Archives

Author Archive for: "Catherine Sprankle"
Home / Author Archive for: "Catherine Sprankle"

Community Blog

Posted in Community Blog on

Postdoctoral Opportunities Available

The U.S. Food and Drug Administration is accepting applications for postdoctoral fellows to develop human cell- and protein-based assays for assessing cardiotoxicity of new drugs. These projects are part of an initiative to design, build, and test new non-animal approaches to assess cardiotoxicity hazard. The initiative is supported jointly by the National Toxicology Program, (Biomolecular […]
0Read More
Posted in Community Blog on

NICEATM and ICCVAM Activities at SOT

A webpage summarizing activities of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) and the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) at the March 10-14 Society of Toxicology (SOT) annual meeting is now available. Please refer to this page as you plan your SOT itinerary. […]
0Read More
Posted in Community Blog on

April Workshop to Focus on Cancer Pathways; Assay Information Requested

The National Toxicology Program (NTP) announces a workshop titled “Converging on Cancer” scheduled for April 29-30 at the William Jefferson Clinton East Building, U.S. Environmental Protection Agency, Washington, DC. The workshop will address using systems biology and knowledge of cancer pathways to better understand how environmental chemicals lead to cancer. This free meeting is open […]
0Read More
Posted in Community Blog on

ICCVAM Members Recognized by SOT

The Society of Toxicology will present awards to two ICCVAM members at its annual meeting in March. Suzanne Fitzpatrick of the U.S. Food and Drug Administration (FDA) Center for Food Safety and Applied Nutrition (CFSAN) will receive the 2019 SOT Enhancement of Animal Welfare Award. This award recognizes contributions that advance toxicological science through development […]
0Read More
Posted in Community Blog on

Availability of the Collaborative Acute Toxicity Modeling Suite

NICEATM has released the Collaborative Acute Toxicity Modeling Suite (CATMoS), a free resource for screening organic chemicals for acute oral toxicity. CATMoS is implemented in v2.0 of the Open Structure-Activity/Property Relationship App (OPERA), a free and open-source quantitative structure-activity relationship (QSAR) tool. OPERA v2.0 can be downloaded from the NIEHS Github repository. CATMoS is the […]
0Read More
Posted in Community Blog on

EPA Seeks Comments on TSCA Panel Nominees

The U.S. Environmental Protection Agency (EPA) is requesting comment on nominees for ad hoc participation and possible membership on the Toxic Substances Control Act (TSCA) Science Advisory Committee on Chemicals (SACC). SACC nominees are experts in toxicology, environmental risk assessment, exposure assessment, and related fields. Nominees will constitute a pool of experts from which EPA […]
0Read More
Posted in Community Blog on

Positions Open for Researchers to Support the EPA EDSP

The U.S. Environmental Protection Agency (EPA) is seeking candidates for three postgraduate research projects in its Endocrine Disruptor Screening Program (EDSP). These appointments are through the Oak Ridge Institute for Science and Education fellows program, a joint venture between EPA and the U.S. Department of Energy. They are one-year appointments with the opportunity for renewal. […]
0Read More
Posted in Community Blog on

NICEATM Integrated Chemical Environment Updated

Updates to the NICEATM Integrated Chemical Environment (ICE) resource were launched in September and November. Successful computational toxicology projects depend on freely available, high-quality data that are formatted for use in computational workflows. ICE provides data from NICEATM and its partners, as well as other resources and tools in an environment designed to support chemical […]
0Read More
Posted in Community Blog on

NICHD Launches Placental Analysis Tool

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) recently launched the Placental Atlas Tool (PAT). PAT is a free resource incorporating placental data from publications and public databases into a reference tool for studying placental development and function throughout pregnancy. Investigators from all backgrounds can use PAT to generate new […]
0Read More
Posted in Community Blog on

Superfund Research Program Webinar Series Concludes October 1

The Superfund Research Program (SRP) Progress in Research webinar series concludes October 1 with presentations from centers at Boston University, Texas A&M University, and the University of California, Davis. The SRP Centers, funded by the National Institute of Environmental Health Sciences (NIEHS), seek practical scientific solutions to protect health, the environment, and communities from exposure […]
0Read More
Posted in Community Blog on

Postdoctoral Opportunities Available at NTP

The U.S. Food and Drug Administration is accepting applications for postdoctoral fellows to develop human cell- and protein-based assays for assessing cardiotoxicity of new drugs. These projects are part of an initiative to design, build, and test new non-animal approaches to assess cardiotoxicity hazard. The initiative is supported jointly by the National Toxicology Program (Biomolecular […]
0Read More
Posted in Community Blog on

Papers Describe Database and Non-animal Approach to Identifying Androgen-active Chemicals

Two recent papers in Reproductive Toxicology describe data and methods used by U.S. Environmental Protection Agency, Organisation for Economic Co-operation and Development, and NICEATM scientists and collaborators to develop a reference database and evaluate an in vitro model to identify chemicals with the potential to interact with the androgen receptor (AR). The AR model is […]
0Read More
Posted in Community Blog on

Webinars for Rabies Vaccine Workshop Begin September 25

Registration is still open for the October 16-17 workshop, “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” The workshop will be held at the National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International Alliance for Biological Standardization. This workshop will […]
0Read More
Posted in Community Blog on

EPA Requests Nominees for TSCA Advisory Committee

The U.S. Environmental Protection Agency (EPA) requests nominations of scientific experts for ad hoc participation and possible membership on the Toxic Substances Control Act (TSCA) Science Advisory Committee for Chemicals (SACC). The SACC will be conducting peer reviews of EPA’s risk evaluations for the first 10 chemical substance addressed under TSCA. Nominations must be submitted […]
0Read More
Posted in Community Blog on

NICEATM Publication Describes In Vitro to In Vivo Extrapolation Models

An article in Environmental Health Perspectives describes in vitro to in vivo extrapolation models developed by NICEATM. These approaches accurately estimate chemical exposure levels that elicit positive responses in the rodent uterotrophic bioassay. A workflow to run these models is freely available and can be parameterized entirely using freely available in silico tools. Reference: Casey […]
0Read More
Posted in Community Blog on

Kleinstreuer Comments on Pathway-based Approaches to Risk Assessment

A commentary on “Pathway-Based Approaches to Chemical Risk Assessment: A Public Health Perspective” by NICEATM Deputy Director Nicole Kleinstreuer appears in the current issue of Adverse Outcome Pathways News. Adverse Outcome Pathways News is a newsletter published by the United Kingdom’s National Centre for the Replacement Refinement & Reduction of Animals in Research. It is […]
0Read More
Posted in Community Blog on

Update of ToxTutor Available

The National Library of Medicine has updated its online ToxTutor course. ToxTutor is a self-paced tutorial for users of NLM chemical and toxicology databases that covers the key principles of toxicology. The August 2018 release of ToxTutor adds “The Microbiome” as a new topic, expands content on alternatives to animal testing and human-on-a-chip testing approaches, […]
0Read More
Posted in Community Blog on

Poster Abstract Deadline Extended to September 14 for Rabies Vaccine Workshop

The abstract submission deadline has been extended to September 14 for the October 16-17 workshop, “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” The workshop will be held at the National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International Alliance […]
0Read More
Posted in Community Blog on

Registration Open for Rabies Vaccine Workshop; Poster Abstracts Due August 31

Registration is open for the October 16-17 workshop, “Implementing Nonanimal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond.” The workshop will be held at the National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International Alliance for Biological Standardization. This workshop will bring […]
0Read More
Posted in Community Blog on

SACATM Meeting September 5-6, Registration and Agenda Available

The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet September 5-6 in the Rodbell Auditorium, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. SACATM meets annually to advise NICEATM, ICCVAM, and the director of the National Institute of Environmental Health Sciences regarding statutorily mandated duties of ICCVAM and activities of […]
0Read More
Posted in Community Blog on

ICATM Partners to Present Public Update September 6

A public meeting of the International Cooperation on Alternative Test Methods (ICATM) is planned for Thursday, September 6 at 2:00 p.m. following the meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM). Representatives from Brazil, Canada, China, Korea, and the United States will provide an update on 3Rs activities in their respective countries. […]
0Read More
Posted in Community Blog on

FIFRA Advisory Panel to Meet in December, Nominations Requested

The scientific advisory panel for the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA SAP) will meet December 4-7 at the U.S. Environmental Protection Agency (EPA) in Arlington, VA. The FIFRA SAP provides independent scientific advice, recommendations, and information to the EPA Administrator relating to the impact of pesticide regulatory actions on human health and the […]
0Read More
Posted in Community Blog on

EPA Announces Funding Opportunity to Support Alternative Methods Development

EPA is funding research to promote the development and use of alternative test methods and strategies that reduce, refine, or replace vertebrate animal testing. Pertinent research includes approaches such as analog/read-across techniques, mathematical models, and tiered-testing approaches that integrate evidence from multiple sources to help accomplish these goals. Research activities should advance the science underpinning […]
0Read More
Posted in Community Blog on

Article Describes New Marker for Androgen Activity

An article published online July 31 in Toxicological Sciences describes the development and validation of a novel gene expression biomarker to identify AR-modulating chemicals using a pattern-matching method. This collaboration between the U.S. Environmental Protection Agency and NICEATM demonstrates how high-throughput transcriptomic approaches can be used to identify molecular targets for environmental chemicals and provide […]
0Read More
Posted in Community Blog on

ICCVAM Publishes 2016-2017 Biennial Report

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has published its 2016-2017 Biennial Report. The report highlights member agency activities supporting toxicology innovation, as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of in vitro methods. Key ICCVAM, […]
0Read More
Posted in Community Blog on

Funding Available for Tissue Chip Models

The National Center for Advancing Translational Sciences (NCATS) has issued funding opportunities to support development of tissue chip technologies. The National Institutes of Health and Centers for Disease Control are offering support to develop technologies and methodologies in the biomedical and behavioral sciences with potential to succeed as commercial products. As part of this opportunity, […]
0Read More
Posted in Community Blog on

FDA Webinar on In Silico Medicine August 9

The U.S. Food and Drug Administration (FDA) will present a webinar on “What We’re Doing to Advance In Silico Medicine at FDA.” Tina Morrison, Ph.D., chair of FDA’s Modeling and Simulation Working Group and Regulatory Advisor of Computational Modeling for FDA’s Office of Device Evaluation will give an overview of in silico modeling and simulation […]
0Read More
Posted in Community Blog on

NICEATM/EPA Project Receives EPA Award

The U.S. Environmental Protection Agency (EPA) annually recognizes outstanding scientific work of its employees with the Scientific Technological Achievement Awards (STAA). An EPA collaboration with NICEATM, “Using Novel Zebrafish Toxicity Assays to Evaluate a Predictive Model of Development Vascular Toxicity,” has received a Level III STAA, for projects accomplishing an unusually notable research or technological […]
0Read More
Posted in Community Blog on

Small Business Funding Available for Assessing Nanomaterials Toxicity

The National Institute of Environmental Health Sciences (NIEHS) has issued a funding opportunity to support development of technologies to assess exposure of engineered nanomaterials and characterize their effects on biological systems. In particular, this funding opportunity supports development of mid- to high-throughput assays or high-content assays for characterizing the effects of specific nanomaterials on biological […]
0Read More
Posted in Community Blog on

FDA Workshop on Dermal Safety Testing September 10

The U.S. Food and Drug Administration (FDA) is hosting a workshop on human dermal safety testing for topical drug products. Workshop participants will review current approaches to the collection of human data during clinical development of topical drug products. The workshop will also address the impact of human skin toxicity studies on drug labeling and […]
0Read More
Posted in Community Blog on

Biologist/Toxicologist Positions Open at EPA Office of Pesticide Programs

The U.S. Environmental Protection Agency has several biologist/toxicologist positions open in the Health Effects Division and the Antimicrobials Division within the Office of Pesticide Programs. The announcement at https://www.usajobs.gov/GetJob/ViewDetails/504164300 describes a one-year developmental program which may lead to a permanent appointment. Candidates should have received bachelor’s, master’s, or doctorate degrees in biology, toxicology, or related […]
0Read More
Posted in Community Blog on

EPA Releases Strategic Plan to Promote Alternative Methods

The U.S. Environmental Protection Agency (EPA) has published its Strategic Plan to Promote the Development and Implementation of Alternative Test Methods Within the TSCA Program. The document describes how EPA will promote development and implementation of methods and strategies that reduce, refine, or replace vertebrate animal testing to provide chemical safety information required under the […]
0Read More
Posted in Community Blog on

Physical Scientist Opportunity at Department of Defense

The Defense Threat Reduction Agency in the Department of Defense is seeking a Physical Scientist to plan, implement, and evaluate research and development programs in drug discovery, development, and safety. Applicants must be U.S. citizens and should have (1) experience in drug discovery and development research and (2) relevant knowledge in the areas of chemistry, […]
0Read More
Posted in Community Blog on

Translations of U.S. Strategic Roadmap Available

The Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States has been translated into Chinese, Japanese, Korean, and Portuguese. The translated documents are available on request from NICEATM. For further information, contact NICEATM at niceatm@niehs.nih.gov.
0Read More
Posted in Community Blog on

EPA Biologist/Toxicologist Positions Available, Deadlines Next Week

The U.S. Environmental Protection Agency (EPA) has Biologist/Toxicologist positions open in the Risk Assessment Division of the Office of Pollution Prevention and Toxics within the Office of Chemical Safety and Pollution Prevention. Multiple positions are available for each of the following opportunities: The announcement at https://www.usajobs.gov/GetJob/ViewDetails/502951800 describes a one-year developmental program which may lead to […]
0Read More
Posted in Community Blog on

Agenda and Registration Available for Workshop on Rabies Vaccine Testing

A preliminary agenda and registration are available for a workshop on Implementing Non-animal Approaches to Human and Veterinary Vaccine Testing: Achieving Scientific and Regulatory Success for Rabies and Beyond. The workshop will be held October 16-17 at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland. It is co-organized by NICEATM and the International […]
0Read More
Posted in Community Blog on

Report Available from BioMed21 Workshop

The June 2017 BioMed21 workshop, co-organized by NICEATM and the Human Toxicology Project Consortium, examined actions needed to implement a human systems-biology approach to understanding disease and improving interventions. The report from the workshop has been published in the journal Drug Discovery Today.
0Read More
Posted in Community Blog on

NICEATM Requests Information on Technologies for Detection and Measurement of Botulinum Neurotoxin

NICEATM requests available data and information on approaches and/or technologies currently used for detection and measurement of botulinum neurotoxin (BoNT). Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to detect the presence of BoNT and measure potency of BoNT preparations. Respondents to […]
0Read More
page 1 of 4