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NICEATM Requests Information on Technologies for Detection and Measurement of Botulinum Neurotoxin

NICEATM requests available data and information on approaches and/or technologies currently used for detection and measurement of botulinum neurotoxin (BoNT). Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to detect the presence of BoNT and measure potency of BoNT preparations. Respondents to […]
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FDA Final Guidance on Toxicokinetics Studies Available

In a May 10 Federal Register notice, the U.S. Food and Drug Administration (FDA) announced availability of final guidance on the benefits and limitations of the use of microsampling techniques in toxicokinetics studies. Benefits of these techniques include reducing the numbers of animals needed for these studies. View all FDA guidance documents
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Workshop on Pyrogen Testing Methods September 18-19

NICEATM is co-organizing a workshop on September 18-19 with the PETA International Science Consortium to discuss non-animal approaches for pyrogen testing. The workshop will be held at NIH in Bethesda, Maryland, and will focus on the use of the monocyte activation test (MAT) as a standalone release test for medical devices. Registration and materials will […]
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NICEATM Requests Information on Technologies for Identifying Developmental Toxicants

NICEATM requests available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce adverse effects in offspring. Respondents to this request should […]
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Comments on EPA Draft Strategy Due May 11

Comments on a U.S. Environmental Protection Agency (EPA) draft strategy to reduce use of vertebrate animals in chemical testing are due Friday, May 11. The draft strategy and related documents are available at https://www.regulations.gov/ under docket EPA-HQ-OPPT-2017-0559. Comments received will be considered in the Agency’s development of the final strategy. The Frank R. Lautenberg Chemical […]
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NIEHS Webinars to Discuss New Approaches and Methodologies for Chemical Safety Evaluation

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program is hosting a webinar series highlighting research that may be useful as new approaches and methodologies for toxicity testing. This series coincides with recent initiatives found in the EPA draft strategic plan discussed above and the Strategic Roadmap for Establishing New Approaches to Evaluate […]
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EPA Releases ToxCast Owner’s Manual

The U.S. Environmental Protection Agency (EPA) recently released its ToxCast Owner’s Manual. Since its launch in 2007, EPA’s Toxicity Forecaster (ToxCast) high throughput screening program has generated data for approximately 1,800 chemicals for more than 700 assay endpoints, making ToxCast a major contributor to the federal Tox21 collaboration. All ToxCast data is publicly available. The […]
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Registration Open for ICCVAM Public Forum

Registration is open for ICCVAM’s May 24 Public Forum. The meeting will be held from 9:00 a.m. to 4:00 p.m. at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. The meeting will also be webcast. Information about the meeting is available on the NICEATM website. ICCVAM holds annual public forums to share information […]
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Integrated Chemical Environment Adds Formulations Viewer

A recent update to the NICEATM Integrated Chemical Environment (ICE) added a formulations viewer that allows users to explore toxicity data on formulations and their active ingredients. ICE currently includes data for about 700 formulations from six-pack studies for pesticide registration: acute oral, dermal, and inhalation toxicity; skin sensitization; and skin and eye irritation. Active […]
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NIH Requests Comments on Draft Strategic Plan for Data Science

To capitalize on the opportunities presented by advances in data science, the National Institutes of Health (NIH) is developing a Strategic Plan for Data Science. This plan describes NIH’s overarching goals, strategic objectives, and implementation tactics for promoting the modernization of the NIH-funded biomedical data science ecosystem. NIH published a Request for Information that seeks […]
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Next Deadline for Small Business Grants April 5

The National Institute of Environmental Health Sciences offers funding for small businesses developing technologies of interest to the Tox21 program. These technologies include improved or expanded testing methods for toxicity screening, computational approaches for predictive toxicology, and other technologies such as alternative or improved methods for fixing and preserving tissues. The funding is offered as […]
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Papers Published Describing Analysis of Defined Approaches to Skin Sensitization

A collaboration between NICEATM and Cosmetics Europe has produced two papers describing important resources for non-animal approaches to identifying potential skin sensitizers. The first paper describes a database that includes data from human, animal, and five non-animal tests for 128 chemicals. The chemicals in the database represent a wide variety of chemistries and use categories. […]
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NICEATM and ICCVAM Activities at SOT

Consider adding these sessions to your Society of Toxicology annual meeting itinerary: In Vitro Toxicology Lecture and Luncheon: Monday, March 12, 11:30 a.m.-1:00 p.m., Hemisfair Ballroom C1 “More than Skin Deep: When Alternative Approaches Outperform Animal Tests,” NICEATM Deputy Director Nicole Kleinstreuer U.S. EPA’s Toxic Substances Control Act: Strategy for Alternative Test Methods to Reduce […]
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Internship Opportunities with the U.S. Air Force

The U.S. Air Force School of Aerospace Medicine is accepting applications for its High Performance Computing Internship Program. Interns are being recruited to work on four projects: High-performance computing of quantitative structure activity relationship models applied to toxicology and adverse outcome cellular pathway analysis Application of machine learning and image analytics methods to improve assessment […]
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ICCVAM Elects Co-chairs

At its January 24 meeting, ICCVAM elected Anna Lowit, U.S. Environmental Protection Agency (EPA), and Emily Reinke, Department of Defense, to serve two-year terms as co-chairs of ICCVAM. Lowit is a senior science advisor in the EPA Office of Pesticide Programs. She has been a member of ICCVAM since 2011 and has served as an […]
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U.S. Strategic Roadmap Published

ICCVAM has coordinated the development of “A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States.” It describes a framework for safety testing that will provide more human-relevant toxicology data while reducing the use of animals. Prepared with support from NICEATM, it was published January […]
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USDA Issues Updated Guidance on Vaccine Testing Exemptions

The U.S. Department of Agriculture (USDA) Center for Veterinary Biologics recently added Veterinary Services (VS) Memorandum 800.116 Target Animal Safety Testing Exemption to its website. View all VS Memoranda VS Memorandum No. 800.116, signed in August 2017, replaces an earlier version issued in July 2013. The memorandum provides guidance to licensed firms on requesting an […]
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ICCVAM Communities of Practice Webinar January 23

The fourth ICCVAM Communities of Practice webinar will be presented January 23, 2018, on the topic “Machine Learning in Toxicology: Fundamentals of Application and Interpretation.” NICEATM is organizing this webinar on behalf of ICCVAM. This webinar will explore the fundamentals of machine learning approaches, including how they work, how they are interpreted, and precautions that […]
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Grants Offer Support for Tissue Chip Development

The National Institutes of Health (NIH) has announced several funding opportunities for research and development of microphysiological systems (MPS; “tissue chips”) for studying human physiology and assessing toxicity and safety of new drugs and other substances. All of these funding opportunities are open to U.S.-based for-profit, non-profit, academic, and government institutions. NIH is offering 1-2 […]
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USDA Releases Guidance Documents on Animal Health

The U.S. Department of Agriculture (USDA) administers the Animal Welfare Act, which sets standards for the humane care and treatment of animals used in research. USDA Animal Care has developed two Tech Notes for Animal Welfare Act licensees and registrants to help improve adherence to animal welfare standards. “Incentives for Identifying, Reporting, Correcting, and Preventing […]
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EPA Requests Nominees for Scientific Advisory Panel

EPA is seeking nominations of ad hoc members for its Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP). The FIFRA SAP will meet in 2018 to consider physiologically based pharmaokinetic models to address species differences in pharmacokinetics for pesticide active ingredients. The request for nominees was published in a December 18 Federal […]
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IVIVE Workshop Report Available

A manuscript summarizing a February 2016 workshop, In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, and a preceding webinar series was published online December 5 by the journal Toxicology In Vitro. The manuscript is available on the journal’s website. The workshop report discusses activities and resources that promote inclusion of […]
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NIDDK Offers Support for Development of Tissue Chips

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is establishing a new research consortium “Microphysiological Systems for Modeling Diabetes.” This consortium will support the development and validation of human tissue chips that closely mimic the normal physiology of key metabolic tissues, including the pancreatic islet, liver, skeletal muscle, and white adipose tissue. […]
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EPA Webinar on Steroidogenesis Assay December 14

The U.S. Environmental Protection Agency (EPA) will present a webinar titled “High-Throughput H295R Steroidogenesis Assay: Utility as an Alternative and a Statistical Approach to Characterize Effects on Steroidogenesis” on Thursday, December 14, from 11:00 a.m.-noon U.S. Eastern Time. The speaker is Dr. Derik Haggard, ORISE Postdoctoral Fellow with the EPA National Center for Computational Toxicology. […]
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Data Available for Project on Predictive Models for Acute Oral Toxicity

NICEATM invites participation in a global project to develop in silico models of acute oral systemic toxicity that predict five specific endpoints needed by regulatory agencies. Data to train models for this project are now available on the NICEATM website. ICCVAM agencies identified multiple endpoints of interest for this project, including identification of “very toxic” […]
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NIEHS Webinar Series on Adverse Outcome Pathways Continues November 29

The Superfund Research Program of the National Institute of Environmental Health Sciences (NIEHS) is presenting a webinar series on adverse outcome pathways (AOPs), structured ways to represent biological events leading to adverse health effects. The second webinar in the series will be presented November 29. Presenters will discuss the development of AOPs and how they […]
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FDA Requests Comments on Draft Guidance for Reproductive Toxicity Testing

The U.S. Food and Drug Administration (FDA) has requested comment on draft guidance ICH S5(R3), “Detection of Toxicity to Reproduction for Human Pharmaceuticals.” This document clarifies the qualification and potential use of alternative assays to assess reproductive risk and includes a list of compounds suggested for qualification of assays. FDA recognizes that this list is […]
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ICATM Position Paper on Skin Sensitization Available

A position paper by representatives of the International Cooperation on Alternative Test Methods (ICATM) proposes practical ways to further promote the regulatory use and facilitate adoption of non-animal defined approaches for skin sensitization assessments. The paper, published online November 10 by Archives of Toxicology, is a work product of the October 2016 workshop, International Regulatory […]
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ICCVAM Initiates Project on Predictive Models for Acute Oral Toxicity

The ICCVAM Acute Toxicity Workgroup is initiating a global project to develop in silico models of acute oral systemic toxicity that predict specific endpoints needed by regulatory agencies. These endpoints include identification of “very toxic” chemicals (LD50 less than 50 mg/kg) and “nontoxic” chemicals (LD50 greater than or equal to 2000 mg/kg), point estimates for […]
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Presentations and Videocast of SACATM Meeting Available

Presentations from the September 18-19 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) are available on the NTP website. Video recordings of the meeting are also available on the National Institutes of Health Videocast website. View recording of the September 18 session View recording of the September 19 session SACATM meets annually […]
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NIEHS Offers Grants for Development of Culture Models

The National Institute of Environmental Health Sciences (NIEHS) is providing grants for development of novel in vitro systems using cells from experimental animal models typically used for toxicology testing. The intent is that these systems will replicate biological responses within the corresponding animal tissues or organs. When developed and validated, these systems will provide information […]
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New Review Describes Use of AOPs in EPA Screening Program

A review in the September issue of the journal Environmental Health Perspectives describes how the U.S. Environmental Protection Agency (EPA) uses adverse outcome pathway (AOP) and toxicity pathway frameworks in its Endocrine Disruptor Screening Program. The review describes how these frameworks help to establish biologically plausible links between endocrine mechanisms and apical responses when those […]
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SACATM Meeting September 18-19

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 18-19 at the Natcher Conference Center, National Institutes of Health (NIH), Bethesda, Maryland. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences (NIEHS) regarding statutorily mandated duties of ICCVAM and activities of NICEATM. The […]
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NICEATM and ICCVAM Activities at World Congress

NICEATM and ICCVAM scientists will be active participants at the Tenth World Congress on Alternatives and Animal Use in the Life Sciences, which runs August 20-24 in Seattle, Washington. ICCVAM members will co-chair four presentation sessions and participate on roundtable panels on regulatory issues and big data. NICEATM and ICCVAM scientists will also share their […]
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Slides Available from BioMed21 Workshop

Presenters’ slides from the June 26-27 workshop “BioMed21 – A Human Pathway-based Approach to Disease and Medicine” are now available. The presentations from government, academic, and industry scientists addressed how to implement a human systems-biology platform for understanding disease and improving interventions. The workshop was co-organized by NICEATM and the Human Toxicology Project Consortium. In […]
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NIEHS Small Business Phase II Grants for Alternative Methods Development

The National Institute of Environmental Health Sciences is funding grants to U.S. small businesses for development of medium- to high-throughput assays. Assays developed under these grants should evaluate the effects of toxicants on pluripotent or induced pluripotent cells with respect to cell differentiation and the resulting differentiated cell populations. The ability to incorporate genetic diversity […]
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