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Author Archive for: "Catherine Sprankle"
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Data Available for Project on Predictive Models for Acute Oral Toxicity

NICEATM invites participation in a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies. Data to train models for this project are now available on the NICEATM website. ICCVAM agencies identified multiple endpoints of interest for this project, including identification of “very toxic” […]
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NIEHS Webinar Series on Adverse Outcome Pathways Continues November 29

The Superfund Research Program of the National Institute of Environmental Health Sciences (NIEHS) is presenting a webinar series on adverse outcome pathways (AOPs), structured ways to represent biological events leading to adverse health effects. The second webinar in the series will be presented November 29. Presenters will discuss the development of AOPs and how they […]
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FDA Requests Comments on Draft Guidance for Reproductive Toxicity Testing

The U.S. Food and Drug Administration (FDA) has requested comment on draft guidance ICH S5(R3), “Detection of Toxicity to Reproduction for Human Pharmaceuticals.” This document clarifies the qualification and potential use of alternative assays to assess reproductive risk and includes a list of compounds suggested for qualification of assays. FDA recognizes that this list is […]
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ICATM Position Paper on Skin Sensitization Available

A position paper by representatives of the International Cooperation on Alternative Test Methods (ICATM) proposes practical ways to further promote the regulatory use and facilitate adoption of non-animal defined approaches for skin sensitization assessments. The paper, published online November 10 by Archives of Toxicology, is a work product of the October 2016 workshop, International Regulatory […]
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ICCVAM Initiates Project on Predictive Models for Acute Oral Toxicity

The ICCVAM Acute Toxicity Workgroup is initiating a global project to develop in silico models of acute oral systemic toxicity that predict specific endpoints needed by regulatory agencies. These endpoints include identification of “very toxic” chemicals (LD50 less than 50 mg/kg) and “nontoxic” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for […]
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Presentations and Videocast of SACATM Meeting Available

Presentations from the September 18-19 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) are available on the NTP website. Video recordings of the meeting are also available on the National Institutes of Health Videocast website. View recording of the September 18 session View recording of the September 19 session SACATM meets annually […]
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NIEHS Offers Grants for Development of Culture Models

The National Institute of Environmental Health Sciences (NIEHS) is providing grants for development of novel in vitro systems using cells from experimental animal models typically used for toxicology testing. The intent is that these systems will replicate biological responses within the corresponding animal tissues or organs. When developed and validated, these systems will provide information […]
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New Review Describes Use of AOPs in EPA Screening Program

A review in the September issue of the journal Environmental Health Perspectives describes how the U.S. Environmental Protection Agency (EPA) uses adverse outcome pathway (AOP) and toxicity pathway frameworks in its Endocrine Disruptor Screening Program. The review describes how these frameworks help to establish biologically plausible links between endocrine mechanisms and apical responses when those […]
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SACATM Meeting September 18-19

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 18-19 at the Natcher Conference Center, National Institutes of Health (NIH), Bethesda, Maryland. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences (NIEHS) regarding statutorily mandated duties of ICCVAM and activities of NICEATM. The […]
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NICEATM and ICCVAM Activities at World Congress

NICEATM and ICCVAM scientists will be active participants at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences, which runs August 20-24 in Seattle, Washington. ICCVAM members will co-chair four presentation sessions and participate on roundtable panels on regulatory issues and big data. NICEATM and ICCVAM scientists will also share their […]
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Slides Available from BioMed21 Workshop

Presenters’ slides from the June 26-27 workshop “BioMed21 – A Human Pathway-based Approach to Disease and Medicine” are now available. The presentations from government, academic, and industry scientists addressed how to implement a human systems-biology platform for understanding disease and improving interventions. The workshop was co-organized by NICEATM and the Human Toxicology Project Consortium. In […]
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NIEHS Small Business Phase II Grants for Alternative Methods Development

The National Institute of Environmental Health Sciences is funding grants to U.S. small businesses for development of medium- to high-throughput assays. Assays developed under these grants should evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. The ability to incorporate genetic diversity […]
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Postdoctoral Fellow Opportunity in Computational Toxicology at NIEHS

A computational toxicology postdoctoral fellowship is available at the National Institute of Environmental Health Sciences (NIEHS). The successful candidate will develop and apply computational methods, tools, and applications across projects in the areas of computational toxicology, bioinformatics, and computational biology. Candidates should have a Ph.D. in computational biology, computer science, biomedical engineering, bioinformatics, or a […]
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NICEATM Research Featured in Special Issue of Reproductive Toxicology

NICEATM Deputy Director Nicole Kleinstreuer is a coauthor of three articles in a special issue of Reproductive Toxicology that focuses on developmental angiogenesis. The three articles coauthored by Kleinstreuer describe projects conducted with the U.S. Environmental Protection Agency and other collaborators that use high throughput screening assays to identify and characterize potential vascular disrupting chemicals. […]
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Registration Extended for BioMed21 Workshop on Human Disease Pathways

Registration has been extended for the June 26-27 workshop “BioMed21: A Human Pathways Approach to Disease Research.” The workshop will explore existing systems biology projects and approaches, and consider how these projects might be better coordinated to optimally improve disease understanding and interventions. Speakers include scientists from the U.S. Food and Drug Administration, National Institutes […]
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EPA Announces Meetings, Requests Nominations of Panel Members

The Environmental Protection Agency will hold two meetings of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) in the coming months. Both meetings will be held at EPA in Arlington, Virginia. The FIFRA SAP provides scientific advice, information, and recommendations to the EPA Administrator on pesticides and pesticide-related issues impacting health […]
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Slides and Video Available from ICCVAM Public Forum

Presenters’ slides and the webcast recording of the May 23 ICCVAM public forum are available. Presentations at this year’s public forum included updates from eight ICCVAM member agencies, as well as summaries of ICCVAM’s interactions with several international organizations. NICEATM Director Warren Casey presented a plan for the development of a U.S. strategic roadmap to […]
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June Workshop to Focus on Human Disease Pathways

A June 26-27 workshop at the National Institutes of Health in Bethesda, Maryland, will focus on human pathway-based approaches to disease and medicine. The “BioMed21” workshop will explore existing systems biology projects and approaches, and consider how these projects might be better coordinated to optimally improve disease understanding and interventions. The workshop is being organized […]
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NICEATM Deputy Director, Collaborators Comment on Progress Toward Animal Replacement

NICEATM Deputy Director Nicole Kleinstreuer and a number of NICEATM collaborators in academia, industry, and animal welfare organizations commented on progress toward replacing animals for chemical safety testing in the April 24 issue of Chemical and Engineering News. The article “Big Data, Big Deadlines Spur Change in Toxicity Testing” is available on the C&E News […]
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Registration Open for May 23 ICCVAM Public Forum

Registration is open to attend the ICCVAM Public Forum on May 23 at the National Institutes of Health in Bethesda, Maryland. ICCVAM holds annual public forums to share information and facilitate direct communication of ideas and suggestions from stakeholders. ICCVAM agencies will give presentation on their activities relevant to the ICCVAM mission. This year’s forum […]
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NICEATM and ICCVAM Activities at SOT

A new page on the NICEATM website summarizes NICEATM and ICCVAM activities at the upcoming meeting of the Society of Toxicology. NICEATM and ICCVAM will be participating in two exhibitor-hosted sessions. “Developing an Implementation Strategy for Toxicity Testing in the 21st Century” will be Monday, March 13, at 12 noon in CC Room 340. This […]
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New Agency Joins ICCVAM

The National Institute of Standards and Technology has joined the Interagency Coordinating Committee on the Validation of Alternative Methods. NIST participation will provide ICCVAM with interest and experience in the study of process controls, measurement artifacts, and interlaboratory testing. ICCVAM was established to facilitate and promote development and regulatory acceptance of new toxicological tests with […]
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NICEATM Webinar Series on Zebrafish Screening Begins Thursday

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins this Thursday, February 2, at 11:30 a.m. with “Introduction to Zebrafish Screening.” This webinar will provide an overview of the NTP’s Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) program and review the variability […]
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ICCVAM Communities of Practice Webinar January 24

The third ICCVAM Communities of Practice webinar will be presented January 24 on the topic “Incorporating Chemical Information: Resources, Limitations, and Characterizing the Domain of Applicability for 21st Century Toxicity Testing.” This webinar is being organized on behalf of ICCVAM by NICEATM and hosted by the U.S. Environmental Protection Agency’s National Center for Computational Toxicology. […]
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NICEATM to Present Webinar Series on Zebrafish Screening

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins on February 2. This three-part webinar series will consider the issues of protocol variability in zebrafish screening studies and how some of these issues might be addressed by implementation of standardized nomenclature systems. The webinars are […]
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NTP Level of Concern Study Phase 2 Recruitment

The National Toxicology Program uses Level of Concern categories to communicate its opinion about whether an environmental substance might cause adverse effects in humans. This study aims to update the Level of Concern categories to better inform and protect public health. If you are a public health professional who is familiar with toxicological risk communication […]
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NICEATM-EPA AR Pathway Article Named Editors’ Choice

NICEATM Deputy Director Nicole Kleinstreuer is the lead author on a paper describing an androgen receptor pathway model that incorporates 11 high throughput screening assays. “Development and Validation of a Computational Model for Androgen Receptor Activity,” which was published online on November 18 in Chemical Research in Toxicology, has been selected as an ACS Editor’s […]
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NLM Requests Stakeholder Input for Strategic Plan

In a November 8 Request for Information, the National Library of Medicine announced that it is soliciting stakeholder input as part of its ongoing strategic planning process. The RFI and NLM’s planning process are organized around the role of NLM in these four areas: Advancing data science, open science, and biomedical informatics Advancing biomedical discovery […]
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Kleinstreuer Receives Lush Cosmetics’ Young Researcher Prize

In a November 2 ceremony, NICEATM Deputy Director Nicole Kleinstreuer received the Lush Cosmetics’ Young Researcher Prize recognizing efforts to eliminate animal use for chemical safety testing. Five researchers in the Americas received the honors presented at Lush Cosmetics headquarters in Vancouver. Kleinstreuer is the first U.S. federal government employee to receive a Lush Prize. […]
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NICEATM Requests Data on Zebrafish Embryo Chemical Screening

NICEATM requests available data and information on zebrafish embryo screening tests and protocol design, including pharmacokinetics measurements. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce developmental effects in offspring. Respondents to this data request […]
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Resources From the National Library of Medicine: ToxTutor and ALTBIB

The National Library of Medicine has updated its online ToxTutor course. ToxTutor is a self-paced tutorial for users of NLM chemical and toxicology databases that covers the key principles of toxicology. The ToxTutor update incorporates recent advances in the science of toxicology, provides more information on alternatives to animal testing, and features responsive design to […]
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NTP Requests Data on Alternative Methods to Assess Inflammation or Exaggerated Immune Responses

The National Toxicology Program at the National Institute of Environmental Health Sciences requests available data and information on approaches and/or technologies currently used to identify substances with the potential to cause excessive inflammation or exaggerated immune responses leading to tissue injury when swallowed, inhaled, or absorbed through the skin. Submitted information will be used to […]
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NICEATM and PISC Convene Meeting on Inhalation Alternatives

NICEATM and the PETA International Science Consortium (PISC) organized an expert meeting on “Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-regulatory Data Requirements.” Participants in the meeting, held September 22-23, 2016, in Bethesda, MD, identified four key activities needed to reduce and replace animal use for required inhalation toxicity testing: […]
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Raymond Tice Honored by ARDF

Raymond Tice, former NICEATM Deputy Director and National Toxicology Program (NTP) Biomolecular Screening Branch chief, received the William and Eleanor Cave Award from the Alternatives Research and Development Foundation (ARDF). The William and Eleanor Cave Award is given to recognize contributions to advancing alternatives to the use of animals in testing, research, or education. The […]
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ICCVAM Advisory Committee Discusses Roadmap for Replacing Six Acute Toxicity Tests

The Scientific Advisory Committee for Alternative Toxicological Methods, which advises NICEATM and ICCVAM, met at the National Institute of Environmental Health Sciences in Research Triangle Park, NC, on September 27. ICCVAM agencies outlined a roadmap for the replacement of animals for the six most commonly used acute toxicity tests: ocular and dermal irritation; dermal sensitization; […]
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NICEATM Director Participates in Congressional Briefing

Catherine Sprankle, NICEATM NICEATM Director Warren Casey was a panelist for a September 13 Congressional briefing on “Alternatives to Animal Testing: Emerging Uses and Policy Implications.” Casey and other panelists discussed how to use non-animal and alternative toxicology and safety testing methods to better protect consumers and public health while using fewer animals. Topics considered […]
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Computational Biology Symposium at NIH September 16

Catherine Sprankle, NICEATM PLoS Computational Biology is presenting a Computational Biology Symposium on the National Institutes of Health campus on Friday, September 16, from 9:30 a.m.-4:00 p.m. Keynote speakers will include Dr. David J. Lipman of the National Center for Biotechnology Information, Dr. Jennifer Lippincott-Schwartz of the Eunice Kennedy Shriver National Institute of Child Health […]
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FDA Seeks Comment on Draft Guidance for Toxicokinetics Studies

Catherine Sprankle, NICEATM A U.S. Food and Drug Administration (FDA) notice in the September 8 Federal Register requested comments on draft guidance titled “ICH S3A Guidance: Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies—Questions and Answers.” The draft guidance facilitates interpretation of the ‘‘S3A Guidance: The Assessment of Systemic Exposure […]
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NICEATM Workshop Report Recognized as an NIEHS Paper of the Month

Catherine Sprankle, NICEATM The September issue of the Environmental Factor, the newsletter of the National Institute of Environmental Health Sciences (NIEHS), recognized the report on the Collaborative Workshop on Aquatic Models and 21st Century Toxicology as an NIEHS Intramural Paper of the Month. The workshop, organized by NICEATM and North Carolina State University, reviewed emerging […]
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U.S. Strategy and Roadmap for Implementing 21st Century Toxicity Testing Approaches

Catherine Sprankle, NICEATM The focus of the September 27 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will be topics related to the development of a U.S. strategy and roadmap for implementing 21st century toxicity testing approaches. Background material and specific questions to be discussed by SACATM are included in an “In […]
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Funding Opportunity for Alternative Methods Development

Catherine Sprankle, NICEATM The National Toxicology Program Interagency Center for the Evaluation of Alternative Methods (NICEATM) encourages U.S. small businesses involved in alternative methods development to apply for Small Business Innovation Research (SBIR) Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing offered by the National Institute of […]
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Chips in Space: Webinar September 6

Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the Center for the Advancement of Science in Space are promoting a new program for research on the International Space Station United States National Laboratory (ISS-NL): we’re sending tissue chips to space! This program will leverage recent advances in tissue engineering and microfabrication […]
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ICCVAM 2014-2015 Biennial Progress Report Now Available

Catherine Sprankle, NICEATM The ICCVAM 2014-2015 Biennial Progress Report is now available on the National Toxicology Program website. This report, prepared in accordance with requirements of the ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3), describes ICCVAM and ICCVAM agency activities from January 2014 through December 2015. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized […]
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Webinar Series on Inhalation Toxicity Concludes September 8

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The last webinar in the series will be Thursday, September 8, from 11:00 a.m. to 12:30 p.m. EDT. Dan Huh, Ph.D., University of Pennsylvania, […]
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