakout […]
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NICEATM Requests Information on Acute Toxicity Testing Technologies

Catherine Sprankle, NICEATM In a July 18 Federal Register notice, NICEATM requested data and information on approaches and technologies currently used to identify substances with the potential to cause acute systemic toxicity when swallowed, inhaled, or absorbed through the skin. Respondents should provide information on any activities relevant to the development or validation of alternatives […]
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NICEATM Requests Data and Information on Developmental Toxicity Test Methods

Catherine Sprankle, NICEATM In a Federal Register notice published today, NICEATM requested available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to […]
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Today: EPA Webinar Provides Overview of TSCA Reform

Catherine Sprankle, NICEATM In a webinar today (June 30) at 2:00 p.m. Eastern time, the U.S. Environmental Protection Agency (EPA) will review changes to the newly amended Toxic Substances Control Act (TSCA). The webinar is free and open to the public, and preregistration is not required. View the webinar: Overview of TSCA Reform The Frank […]
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FDA Issues Final Guidance and Presents Webinar on Biological Evaluation of Medical Devices

Catherine Sprankle, NICEATM The U.S. Food and Drug Administration (FDA) has issued a final guidance document on the use of International Standard ISO 10993-1, “Biological Evaluation of Medical Devices – Part 1: Evaluation and Testing Within a Risk Management Process.” FDA developed the guidance document to assist industry in preparing applications and notifications on medical […]
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EPA Releases Training Videos on Data Requirements for Antimicrobials

Catherine Sprankle, NICEATM The U.S. Environmental Protection Agency (EPA) is releasing five training videos providing guidance on EPA’s 40 CFR Part 158W data requirements for antimicrobial pesticides. These training videos will help the public and the pesticide industry better understand the pesticide registration process and make the process more efficient and transparent. The videos include […]
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ICCVAM Public Forum Slides and Webcast Recording Available

Catherine Sprankle, NICEATM Presentation slides and a recording of the webcast of the May 25 ICCVAM public forum are now available on the NICEATM website. At the May 25 meeting at the National Institutes of Health, representatives from 12 ICCVAM member agencies were joined by stakeholder group representatives and over 100 webcast viewers. Agencies presented […]
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Webinar Series on Inhalation Toxicity Continues June 28

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The next webinar will be Tuesday, June 28, from 11:00 a.m. to noon EDT. Marco Corvaro, Ph.D., Dow AgroSciences, will present on the “GHS […]
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ICCVAM Advisory Committee to Discuss Developing a U.S. National 3Rs Strategy

Contributor: Catherine Sprankle, NICEATM The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet Sept. 27-28, 2016, at NIEHS in Research Triangle Park, North Carolina. SACATM advises ICCVAM, NICEATM, and the NIEHS director on activities relevant to the ICCVAM mission. The focus of this year’s SACATM meeting will be to discuss and develop recommendations […]
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Register by Friday to Attend ICCVAM Public Forum

Contributor: Catherine Sprankle, NICEATM Friday, May 13, is the in-person registration deadline to attend the ICCVAM public forum. While webcast viewing will be available, those wishing to make a public statement are encouraged to attend in person to enable face-to-face dialog with ICCVAM members. Registration for webcast viewing will be available through the end of […]
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Agenda Available for ICCVAM Public Forum

Contributor: Catherine Sprankle, NICEATM An agenda is available for the May 25 ICCVAM public forum. Representatives from the Environmental Protection Agency, the Food and Drug Administration, the Department of Defense, and other ICCVAM member agencies will present updates on activities related to the development and validation of test methods and approaches that may replace, reduce, […]
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ICCVAM to Hold Public Forum May 25

Contributor: Catherine Sprankle, NICEATM ICCVAM will hold a public forum on Wednesday, May 25, 2016, from 9:00 a.m. to approximately 4:00 p.m. at the National Institutes of Health Natcher Conference Center in Bethesda, Maryland. Representatives of the federal agencies on ICCVAM will be present to hear ideas and suggestions from interested stakeholders and the public. […]
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NCATS and FDA Hold Workshop on Assay Development for High Throughput Screening

Contributor: Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the U.S. Food and Drug Administration (FDA) will hold a workshop on April 5-6, 2016, at the Harvey W. Wiley Federal Building in College Park, Maryland, for scientists involved in assay development for high throughput screening and lead optimization. The goal of […]
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Webinar Series on Inhalation Toxicity Begins March 29

Contributor: Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The first webinar will be on March 29 from 11:00 a.m. to noon EDT; the topic is “Current Testing Practices: Regulatory Requirements and […]
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NICEATM Deputy Director to Receive Teratology Society Award

Contributor: Catherine Sprankle, NICEATM NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., has been named to receive the 2016 F. Clarke Fraser New Investigator Award from the Teratology Society. This award recognizes an active Teratology Society member that has, within 10 years of completion of training, established a successful independent research career in a field relevant to […]
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NICEATM Director Elected to Lead SOT IVAM Specialty Section

Contributor: Catherine Sprankle, NICEATM NICEATM Director Warren Casey, Ph.D., has been elected Vice President-Elect of the In Vitro and Alternative Methods (IVAM) Specialty Section of the Society of Toxicology (SOT). Casey will serve as Vice President-Elect for 2016-2017 and will then serve subsequent one-year terms as Vice President, President, and Past President of the specialty […]
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Next SBIR/STTR Deadline April 5

Contributor: Catherine Sprankle, NICEATM The next application deadline for Department of Health and Human Services (HHS) Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants is April 5. The SBIR and STTR grant programs are important sources of early-stage capital for innovative small companies in the United States. These programs allow U.S.-owned […]
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IVIVE Workshop: Registration and Abstract Submission Closes February 5

Contributor: Catherine Sprankle, NICEATM Friday, February 5, is the deadline for registration and abstract submissions for the workshop on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making. The workshop, organized by NICEATM and the U.S. Environmental Protection Agency (EPA), will take place Feb. 17-18 at EPA in Research Triangle Park, […]
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NICEATM Scientists Receive NIEHS Merit Award

Contributor: Catherine Sprankle, NICEATM NICEATM Director Warren Casey, Ph.D., and nine current or former members of the ILS NICEATM contract support team have been named to receive a Merit Award from the National Institute of Environmental Health Sciences (NIEHS). The Merit Award is the highest level honor award given by the NIEHS director and recognizes […]
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Deadlines February 5 for IVIVE Workshop

Contributor: Catherine Sprankle, NICEATM Registration and abstract submission for the Feb. 17-18 workshop on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making is open until February 5. Information about the workshop, which is being organized by NICEATM and EPA, is available on the NICEATM website. Links to webinars that provided […]
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ICCVAM Webinar on Fundamentals of QSAR and Read-across

Contributor: Catherine Sprankle, NICEATM ICCVAM will present its second Communities of Practice webinar on Jan. 26, 2016, from 1:00-2:30 p.m. The webinar, on “Fundamentals of Using Quantitative Structure–Activity Relationship Models and Read-across Techniques in Predictive Toxicology,” is being organized on behalf of ICCVAM by NICEATM and hosted by the U.S. Environmental Protection Agency’s (EPA’s) National […]
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NICEATM Director Casey Recognized for Contributions to Animal Welfare

Contributor: Catherine Sprankle, NICEATM In a Dec. 14 announcement, the Society of Toxicology (SOT) recognized NICEATM Director Warren Casey, Ph.D., with the 2016 Enhancement of Animal Welfare Award. This award is given for advancing toxicology through the development and application of methods that replace, refine, or reduce the need for experimental animals. In recognizing the […]
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NICEATM and ICCVAM to Hold Forum at SOT

Contributor: Catherine Sprankle, NICEATM NICEATM Director Warren Casey, Ph.D. and ICCVAM Co-chair Anna Lowit, Ph.D. (U.S. Environmental Protection Agency), will lead a discussion forum during the 2016 SOT Annual Meeting. Casey and Lowit will begin the forum with summaries of recent ICCVAM and NICEATM activities, focusing on efforts to reduce animal use for acute systemic […]
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Presentations from Acute Toxicity Workshop

Contributor: Catherine Sprankle, NICEATM Presentations from the Sept. 24–25 workshop on Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing are now available on the NICEATM website. At this workshop, representatives from regulatory agencies, academia, and industries developed strategies for advancing alternative methods for product safety testing that meet the needs […]
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USDA Issues Guidance on Vaccine Testing

Contributor: Catherine Sprankle, NICEATM The U.S. Department of Agriculture (USDA) Center for Veterinary Biologics (CVB) recently issued CVB Notice 15-13, Option to Remove Back-titration Hamsters from In Vivo Potency Tests for Leptospira Serogroups Canicola and Icterohaemorrhagiae. The notice describes an exemption from the titration requirement in vaccination-challenge potency assays for Leptospira Serogroups Canicola and Icterohaemorrhagiae. […]
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NAS to Examine Low-dose Toxicity

Contributor: Catherine Sprankle, NICEATM A new committee of the National Academy of Sciences (NAS) will examine whether the current toxicity testing practices of the U.S. Environmental Protection Agency adequately consider adverse human health effects of low doses of endocrine-active chemicals. Committee activities will include convening a scientific workshop to support systematic reviews of human and […]
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Rodent Uterotrophic Database Now Available

Contributor: Catherine Sprankle, NICEATM An article published October 2 as an advance publication in Environmental Health Perspectives describes curation and evaluation of a database of rodent uterotrophic bioactivity. The uterotrophic assay is a widely accepted in vivo test for identifying chemicals with potential estrogen receptor agonist activity. The new database, which includes data from studies […]
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IVIVE Webinars and Workshop

Contributor: Catherine Sprankle, NICEATM A series of four webinars on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making are being presented by the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the U.S. Environmental Protection Agency (EPA). The webinar series began October 7 and […]
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New Resource for Small Business Grant Applicants

Contributor: Catherine Sprankle, NICEATM A November 4 webinar will explain how to use the ASSIST (Application Submission System and Interface for Submission Tracking) system for submitting grant applications. ASSIST is an alternative to Grants.gov downloadable forms for applying for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants. Advantages to using ASSIST […]
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Version 2 of S1500+ Human Gene Set Now Available

Contributor: Catherine Sprankle, NICEATM National Institute of Environmental Health Sciences and National Toxicology Program (NTP) scientists along with Tox21 partners have developed a list of environmentally responsive genes to be used in toxicogenomics approaches to screening large numbers of chemicals. Genes on the list were identified through both bioinformatics approaches and experimental data establishing certain […]
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Pre-Applications for Translational Science Awards

Contributor: Catherine Sprankle, NICEATM The NIH invites interested applicants to pre-apply for PAR-15-172 “Collaborative Innovation Award, Clinical and Translational Science Award (CTSA) Program (U01)”. While not required, pre-application for this award is recommended. Applicants submitting pre-applications that are meritorious and programmatically relevant will be notified of the opportunity to submit a full application. NCATS is […]
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Agenda Available for Sept. 2 SACATM Meeting

Contributor: Catherine Sprankle, NICEATM The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet on September 2 in the Rodbell Auditorium at NIEHS. SACATM is the advisory committee to ICCVAM. Topics to be discussed at the September 2 meeting include updates on recent activities from NICEATM and ICCVAM member agencies; international interactions and current […]
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NIH Presents Conference for Small Business Grant Applicants

Contributor: Catherine Sprankle, NICEATM The National Institutes of Health (NIH) Small Business Innovation Research (SBIR)/Small Business Technology Transfer (STTR) Conference will be held in Seattle, Washington, on October 27–29. This event is the largest annual conference for SBIR/STTR applicants. Presentations will provide overviews of Department of Health and Human Services (HHS) SBIR/STTR programs, funding opportunities, […]
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NIEHS Funding Opportunities and Resources

Contributor: Catherine Sprankle, NICEATM The National Institutes of Environmental Health Sciences (NIEHS) invites qualified small businesses to apply for the following grant opportunities: Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science: applications due Sept. 5, 2015; Jan. 5, 2016; and April 5, 2016. View Small Business Innovation Research (SBIR) grant […]
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NIH Invites Comments and Suggestions on a Framework for the NIH-Wide Strategic Plan

Contributor: Catherine Sprankle, NICEATM In order to advance its mission, NIH is developing an NIH-wide Strategic Plan. The goal of this 5-year plan is to outline a vision for biomedical research that ultimately extends healthy life and reduces illness and disability. NIH senior leadership and staff have developed a proposed framework for the Strategic Plan […]
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Report Outlines Predictive Toxicology Approach for Defense Applications

Contributor: Catherine Sprankle, NICEATM The National Academies Press has issued a report on “Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense.” Prepared in response to a request by the U.S. Department of Defense, the report provides a conceptual approach that could be used to evaluate chemicals that could pose threats to […]
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NIEHS Offers Financial Support for Later Stages of Test Method Development

Contributor: Catherine Sprankle, NICEATM The National Institute of Environmental Health Sciences (NIEHS) will provide additional support to current federal grantees for validation and commercialization of replacement or reduction alternatives to tests required by U.S. government agencies. These Small Business Innovation Research (SBIR) Phase IIB awards will support further development of non-clinical toxicology tests for use […]
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ICCVAM Advisory Committee to Meet September 2

Contributor: Catherine Sprankle, NICEATM ICCVAM’s advisory committee, the Scientific Advisory Committee on Alternative Toxicological Methods, will hold its annual meeting on September 2 in the Rodbell Auditorium at NIEHS in Research Triangle Park, North Carolina. You must preregister to attend the meeting in person; the meeting will also be webcast. An agenda, other materials, and […]
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USDA Requests Comments on Petition to Revise Animal Use Reporting Requirements

Contributor: Catherine Sprankle, NICEATM The Department of Agriculture Animal and Plant Health Inspection Service (USDA APHIS) has received a petition from the National Anti-Vivisection Society (NAVS) to increase the level of detail in information collected from research facilities in their reports on animal use. NAVS is asking that the annual report required under the Animal […]
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NIH Updates Solicitation for SBIR/STTR Grant Applications

Contributor: Catherine Sprankle, NICEATM The NIH has updated the solicitation announcement for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications. The NIEHS section has been updated to include a section on “Toxicity Screening, Testing, and Modeling,” which states an interest in “technologies to improve predictivity in toxicology testing to support […]
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