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Author: Sherry Ward, AltTox

Author: Sherry Ward, AltTox “The Threshold of Toxicological Concern (TTC) is a methodology that may be used to assess potential human health concerns for a chemical based on its chemical characteristics and estimated exposure when chemical-specific toxicity data are scarce or absent. Overall, the TTC approach integrates data on exposure, chemical structure, metabolism, and toxicity […]

Author: Sherry Ward, AltTox Source: http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm438068.htm On April 16, 2015, the U.S. Food and Drug Administration will sponsor a public meeting to discuss the use of in vitro methods as a mechanism for assessing the in vivo product bioequivalence (BE) of non-systemically absorbed (locally acting) drug products intended for use in veterinary species. The meeting […]

Liver models for studying DILI Drug induced liver injury (DILI) is a major health problem in the United States and accounts for the majority of clinical holds and postmarketing use restrictions by the FDA (Olson et al., 2000; Khetani et al., 2008). The current models for liver toxicity testing in preclinical development seem inadequate. Currently, […]

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) “A discussion of the NIH BD2K initiative and how it might advance the practice of Toxicology and Risk Assessment The fields of toxicology, pharmacology and risk assessment are undergoing a revolution in the use of pathway-based approaches to evaluate the biological effects of chemicals. […]

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) (This is an updated version of the feature that appeared in the recent AltTox Digest.) AltTox Management Team and Editorial Board members will be at the Society of Toxicology’s 2015 meeting in San Diego. Here is a partial list of posters, presentations, and workshops […]

Author: Jessica Sandler, PETA International Science Consortium Ltd The PETA International Science Consortium Ltd. (PISC), recently organized an international workshop that was held at the US EPA headquarters in Washington, DC on February 24-25, 2015. The workshop included experts from different sectors and disciplines to discuss the technical details for the development of an in […]

Author: Kristie Sullivan, PCRM The ASCCT is supporting efforts of the Center for Alternatives to Animal Testing (CAAT) at Johns Hopkins University to codify Good Cell Culture Practice (GCCP) for induced pluripotent stem (iPS) cells. With this email, we would like to request nominations (including self) for participation in a 2.5-day workshop to take place […]

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) Abstract submissions are welcome for the oral presentations in the above American Chemical Society (ACS) Division of Chemical Information (CINF) Symposium at the ACS Fall 2015 Meeting in Boston, MA, August 16-20, 2015 (http://www.acs.org/content/acs/en/meetings/boston—fall-2015.html). The session is expected to cover the recent trends in […]

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) Cosmetics Europe is setting up a research consortium to advance non-animal testing and invites “interested parties with a vested interest in research areas covered by the LRSS Research Programme” to join. Following is the full text of the announcement, including deadline and contact information: […]

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The Annual Meeting of the Society of Toxicology is March 22–26 at the San Diego Convention Center in San Diego, California. NICEATM and ICCVAM activities at SOT include: NICEATM Director Dr. Warren Casey will co-chair sessions titled “Applications of ToxCast/Tox21 Data: Confidence and Predictivity” and “Incorporating In Vitro Pharmacokinetic […]

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The National Library of Medicine (NLM) has issued a Request for Information on the current value and future need for NLM programs, resources, research and training efforts, and services such as databases, software and collections. Input is requested from the general public and specifically from stakeholder groups such as […]

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM The U.S. Food and Drug Administration will hold a workshop titled “What is Systematic Review? An Introductory Course” on March 9 at the Center for Food Safety and Applied Nutrition in College Park, Maryland. This workshop will present a framework for systematic review and evidence integration for reaching hazard […]

Author: Catherine Sprankle, ILS/Contractor supporting NICEATM Slides and a video recording are now available from the ICCVAM January 27 Communities of Practice webinar on “Reverse Toxicokinetics: Using In Vitro Data to Estimate Exposures that Could Be Associated with Adverse Effects In Vivo.” Links to both are available at http://ntp.niehs.nih.gov/go/ivive-webinar.

Industry, small and medium-sized enterprises and academia are coming together, through the NC3Rs CRACK IT program, to solve three challenges faced by the pharmaceutical and chemical industries; all of which should reduce the number of animals used in scientific research. Nine research and development consortia have been awarded up to £100,000 each, as part of […]

Author: Marilyn Matevia, The Humane Society of the United States (HSUS) The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report: Toxicity Testing in the 21st Century: A Vision and a Strategy. In addition to proposals for refinement methods, CAAT invites proposals for […]