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NICEATM Deputy Director, Collaborators Comment on Progress Toward Animal Replacement

NICEATM Deputy Director Nicole Kleinstreuer and a number of NICEATM collaborators in academia, industry, and animal welfare organizations commented on progress toward replacing animals for chemical safety testing in the April 24 issue of Chemical and Engineering News. The article “Big Data, Big Deadlines Spur Change in Toxicity Testing” is available on the C&E News […]
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Registration Open for May 23 ICCVAM Public Forum

Registration is open to attend the ICCVAM Public Forum on May 23 at the National Institutes of Health in Bethesda, Maryland. ICCVAM holds annual public forums to share information and facilitate direct communication of ideas and suggestions from stakeholders. ICCVAM agencies will give presentation on their activities relevant to the ICCVAM mission. This year’s forum […]
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NICEATM and ICCVAM Activities at SOT

A new page on the NICEATM website summarizes NICEATM and ICCVAM activities at the upcoming meeting of the Society of Toxicology. NICEATM and ICCVAM will be participating in two exhibitor-hosted sessions. “Developing an Implementation Strategy for Toxicity Testing in the 21st Century” will be Monday, March 13, at 12 noon in CC Room 340. This […]
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New Agency Joins ICCVAM

The National Institute of Standards and Technology has joined the Interagency Coordinating Committee on the Validation of Alternative Methods. NIST participation will provide ICCVAM with interest and experience in the study of process controls, measurement artifacts, and interlaboratory testing. ICCVAM was established to facilitate and promote development and regulatory acceptance of new toxicological tests with […]
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NICEATM Webinar Series on Zebrafish Screening Begins Thursday

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins this Thursday, February 2, at 11:30 a.m. with “Introduction to Zebrafish Screening.” This webinar will provide an overview of the NTP’s Systematic Evaluation of the Application of Zebrafish in Toxicology (SEAZIT) program and review the variability […]
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ICCVAM Communities of Practice Webinar January 24

The third ICCVAM Communities of Practice webinar will be presented January 24 on the topic “Incorporating Chemical Information: Resources, Limitations, and Characterizing the Domain of Applicability for 21st Century Toxicity Testing.” This webinar is being organized on behalf of ICCVAM by NICEATM and hosted by the U.S. Environmental Protection Agency’s National Center for Computational Toxicology. […]
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NICEATM to Present Webinar Series on Zebrafish Screening

A NICEATM webinar series on “Using Informatics to Improve Data Analysis of Chemical Screening Assays Conducted in Zebrafish” begins on February 2. This three-part webinar series will consider the issues of protocol variability in zebrafish screening studies and how some of these issues might be addressed by implementation of standardized nomenclature systems. The webinars are […]
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NTP Level of Concern Study Phase 2 Recruitment

The National Toxicology Program uses Level of Concern categories to communicate its opinion about whether an environmental substance might cause adverse effects in humans. This study aims to update the Level of Concern categories to better inform and protect public health. If you are a public health professional who is familiar with toxicological risk communication […]
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NICEATM-EPA AR Pathway Article Named Editors’ Choice

NICEATM Deputy Director Nicole Kleinstreuer is the lead author on a paper describing an androgen receptor pathway model that incorporates 11 high throughput screening assays. “Development and Validation of a Computational Model for Androgen Receptor Activity,” which was published online on November 18 in Chemical Research in Toxicology, has been selected as an ACS Editor’s […]
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NLM Requests Stakeholder Input for Strategic Plan

In a November 8 Request for Information, the National Library of Medicine announced that it is soliciting stakeholder input as part of its ongoing strategic planning process. The RFI and NLM’s planning process are organized around the role of NLM in these four areas: Advancing data science, open science, and biomedical informatics Advancing biomedical discovery […]
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Kleinstreuer Receives Lush Cosmetics’ Young Researcher Prize

In a November 2 ceremony, NICEATM Deputy Director Nicole Kleinstreuer received the Lush Cosmetics’ Young Researcher Prize recognizing efforts to eliminate animal use for chemical safety testing. Five researchers in the Americas received the honors presented at Lush Cosmetics headquarters in Vancouver. Kleinstreuer is the first U.S. federal government employee to receive a Lush Prize. […]
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NICEATM Requests Data on Zebrafish Embryo Chemical Screening

NICEATM requests available data and information on zebrafish embryo screening tests and protocol design, including pharmacokinetics measurements. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to induce developmental effects in offspring. Respondents to this data request […]
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Resources From the National Library of Medicine: ToxTutor and ALTBIB

The National Library of Medicine has updated its online ToxTutor course. ToxTutor is a self-paced tutorial for users of NLM chemical and toxicology databases that covers the key principles of toxicology. The ToxTutor update incorporates recent advances in the science of toxicology, provides more information on alternatives to animal testing, and features responsive design to […]
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NTP Requests Data on Alternative Methods to Assess Inflammation or Exaggerated Immune Responses

The National Toxicology Program at the National Institute of Environmental Health Sciences requests available data and information on approaches and/or technologies currently used to identify substances with the potential to cause excessive inflammation or exaggerated immune responses leading to tissue injury when swallowed, inhaled, or absorbed through the skin. Submitted information will be used to […]
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NICEATM and PISC Convene Meeting on Inhalation Alternatives

NICEATM and the PETA International Science Consortium (PISC) organized an expert meeting on “Alternative Approaches for Acute Inhalation Toxicity Testing to Address Global Regulatory and Non-regulatory Data Requirements.” Participants in the meeting, held September 22-23, 2016, in Bethesda, MD, identified four key activities needed to reduce and replace animal use for required inhalation toxicity testing: […]
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Raymond Tice Honored by ARDF

Raymond Tice, former NICEATM Deputy Director and National Toxicology Program (NTP) Biomolecular Screening Branch chief, received the William and Eleanor Cave Award from the Alternatives Research and Development Foundation (ARDF). The William and Eleanor Cave Award is given to recognize contributions to advancing alternatives to the use of animals in testing, research, or education. The […]
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ICCVAM Advisory Committee Discusses Roadmap for Replacing Six Acute Toxicity Tests

The Scientific Advisory Committee for Alternative Toxicological Methods, which advises NICEATM and ICCVAM, met at the National Institute of Environmental Health Sciences in Research Triangle Park, NC, on September 27. ICCVAM agencies outlined a roadmap for the replacement of animals for the six most commonly used acute toxicity tests: ocular and dermal irritation; dermal sensitization; […]
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NICEATM Director Participates in Congressional Briefing

Catherine Sprankle, NICEATM NICEATM Director Warren Casey was a panelist for a September 13 Congressional briefing on “Alternatives to Animal Testing: Emerging Uses and Policy Implications.” Casey and other panelists discussed how to use non-animal and alternative toxicology and safety testing methods to better protect consumers and public health while using fewer animals. Topics considered […]
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Computational Biology Symposium at NIH September 16

Catherine Sprankle, NICEATM PLoS Computational Biology is presenting a Computational Biology Symposium on the National Institutes of Health campus on Friday, September 16, from 9:30 a.m.-4:00 p.m. Keynote speakers will include Dr. David J. Lipman of the National Center for Biotechnology Information, Dr. Jennifer Lippincott-Schwartz of the Eunice Kennedy Shriver National Institute of Child Health […]
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FDA Seeks Comment on Draft Guidance for Toxicokinetics Studies

Catherine Sprankle, NICEATM A U.S. Food and Drug Administration (FDA) notice in the September 8 Federal Register requested comments on draft guidance titled “ICH S3A Guidance: Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxicity Studies—Questions and Answers.” The draft guidance facilitates interpretation of the ‘‘S3A Guidance: The Assessment of Systemic Exposure […]
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NICEATM Workshop Report Recognized as an NIEHS Paper of the Month

Catherine Sprankle, NICEATM The September issue of the Environmental Factor, the newsletter of the National Institute of Environmental Health Sciences (NIEHS), recognized the report on the Collaborative Workshop on Aquatic Models and 21st Century Toxicology as an NIEHS Intramural Paper of the Month. The workshop, organized by NICEATM and North Carolina State University, reviewed emerging […]
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U.S. Strategy and Roadmap for Implementing 21st Century Toxicity Testing Approaches

Catherine Sprankle, NICEATM The focus of the September 27 meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will be topics related to the development of a U.S. strategy and roadmap for implementing 21st century toxicity testing approaches. Background material and specific questions to be discussed by SACATM are included in an “In […]
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Funding Opportunity for Alternative Methods Development

Catherine Sprankle, NICEATM The National Toxicology Program Interagency Center for the Evaluation of Alternative Methods (NICEATM) encourages U.S. small businesses involved in alternative methods development to apply for Small Business Innovation Research (SBIR) Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing offered by the National Institute of […]
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Chips in Space: Webinar September 6

Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the Center for the Advancement of Science in Space are promoting a new program for research on the International Space Station United States National Laboratory (ISS-NL): we’re sending tissue chips to space! This program will leverage recent advances in tissue engineering and microfabrication […]
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ICCVAM 2014-2015 Biennial Progress Report Now Available

Catherine Sprankle, NICEATM The ICCVAM 2014-2015 Biennial Progress Report is now available on the National Toxicology Program website. This report, prepared in accordance with requirements of the ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3), describes ICCVAM and ICCVAM agency activities from January 2014 through December 2015. Key ICCVAM, ICCVAM agency, and NICEATM accomplishments summarized […]
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Webinar Series on Inhalation Toxicity Concludes September 8

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The last webinar in the series will be Thursday, September 8, from 11:00 a.m. to 12:30 p.m. EDT. Dan Huh, Ph.D., University of Pennsylvania, […]
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Workshop Report on Carcinogenicity of Mixtures Now Available

Catherine Sprankle, NICEATM An August 2015 workshop sponsored by the National Institute of Environmental Health Sciences evaluated the scientific support for the Low-Dose Mixture Hypothesis of Carcinogenesis and developed a research agenda. A report from this workshop is now available on the Environmental Health Perspectives website. NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., was a breakout […]
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NICEATM Requests Information on Acute Toxicity Testing Technologies

Catherine Sprankle, NICEATM In a July 18 Federal Register notice, NICEATM requested data and information on approaches and technologies currently used to identify substances with the potential to cause acute systemic toxicity when swallowed, inhaled, or absorbed through the skin. Respondents should provide information on any activities relevant to the development or validation of alternatives […]
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NICEATM Requests Data and Information on Developmental Toxicity Test Methods

Catherine Sprankle, NICEATM In a Federal Register notice published today, NICEATM requested available data and information on approaches and/or technologies currently used for identifying potential developmental toxicants. Submitted information will be used to assess the state of the science and determine technical needs for non-animal test methods used to evaluate the potential of chemicals to […]
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Today: EPA Webinar Provides Overview of TSCA Reform

Catherine Sprankle, NICEATM In a webinar today (June 30) at 2:00 p.m. Eastern time, the U.S. Environmental Protection Agency (EPA) will review changes to the newly amended Toxic Substances Control Act (TSCA). The webinar is free and open to the public, and preregistration is not required. View the webinar: Overview of TSCA Reform The Frank […]
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FDA Issues Final Guidance and Presents Webinar on Biological Evaluation of Medical Devices

Catherine Sprankle, NICEATM The U.S. Food and Drug Administration (FDA) has issued a final guidance document on the use of International Standard ISO 10993-1, “Biological Evaluation of Medical Devices – Part 1: Evaluation and Testing Within a Risk Management Process.” FDA developed the guidance document to assist industry in preparing applications and notifications on medical […]
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EPA Releases Training Videos on Data Requirements for Antimicrobials

Catherine Sprankle, NICEATM The U.S. Environmental Protection Agency (EPA) is releasing five training videos providing guidance on EPA’s 40 CFR Part 158W data requirements for antimicrobial pesticides. These training videos will help the public and the pesticide industry better understand the pesticide registration process and make the process more efficient and transparent. The videos include […]
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ICCVAM Public Forum Slides and Webcast Recording Available

Catherine Sprankle, NICEATM Presentation slides and a recording of the webcast of the May 25 ICCVAM public forum are now available on the NICEATM website. At the May 25 meeting at the National Institutes of Health, representatives from 12 ICCVAM member agencies were joined by stakeholder group representatives and over 100 webcast viewers. Agencies presented […]
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Webinar Series on Inhalation Toxicity Continues June 28

Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The next webinar will be Tuesday, June 28, from 11:00 a.m. to noon EDT. Marco Corvaro, Ph.D., Dow AgroSciences, will present on the “GHS […]
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ICCVAM Advisory Committee to Discuss Developing a U.S. National 3Rs Strategy

Contributor: Catherine Sprankle, NICEATM The Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) will meet Sept. 27-28, 2016, at NIEHS in Research Triangle Park, North Carolina. SACATM advises ICCVAM, NICEATM, and the NIEHS director on activities relevant to the ICCVAM mission. The focus of this year’s SACATM meeting will be to discuss and develop recommendations […]
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Register by Friday to Attend ICCVAM Public Forum

Contributor: Catherine Sprankle, NICEATM Friday, May 13, is the in-person registration deadline to attend the ICCVAM public forum. While webcast viewing will be available, those wishing to make a public statement are encouraged to attend in person to enable face-to-face dialog with ICCVAM members. Registration for webcast viewing will be available through the end of […]
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Agenda Available for ICCVAM Public Forum

Contributor: Catherine Sprankle, NICEATM An agenda is available for the May 25 ICCVAM public forum. Representatives from the Environmental Protection Agency, the Food and Drug Administration, the Department of Defense, and other ICCVAM member agencies will present updates on activities related to the development and validation of test methods and approaches that may replace, reduce, […]
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ICCVAM to Hold Public Forum May 25

Contributor: Catherine Sprankle, NICEATM ICCVAM will hold a public forum on Wednesday, May 25, 2016, from 9:00 a.m. to approximately 4:00 p.m. at the National Institutes of Health Natcher Conference Center in Bethesda, Maryland. Representatives of the federal agencies on ICCVAM will be present to hear ideas and suggestions from interested stakeholders and the public. […]
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NCATS and FDA Hold Workshop on Assay Development for High Throughput Screening

Contributor: Catherine Sprankle, NICEATM The National Center for Advancing Translational Sciences (NCATS) and the U.S. Food and Drug Administration (FDA) will hold a workshop on April 5-6, 2016, at the Harvey W. Wiley Federal Building in College Park, Maryland, for scientists involved in assay development for high throughput screening and lead optimization. The goal of […]
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Webinar Series on Inhalation Toxicity Begins March 29

Contributor: Catherine Sprankle, NICEATM NICEATM and the PETA International Science Consortium (PISC) are co-hosting a webinar series on Alternative Approaches for Acute Inhalation Toxicity to Address Global Regulatory and Non-regulatory Data Requirements. The first webinar will be on March 29 from 11:00 a.m. to noon EDT; the topic is “Current Testing Practices: Regulatory Requirements and […]
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NICEATM Deputy Director to Receive Teratology Society Award

Contributor: Catherine Sprankle, NICEATM NICEATM Deputy Director Nicole Kleinstreuer, Ph.D., has been named to receive the 2016 F. Clarke Fraser New Investigator Award from the Teratology Society. This award recognizes an active Teratology Society member that has, within 10 years of completion of training, established a successful independent research career in a field relevant to […]
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NICEATM Director Elected to Lead SOT IVAM Specialty Section

Contributor: Catherine Sprankle, NICEATM NICEATM Director Warren Casey, Ph.D., has been elected Vice President-Elect of the In Vitro and Alternative Methods (IVAM) Specialty Section of the Society of Toxicology (SOT). Casey will serve as Vice President-Elect for 2016-2017 and will then serve subsequent one-year terms as Vice President, President, and Past President of the specialty […]
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Next SBIR/STTR Deadline April 5

Contributor: Catherine Sprankle, NICEATM The next application deadline for Department of Health and Human Services (HHS) Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants is April 5. The SBIR and STTR grant programs are important sources of early-stage capital for innovative small companies in the United States. These programs allow U.S.-owned […]
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IVIVE Workshop: Registration and Abstract Submission Closes February 5

Contributor: Catherine Sprankle, NICEATM Friday, February 5, is the deadline for registration and abstract submissions for the workshop on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making. The workshop, organized by NICEATM and the U.S. Environmental Protection Agency (EPA), will take place Feb. 17-18 at EPA in Research Triangle Park, […]
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NICEATM Scientists Receive NIEHS Merit Award

Contributor: Catherine Sprankle, NICEATM NICEATM Director Warren Casey, Ph.D., and nine current or former members of the ILS NICEATM contract support team have been named to receive a Merit Award from the National Institute of Environmental Health Sciences (NIEHS). The Merit Award is the highest level honor award given by the NIEHS director and recognizes […]
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Deadlines February 5 for IVIVE Workshop

Contributor: Catherine Sprankle, NICEATM Registration and abstract submission for the Feb. 17-18 workshop on In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making is open until February 5. Information about the workshop, which is being organized by NICEATM and EPA, is available on the NICEATM website. Links to webinars that provided […]
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