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Author Archive for: "Catherine Sprankle"
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FIFRA Advisory Panel to Meet in December, Nominations Requested

The scientific advisory panel for the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA SAP) will meet December 4-7 at the U.S. Environmental Protection Agency (EPA) in Arlington, VA. The FIFRA SAP provides independent scientific advice, recommendations, and information to the EPA Administrator relating to the impact of pesticide regulatory actions on human health and the […]
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EPA Announces Funding Opportunity to Support Alternative Methods Development

EPA is funding research to promote the development and use of alternative test methods and strategies that reduce, refine, or replace vertebrate animal testing. Pertinent research includes approaches such as analog/read-across techniques, mathematical models, and tiered-testing approaches that integrate evidence from multiple sources to help accomplish these goals. Research activities should advance the science underpinning […]
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Article Describes New Marker for Androgen Activity

An article published online July 31 in Toxicological Sciences describes the development and validation of a novel gene expression biomarker to identify AR-modulating chemicals using a pattern-matching method. This collaboration between the U.S. Environmental Protection Agency and NICEATM demonstrates how high-throughput transcriptomic approaches can be used to identify molecular targets for environmental chemicals and provide […]
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ICCVAM Publishes 2016-2017 Biennial Report

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has published its 2016-2017 Biennial Report. The report highlights member agency activities supporting toxicology innovation, as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of in vitro methods. Key ICCVAM, […]
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Funding Available for Tissue Chip Models

The National Center for Advancing Translational Sciences (NCATS) has issued funding opportunities to support development of tissue chip technologies. The National Institutes of Health and Centers for Disease Control are offering support to develop technologies and methodologies in the biomedical and behavioral sciences with potential to succeed as commercial products. As part of this opportunity, […]
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FDA Webinar on In Silico Medicine August 9

The U.S. Food and Drug Administration (FDA) will present a webinar on “What We’re Doing to Advance In Silico Medicine at FDA.” Tina Morrison, Ph.D., chair of FDA’s Modeling and Simulation Working Group and Regulatory Advisor of Computational Modeling for FDA’s Office of Device Evaluation will give an overview of in silico modeling and simulation […]
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NICEATM/EPA Project Receives EPA Award

The U.S. Environmental Protection Agency (EPA) annually recognizes outstanding scientific work of its employees with the Scientific Technological Achievement Awards (STAA). An EPA collaboration with NICEATM, “Using Novel Zebrafish Toxicity Assays to Evaluate a Predictive Model of Development Vascular Toxicity,” has received a Level III STAA, for projects accomplishing an unusually notable research or technological […]
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Small Business Funding Available for Assessing Nanomaterials Toxicity

The National Institute of Environmental Health Sciences (NIEHS) has issued a funding opportunity to support development of technologies to assess exposure of engineered nanomaterials and characterize their effects on biological systems. In particular, this funding opportunity supports development of mid- to high-throughput assays or high-content assays for characterizing the effects of specific nanomaterials on biological […]
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FDA Workshop on Dermal Safety Testing September 10

The U.S. Food and Drug Administration (FDA) is hosting a workshop on human dermal safety testing for topical drug products. Workshop participants will review current approaches to the collection of human data during clinical development of topical drug products. The workshop will also address the impact of human skin toxicity studies on drug labeling and […]
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Biologist/Toxicologist Positions Open at EPA Office of Pesticide Programs

The U.S. Environmental Protection Agency has several biologist/toxicologist positions open in the Health Effects Division and the Antimicrobials Division within the Office of Pesticide Programs. The announcement at https://www.usajobs.gov/GetJob/ViewDetails/504164300 describes a one-year developmental program which may lead to a permanent appointment. Candidates should have received bachelor’s, master’s, or doctorate degrees in biology, toxicology, or related […]
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EPA Releases Strategic Plan to Promote Alternative Methods

The U.S. Environmental Protection Agency (EPA) has published its Strategic Plan to Promote the Development and Implementation of Alternative Test Methods Within the TSCA Program. The document describes how EPA will promote development and implementation of methods and strategies that reduce, refine, or replace vertebrate animal testing to provide chemical safety information required under the […]
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Physical Scientist Opportunity at Department of Defense

The Defense Threat Reduction Agency in the Department of Defense is seeking a Physical Scientist to plan, implement, and evaluate research and development programs in drug discovery, development, and safety. Applicants must be U.S. citizens and should have (1) experience in drug discovery and development research and (2) relevant knowledge in the areas of chemistry, […]
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Translations of U.S. Strategic Roadmap Available

The Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States has been translated into Chinese, Japanese, Korean, and Portuguese. The translated documents are available on request from NICEATM. For further information, contact NICEATM at niceatm@niehs.nih.gov.
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EPA Biologist/Toxicologist Positions Available, Deadlines Next Week

The U.S. Environmental Protection Agency (EPA) has Biologist/Toxicologist positions open in the Risk Assessment Division of the Office of Pollution Prevention and Toxics within the Office of Chemical Safety and Pollution Prevention. Multiple positions are available for each of the following opportunities: The announcement at https://www.usajobs.gov/GetJob/ViewDetails/502951800 describes a one-year developmental program which may lead to […]
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Agenda and Registration Available for Workshop on Rabies Vaccine Testing

A preliminary agenda and registration are available for a workshop on Implementing Non-animal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond. The workshop will be held October 16-17 at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International […]
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Report Available from BioMed21 Workshop

The June 2017 BioMed21 workshop, co-organized by NICEATM and the Human Toxicology Project Consortium, examined actions needed to implement a human systems-biology approach to understanding disease and improving interventions. The report from the workshop has been published in the journal Drug Discovery Today.
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NICEATM Requests Information on Technologies for Detection and Measurement of Botulinum Neurotoxin

NICEATM requests available data and information on approaches and/or technologies currently used for detection and measurement of botulinum neurotoxin (BoNT). Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to detect the presence of BoNT and measure potency of BoNT preparations. Respondents to […]
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FDA Final Guidance on Toxicokinetics Studies Available

In a May 10 Federal Register notice, the U.S. Food and Drug Administration (FDA) announced availability of final guidance on the benefits and limitations of the use of microsampling techniques in toxicokinetics studies. Benefits of these techniques include reducing the numbers of animals needed for these studies. View all FDA guidance documents
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Workshop on Pyrogen Testing Methods September 18-19

NICEATM is co-organizing a workshop on September 18-19 with the PETA International Science Consortium to discuss non-animal approaches for pyrogen testing. The workshop will be held at NIH in Bethesda, Maryland, and will focus on the use of the monocyte activation test (MAT) as a standalone release test for medical devices. Registration and materials will […]
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NICEATM Requests Information on Technologies for Identifying Developmental Toxicants

NICEATM requests available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce adverse effects in offspring. Respondents to this request should […]
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Comments on EPA Draft Strategy Due May 11

Comments on a U.S. Environmental Protection Agency (EPA) draft strategy to reduce use of vertebrate animals in chemical testing are due Friday, May 11. The draft strategy and related documents are available at https://www.regulations.gov/ under docket EPA-HQ-OPPT-2017-0559. Comments received will be considered in the Agency’s development of the final strategy. The Frank R. Lautenberg Chemical […]
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NIEHS Webinars to Discuss New Approaches and Methodologies for Chemical Safety Evaluation

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program is hosting a webinar series highlighting research that may be useful as new approaches and methodologies for toxicity testing. This series coincides with recent initiatives found in the EPA draft strategic plan discussed above and the Strategic Roadmap for Establishing New Approaches to Evaluate […]
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EPA Releases ToxCast Owner’s Manual

The U.S. Environmental Protection Agency (EPA) recently released its ToxCast Owner’s Manual. Since its launch in 2007, EPA’s Toxicity Forecaster (ToxCast) high throughput screening program has generated data for approximately 1,800 chemicals for more than 700 assay endpoints, making ToxCast a major contributor to the federal Tox21 collaboration. All ToxCast data is publicly available. The […]
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Registration Open for ICCVAM Public Forum

Registration is open for ICCVAM’s May 24 Public Forum. The meeting will be held from 9:00 a.m. to 4:00 p.m. at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. The meeting will also be webcast. Information about the meeting is available on the NICEATM website. ICCVAM holds annual public forums to share information […]
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Integrated Chemical Environment Adds Formulations Viewer

A recent update to the NICEATM Integrated Chemical Environment (ICE) added a formulations viewer that allows users to explore toxicity data on formulations and their active ingredients. ICE currently includes data for about 700 formulations from six-pack studies for pesticide registration: acute oral, dermal, and inhalation toxicity; skin sensitization; and skin and eye irritation. Active […]
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NIH Requests Comments on Draft Strategic Plan for Data Science

To capitalize on the opportunities presented by advances in data science, the National Institutes of Health (NIH) is developing a Strategic Plan for Data Science. This plan describes NIH’s overarching goals, strategic objectives, and implementation tactics for promoting the modernization of the NIH-funded biomedical data science ecosystem. NIH published a Request for Information that seeks […]
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Next Deadline for Small Business Grants April 5

The National Institute of Environmental Health Sciences offers funding for small businesses developing technologies of interest to the Tox21 program. These technologies include improved or expanded testing methods for toxicity screening, computational approaches for predictive toxicology, and other technologies such as alternative or improved methods for fixing and preserving tissues. The funding is offered as […]
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Papers Published Describing Analysis of Defined Approaches to Skin Sensitization

A collaboration between NICEATM and Cosmetics Europe has produced two papers describing important resources for non-animal approaches to identifying potential skin sensitizers. The first paper describes a database that includes data from human, animal, and five non-animal tests for 128 chemicals. The chemicals in the database represent a wide variety of chemistries and use categories. […]
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NICEATM and ICCVAM Activities at SOT

Consider adding these sessions to your Society of Toxicology annual meeting itinerary: In Vitro Toxicology Lecture and Luncheon: Monday, March 12, 11:30 a.m.-1:00 p.m., Hemisfair Ballroom C1 “More than Skin Deep: When Alternative Approaches Outperform Animal Tests,” NICEATM Deputy Director Nicole Kleinstreuer U.S. EPA’s Toxic Substances Control Act: Strategy for Alternative Test Methods to Reduce […]
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Internship Opportunities with the U.S. Air Force

The U.S. Air Force School of Aerospace Medicine is accepting applications for its High Performance Computing Internship Program. Interns are being recruited to work on four projects: High-performance computing of quantitative structure activity relationship models applied to toxicology and adverse outcome cellular pathway analysis Application of machine learning and image analytics methods to improve assessment […]
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ICCVAM Elects Co-chairs

At its January 24 meeting, ICCVAM elected Anna Lowit, U.S. Environmental Protection Agency (EPA), and Emily Reinke, Department of Defense, to serve two-year terms as co-chairs of ICCVAM. Lowit is a senior science advisor in the EPA Office of Pesticide Programs. She has been a member of ICCVAM since 2011 and has served as an […]
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U.S. Strategic Roadmap Published

ICCVAM has coordinated the development of “A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States.” It describes a framework for safety testing that will provide more human-relevant toxicology data while reducing the use of animals. Prepared with support from NICEATM, it was published January […]
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USDA Issues Updated Guidance on Vaccine Testing Exemptions

The U.S. Department of Agriculture (USDA) Center for Veterinary Biologics recently added Veterinary Services (VS) Memorandum 800.116 Target Animal Safety Testing Exemption to its website. View all VS Memoranda VS Memorandum No. 800.116, signed in August 2017, replaces an earlier version issued in July 2013. The memorandum provides guidance to licensed firms on requesting an […]
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ICCVAM Communities of Practice Webinar January 23

The fourth ICCVAM Communities of Practice webinar will be presented January 23, 2018, on the topic “Machine Learning in Toxicology: Fundamentals of Application and Interpretation.” NICEATM is organizing this webinar on behalf of ICCVAM. This webinar will explore the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that […]
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Grants Offer Support for Tissue Chip Development

The National Institutes of Health (NIH) has announced several funding opportunities for research and development of microphysiological systems (MPS; “tissue chips”) for studying human physiology and assessing toxicity and safety of new drugs and other substances. All of these funding opportunities are open to U.S.-based for-profit, non-profit, academic, and government institutions. NIH is offering 1-2 […]
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USDA Releases Guidance Documents on Animal Health

The U.S. Department of Agriculture (USDA) administers the Animal Welfare Act, which sets standards for the humane care and treatment of animals used in research. USDA Animal Care has developed two Tech Notes for Animal Welfare Act licensees and registrants to help improve adherence to animal welfare standards. “Incentives for Identifying, Reporting, Correcting, and Preventing […]
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EPA Requests Nominees for Scientific Advisory Panel

EPA is seeking nominations of ad hoc members for its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP). The FIFRA SAP will meet in 2018 to consider physiologically based pharmaokinetic models to address species differences in pharmacokinetics for pesticide active ingredients. The request for nominees was published in a December 18 Federal […]
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IVIVE Workshop Report Available

A manuscript summarizing a February 2016 workshop, In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, and a preceding webinar series was published online December 5 by the journal Toxicology In Vitro. The manuscript is available on the journal’s website. The workshop report discusses activities and resources that promote inclusion of […]
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